Article
Immunology
Raja Aadil Hussain Bhat, Dimpal Thakuria, Maneesh Kumar Dubey, Ritesh Shantilal Tandel, Prakash Sharma, Victoria C. Khangembam, Pragyan Dash, Gayatri Tripathi, Debajit Sarma
Summary: The study successfully induced typical A. salmonicida infection in common carp, providing a research foundation for further studies.
MICROBIAL PATHOGENESIS
(2021)
Article
Fisheries
Latifeh Chupani, Bernard Erasmus, Miroslava Soldanova, Eliska Zuskova
Summary: This study demonstrates the effectiveness of beta-glucan, nucleotides, and chitosan in combating Diplostomum infection in juvenile common carp, providing valuable insight into the use of immunostimulants to alleviate parasitic infections.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Psychiatry
Diego Fabian Karvat Gracia, Eloisa Maria Pontarolo Gomes, Tamires Amelotti Coelho, Marcelo Carriello, Fabiana Antunes de Andrade, Lorena Bavia, Iara Jose Messias-Reason, Raffael Massuda
Summary: The study analyzed 49 patients with schizophrenia and found a negative association between the Positive and Negative Syndrome Scale total score and ficolin activation, and a positive association between body mass index and serum levels of C3 and CRP. MBL activation was not associated with any independent variables. More studies with larger sample populations are needed to confirm the results.
PSYCHIATRY RESEARCH
(2021)
Article
Immunology
Johannes Zeller, Balazs Bogner, Jurij Kiefer, David Braig, Oscar Winninger, Mark Fricke, Ebru Karasu, Karlheinz Peter, Markus Huber-Lang, Steffen Ulrich Eisenhardt
Summary: Research has shown that the activation of monomeric CRP can activate immune cells through the classical complement pathway, inducing the generation of ROS. This process is conformation-specific and complement-dependent, with classical monocytes being the primary source of ROS among human monocyte subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Radim Dobias, Marcela Kanova, Nadezda Petejova, Stefan Kis Pisti, Robert Bocek, Eva Krejci, Helena Struzkova, Michaela Cachova, Hana Tomaskova, Petr Hamal, Vladimir Havlicek, Milan Raska
Summary: A new biomarker panel has been developed to improve the diagnosis of invasive candidiasis in critically ill adult patients. Levels of certain biomarkers were correlated with culture-confirmed candidemia or bacteremia, and the sensitivity and specificity of these markers were evaluated. The results showed that BDG was the most effective marker for IC, while PSEP was more accurate in predicting 28-day mortality.
Article
Fisheries
Yanjing Zhao, Jie Zhang, Dan Qiao, Feng Gao, Xinyu Jiang, Xianliang Zhao, Libo Hou, Hao Li, Li Li, Xianghui Kong
Summary: In this study, the molecular and structural characteristics of CcGSDMEa-like were analyzed, and its role in the inflammatory response against Aeromonas hydrophila in fish was studied. The results showed that CcGSDMEa-like could regulate the content of bacteria in fish through mediating the expression and secretion of CcIL-1 beta.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daisuke Yamanaka, Suzuka Kurita, Yuka Hanayama, Yoshiyuki Adachi
Summary: Beta-glucan, consisting of beta-1,3-linked D-glucose units, is present in various plants and microorganisms with diverse structures and bioactivities. A split-luciferase complementation assay was developed for the structural analysis of long-chain beta-1,6-branched beta-1,3-glucan, demonstrating the potential for real-time monitoring and differentiation of beta-glucans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Margaret E. Olson, Mary G. Hornick, Ashley Stefanski, Haya R. Albanna, Alesia Gjoni, Griffin D. Hall, Peter C. Hart, Ibraheem M. Rajab, Lawrence A. Potempa
