Article
Environmental Sciences
Sathisaran Umamaheswari, Sheela Priyadarshinee, Monojit Bhattacharjee, Krishna Kadirvelu, Mathan Ramesh
Summary: The study shows that polystyrene microplastics induce various toxic effects in zebrafish, including disrupting the antioxidant defense system, causing histopathological lesions, and altering gene expression patterns.
Article
Environmental Sciences
Shiyang Gao, Ping Sun, Xiaoyu Zhao, Kuo Chang, Weijun Chen
Summary: The study aimed to investigate the effect of Cu exposure on largemouth bass juveniles. It was found that high concentrations of Cu can significantly reduce fish growth and survival rate. Fish exposed to Cu exhibited histopathological damages in the gills and liver, as well as increased oxidative stress. Furthermore, high levels of Cu also led to hepatic inflammation and apoptosis. Pearson correlation analysis showed that fish growth and survival were positively correlated with histological and antioxidant defense parameters, and negatively correlated with oxidative stress parameters, hepatic inflammation, and hepatic apoptosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Nico Cattaneo, Matteo Zarantoniello, Federico Conti, Andrea Frontini, Giulia Chemello, Beniamino Dimichino, Fabio Marongiu, Gloriana Cardinaletti, Giorgia Gioacchini, Ike Olivotto
Summary: This study investigated the effects of different-sized fluorescent microplastics (MPs) on the growth and welfare of zebrafish, and found that smaller MPs and longer exposure time can lead to the translocation of MPs from the gut to other tissues and organs. However, the biological barriers of zebrafish can limit the translocation of MPs to the muscle.
Article
Environmental Sciences
Sheela Priyadarshinee, Sathisaran Umamaheswari, Mathan Ramesh
Summary: The study evaluated the chronic toxicity of naproxen on Labeo rohita fish by exposing them to environmentally relevant concentrations of 1 μg/L and 50 μg/L for 35 days. The results showed that naproxen induced oxidative stress and modulated the antioxidant defense system in a dose- and time-dependent manner. The levels of hepatic enzymes also increased significantly, and histopathological analysis revealed liver damage in naproxen-treated fish. This study highlights the potential ecological risk of naproxen and calls for a reevaluation of its permissible levels in wastewater.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Environmental Sciences
Aasma Noureen, Farhat Jabeen, Abdul Wajid, Muhammad Zafarullah Kazim, Nafeesa Safdar, Tiziana Cappello
Summary: This study investigated the effects of Myristiga fragrans seed extract (MFSE) on the biological responses of common carp after exposure to copper oxide (CuO) or copper nanoparticles (Cu-NPs). The results showed that MFSE reduced the accumulation of copper in fish, modulated blood parameters, and mitigated the histological damage in gills and kidneys caused by CuO and Cu-NPs. Therefore, MFSE demonstrated a protective role against the toxicity of nanomaterials in common carp.
Article
Fisheries
Asma W. Al-Thomali, Hend M. Tag, Amaal Mohammadein, Nahla S. El-Shenawy, Mohamed Salah El-Naggar
Summary: The study revealed that exposure to mercaptophos had negative effects on the endocrine system and liver tissue of Cyprinus carpio, leading to exacerbated oxidative stress reactions, alterations in hormone levels, and pathological changes in liver and pancreatic cells.
