Review
Immunology
Chenglin Lu, Ying Liu, Nasra Mohamoud Ali, Bin Zhang, Xiaonan Cui
Summary: Innate immune cells in the tumor microenvironment determine the occurrence and development of tumors by secreting various factors. Understanding their role can improve therapeutic approaches and prognosis. This review provides an overview of the biology, role, and immunotherapy of innate immune cells, aiming to guide future research and clinical trials.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Anne E. Geller, Rejeena Shrestha, Matthew R. Woeste, Haixun Guo, Xiaoling Hu, Chuanlin Ding, Kalina Andreeva, Julia H. Chariker, Mingqian Zhou, David Tieri, Corey T. Watson, Robert A. Mitchell, Huang-ge Zhang, Yan Li, Robert C. G. Martin, Eric C. Rouchka, Jun Yan
Summary: The application of immunotherapy in pancreatic ductal adenocarcinoma has been limited, but researchers have found that fungal beta-glucan can induce trained immunity, resulting in reduced tumor burden and improved survival in mouse models. This study highlights the importance of innate immune cells in anti-tumor immunosurveillance and suggests a potential application of trained immunity in cancer therapy.
NATURE COMMUNICATIONS
(2022)
Article
Fisheries
Ghada Tafesh-Edwards, Ioannis Eleftherianos
Summary: This review discusses the role of thioester-containing proteins (TEPs) in the immune response of the insect Drosophila melanogaster. It highlights the importance and evolutionary conservation of TEPs in animal physiology, as well as their potential therapeutic benefits.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Cell Biology
Nivine Srour, Oscar D. Villarreal, Swanand Hardikar, Zhenbao Yu, Samuel Preston, Wilson H. Miller, Magdelena M. Szewczyk, Dalia Barsyte-Lovejoy, Han Xu, Taiping Chen, Sonia Del Rincon, Stephane Richard
Summary: Combining PRMT7 inhibition with ICI therapy induces a strong anti-tumor T cell immunity and restrains tumor growth in vivo by increasing immune cell infiltration.
Review
Cell Biology
Alessandro Sacco, Anna Martina Battaglia, Cirino Botta, Ilenia Aversa, Serafina Mancuso, Francesco Costanzo, Flavia Biamonte
Summary: New insights have been gained into the impact of iron metabolism within the tumor microenvironment on cancer development. Iron promotes the production of reactive oxygen species, which can trigger cell death or malignant transformation, affecting tumor immunosurveillance. The potential and controversies of using iron metabolism as a target for anticancer treatments are discussed, particularly in the context of hot and cold tumors.
Article
Fisheries
K. P. Madushani, K. A. S. N. Shanaka, Rajamanthrilage Kasun Madusanka, Jehee Lee
Summary: The research identified the antiviral protein Gig2 in rockfish, which plays a protective role against viral infection, expanding our understanding of innate immunity in fish.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Oncology
Luis Alejandro Zuniga, Torben Lessmann, Karan Uppal, Nicola Bisek, Enping Hong, Caroline E. Rasmussen, Jens-Jakob Karlsson, Joachim Zettler, Lars Holten-Andersen, Kathy Bang, Dhruv Thakar, Yu-Chi Lee, Salomon Martinez, Simran Singh Sabharwal, Sebastian Stark, Frank Faltinger, Oliver Kracker, Samuel Weisbrod, Robin Mueller, Tobias Voigt, Kornelia Bigott, Mohammad Tabrizifard, Vibeke Miller Breinholt, Amer M. Mirza, David B. Rosen, Kennett Sprogoe, Juha Punnonen
Summary: The TransCon TLR7/8 Agonist has been developed as a sustained-release prodrug of resiquimod, showing potent anti-tumor effects and activation of immune cells in the tumor microenvironment when used alone or in combination with systemic immunotherapy. This study highlights the potential of TransCon TLR7/8 Agonist as a novel intratumoral TLR agonist for cancer therapy.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemical Research Methods
Reese A. Martin, Ann T. Tate
Summary: Genes involved in immune defense resist rapidly evolving parasites and pathogens and are highly represented in the immune system. Pleiotropic signaling genes affect multiple phenotypes and may play a role in the evolution of inducible immunity. Pleiotropy is prevalent in immune signaling networks, and it provides an advantage for host fitness during infection.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jeehye Maeng, Kyunglim Lee
Summary: It has been discovered that translationally controlled tumor protein (TCTP) exhibits cytokine-like activities associated with allergic responses after forming dimers (dTCTP). Inhibitors targeting dTCTP can block the development of allergic reactions and serve as potential drugs for allergic diseases. Peptides and antibodies that specifically inhibit the interactions between dTCTP and its receptor or immunoglobulins show significant efficacy as anti-inflammatory agents in murine models of allergic inflammatory diseases. This review focuses on the development of dTCTP inhibitors and discusses their effects on the pathophysiological processes of allergic and inflammatory diseases in animal models, providing new perspectives on anti-allergic drug discovery.
