期刊
FITOTERAPIA
卷 81, 期 5, 页码 343-349出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2009.10.008
关键词
Lippia origanoides; Essential oil; Thymol; Carvacrol; Antigenotoxicity; Bleomycin; SOS chromotest
资金
- Vice-Rectory for Science Research at Universidad Industrial de Santander (UIS) [5154]
- Colombian Institute of Science and Technology, CENIVAM-COLCIENCIAS [RC-432-2004]
The present work evaluated the chemical composition of the essential oils (EO) obtained from Lippia origanoides and their DNA protective effect against bleomycin-induced genotoxicity. L origanoides EO chemical composition was determined by gas chromatography-mass spectrometry (GC-MS). The major compounds of the L origanoides EOs were thymol (34-58%) and carvacrol (26%). The antigenotoxic effects of the EOs, major compounds and standard compound (epigallocatechin gallate) were assayed in co-incubation procedures using the SOS chromotest in Escherichia coli. Both EOs and their major compounds protected bacterial cells against bleomycin-induced genotoxicity indicating that these two compounds were principally responsible for the antigenotoxicity detected in the oils. Thymol and carvacrol antigenotoxicity was lower than those observed with epigallocatechin gallate. The results were discussed in relation to the chemopreventive potential of L. origanoides EOs and their major components, carvacrol and thymol. (C) 2009 Elsevier B.V. All rights reserved.
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