AQUACULTURE REPORTS
(2022)
Article
Environmental Sciences
Rosane Bossle Bernardi, Ana Claudia Tedesco Zanchi, Nilsa Regina Damaceno-Rodrigues, Mariana Matera Veras, Paulo Hilario Nascimento Saldiva, Helena Maria Tannhauser Barros, Claudia Ramos Rhoden
Summary: The study found that the striatum and cortex have different reactions to air pollution, with the cortex able to avoid or reverse oxidative stress when transitioning to a non-polluted environment early in life, although some changes in the enzymatic antioxidant system may be permanent.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sharmeen Ishteyaque, Karan Singh Yadav, Smriti Verma, Kaveri R. Washimkar, Madhav Nilakanth Mugale
Summary: This study investigates the potential role of CYP2E1-triggered endoplasmic reticulum stress in the progression of hepatocellular carcinoma (HCC) by inhibiting apoptosis. In vitro experiments show that CYP2E1 promotes the migration of HepG2 cells, reduces chromatin condensation, increases intracellular ROS accumulation, and induces cell cycle progression.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Pharmacology & Pharmacy
Rita Roque Bravo, Helena Carmo, Maria Joao Valente, Joao Pedro Silva, Felix Carvalho, Maria de Lourdes Bastos, Diana Dias da Silva
Summary: This study found that 4-FMA has hepatotoxic potential, potentially causing cell death through mechanisms involving mitochondrial dysfunction, production of reactive oxygen and nitrogen species, and interference with apoptosis and necrosis pathways.
Article
Endocrinology & Metabolism
Oksana Maksymchuk, Angela Shysh, Dmytro Stroy
Summary: Long-term treatment with omega-3 PUFAs does not increase the risk of CYP2E1-dependent oxidative stress and development of liver pathology but prevents some diabetic ultrastructural damage to hepatocytes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Hamid Reza Rafieian-Naeini, Mahdi Zhandi, Mostafa Sadeghi, Ali Reza Yousefi, Andrew Parks Benson
Summary: The study concluded that dietary supplementation of CoQ10 had beneficial effects on reproduction characteristics of female Japanese quail under Cd-induced oxidative stress, resulting in increased egg production and hatchling quality.
Article
Biochemistry & Molecular Biology
Xiaoyin Ma, Huaicheng Chen, Shuhui Jian, Junhao He, Youjia Liu, Shuxian Han, Lifu Chang, Pingping Li, Ying-ao Chen, Xiaoyan Liu, Xiaojuan Hu, Yu Chen, Ling Hou
Summary: Deficiencies in Dapl1 lead to decreased antioxidant capacity in the RPE, resulting in age-related retinal degeneration. Dapl1 regulates the antioxidant function of the RPE by inhibiting MYC expression, protecting the retina from oxidative damage, and potentially playing a critical role in the pathogenesis of age-related retinal degenerative diseases.
Article
Biochemistry & Molecular Biology
Magdalena Gozdowska, Ewa Sokolowska, Konrad Pomianowski, Ewa Kulczykowska
Summary: Recent studies have shown that fish also have a local stress response system in the skin, similar to mammals, where melatonin and cortisol play important roles in coping with oxidative stress. The dispersion of pigment in the skin can serve as a valuable marker of oxidative stress and be useful in assessing fish welfare.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mariana Conceicao da Silva, Lilian Catarim Fabiano, Karile Cristina da Costa Salomao, Pedro Luiz Zonta de Freitas, Camila Quaglio Neves, Stephanie Carvalho Borges, Maria das Gracas de Souza Carvalho, Ana Cristina Breithaupt-Faloppa, Andre Alexandre de Thomaz, Aline Mara dos Santos, Nilza Cristina Buttow
Summary: This study examined the effects of 5-FU clinical treatment on the liver, kidneys, and lungs of rats, and found different levels of toxicity, including oxidative stress and inflammation, in these organs. These results will contribute to the search for new adjuvant therapies to attenuate the adverse effects of 5-FU.
Article
Environmental Sciences
Nikola Tresnakova, Sergio Famulari, Giorgia Zicarelli, Federica Impellitteri, Maria Pagano, Giovanni Presti, Mariacristina Filice, Alessia Caferro, Eleonora Gulotta, Guiliano Salvatore, Marie Sandova, Irene Vazzana, Sandra Imbrogno, Gioele Capillo, Serena Savoca, Josef Velisek, Caterina Faggio
Summary: This study evaluates the chronic effects of tebuconazole on nontarget aquatic organisms and reveals the negative impacts on the viability and cellular activity of the bioindicator species Mytilus galloprovincialis. It highlights the potential risks and comprehensive toxicity of tebuconazole.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)