Article
Fisheries
Nongnuch Singrang, Thassanai Sitthiyotha, Nusara Chomanee, Chaninat Watthanasak, Surasak Chunsrivirot, Kittikhun Wangkanont
Summary: By studying zebrafish intelectin-2, we have gained insights into its basic biochemical properties and bacterial binding specificities, providing essential knowledge for the aquaculture industry and laying a foundation for further application of DrIntL-2 in bacteria detection and identification.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Immunology
Giuseppe Stefanetti, Francesco Borriello, Barbara Richichi, Ivan Zanoni, Luigi Lay
Summary: Carbohydrates play a critical role in immunobiological processes and can be used as antigens or adjuvants in vaccines. However, adjuvants have shown limited ability to improve immune response to carbohydrate-based vaccines in humans. Aluminum salts remain the only authorized adjuvant for carbohydrate-based vaccines.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Fisheries
Jing Wang, Xin-Lu Guo, Hong-Ye Chen, Lin-Xi Xiao, Gui-Wen Yang, Hui-Ting Yang
Summary: In this study, a novel L-rhamnose binding lectin (DrRBL) was discovered and its innate immune function was studied. DrRBL can inhibit the growth of gram-positive/negative bacteria, bind to several bacteria and cause agglutination. However, it cannot bind to an important component of LTA. The DPC domain is important for agglutination, while the conserved domain ANYGRTD is essential for inhibiting bacterial growth.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Brian J. J. Timmer, Arjaan Kooijman, Xander Schaapkens, Tiddo J. Mooibroek
Summary: Galectins are a subclass of carbohydrate binding proteins that play a role in various biological processes. A synthetic galectin mimic with high selectivity for a specific galactoside has been designed and synthesized for the first time, showing a selectivity over 65-fold compared to a glucoside.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Fisheries
Jinyi Li, Yanru Chen, Wei Gu, Fojiao Xu, Hua Li, Shijuan Shan, Xiaojie Sun, Miao Yin, Guiwen Yang, Lei Chen
Summary: The newly discovered cITLN is a potential player in intestinal mucosal immunity, able to agglutinate both gram-positive and gram-negative bacteria with a stronger effect on the former. This differs from previous expectations as it was not found to inhibit bacterial growth but rather enhance bacterial agglutination through binding to peptidoglycan (PGN).
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Immunology
Nanxin Liu, Xiaoxiao Pang, Hua Zhang, Ping Ji
Summary: The cGAS-STING pathway is crucial in protecting the host against viral infections and has also been found to play a role in response to bacterial infections. However, its functions in bacterial infections are more complex and diverse compared to viral infections, as the effects on the host vary depending on the bacterial species and infection mode.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Martha Reyes-Becerril, Miriam Angulo, Veronica Sanchez, Cristian Machuca, Yuniel Mendez-Martinez, Carlos Angulo
Summary: This study aimed to explore the immunostimulant potential of Cystobacidium benthicum-beta-glucans, which was characterized to be safe with strong antioxidant capacity. It was found to stimulate immune parameters and up-regulate immune-related gene expressions on thymus cells from Totoaba macdonaldi, indicating its potential as an alternative to antibiotics in aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Immunology
Xiao Xiao, Zhangluxi Liu, Guannan Su, Huan Liu, Wenhui Yin, Yuxuan Guan, Shixiang Jing, Liping Du, Fuzhen Li, Na Li, Peizeng Yang
Summary: A novel endotoxin-induced uveitis (EIU) model in zebrafish was successfully developed using intravitreal lipopolysaccharide (LPS) injection. Various methods, including optical coherence tomography (OCT), histological evaluation, immunofluorescence, and RNA sequencing (RNA-Seq), were used to assess inflammation. The study identified gene clusters related to different signaling pathways during inflammation. Furthermore, prednisone immersion was found to inhibit the inflammatory response in zebrafish.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Aaron DiAntonio, Jeffrey Milbrandt, Matthew D. D. Figley
Summary: The TIR domain is a key signaling motif in innate immunity, with its primary function being NAD(+) metabolism. SARM1, as a founding member of TIR-domain NAD(+) hydrolases, demonstrates evolutionarily conserved enzymatic activity essential for innate immune function. The recent discovery of SARM1 activation mechanism further strengthens the link between SARM1 and ancient self-defense mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Elizabeth Ficko-Blean
Summary: The study investigates the ligand specificity of the human mannose receptor, particularly focusing on carbohydrate-recognition domain 4, and elucidates the molecular mechanisms driving binding specificity. The data contribute to understanding Ca2+-mediated binding promiscuity in the receptor and highlight unexpected interactions for further study.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Fisheries
Li Wang, Qiuxia Wang, Lei Wang, Shixiu Wu, Yan Yu, Yanhong Zhang, Pei Gao, Xianghui Kong, Jinyou Ma
Summary: Galectin-9, identified from Qihe crucian carp, contains two carbohydrate recognition domains (CRDs) and can recognize and bind pathogen-associated molecular patterns (PAMPs) to initiate agglutination reactions against Gram-negative and Gram-positive bacteria. This study suggests that CaGal-9 plays an important role in immune defense against pathogenic microorganisms in Carassius auratus.
JOURNAL OF FISH DISEASES
(2021)
Review
Immunology
Gael Galli, Maya Saleh
Summary: Macrophages play crucial roles in tissue homeostasis, inflammation, and host defense by recognizing microbial or danger signals and eliciting immune responses. The interaction between cellular metabolism and macrophage innate immunity involves metabolic adaptations that modulate immune signaling and macrophage function. Intracellular bacterial pathogens can exploit macrophage metabolic pathways to evade immune defenses. This review highlights recent evidence on host-bacterial immunometabolic interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria H. C. Santos, Valdenice F. Santos, Priscilla R. Freitas, Renato Rodrigues Roma, Ana L. E. Santos, Daiany Alves Ribeiro, Henrique D. M. Coutinho, Bruno A. M. Rocha, Manoel M. E. Oliveira, Claudener S. Teixeira
Summary: This study evaluated the interaction between DVL and neomycin via CRD and the ability of DVL to modulate the antibiotic effect of neomycin against multidrug-resistant strains (MDR). The results showed that neomycin interacts with DVL via the CRD and that DVL enhances the antibiotic activity of neomycin against S. aureus and P. aeruginosa.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Mohamed L. Sobah, Aimee C. Scott, Miranda Laird, Cassandra Koole, Clifford Liongue, Alister C. Ward
Summary: By investigating the zebrafish socs3b gene, it was found that socs3b gene plays a critical role in regulating neutrophil production and macrophage activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aotian Ouyang, Mengwei Zhang, Gailing Yuan, Xiaoling Liu, Jianguo Su
Summary: This study reveals that chitooligosaccharide (COS) has the ability to reverse cortisol-induced immunosuppression in fish and enhance the immune activity of macrophages. Oral administration of COS directly absorbed through the intestine significantly improves the innate immunity of blunt snout bream, leading to increased survival and reduced tissue damage. Thus, COS offers potential strategies for immunosuppression prevention and control in fish.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)