Article
Immunology
Byron Morales-Lange, Felipe Ramirez-Cepeda, Paulina Schmitt, Fanny Guzman, Leidy Lagos, Margareth Overland, Valentina Wong-Benito, Monica Imarai, Derie Fuentes, Sebastian Boltana, Javier Alcaino, Carlos Soto, Luis Mercado
Summary: This study investigated the effect of IFN gamma on the expression of cell-surface markers on splenocytes of Atlantic salmon. The results showed that IFN gamma could stimulate the gene expression and protein availability of cell-surface markers, enhancing the function of immune cells. In vivo experiments demonstrated that during a natural outbreak of Piscirickettsia salmonis, the expression of IFN gamma in Atlantic salmon increased simultaneously with the up-regulation of cell-surface markers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Zhiwen Wu, Toshiaki Yoshikawa, Satoshi Inoue, Yusuke Ito, Hitomi Kasuya, Takahiro Nakashima, Haosong Zhang, Saki Kotaka, Waki Hosoda, Shiro Suzuki, Yuki Kagoya
Summary: T cell exhaustion is a major obstacle to effective cancer immunotherapy. CD83 is identified as a marker to distinguish precursor exhausted T cells from other tumor-infiltrating T lymphocyte subsets. CD83 is predominantly expressed in CCR7(+)PD1(+) T cells and is associated with superior antigen-induced proliferation and IL-2 production.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Sudarshan Singh Rathore, Lalitha Cheepurupalli, Jaya Gangwar, Thiagarajan Raman, Jayapradha Ramakrishnan
Summary: This study aimed to unravel the interaction between Klebsiella biofilm and macrophages. The results showed that the phagocytic rate against heat inactivated and live biofilms significantly increased when macrophages were activated by LPS + IFN-gamma. Heat-inactivated and live biofilms induced similar phagocytic responses and up-regulation of pro-inflammatory genes in macrophages.
Article
Biology
Lianbo Li, Tomoaki Irie, Daiki Yoshii, Yoshihiro Komohara, Yukio Fujiwara, Shigeyuki Esumi, Masashi Kadohisa, Masaki Honda, Shinya Suzu, Toshiharu Matsuura, Kenichi Kohashi, Yoshinao Oda, Taizo Hibi
Summary: This study revealed that the density of CD204-positive TAMs was significantly higher in the embryonal component of hepatoblastoma compared to other histological subtypes. Co-culture experiments showed that macrophage-colony-stimulating factor receptor (M-CSFR) expression was up-regulated in hepatoblastoma cells when in direct contact with human monocyte-derived macrophages (HMDMs). In addition, M-CSFR inhibitor demonstrated potential effectiveness against M-CSFR-positive hepatoblastoma, particularly in recurrent cases.
MEDICAL MOLECULAR MORPHOLOGY
(2022)
Article
Hematology
Martina Hason, Tereza Mikulasova, Olga Machonova, Antonio Pombinho, Tjakko J. van Ham, Uwe Irion, Christiane Nuesslein-Volhard, Petr Bartunek, Ondrej Svoboda
Summary: The CSF1R signaling pathway plays a crucial role in the differentiation, proliferation, and survival of myeloid cells. Understanding the function of cytokine signaling in zebrafish is important for disease modeling and therapeutic screening. This study investigates the roles of zebrafish Csf1rs and their ligands in myelopoiesis and uncovers the importance of Csf1rb in granulopoiesis. These findings contribute to the understanding of myeloid cell function and have implications for studying CSF1R pathway deregulation in diseases like cancer.
Review
Cell Biology
Tamas Roeszer
Summary: The safe removal of apoptotic cells by macrophages is crucial for tissue health, but in the case of adipocyte apoptosis, the clearance process can lead to inflammation and metabolic diseases. Metabolites released by apoptotic cells and produced by macrophages during digestion of apoptotic cells control macrophage immune functions.
Article
Microbiology
B. Shoshana Zha, Ludovic Desvignes, Tawania J. Fergus, Amber Cornelius, Tan-Yun Cheng, D. Branch Moody, Joel D. Ernst
Summary: In the early stages of tuberculosis infection, the interactions between different strains of Mycobacterium tuberculosis and lung leukocytes can shape the adaptive immune responses.