Review
Chemistry, Multidisciplinary
Shan Gao, Xiaoye Yang, Jiangkang Xu, Na Qiu, Guangxi Zhai
Summary: Immunotherapy utilizing the human immune system against cancer has become a mainstream strategy, with the potential to eliminate tumors and treat metastasis and recurrence. The development of nanotechnology has enabled the application of nanomaterials in cancer immunotherapy, offering significant potential for improving treatment efficacy. Nanotechnology-based immunotherapy aims to produce effective anti-tumor immune responses and enhance tumor immune defense by modulating the immune suppression mechanism in the tumor microenvironment.
Review
Biochemistry & Molecular Biology
Lin Fu, Xiaotong Zhou, Qian Jiao, Xi Chen
Summary: As a member of the TRIM protein family, TRIM56 acts as an E3 ubiquitin ligase and exhibits deubiquitinase activity and RNA binding ability. Its role in innate immune response regulation, antiviral defense, and tumor development has attracted attention from researchers. However, there is a lack of systematic review on TRIM56.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Pablo S. Contreras, Pablo J. Tapia, Eutteum Jeong, Sourish Ghosh, Nihal Altan-Bonnet, Rosa Puertollano
Summary: Beta-coronaviruses pose a severe threat to global health. Understanding the interaction between host and beta-coronaviruses is crucial for comprehending disease pathogenesis and developing effective treatments. This study reveals that TFEB and TFE3, transcription factors, translocate into the nucleus upon beta-coronavirus infection through the activation of calcineurin phosphatase. In the nucleus, TFEB and TFE3 bind to the promoters of lysosomal and immune genes, influencing the immune response and viral infectivity.
Article
Multidisciplinary Sciences
Nehal A. Younis, Hasnaa Thabit, Salma I. El-Samannoudy, Marwa M. Attia
Summary: This study evaluated the immunological status of Oreochromis niloticus (O. niloticus) by examining the presence of encysted metacercariae and assessing immune responses and biochemical markers in infected fish. The prevalence of encysted metacercariae from the family Cyathocotylidae (Prohemistomum vivax) was 25%. Infected organs showed elevated expression of immune-related genes, and infected fish exhibited higher levels of liver enzymes (AST, ALT), blood glucose, cortisol, and lysozyme activity compared to non-infected fish.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Yangyang Zhu, Lei Liu, Chuchu Zhang, Chao Zhang, Tingting Han, Renjie Duan, Yiheng Jin, Huimin Guo, Kan She, Yihua Xiao, Akira Goto, Qingshuang Cai, Shanming Ji
Summary: In Drosophila, the endoplasmic reticulum-associated protein degradation (ERAD) is involved in regulating various biological processes. This study found that ERAD plays a role in mediating the Toll innate immune response, but not the IMD immune response in fly fat bodies. The gene Me31B was identified to have a functional role in ERAD-mediated immune defense. Additionally, the study showed that silencing Xbp1 partially rescued the immune defects caused by dysregulated ERAD. These findings highlight the essential function of ERAD in the Toll immune reaction in Drosophila.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Fisheries
Dan Qiao, Yanjing Zhao, Chao Pei, Xianliang Zhao, Xinyu Jiang, Lei Zhu, Jie Zhang, Li Li, Xianghui Kong
Summary: In this study, two CCL19b genes (CcCCL19b_a and CcCCL19b_b) were cloned from Yellow River carp. The expression of CcCCL19bs was found to be high in gill and intestine of healthy fish, and up-regulated after infection and stimulation. Furthermore, CcCCL19bs were found to have chemotactic and antibacterial activity, attracting leukocytes and promoting their proliferation, as well as exhibiting antibacterial activity against certain pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Hongmei Li, Qilin Meng, Ting Chen, Chunhua Ren, Wen Huang, Da Huo, Xiao Jiang, Chaoqun Hu
AQUACULTURE RESEARCH
(2020)
Article
Biotechnology & Applied Microbiology
Xiaofen Wu, Ting Chen, Da Huo, Zonghe Yu, Yao Ruan, Chuhang Cheng, Xiao Jiang, Chunhua Ren
Article
Physiology
Yao Ruan, Nai-Kei Wong, Xin Zhang, Chunhua Zhu, Xiaofen Wu, Chunhua Ren, Peng Luo, Xiao Jiang, Jiatai Ji, Xugan Wu, Chaoqun Hu, Ting Chen
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Cell Biology
Lin Wang, Qing Guo, Tom Levy, Ting Chen, Xugan Wu
CELL AND TISSUE RESEARCH
(2020)
Article
Neurosciences
Xiao-Fan Zhang, Ting Chen, Aifen Yan, Jia Xiao, Yong-Li Xie, Jing Yuan, Pin Chen, Anderson On-Lam Wong, Yang Zhang, Nai-Kei Wong
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Fisheries
Meimei Liu, Xiaodong Jiang, Aqin Chen, Ting Chen, Yongxu Cheng, Xugan Wu
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Xiaofen Wu, Yao Ruan, Ting Chen, Zonghe Yu, Da Huo, Xiaomin Li, Feifei Wu, Xiao Jiang, Chunhua Ren
Article
Multidisciplinary Sciences
Ziyuan Zhou, Qing Pan, Xinchen Lv, Jing Yuan, Yang Zhang, Ming-Xia Zhang, Ming Ke, Xiao-Mei Mo, Yong-Li Xie, Yingxia Liu, Ting Chen, Mingchan Liang, Feng Yin, Lei Liu, Yiqing Zhou, Kun Qiao, Rui Liu, Zigang Li, Nai-Kei Wong
Summary: The study suggests that NPS may interact with specific residues of RecA protein, with Y103 being critical for RecA-NPS interaction. This conclusion was experimentally validated through biochemical assays.
