期刊
FITOTERAPIA
卷 81, 期 2, 页码 75-80出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2009.08.006
关键词
Quercetin; Collagen; Fibrinogen; Platelet; Spreading; Kinase
资金
- Spanish Ministry of Education [BES-2005-7496]
- FEDER [SAF 2004-07535, SAF 2006-06212]
- Fundacion Seneca [04515/GERM/06]
alpha(2)beta(1) and alpha(IIb)beta(3) integrins, that support platelet adhesion to collagen and fibrinogen, respectively, share common signaling molecules. The effect of quercetin on platelet static adhesion to collagen and fibrinogen was assessed and correlated with its kinase inhibitory activity. Quercetin strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin or the combined use of adenosine diphosphate and thromboxane A(2) inhibitors abrogated platelet spreading on these surfaces to a similar extent. We suggest that the inhibitory effect of quercetin on platelet kinases blocks early signaling events preventing a complete platelet spreading. (C) 2009 Elsevier B.V. All rights reserved.
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