Summary: C-reactive protein (CRP) is an acute phase protein synthesized in the liver in response to tissue injury or infection. Recent studies have revealed at least three distinct isoforms of CRP: pentamer, modified monomer, and transitional isoform. This review discusses the interaction of these isoforms with specific immune cells and the innate immune system, as well as their roles in inflammation and immune mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Irving Kushner
Summary: C-reactive protein (CRP), discovered in 1930, is a pentraxin that binds to the C-polysaccharide of the pneumococcal cell wall. It is found in trace amounts in normal serum and is produced by hepatocytes. CRP activates the complement system and stimulates phagocytosis via binding to Fc receptors. It also exhibits protective effects against pneumococcus in vivo and may be involved in tissue clearance.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Psychiatry
Jingfeng Su, Xia Feng, Kaiyuan Chen, Zeman Fang, Handi Zhang
Summary: This study found that the plasma level of C4 is increased in schizophrenia patients at the acute stage of illness and can be decreased by antipsychotic medication.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Immunology
Valerie Cornet, Trinh Dinh Khuyen, Syaghalirwa N. M. Mandiki, Stephane Betoulle, Peter Bossier, Felipe E. Reyes-Lopez, Lluis Tort, Patrick Kestemont
Summary: Beta-glucans, prebiotic and/or food additives used in aquaculture, have varying effects on fish immune response and disease resistance. Gas1 beta-glucan may be more efficient in enhancing immunity and preventing diseases compared to other types already in use.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Ngairangbam Sushila, Basanta Kumar Das, Rajesh Bharathi Rathinam, Gayatri Tripathi
Summary: The present study demonstrates that vaccination or immunostimulation with beta-glucan can enhance the immune response of Pterophyllum scalare against Aeromonas hydrophila infection, reducing mortality rate during early larval rearing.
AQUACULTURE RESEARCH
(2022)
Article
Immunology
Abdull Jalil Mohd Asyraf, Abd Rahim Nour El Huda, Mohd Noor Hanisah, Ku Zaifah Norsidah, A. Talib Norlelawati
Summary: The study found that complement markers C3 and C4 may be potential peripheral biomarkers in schizophrenia. These markers were significantly elevated in patients and subjects with elevated CRP, and positively correlated with BMI. Schizophrenia, BMI, and CRP were found to be significant predictors for C3 and C4 levels.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Infectious Diseases
Sumeyye Kazancioglu, Aliye Bastug, Bircan Kayaaslan, Nevzat Mehmet Mutlu, Esin Calci, Turan Turhan, Ipek Mumcuoglu, Esragul Akinci, Hurrem Bodur
Summary: This study compared the diagnostic value of Candida score, colonization index, serum BDG detection, and routine laboratory parameters in ICU patients. The findings suggest that serum BDG may be useful for predicting candidemia in ICU, and combining BDG with CRP could be a stronger predictor for candidemia.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Microbiology
Lin Liu, Chang Liu, Jianrong Cai, Jiayun Chen, Jie Chen, Yuanyuan Fu, Kexin Yi, Hui Wang, Xue Li
Summary: This study validates the relationship between invasive fungal infections (IFI) and hypostatic pneumonia (HP), showing that elevated beta-D-glucan (BDG) concentrations are associated with a higher risk of HP. The study also reveals a trend of decreasing globulin (GLB) concentration and increasing C-reactive protein (CRP) concentration in the high BDG concentration group.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biology
Melissa Bello-Perez, Mikolaj Adamek, Julio Coll, Antonio Figueras, Beatriz Novoa, Alberto Falco
Summary: The study suggests that fish short pentraxins may serve as health biomarkers for bacterial and viral infections, with antiviral activity. Experiments in zebrafish show that skin is an important sampling source for the analysis of these short pentraxins' expression levels.
