Article
Fisheries
Wenwen Wang, Qian Xu, Xinbao Liu, Hongning Liu, Zhujun Li, Qingxin Fan, Suxu Tan, Kunpeng Shi, Yanting Xia, Zhenxia Sha
Summary: This study explored the relationship between bacterial concentrations and host mortality, inflammatory reaction, and immune response in half-smooth tongue sole after infection with Vibrio anguillarum. The results indicated that the 24-48 hour period post-infection was a key time node for early detection and intervention of vibriosis. Excessive activation of the complement system and inflammatory reaction may contribute to mass death in fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Na Zhao, Lei Jia, Xiaoxu He, Bo Zhang
Summary: By analyzing the proteins in exosomes, potential biomarkers for disease diagnosis and prognosis can be discovered. The research on Cynoglossus semilaevis explored the impact of Vibrio harveyi from a different perspective and identified potential infection biomarkers.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Na Zhao, Lei Jia, Guangli Li, Xiaoxu He, Chunhua Zhu, Bo Zhang
Summary: This study identified specific miRNAs in the epidermal mucus of fish infected with Vibrio harveyi, which can serve as disease-related biomarkers. These miRNAs can be used to differentiate diseased and healthy fish and provide new insights into the mechanism of bacterial infections in fish.
MARINE BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhujun Li, Suxu Tan, Longjiang Qi, Yadong Chen, Hongning Liu, Xinbao Liu, Zhenxia Sha
Summary: The study identified and characterized a set of 28 ITG genes in half-smooth tongue sole, most of which are involved in immune function. The selection pressure analysis showed that these ITG genes were under purifying selection, with the exception of ITG alpha11b and ITG alphaL. Expression analysis of eight selected ITG genes in healthy tissues and after bacterial infection revealed their significant role in immune response.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2023)
Article
Biochemistry & Molecular Biology
Hongning Liu, Suxu Tan, Yadong Chen, Xuejie Chen, Xinbao Liu, Zhujun Li, Ningning Wang, Sen Han, Zhendong Wu, Jie Ma, Kunpeng Shi, Wenwen Wang, Zhenxia Sha
Summary: This study elucidated the regulatory mechanism of Cse-miR-722 on CsC5aR1 and demonstrated its important role in immune response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Longjiang Qi, Yadong Chen, Kunpeng Shi, Hui Ma, Shu Wei, Zhenxia Sha
Summary: The study analyzed the transcriptomics and proteomics of the liver of Cynoglossus semilaevis infected with Vibrio anguillarum, revealing the significance of five key signaling pathways in enhancing liver immune defense. It identified important genes and proteins involved in immune response, recognition of pathogens, inflammatory response, and phagocytosis. The findings provide valuable information for further research on the mechanisms of liver immune response.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2021)
Article
Agriculture, Dairy & Animal Science
Xianghui Zhang, Xiancai Hao, Wenxiu Ma, Tengfei Zhu, Zhihua Zhang, Qian Wang, Kaiqiang Liu, Changwei Shao, Hong-Yan Wang
Summary: This study analyzed the gene expression changes in the kidney of Chinese tongue sole after Vibrio harveyi infection and found rapid up-regulation of immune-related pathways in the early stage, as well as a close connection between the immune system and neuroendocrine system.
Article
Fisheries
Yating Liu, Yaotong Hao, Yufeng Liu, Guixing Wang, Zhongwei He, Yaxian Zhao, Zixiong Xu, Xiaochen Liu, Yufeng Wang, Chunguang Gong, Jilun Hou
Summary: The study highlights the important role of atp6v0b in the response of half-smooth tongue sole to Vibrio vulnificus infection, indicating its crucial role in regulating the immune response.
AQUACULTURE REPORTS
(2021)
Article
Fisheries
Na Zhao, Bo Zhang, Lei Jia, Xiaoxu He, Baolong Bao
Summary: Extracellular vesicles play a regulatory role in intracellular and intercellular transmission through various biological information molecules. piRNAs, a type of small regulatory RNAs in these vesicles, were isolated from skin mucus of Cynoglossus semilaevis and screened for potential biomarkers related to bacterial infections. Different piRNA profiles were compared between infected and healthy fish, with specific piRNAs identified as potential markers for disease detection and resistance breeding.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Microbiology
Yaotong Hao, Yaxian Zhao, Yitong Zhang, Yufeng Liu, Guixing Wang, Zhongwei He, Wei Cao, Tian Han, Xun Zhang, Ziying Zhang, Yufen Wang, Chunguang Gong, Jilun Hou
Summary: This study investigated the intestinal microbial response to different doses of Vibrio alginolyticus infection in half-smooth tongue sole. The results showed that high-dose infection significantly altered the intestinal microbiota, decreased microbial diversity, and increased the number of potential pathogens such as Vibrio and Shewanella.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Fisheries
Chunguang Gong, Yaotong Hao, Yating Liu, Yaxian Zhao, Yufeng Liu, Guixing Wang, Zhongwei He, Jiaqi Liu, Bo An, Yanling Zhang, Qinghai Yu, Yufeng Wang, Jilun Hou
Summary: The study found that the immune system of the half-smooth tongue sole is not sensitive to moderate- or low-dose Vibrio vulnificus infection, while leukocytes, ALP, and complement primarily play a role in resisting high-dose infection. A variety of intestinal microbial taxa are important in inhibiting Vibrio vulnificus growth.
