期刊
FITOTERAPIA
卷 81, 期 6, 页码 475-479出版社
ELSEVIER
DOI: 10.1016/j.fitote.2010.01.011
关键词
Dodecadenia grandiflora; Glucose-6-phosphatase; Phenolic glycoside; Coumaroyl
资金
- CSIR, New Delhi, India [NWP 0032]
Phytochemical investigation of Dodecadenia grandiflora leaves led to the isolation and identification of three phenolic glycosides, designated 1-[(4'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol (1), 1-[(6'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol (2) and 1-[O-beta-D-glucopyranosyl(1 -> 2)-beta-D-glucopyranosyl]-oxy-2-phenol (3), along with nine known compounds. Compounds 1, 2, 5 and 9 exhibited significant glucose-6-phosphatase inhibitory activity (63.7, 66.9, 82.9 and 85.4%) with IC50 values of 88.5, 81.0, 51 and 50 mu M respectively. On the basis of biological results, a structure-activity relationship has been discussed. (C) 2010 Elsevier B.V. All rights reserved.
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