Article
Plant Sciences
Moena Tanaka, Takao Koeduka, Kenji Matsui
Summary: Green leaf volatiles (GLVs) are six-carbon volatile aldehydes, alcohols, and esters formed from polyunsaturated fatty acids, involved in plant defense. GLVs are quickly activated in plant tissues by mechanical damage. Monilophytes and lycophytes show substantial GLV-burst ability, while bryophytes have limited capability.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Anna Berim, David R. Gang
Summary: Salicylic acid (SA) is a key plant hormone involved in various physiological processes, with its concentration in plants finely regulated by structural modifications. The lycophyte Selaginella moellendorffii, representing an ancient clade of vascular plants, primarily stores SA and related metabolites as glucosides in its aerial parts. The study highlights the need for further experimental characterization of enzymes in SA metabolism to elucidate physiological functions and mechanisms in ancestral plant species.
Article
Pharmacology & Pharmacy
Bo Wang, Chao Shi, Lei Feng, Wei Pan, Xiang-Ge Tian, Cheng-Peng Sun, Chao Wang, Jing Ning, Xia Lv, Yan Wang, Qian-Hui Yuan, Rui-Xuan Guan, Hou-Li Zhang, Xiao-Chi Ma, Tong-Hui Ma
Summary: This study evaluated the inhibitory effects of nearly hundred kinds of herbal medicines against CYP3A4 enzyme and found that biflavones in Ginkgo biloba and Selaginella tamariscina have strong inhibitory effects on CYP3A4. Additionally, potential pharmacokinetic interactions were identified between these biflavones and clinical drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yapei Zhao, Tian Hu, Ruiqi Liu, Zhiqiang Hao, Guoyan Liang, Guanglin Li
Summary: This study investigated the biochemical functions of SmMTPSLs in Selaginella moellendorffii, identifying their roles in synthesizing monoterpenes and sesquiterpenes, as well as their potential involvement in plant response to stress. Additionally, it demonstrated the antibacterial effects of terpenoids produced by specific SmMTPSLs on Pseudomonas syringae pv. tomato DC3000 and Staphylococcus aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Shijun Yuan, Zihan Li, Wei Huang, Keli Chen, Juan Li
Summary: In this study, it was found that flavonoid glycosides extract, some flavonoid glycosides, and apigenin in Selaginella moellendorffii have estrogenic activity and induce cell proliferation in estrogen receptor-positive cells. The induction of ER alpha expression through MAPK and PI3K/Akt/mTOR pathways might be the possible mechanism underlying the phytoestrogen effect, and flavonoid glycosides could be the critical estrogenic constituents.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mengdie Ren, Sihui Li, Qiong Gao, Lei Qiao, Qianping Cao, Ze Yang, Chaoqiang Chen, Yongmei Jiang, Gang Wang, Shaobin Fu
Summary: Despite efforts to slow down cancer spread, the focus in anti-tumor research has been on developing new drugs with minimal side effects. Natural drugs, particularly those derived from the Selaginella species, have been widely used as anti-tumor agents in clinical practice. Biflavonoids, the active components in Selaginella, have shown promising biological and anti-tumor activities, leading to extensive research. Recent studies reveal the potential of biflavonoids from Selaginella as multi-targeting therapeutic agents in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xueyan Zhang, Yingbo Liu, Guangrui Deng, Bisheng Huang, Guoyin Kai, Keli Chen, Juan Li
Summary: The results showed that the flavonoid extract TF and its main constituent AM alleviate gout arthritis through the suppression of the NLRP3/ASC/Caspase-1 axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Chemical
Jie Lei, Yiming Wang, Weiwei Li, Shaobin Fu, Jinquan Zhou, Demin Lu, Chunhua Wang, Xiaona Sheng, Maosheng Zhang, Shiji Xiao, Chengxin Sun, Gang Wang
Summary: In this study, ultrasound-assisted natural deep eutectic solvents (DES) were used to efficiently and eco-friendly extract total flavonoids (TF) from Selaginella moellendorffii. The optimal DES was choline chloride-lactic acid (ChCl-Lac). Response surface methodology (RSM) was employed to obtain the highest TF content, resulting in an TF content of 5.72 +/- 0.13 mg/g. DESUAE not only saved time but also increased TF content by nearly 2-3 times compared to other extraction methods. Furthermore, the TF extract exhibited potent antioxidant activities and antimicrobial activity against six bacteria, as well as inhibition effects on the growth rate of cancer cells.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yana Y. Toporkova, Elena K. Askarova, Svetlana S. Gorina, Lucia S. Mukhtarova, Alexander N. Grechkin
Summary: This study describes the cloning and catalytic properties of three CYP74L genes in Selaginella moellendorffii, showing that they exhibit different activities towards different types of hydroperoxides. The study also reveals the complex oxylipin patterns in Selaginella moellendorffii.
