期刊
FITOTERAPIA
卷 81, 期 8, 页码 1079-1087出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.07.002
关键词
American ginseng leaves; PDG; Pancreatic lipase activity; Obese mice; Triglycerides
Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1 mg/ml. It inhibited hydrolysis of about 83.2% of triolein at about 1 mg/ml of PDG. However, PTG showed no inhibitory activity. Therefore, anti-obesity activity of PDG was evaluated in mice fed a high-fat diet. The results demonstrated that PDG was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet. (C) 2010 Elsevier B.V. All rights reserved.
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