Article
Fisheries
Agnieszka Troszok, Ludmila Kolek, Joanna Szczygiel, Joanna Wawrzeczko, Patrycja Jurecka, Mikolaj Adamek, Ilgiz Irnazarow
AQUACULTURE RESEARCH
(2022)
Article
Immunology
Mikolaj Adamek, Marek Matras, Alexander Rebl, Magdalena Stachnik, Alberto Falco, Julia Bauer, Anne-Carina Miebach, Felix Teitge, Verena Jung-Schroers, Muhammad Abdullah, Torben Krebs, Lars Schroeder, Walter Fuchs, Michal Reichert, Dieter Steinhagen
Summary: Vaccination is the best way to protect fish from viral diseases. Live attenuated virus vaccines have shown to be most effective. This study demonstrates that vaccination with a live attenuated virus can enhance fish immune responses and protect against severe disease caused by a specific pathogen.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Mikolaj Adamek, Alexander Rebl, Marek Matras, Christian Lodder, Sahar El Rahman, Magdalena Stachnik, Krzysztof Rakus, Julia Bauer, Alberto Falco, Verena Jung-Schroers, Chutchai Piewbang, Somporn Techangamsuwan, Win Surachetpong, Michal Reichert, Jens Tetens, Dieter Steinhagen
Summary: The emergence of viral diseases in fish, such as tilapia lake virus (TiLV), can cause high mortality and disrupt aquaculture production. A study found that different genetic strains of tilapia have varying levels of resistance to TiLV, with one strain exhibiting a survival rate of nearly 100%. The resistant strain showed lower viral loads and pro-inflammatory responses, suggesting that a stronger antiviral response and reduced pathology contribute to its resistance. These findings suggest the possibility of using TiLV-resistant strains as a cost-effective solution, but integrated measures of biosecurity, diagnostics, and vaccination should still be employed.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Chemistry, Medicinal
Alberto Falco, Mikolaj Adamek, Patricia Pereiro, David Hoole, Jose Antonio Encinar, Beatriz Novoa, Ricardo Mallavia
Summary: This review discusses the high proliferation of microorganisms in aquatic environments and their coevolution with other organisms. The study highlights the potential of the broad biodiversity in marine habitats for the discovery and development of antimicrobial compounds. Antimicrobial peptides and antimicrobial metabolites are of particular interest due to their structural diversity, mechanisms of action, and target pathogen ranges.
Article
Multidisciplinary Sciences
Rachael Morgan, Anna H. Andreassen, Eirik R. Asheim, Mette H. Finnoen, Gunnar Dresler, Tore Brembu, Adrian Loh, Joanna J. Miest, Fredrik Jutfelt
Summary: Plasticity allows organisms to adapt to different environmental conditions, but the cost of plasticity and the trade-off between plasticity and performance under optimal conditions are still largely unknown. Zebrafish in the wild show high physiological plasticity due to large temperature fluctuations, while laboratory zebrafish, adapted to stable temperatures for over 150 generations, have reduced plasticity compared to their wild counterparts. Rapid selection for faster growth in the laboratory environment seems to have led to a trade-off against physiological plasticity in captive zebrafish.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Infectious Diseases
Amy E. Marriott, Julio Furlong Silva, Nicolas Pionnier, Hanna Sjoberg, John Archer, Andrew Steven, Dale Kempf, Mark J. Taylor, Joseph D. Turner
Summary: The lack of a robust long-term in vitro culture model for adult-stage lymphatic filarial nematodes hinders the development of new drugs. Testing potential therapeutic candidates against adult lymphatic filariae in vitro requires chronic infection of gerbils. Evaluation of parasite burden data from different animal models suggests that immune-deficient mice may be superior to gerbils in generating adult worms for drug screening.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Environmental Sciences
Melissa Bello-Perez, Iris Esparza, Arancha De la Encina, Teresa Bartolome, Teresa Molina, Elena Sanjuan, Alberto Falco, Luis Enjuanes, Isabel Sola, Fernando Usera
Summary: In the context of ongoing and future pandemics, non-pharmaceutical interventions are crucial in reducing viral infections and limiting viral transmission. This study demonstrates that a pulsed-xenon ultraviolet (PX-UV) light source can efficiently and rapidly disinfect surfaces contaminated with different human coronaviruses, providing a promising decontamination measure for future outbreaks.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Nicolas Pionnier, Julio Furlong-Silva, Stefano A. P. Colombo, Amy E. E. Marriott, Valerine C. C. Chunda, Bertrand L. L. Ndzeshang, Hanna Sjoberg, John Archer, Andrew Steven, Samuel Wanji, Mark J. J. Taylor, Joseph D. D. Turner
Summary: Lymphatic filariasis and onchocerciasis are major tropical diseases that affect millions of people worldwide. This study found that NKp46(+) NK cells play a crucial role in immune protection against primary and secondary filarial infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Sebastian N. Politis, Elisa Benini, Joanna J. Miest, Sofia Engrola, Sune R. Sorensen, Elisavet Syropoulou, Ian A. E. Butts, Jonna Tomkiewicz
Summary: In this study, prebiotics, probiotics, and synbiotics were administered to European eel larvae to stimulate gut-priming. The results showed that synbiotics increased mortality, while probiotics and synbiotics impaired growth. Larvae receiving prebiotics showed similar survival and growth to the control group. Water management strategies and rearing options need to be further explored to establish optimized culture conditions for future eel larval culture.