Article
Food Science & Technology
Na Gyeong Geum, Ho Jun Son, Joo Ho Yeo, Ju Hyeong Yu, Min Yeong Choi, Jae Won Lee, Jueng Kyu Baek, Jin Boo Jeong
Summary: HMR inhibited lipid accumulation in 3T3-L1 cells by suppressing the expression of proteins related to lipid accumulation and inducing proteasomal degradation of CEBP alpha via JNK and GSK3 beta activation.
FOOD SCIENCE & NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Armando A. Roca A. Suarez, Enkhtuul Batbold, Birke Bartosch, Naranjargal Dashdorj, Barbara Testoni, Fabien Zoulim
Summary: Hepatitis delta virus (HDV) is a satellite RNA virus that requires hepatitis B virus (HBV) for replication. Co-infection with HDV/HBV leads to faster disease progression compared to HBV mono-infection. Developing antiviral therapies targeting HDV is crucial. Evaluating promising HDV-specific drugs and combination therapies, as well as exploring anti-HBV drugs with potential effects against HDV, are key areas of research.
LIVER INTERNATIONAL
(2023)
Article
Chemistry, Applied
Li-Fei Liu, Hui-Hui Sun, Jian-Bing Tan, Qi Huang, Fei Cheng, Kang-Ping Xu, Zhen-Xing Zou, Gui-Shan Tan
Summary: Three new biflavones were isolated from Selaginella doederleinii, with Compound 2 showing potent cytotoxic activity against three human cancer cell lines A549, MCF-7, and SMMC-7721, with IC50 values ranging from 6.35 to 10.18 μM.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Yang Xie, Ping-Sheng Xu, Kang-Ping Xu, Zhen-Xing Zou, Gan Zhou, Dai Li, Dan Li, Xiao-Min Li, Jing Li, Gui-Shan Tan
Summary: Two new robustaflavones were isolated from the 70% EtOH extract of Selaginella trichoclada, along with seven known biflavanoids. The structures and absolute configurations were determined through extensive spectroscopic and circular dichroism analyses. Compounds 1 and 2 exhibited moderate cytotoxicity against A549 and HepG2 human cancer cell lines.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Shuo Wei, Yuting Xiang, Yang Zhang, Rao Fu
Summary: This study confirmed the presence of flavones in MicroTom tomatoes and discovered a tomato polyphenol oxidase with a flavone synthase-like activity. The findings have important implications for understanding the biosynthesis of flavones and the biochemical mechanisms in tomatoes.
Article
Biochemistry & Molecular Biology
Jiayin Long, Qingqing Mao, Yujie Peng, Lei Liu, Yin Hong, Honglin Xiang, Ming Ma, Hui Zou, Junwei Kuang
Summary: Six compounds, including three new benzophenones and two known selaginellins and one known flavonoid, were isolated from Selaginella tamariscina. The structures of the new compounds were determined using spectroscopic analysis. The compounds were evaluated for their cytotoxicity and inhibitory activity against cancer cells and nitric oxide production. Compound 2 showed moderate inhibitory activity against cancer cells and also exhibited inhibitory activity against nitric oxide production.
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
