期刊
FITOTERAPIA
卷 81, 期 7, 页码 894-896出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.05.019
关键词
Goniothalamus laoticus; Cytotoxicity; 1-azaanthraquinone; Laoticuzanone A
资金
- Graduate School of Chulalongkorn University
- Center for Petroleum, Petrochemical, and Advanced Materials
A new 1-azaanthraquinone, named laoticuzanone A (1), and a synthetically known 3-methyl-1H-1-azaanthracene-2,9,10-trione (2), together with four known compounds, Griffithazanone A (3), methyl sinapate (4), methyl p-coumarate (5), and p-hydroxyphenylethyl p-coumarate (6) were isolated from the stems of Goniothalamus laoticus. Their structures were established on the basis of spectroscopic data as well as comparisons with the previous literature data. Compound 1 showed the highest cytotoxicity against KB and HeLa cells with IC(50) values of 0.68 and 0.50 mu g/ml, respectively. (C) 2010 Elsevier B.V. All rights reserved.
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