Article
Fisheries
Houfu Liu, Xiucai Hu, Zhengyi Lian, Zhang Luo, Aijun Lv, Jing Tan
Summary: In this study, immune-related protein in the skin of half-smooth tongue sole infected with Vibrio vulnificus was screened and identified using iTRAQ analysis. Differentially expressed proteins in skin immune response were found in the focal adhesion signaling pathway. Validation analysis of focal adhesion-related genes showed consistent results with iTRAQ data, and their spatio-temporal expressions were confirmed by qPCR analysis. The molecular characterization of vinculin of half-smooth tongue sole was also described. This study provides a new perspective for understanding the molecular mechanism of focal adhesion signaling pathway in the skin immune response in marine fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Zhangfan Chen, Lei Wang, Xiwen Xu, Qian Zhou, Jie Wang, Yadong Chen, Na Wang, Zhihong Gong, Songlin Chen
Summary: The research found that Cs-CIITA plays a crucial role in the inflammatory response of C. semilaevis against V. harveyi, regulating the expression of other inflammation-related genes through MHC II transcriptional regulation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Fisheries
Na Zhao, Qiuxia Deng, Chunhua Zhu, Bo Zhang
Summary: The study identified differentially expressed piRNAs in the mucus of sick and healthy half-smooth tongue sole, with immunity-related target genes being the main focus. qRT-PCR results revealed significant differences in expression levels of specific piRNAs, which could serve as potential biomarkers during Vibrio harveyi infection in the fish.
JOURNAL OF FISH DISEASES
(2022)
Article
Immunology
Tengfei Zhu, Ming Kong, Chen Li, Changwei Shao
Summary: This study investigated the role of exosomal miRNAs in Chinese tongue sole's response to Vibrio harveyi infection. The results demonstrated the important regulatory roles of exosomal miRNAs in the inflammatory and immune responses, and their potential as biomarkers for the prognosis and diagnosis of infection in teleost fish.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Weili Shi, Qiqi Xin, Rong Yuan, Yahui Yuan, Weihong Cong, Keji Chen
Summary: Mesenchymal stem cells play a crucial role in angiogenesis and vasculogenesis through their paracrine function, regulating the formation of blood vessels and improving ischemic myocardium. These cells are able to differentiate into various cell lineages and support the survival of myocardial tissue.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yun Cai, Qiqi Xin, Jinjin Lu, Yu Miao, Qian Lin, Weihong Cong, Keji Chen
Summary: Cardiovascular diseases are the leading cause of death worldwide, with current treatments showing limited effectiveness. However, recent studies have shown promising prospects for berberine in preventing and treating cardiovascular diseases, offering hope for improved outcomes.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Integrative & Complementary Medicine
Xin Qi-qi, Chen Xun, Yuan Rong, Yuan Ya-hui, Hui Jia-qi, Miao Yu, Cong Wei-hong, Chen Ke-ji
Summary: The study found that among CHD patients, those with BSS exhibited increased platelet function, hypercoagulability, and decreased fibrinolytic activity.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Lidan Wang, Qiqi Xin, Ya Wang, Zhuhong Chen, Rong Yuan, Yu Miao, Guangde Zhang, Weihong Cong
Summary: Liraglutide showed favorable effects on blood glucose, cardiac function, and lipid profile in patients with Type 2 Diabetes Mellitus complicated with Coronary Artery Disease, with an acceptable safety profile.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Rong Yuan, Yahui Yuan, Lidan Wang, Qiqi Xin, Ya Wang, Weili Shi, Yu Miao, Sean Xiao Leng, Keji Chen, Weihong Cong
Summary: The systematic review and meta-analysis showed that red yeast rice preparations significantly improved outcomes related to MetS, reducing mortality and major adverse cardiovascular events, as well as improving blood glucose, lipid profiles, and blood pressure. The preparations did not increase the incidence of adverse reactions, supporting their application for the prevention and treatment of MetS. Additional high-quality studies are needed to further establish the effectiveness of red yeast rice on MetS due to study heterogeneity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ecology
V. H. Nirmale, S. Y. Metar, N. D. Chogale, R. A. Pawar, B. T. Sawant, M. J. Gitte, S. J. Meshram, R. K. Sadawarte, R. B. Bondre, B. M. Yadav
Summary: The study on the growth and mortality of Kiddy Shrimp along the coasts of Ratnagiri, Alibag and Mumbai showed variations in size range, mean length, mortality rate, and exploitation ratio at different localities.
