Article
Metallurgy & Metallurgical Engineering
Man-fei Yi, Liang-jian Chen, Hui-li He, Lei Shi, Chun-sheng Shao, Bo Zhang
Summary: Improvements in calcium phosphate nanoparticles carriers can enhance gene transfection efficiency and promote osteoblast differentiation. The Mg-CaPNPs-RGD-TAT-CKIP-1 siRNA carrier system showed enhanced cellular uptake and inducement of osteogenesis.
JOURNAL OF CENTRAL SOUTH UNIVERSITY
(2021)
Article
Fisheries
Rui Zhang, Kun Wan, Yudan Liu, Zhangping Wang, Daochuan Zhang, Hong Yin
Summary: ApMKK4, an important gene in Artemia parthenogenetica, plays a pivotal role in early development and immune responses, with significantly increased expression levels in response to bacterial infections.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jiandong Yang, Shanzhou Duan, Huan Ye, Chenglong Ge, Chunxian Piao, Yongbing Chen, Minhyung Lee, Lichen Yin
Summary: TNF-alpha siRNA delivery nanocomplexes with mucus/cytomembrane dual-penetration capabilities have been engineered by coating with RC, enabling the efficient transfection of alveolar macrophages and silencing TNF-alpha, thus cooperatively alleviating uncontrolled inflammation during acute lung injury.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Infectious Diseases
Gabriela Silva Cruz, Ariane Teixeira dos Santos, Erika Helena Salles de Brito, Gandhi Radis-Baptista
Summary: This review presents the antibacterial, antiparasitic, and antiviral effects of cell-penetrating antimicrobial peptides and highlights their potential for treating intracellular infections.
Article
Immunology
Santosh Pandit, Lucas Jacquemin, Jian Zhang, Zhengfeng Gao, Yuta Nishina, Rikke Louise Meyer, Ivan Mijakovic, Alberto Bianco, Chengfang Pang
Summary: The absorption of antimicrobial peptide polymyxin B onto the surface of graphene oxide significantly enhances its antibacterial activity and can effectively combat bacterial biofilms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alicia Malone, Rikki F. Clark, David W. Hoskin, Melanie R. Power Coombs
Summary: Lactoferricin AMPs have immunomodulatory effects and may be used to treat inflammatory diseases.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Chemistry, Multidisciplinary
Jingjing Zhou, Hanru Zhang, Muhammad Subaan Fareed, Yuhang He, Yaqi Lu, Changyan Yang, Zhaopeng Wang, Jie Su, Panpan Wang, Wenjin Yan, Kairong Wang
Summary: This study reports the potential use of a hydrogel formed by self-assembling a natural antimicrobial peptide J-1 in an ADP solution to prevent postoperative adhesion formation. The hydrogel showed good antimicrobial and hemostatic activities, and demonstrated significant antiadhesion effects in animal models.
Review
Immunology
Ewa Oleszycka, Kamila Kwiecien, Patrycja Kwiecinska, Agnieszka Morytko, Natalia Pocalun, Michelle Camacho, Piotr Brzoza, Brian A. A. Zabel, Joanna Cichy
Summary: The skin, as the largest organ exposed to the environment, plays a critical role in integrating signals and defending against external threats. The interactions between the epidermis, immune system, and nervous system are now recognized for their importance in regulating and maintaining the skin barrier function in relation to skin pathophysiology. Dysregulation of these connections can lead to chronic inflammatory diseases and conditions associated with chronic pain or itch.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Darya V. Poshvina, Diana S. Dilbaryan, Alexey S. Vasilchenko
Summary: Antibiotic resistance is a significant issue in the medical field, and Staphylococcus aureus poses a serious threat as it is responsible for many infections and has high mortality rates. We studied the gene expression of gausemycin A-resistant S. aureus and found that changes in the cell wall and cell membrane are crucial for bacterial resistance. In the late-exponential phase, genes involved in cell wall turnover, membrane charge, phospholipid metabolism, stress response, and proteolytic system showed increased expression, while in the stationary phase, genes involved in phospholipid metabolism and proteolytic system showed decreased expression.
Article
Cell Biology
David Salehi, Saghar Mozaffari, Khalid Zoghebi, Sandeep Lohan, Dindyal Mandal, Rakesh K. Tiwari, Keykavous Parang
Summary: A series of cyclic and linear peptides containing arginine and either tryptophan or diphenylalanine residues were synthesized and evaluated for their molecular transporter efficiency. Among them, the [DipR](5) peptide showed significantly improved uptake of small molecules and negatively charged molecules, such as siRNA and phosphopeptide, suggesting its potential as an efficient membrane transporter.
Article
Biochemistry & Molecular Biology
Kyona Hiroshima, Nana Sakata, Tadafumi Konogami, Shigeru Shimamoto, Yuji Hidaka
Summary: The joining peptide region (JP) in POMC was found to have cell adhesion activity mediated by integrin. The cell adhesion activity of JP is developed during the molecular evolution of POMC.
Article
Engineering, Biomedical
Qi Tang, Peng Tan, Zhaolai Dai, Tao Wang, Shenrui Xu, Yakun Ding, Junqi Jin, Xin Zhang, Yucheng Zhang, Chenlong Zhou, Zitian Yue, Huiyang Fu, Junshu Yan, Xi Ma
Summary: This study investigates the association between hydrophobicity and cell-penetrating peptide delivery efficiency, and successfully develops chimeric peptides P3I7 and P3L7 with strong antibacterial activity and low cytotoxicity. These peptides can effectively penetrate cells to eliminate intracellular pathogens mainly through endocytosis. The mechanism of membrane destruction makes them fast sterilizers and less prone to drug resistance. In vivo trials confirm their good biocompatibility and antibacterial infection effects, indicating their potential as affordable and effective antimicrobial agents against intracellular bacterial infections.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Anna Golunova, Nadiia Velychkivska, Zuzana Miksovska, Vaclav Chochola, Josef Jaros, Ales Hampl, Ognen Pop-Georgievski, Vladimir Proks
Summary: In this study, bone-sialoprotein derived peptide was successfully conjugated to the alginate molecule using four different methods, leading to efficient peptide conjugation. Cell culture experiments demonstrated the positive effect of peptide presence on the adhesion of human embryonic stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Tianran Lin, Yunping Lai, Gaoyan Jiang, Xinlian Chen, Li Hou, Shulin Zhao
Summary: A novel probe for bacteria was synthesized using a simple method without complicated modification. The probe showed good sensitivity in colorimetric detection of Escherichia coli with the assistance of a smartphone-based app.
CHEMICAL COMMUNICATIONS
(2023)
Review
Fisheries
Gabriel Machado Matos, Rafael Diego Rosa
Summary: Antimicrobial peptides (AMPs) are diverse effector molecules widely distributed in crustaceans, with unique molecular structures and biological properties, playing important roles in immune responses and host-microbe interactions.
REVIEWS IN AQUACULTURE
(2022)