Article
Fisheries
Shang Geng, Tianjun Xu, Yuena Sun
Summary: In this study, we identified 27 ChemR genes in miiuy croaker and analyzed their characteristics, including gene structure, evolutionary mechanism, and expression levels upon bacterial infection. The results showed that these genes underwent tandem and segmental duplication events during evolution, and teleost fishes' ChemRs may have a higher evolutionary dynamic compared to vertebrates. Additionally, 21 positively selected codons were detected in vertebrate ChemRs under Model 8, and certain genes were significantly up-regulated upon Vibrio harveyi infection, providing valuable information for further functional analysis.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Yan Zhao, Qiang Luo, Wansu Wang, Shang Geng, Yuena Sun, Tianjun Xu
Summary: This study identified METTL16 in miiuy croaker and found that its expression was increased after poly(I:C) stimulation, suggesting its involvement in antiviral immunity. Functional experiments showed that mmiMETTL16 could inhibit immune response caused by viral stimulation. Overall, the study on mmiMETTL16 will contribute to understanding the role of METTL16 in the teleost immune system and the potential mechanisms of the m6A regulation network.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Fisheries
Xing Lv, Qiang Luo, Shiying Xin, Weiwei Zheng, Tianjun Xu, Yuena Sun
Summary: In recent years, there has been an increasing focus on the study of circular RNAs (circRNAs) in noncoding RNAs. While circRNAs are abundant in mammalian studies, research in lower vertebrates has been lacking. In this study, a circRNA called circPlce1 was found to be related to the innate immune response in Miichthys miiuy (miiuy croaker). Experimental results showed that circPlce1 could promote the production of antiviral genes and inflammatory response. It was also observed that circPlce1 can promote cell proliferation and improve cell viability. The study provides a foundation for understanding the biological function of circRNAs in the innate immune response in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Han Zhang, Ya Chen, Junxia Cui, Xiaolong Yan, Yuena Sun, Tianjun Xu
Summary: PCNA degrades MITA through autophagy pathway to regulate immune response and prevent excessive immunization.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Shiying Xin, Xing Lv, Linchao Wang, Wei Wei Zheng, Tianjun Xu, Yuena Sun
Summary: With the in-depth study of circRNA, its important role in mammals, such as cell proliferation, apoptosis, invasion, development, and disease state, has been demonstrated. However, the regulatory mechanism of circRNA in lower vertebrates remains unclear. In this study, a new circRNA named circRara was identified and its positive regulatory effect on the antiviral and antibacterial response, cell proliferation, and activity in miiuy croaker was confirmed.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Xiaomeng Ren, Han Zhang, Xiaolong Yan, Yuena Sun, Tianjun Xu
Summary: The study found that NOP56 acts as a negative regulator of the MyD88-mediated NF-KB signaling pathway by inhibiting MyD88 protein expression, providing new insights into the regulatory mechanism in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Guiliang Liu, Shiying Xin, Shang Geng, Weiwei Zheng, Tianjun Xu, Yuena Sun
Summary: In this study, a novel NLRC3-NLRP12 fusion gene was identified in the miiuy croaker. The fusion gene was significantly upregulated after infection with V. anguillarum or stimulation with LPS, and its overexpression inhibited NF-kappa B activation. These findings suggest that the newly discovered NLRC3-NLRP12 fusion gene may play an important role in innate immunity in miiuy croaker.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Liyuan Yang, Weiwei Zheng, Shiying Xin, Xing Lv, Yuena Sun, Tianjun Xu
Summary: This study finds that miR-122 can promote the activation of NF-kappa B pathway by regulating the expression of I kappa B alpha, thus playing an important role in the immune response of teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Baolan Cao, Yan Zhao, Qiang Luo, Ya Chen, Tianjun Xu, Yuena Sun
Summary: In this study, Vclb was found to inhibit the NF-KB signaling pathway, and its inhibitory effect was enhanced by LPS induction. Furthermore, Vclb inhibits NF-KB activation by targeting MyD88, thereby suppressing the production of inflammatory cytokines. Mechanistically, Vclb inhibits the NF-KB signaling pathway by targeting MyD88 ubiquitin-proteasome pathway.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Qi Li, Ya Chen, Pengfei Wang, Yuena Sun, Tianjun Xu
Summary: PSMD13 inhibits the activation of the NF-κB pathway by targeting TAK1 in mammalian innate immune regulation. This discovery enriches the research of the PSMD family in regulating the innate immune response and provides a new idea for studying the mechanism of mammalian innate immune regulation.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Jiajia Pan, Weiwei Zheng, Yuena Sun, Tianjun Xu
Summary: By studying the miiuy croaker, a lncRNA named LTCONS5539 was found to play a critical regulatory role in its antiviral and antibacterial response through modulating TRAF6-mediated immune responses.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Lingping Sun, Weiwei Zheng, Yuena Sun, Tianjun Xu
Summary: This study reports a novel lncRNA, LTCONS7822, in miiuy croaker that plays a positive regulatory role in antiviral immunity. The lncRNA was found to positively regulate MITA at the posttranscriptional level. The study provides new information on the immune regulation network of lncRNA in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Renjie Chang, Weiwei Zheng, Qiang Luo, Guiliang Liu, Tianjun Xu, Yuena Sun
Summary: The study revealed that miR-148-1-5p functions as a negative regulator in immune responses by targeting the IRAK1 gene and modulating the NF-kappa B signaling pathway in miiuy croaker.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Fisheries
Qiang Luo, Xuefeng Zhou, Xing Lv, Weiwei Zheng, Shang Geng, Tianjun Xu, Yuena Sun
Summary: Alternative splicing is an important mechanism for controlling gene expression in eukaryotes. This study identified three different splicing isoforms in the ferritin gene fthl27 of Miichthys miiuy and found that they showed an upregulation trend after stimulation. These isoforms may have different regulatory effects on inflammatory factors and antiviral immune factors, playing a significant role in the innate immune response of fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Liyuan Yang, Weiwei Zheng, Xing Lv, Shiying Xin, Yuena Sun, Tianjun Xu
Summary: In this study, miR-144 was investigated as a regulator of I kappa B alpha, promoting the activation of the NF-kappa B signaling pathway. The findings suggest that miR-144 can promote p65 activation by inhibiting I kappa B alpha, thus affecting the NF-kappa B signaling pathway.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