REGIONAL STUDIES IN MARINE SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Qiqi Xin, Weili Shi, Yan Wang, Rong Yuan, Yu Miao, Keji Chen, Weihong Cong
Summary: The study demonstrates that Pantao Pill (PTP) significantly improves cognitive impairment by regulating autophagy, apoptosis, and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Jiaqi Hui, Rong Yuan, Pengqi Li, Qiqi Xin, Yu Miao, Xiaoxu Shen, Fengqin Xu, Weihong Cong
Summary: This study found that TXLC combined with conventional treatment significantly reduced the risk of cardiovascular events for CHD patients after PCI. The efficacy of TXLC was observed after a 6-month treatment, but not after a 3-month treatment. Therefore, TXLC may be beneficial for patients and is safe to use.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Jing Cong, Wei Cong, Hui Lu, Yuguang Zhang
Summary: This study investigated the community structure of soil bacteria and plant diversity along an elevation gradient in an alpine meadow ecosystem of the Qinghai-Tibetan Plateau. The results show that soil bacterial diversity and plant diversity exhibit different distribution patterns along the elevation gradient, without significant linkages between them.
Article
Cardiac & Cardiovascular Systems
Ya Wang, Dandan Li, Zijun Jia, Jiaqi Hui, Qiqi Xin, Qingbing Zhou, Weihong Cong, Fengqin Xu
Summary: The study analyzed the development of gut microbiota (GM) in atherosclerosis (AS) over the past decades and provided valuable insights. It found a rapid growth in publications on GM in AS since 2008. China and Cleveland Clin were identified as the most prolific country and institution, respectively. The journal with the most publications was Nutrients, while Nature was the most co-cited journal. The research focus in this area has changed over time, with recent studies focusing on choline, hypertension, butyrate, and berberine. The study concluded that GM plays a critical role in atherosclerotic diseases and suggested that this topic deserves more attention in the future.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Jiaqi Hui, Ya Wang, Junnan Zhao, Weihong Cong, Fengqin Xu
Summary: This study evaluated the effects of Tai Chi on health status in adults with chronic heart failure (CHF). The results showed that Tai Chi combined with usual care improved the quality of life, exercise capacity, cardiac function, and reduced the risk of heart failure hospitalization in patients with CHF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Raju M. Tibile, Gajanan S. Ghode, Ravindra A. Pawar
Summary: The study describes the weight changes in the length-weight relationships (LWRs) and the weight-weight relationships (WWRs) of mrigal males and females used as broodstock in a commercial IMC hatchery. Significant differences in pre-and post-spawning weights were observed in both sexes. Trends in the LWR and weight-weight slopes are discussed in the article.
INDIAN JOURNAL OF ANIMAL SCIENCES
(2022)
Article
Cell Biology
Lin Wang, Bi-Qiang Zhou, Ying-Hong Li, Qian-Qian Jiang, Wei-Hong Cong, Ke-Ji Chen, Xiao-Min Wen, Zheng-Zhi Wu
Summary: This study found that lactoferrin-modified berberine nanoliposomes can inhibit acetylcholinesterase activity and apoptosis, reduce tau over-phosphorylation, and improve behavior in a mouse model of Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biology
Udai R. Gurjar, Suman Takar, Milind S. Sawant, Ravindra A. Pawar, Vivek H. Nirmale, Anil S. Pawase, Sushanta K. Chakraborty, Karan K. Ramteke, Tarachand Kumawat
Summary: The study evaluated the growth and mortality parameters of white sardine, Escualosa thoracata, due to its high local demand. Results indicated over-fishing conditions with an exploitation ratio (E) of 0.68, suggesting a need to reduce fishing pressure for the sustainability of the resource along the central west coast of India.
JOURNAL OF BASIC AND APPLIED ZOOLOGY
(2021)
Article
Biology
Udai R. Gurjar, Suman Takar, Milind S. Sawant, Ravindra A. Pawar, Vivek H. Nirmale, Anil S. Pawase, Sushanta K. Chakraborty, Karan K. Ramteke, Tarachand Kumawat
Summary: The study evaluated the growth and mortality parameters of white sardine, Escualosa thoracata, a species in high demand locally. Results indicate that overfishing is a concern for the sustainability of white sardine population along the central west coast of India.
JOURNAL OF BASIC AND APPLIED ZOOLOGY
(2021)