Article
Immunology
Susan Moradinasab, Atieh Pourbagheri-Sigaroodi, Seyed H. Ghaffari, Davood Bashash
Summary: Immunotherapy in cancer treatment is rapidly developing, and the focus is shifting towards the phagocytosis of macrophages and adaptive immune cross-priming. Targeting macrophage phagocytosis has become a promising therapeutic strategy, with blocking phagocytosis checkpoints and using nanoparticles as methods to enhance macrophage-mediated phagocytosis. CAR-macrophages serve as a bridge between the innate and adaptive immune system, showing superior antitumor response in cancer treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Takayuki Ueno, Yumi Yamamoto, Kiyoshi Kawasaki
Summary: The phagocytosis of polystyrene latex beads by macrophage-like U937 and THP-1 cells enhances pro-inflammatory responses induced by bacterial components, regardless of the uptake mechanism. Additionally, phagocytosis enhances LPS-induced NF-kappa B activation, suggesting that Toll-like receptor (TLR) 4 signaling is enhanced by phagocytosis. Overall, microparticle phagocytosis enhances the innate immune response induced by bacterial components.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
James M. Baker, Molly Hammond, Josiah Dungwa, Rajesh Shah, Angeles Montero-Fernandez, Andrew Higham, Simon Lea, Dave Singh
Summary: The study found that lung macrophage iron levels are increased in COPD patients and are significantly correlated with airflow obstruction. Red blood cells (RBCs) are identified as a plausible source of pulmonary iron overload in COPD, which dysregulates macrophage phenotype and function.
Article
Immunology
Josephine Moran, Liam Feltham, James Bagnall, Marie Goldrick, Elizabeth Lord, Catherine Nettleton, David G. Spiller, Ian Roberts, Pawel Paszek
Summary: The paper investigates the real-time interaction between the food-borne pathogen L. monocytogenes and host macrophages, revealing heterogeneous outcomes of infection and the impact of bacterial quantity on macrophage phagocytosis ability. It also highlights the role of population-level PrfA-mediated activity in regulating host-pathogen interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soraya Jativa, Priscila Calle, Selene Torrico, Angeles Munoz, Miriam Garcia, Ivet Martinez, Anna Sola, Georgina Hotter
Summary: A study has shown that transplanting healthy mitochondria into cholesterol-loaded macrophages can restore phagocytosis and reduce lipid accumulation, leading to a decrease in foam cell formation.
Review
Immunology
Gerone A. Gonzales, Johnathan Canton
Summary: This article reviews the active cytosolic transfer of various macromolecular danger signals across endocytic organelle membranes. It highlights the developing trends and discusses the potential molecular mechanisms driving this emerging phenomenon.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ophelie Gervais, Carolina Penaloza, Remi Gratacap, Athina Papadopoulou, Mariana Beltran, Neil C. Henderson, Ross D. Houston, Musa A. Hassan, Diego Robledo
Summary: In this study, single-cell RNA sequencing was used to provide a high-dimensional insight into the transcriptional landscape of Atlantic salmon cells during early Infectious Salmon Anaemia Virus (ISAV) infection. The results showed a clear anti-viral response in infected cells, characterized by the upregulation of IFNA2 or IRF2. Additionally, uninfected bystander cells exhibited transcriptional differences, suggesting paracrine signaling from infected cells. This study identified potential key genes involved in the host-virus interaction, which can be targeted in future functional studies to enhance the resistance of Atlantic salmon to ISAV.
Article
Immunology
Xue Liu, Ling-Yuan Zhang, Yu-Ge Zhang, Ting-Hong Duan, Yi Ding, Cai-long Pan, Lu Xu, Cheng Qian, Min Ni, Zhi-Yuan Zhang
Summary: Systemic immune activation and excessive inflammatory response, induced by intestinal barrier damage, are the major characteristics of inflammatory bowel disease (IBD). Activating the homodimeric erythropoietin receptor (EPOR) can alleviate colitis in mice, promote the clearance of apoptotic cells in macrophages, and facilitate the expression of phagocytosis- and tissue-repair-related factors, providing a new mechanism for understanding pathological progression and a novel potential therapeutic target for colitis.
Article
Fisheries
H. C. Ingerslev, T. Lunder, M. E. Nielsen
FISH & SHELLFISH IMMUNOLOGY
(2010)
Article
Food Science & Technology
H. -C. Ingerslev, G. Hyldig, D. Przybylska, S. Frosch, M. E. Nielsen
JOURNAL OF FOOD QUALITY
(2012)
Article
Multidisciplinary Sciences
Hans-Christian Ingerslev, Carlo Gunnar Ossum, Thomas Lindenstrom, Michael Engelbrecht Nielsen
Article
Multidisciplinary Sciences
Rebecca Pedersen, Hans-Christian Ingerslev, Michael Sturek, Mouhamad Alloosh, Susanna Cirera, Berit O. Christoffersen, Sophia G. Moesgaard, Niels Larsen, Mette Boye
Article
Immunology
H. -C. Ingerslev, A. Ronneseth, E. F. Pettersen, H. I. Wergeland
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2009)
Article
Fisheries
Per Kania, Thomas B. Larsen, Hans C. Ingerslev, Kurt Buchmann
DISEASES OF AQUATIC ORGANISMS
(2007)
Article
Fisheries
HC Ingerslev, C Cunningham, HI Wergeland
FISH & SHELLFISH IMMUNOLOGY
(2006)
Article
Biochemistry & Molecular Biology
HC Ingerslev, EF Pettersen, RA Jakobsen, CB Petersen, HI Wergeland
MOLECULAR IMMUNOLOGY
(2006)