Article
Multidisciplinary Sciences
Long Yun, Wei Wang, Yingying Li, Mei Xie, Ting Chen, Chaoqun Hu, Peng Luo, Daning Li
Summary: Marine red yeast YLY01 shows promising potential in aquaculture as a versatile probiotic, with functions including ammonia nitrogen removal, enhancement of shrimp biosecurity, and inhibition of Vibrio growth, making it a valuable microbial agent for high-ammonia tail water treatment.
Article
Fisheries
Xiao Jiang, Xin Zhang, Chunhua Ren, Yao Ruan, Yongtong Lu, Lihong Yuan, Jiaxi Li, Aifen Yan, Yanhong Wang, Peng Luo, Chaoqun Hu, Ting Chen
Summary: The study presented the first evidence of a novel splicing mechanism of ILF2 transcripts and established a functional link between the Lv-ILF2 isoforms and the capacity against pathogenic Vibrio in penaeid shrimp.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Fisheries
Chuhang Cheng, Feifei Wu, Chunhua Ren, Xiao Jiang, Xin Zhang, Xiaomin Li, Peng Luo, Chaoqun Hu, Ting Chen
Summary: This study found that low-temperature stimulation can effectively induce spawning of S. monotuberculatus, and enhancing larval breeding by supplementing multiple digestive enzymes. The period from July to September is identified as the optimal breeding time for S. monotuberculatus in Hainan Province.
Article
Fisheries
Feifei Wu, Chuhang Cheng, Xiaomin Li, Chunhua Ren, Peng Luo, Xiao Jiang, E. Zixuan, Xin Zhang, Chaoqun Hu, Ting Chen
Summary: This study identified sex-specific markers in the tropical sea cucumber Stichopus monotuberculatus and established a rapid PCR-based method for sex identification, contributing to understanding the sex determination system in sea cucumbers and benefiting their aquaculture.
Article
Biochemistry & Molecular Biology
Hao Yang, Xiaoli Chen, Zhi Li, Xugan Wu, Mingyu Zhou, Xin Zhang, Yujie Liu, Yuying Sun, Chunhua Zhu, Qiuhui Guo, Ting Chen, Jiquan Zhang
Summary: This study provides basic knowledge about the synthesis and inactivation pathway of prostaglandins in crustaceans, which is more complete compared to insects and mollusks. The expression patterns of different genes in various tissues and developmental processes were analyzed, revealing their specific roles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Xin Zhang, Hao Yang, Hongmei Li, Ting Chen, Yao Ruan, Chunhua Ren, Peng Luo, Yanhong Wang, Bing Liu, Huo Li, Ping Zhong, Jiquan Zhang, Xiao Jiang, Chaoqun Hu
Summary: Bicarbonate transport through the AE3 protein is crucial for acid-base balance in aquatic animals. The study identified the Lv-AE3 gene in the Pacific white shrimp, showing its correlation with water and ion absorption activities. The research suggests a potential link between Lv-AE3 expression and gill damage, particularly under fluctuating aquatic environments.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaomin Li, Ting Chen, Xiaofen Wu, Xiao Jiang, Peng Luo, E. Zixuan, Chaoqun Hu, Chunhua Ren
Summary: Apoptosis is a critical biological process for embryonic development, tissue differentiation, and organism homeostasis. A novel apoptosis-inducing factor called AIF-2 has been identified in sea cucumbers, and it is involved in heavy metal-induced apoptosis, contributing to the understanding of the caspase-independent apoptotic pathway in ancient echinoderm species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)