Review
Fisheries
Yongji Dang, Yanling Sun, Yangen Zhou, Xianhui Men, Bowen Wang, Bing Li, Yichao Ren
Summary: This study evaluated the effects of probiotics on growth, immune response, and susceptibility to bacterial infection in rainbow trout. The results showed that probiotics promoted weight gain and resistance to bacterial infection in rainbow trout. Different Toll-like receptors were involved in the recognition of beneficial bacteria, and probiotics enhanced the innate immune function of rainbow trout by training immune response pathways.
Review
Cell Biology
Stavros Garantziotis, Rashmin C. Savani
Summary: The extracellular matrix (ECM) is not only a structure but also plays key roles in cellular responses. Proteoglycans (PGs), a component of ECM, have been found to be crucial in both health maintenance and disease development by activating the innate immune system and influencing cell fate.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Fisheries
Ertugrul Terzi, Bunyamin Kucukkosker, Soner Bilen, Osman Nezih Kenanoglu, Orhan Corum, Mehmet Ozbek, Sukru Senol Parug
Summary: The aqueous methanolic extract of thin-skinned plum showed positive effects on the growth, immune response, and resistance to a pathogenic bacterium in rainbow trout. Specifically, it improved innate immunity, survival against Yersinia ruckeri, and decreased the feed conversion ratio level significantly.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Ju Hye Jang, In Young Jung, Hyun Kim, Ju Hyun Cho
Summary: The study reveals that OmUSP4 plays an important role in regulating TLR signaling response in rainbow trout, mitigating inflammation in cells. This suggests that OmUSP4 may have a similar mechanism of action to mammals.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Sahar Farahnak Roudsari, Houman Rajabi Islami, Seyed Abdolmajid Mousavi, Mehdi Shamsaie Mehrgan
Summary: The study showed that dietary FA-coated nanochitosan significantly improved the growth performance, feed utilization, antioxidant status, and immune responses of rainbow trout. The antioxidant responses were highest in fish fed with 0.50 mg/kg FA-coated nanochitosan, and immune responses showed a linear increase with increasing dietary FA-coated nanochitosan levels.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Fabio Sarais, Sophia Kummerow, Ruth Montero, Henrike Rebl, Bernd Koellner, Tom Goldammer, Bertrand Collet, Alexander Rebl
Summary: The study revealed the existence of eight pias genes in the rainbow trout genome, each showing differential expression in tissues and cells. Three structurally different Pias protein variants were found to suppress the activity of the NF-kappa B promoter in a dose-dependent manner, with potential different immune gene regulation in ifn γ-expressing cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Ryma Haroun, Sahar Naasri, Ayman J. Oweida
Summary: TLRs are essential for immune responses and can mediate inflammation by recognizing molecular patterns in pathogens and damaged cells. TLR ligands have gained attention in cancer research, especially in combination with cancer treatments like immunotherapy, chemotherapy, and radiotherapy (RT). However, the role of TLRs in cancer, particularly in response to radiation, is still poorly understood. This review examines how TLR signaling affects tumor response to RT and proposes a framework for TLR-based therapies with RT.
Article
Fisheries
Marzieh Abolfathi, Arash Akbarzadeh, Abdolmajid Hajimoradloo, Hamid Reza Joshaghani, Neil W. Ross
Summary: This study aimed to investigate the seasonal changes in the epidermal structure and innate immunity parameters of skin mucus in rainbow trout. The results showed that the skin mucosal immunity increased with increasing fish size and water bacterial load. The histological analysis of rainbow trout skin revealed an increase in goblet cell density and mucus secretion during the summer. The mucus of rainbow trout could potentially be used to develop antimicrobial agents for both human and fish diseases.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Allison M. Owen, Liming Luan, Katherine R. R. Burelbach, Margaret A. A. McBride, Cody L. L. Stothers, Olivia A. A. Boykin, Kalkena Sivanesam, Jessica F. F. Schaedel, Tazeen K. K. Patil, Jingbin Wang, Antonio Hernandez, Naeem K. K. Patil, Edward R. R. Sherwood, Julia K. K. Bohannon
Summary: Immunocompromised populations are at high risk of life-threatening infections, and strategies to protect these patients are urgently needed. This study explores the use of trained immunity, which enhances the immune response to subsequent infections, as a promising approach. The researchers demonstrate that the MyD88-dependent signaling pathway plays a critical role in TLR-mediated trained immunity, providing valuable insights into the mechanisms underlying this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Antonios Lazaridis, Eleni Gavriilaki, Stella Douma, Eugenia Gkaliagkousi
Summary: Essential hypertension is a highly heterogeneous disease with a complex etiology, where subclinical inflammation and abnormal activation of TLR signaling play crucial roles in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jinta Asami, Toshiyuki Shimizu
Summary: TLRs are crucial in recognizing pathogenic molecular patterns and initiating immune responses. Recent advances in structural and mechanistic studies have provided insights into the activation and inhibition mechanisms of TLRs, enhancing our understanding of their functional properties.