AQUACULTURE RESEARCH
(2023)
Review
Chemistry, Medicinal
Rocio Diaz-Puertas, Mikolaj Adamek, Ricardo Mallavia, Alberto Falco
Summary: The antimicrobial molecules found in fish skin mucus, including peptides, proteins, and other metabolites, have been shown to have antimicrobial capacity against bacteria, fungi, and viruses. This review highlights the different methods of mucus extraction and emphasizes the importance of omic techniques in identifying and isolating new antimicrobial compounds. Overall, fish skin mucus is a promising source for the discovery of new antimicrobial agents.
Review
Polymer Science
Rocio Diaz-Puertas, Francisco Javier Alvarez-Martinez, Alberto Falco, Enrique Barrajon-Catalan, Ricardo Mallavia
Summary: Antibiotic-resistant bacteria (ARB) pose a significant global health threat, and researchers are exploring alternative strategies to fight bacterial infections. Phytochemicals found in plants have shown potential as antimicrobial agents, but their use has limitations. Combining nanotechnology and antibacterial phytochemicals can enhance the antibacterial capacity against ARB by improving mechanical, chemical, and biological properties. This review provides an overview of phytochemical-based nanomaterials, focusing on polymeric nanofibers and nanoparticles, and discusses their synthesis and antimicrobial activity. The review emphasizes the potential of phytochemical-based nanomaterials for ARB treatment, but highlights the need for further research to optimize their use in clinical settings.
Article
Chemistry, Multidisciplinary
Rocio Diaz-Puertas, Enrique Rodriguez-Canas, Melissa Bello-Perez, Marta Fernandez-Oliver, Ricardo Mallavia, Alberto Falco
Summary: The incorporation of ceramic-coated silver nanoparticles (AgNPs) into thermoplastic polyurethane (TPU) plates showed significant antiviral activity against Spring viraemia of carp virus (SVCV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Article
Fisheries
Teresa Kaminska-Gibas, Joanna Szczygiel, Annemiek Blasweiler, Lukasz Gajda, Ebru Yilmaz, Patrycja Jurecka, Ludmila Kolek, Marek Ples, Ilgiz Irnazarow
Summary: Iron uptake, transport, and storage involve multiple proteins, including ferroportin (fpn). This study identified two functional fpns in common carp with distinct expression patterns.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Environmental Sciences
Agnieszka Babczynska, Monika Tarnawska, Piotr Laszczyca, Pawel Migula, Bartosz Lozowski, Andrzej Woznica, Ilgiz Irnazarow, Maria Augustyniak
Summary: The study of stress protein concentration in caged carp exposed to a transplantation experiment model dam reservoir revealed the variability in young carp individuals. Analysis of water conditions and pollution detection showed that the differences in stress protein concentration levels between the groups were mainly influenced by natural conditions. This suggests that regular monitoring using the transplantation method and young carp individuals can be reliable for assessing reservoir conditions.
ARCHIVES OF ENVIRONMENTAL PROTECTION
(2021)