Article
Fisheries
Kai Lun Wang, Shan Nan Chen, Hui Jun Huo, Pin Nie
Summary: Sixteen Toll-like receptors were identified and characterized in mandarin fish, showing high expression levels in immune-related tissues and mucosa-related tissues and significant up-regulation after stimulation. This study provides valuable information for further research on TLR genes in mandarin fish.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Fisheries
Hansam Cho, Ki Hoon Park, Yuyeon Jang, Yeondong Cho, Yoon-Ki Heo, Minjee Kim, Young Bong Kim
Summary: Outbreaks of infectious disease in shrimp pose a serious threat to shrimp agriculture worldwide. Shrimp lack adaptive immunity and rely solely on innate immunity for defense against infectious disease. Toll-like receptors play a critical role in the shrimp innate immune system, with the identification of a new Toll-like receptor gene (MnToll) in Macrobrachium nipponense potentially involved in defense against WSSV.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Sarker Mohammed Ibrahim Khalil, Chiara Bulfon, Marco Galeotti, Pier Luigi Acutis, Ilhan Altinok, Charalampos Kotzamanidis, Ana Isabel Vela, Lucio Fariano, Marino Prearo, Silvia Colussi, Donatella Volpatti
Summary: This study provides preliminary knowledge on the immunological relationship between rainbow trout and L. garvieae, suggesting that specific immune parameters could serve as reliable indicators of the fish's innate ability to fight infection.
JOURNAL OF FISH DISEASES
(2023)
Article
Immunology
Luke S. Uebelhoer, Agnes Gwela, Bonnie Thiel, Sophie Nalukwago, John Mukisa, Christopher Lwanga, Justine Getonto, Emily Nyatichi, Grace Dena, Alexander Makazi, Shalton Mwaringa, Ezekiel Mupere, James A. Berkley, Christina L. Lancioni, Childhood Acute Illness
Summary: Severely ill children in low- and middle-income countries experience high mortality rates from infectious diseases, and the risk of infection-related death is compounded by undernutrition. This study found that T cell function is impaired and innate immune responses are exaggerated in acutely ill children. Nutritional status is associated with the magnitude of cytokine responses. Further research is needed to understand the mechanisms of innate immune dysregulation in this population.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
K. A. Garver, G. D. Marty, S. N. Cockburn, J. Richard, L. M. Hawley, A. Mueller, R. L. Thompson, M. K. Purcell, S. Saksida
JOURNAL OF FISH DISEASES
(2016)
Article
Fisheries
M. K. Purcell, C. L. McKibben, S. Pearman-Gillman, D. G. Elliott, J. R. Winton
JOURNAL OF FISH DISEASES
(2016)
Article
Genetics & Heredity
Roger L. Vallejo, Sixin Liu, Guangtu Gao, Breno O. Fragomeni, Alvaro G. Hernandez, Timothy D. Leeds, James E. Parsons, Kyle E. Martin, Jason P. Evenhuis, Timothy J. Welch, Gregory D. Wiens, Yniv Palti
FRONTIERS IN GENETICS
(2017)
Article
Fisheries
Cassidy H. Shaw, Guangtu Gao, Gregory D. Wiens
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2018)
Article
Agriculture, Dairy & Animal Science
Roger L. Vallejo, Rafael M. O. Silva, Jason P. Evenhuis, Guangtu Gao, Sixin Liu, James E. Parsons, Kyle E. Martin, Gregory D. Wiens, Daniela A. L. Lourenco, Timothy D. Leeds, Yniv Palti
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2018)
Article
Microbiology
Eric Duchaud, Tatiana Rochat, Christophe Habib, Paul Barbier, Valentin Loux, Cyprien Guerin, Inger Dalsgaard, Lone Madsen, Hanne Nilsen, Krister Sundell, Tom Wiklund, Nicole Strepparava, Thomas Wahli, Greta Caburlotto, Amedeo Manfrin, Gregory D. Wiens, Erina Fujiwara-Nagata, Ruben Avendano-Herrera, Jean-Francois Bernardet, Pierre Nicolas
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Fisheries
Gregory D. Wiens, Yniv Palti, Timothy D. Leeds
Article
Fisheries
G. Kurath, J. R. Winton, O. B. Dale, M. K. Purcell, K. Falk, R. A. Busch
JOURNAL OF FISH DISEASES
(2016)
Article
Biotechnology & Applied Microbiology
Christopher Knupp, Gregory D. Wiens, Mohamed Faisal, Douglas R. Call, Kenneth D. Cain, Pierre Nicolas, Danielle Van Vliet, Coja Yamashita, Jayde A. Ferguson, Dave Meuninck, Hui-Min Hsu, Bridget B. Baker, Ling Shen, Thomas P. Loch
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Fisheries
Ryan M. Brown, Gregory D. Wiens, Irene Salinas
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Paul Barbier, Tatiana Rochat, Haitham H. Mohammed, Gregory D. Wiens, Jean-Francois Bernardet, David Halpern, Eric Duchaud, Mark J. McBride
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
William N. Batts, Tony R. Capps, Lisa M. Crosson, Rachel L. Powers, Rachel Breyta, Maureen K. Purcell
Summary: This article reports the development of a new diagnostic test for Infectious hematopoietic necrosis virus (IHNV), which can detect the presence of the virus and discriminate between different virus groups. The test showed high sensitivity and specificity when applied to free-ranging adult Pacific salmon.
Article
Fisheries
Patty Zwollo, Erin Hennessey, Catherine Moore, David P. Marancik, Gregory D. Wiens, Lidia Epp
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Ivan Kutyrev, Beth Cleveland, Timothy Leeds, Gregory D. Wiens
Article
Agriculture, Dairy & Animal Science
Roger L. Vallejo, Timothy D. Leeds, Guangtu Gao, James E. Parsons, Kyle E. Martin, Jason P. Evenhuis, Breno O. Fragomeni, Gregory D. Wiens, Yniv Palti
GENETICS SELECTION EVOLUTION
(2017)