Article
Oncology
Mingyue Xu, You Liu, Tianhui Xue, Qianwen Ye, Jia Xiang, Long Liu, Bing Yan
Summary: This study found that the preoperative albumin to carcinoembryonic antigen ratio (ACR) is a robust prognostic factor in colorectal cancer (CRC), and patients with a lower ACR have significantly worse survival.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Surgery
Chih-Sheng Huang, Li-Kuo Huang, Chin-Yau Chen, Wei-Shu Wang, Shung-Haur Yang
Summary: This study demonstrates that chronic kidney disease (CKD) can increase postoperative serum carcinoembryonic antigen (CEA) levels in colorectal cancer patients, and elevated CEA levels are associated with shorter disease-free survival (DFS) in non-CKD patients.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Amanda Thomson, Diana F. Costa Bento, Martin J. Scurr, Kathryn Smart, Michelle S. Somerville, Asa Keita, Awen Gallimore, Andrew Godkin
Summary: Tumor antigen-specific T(H)17 responses can be detected in early-stage colorectal cancer patients, mainly in association with IFN-gamma responses. The production of IL-17A is mainly from two distinct T cell populations.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Xiao-Dong Zhu, Li-Xiang Zhang, Pan-Quan Luo, Hai Zhu, Zhi-Jian Wei, A-Man Xu
Summary: This study found that the elevation of tumor markers CEA and CA19-9 before and after gastric cancer surgery is associated with poor prognosis, and this increment has a greater impact on prognosis than preoperative CEA/CA19-9 levels. A new prognostic model was established and shown to have reliable accuracy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Sang Hun Park, Jun Ho Shin, Kyung Uk Jung, Sung Ryol Lee
Summary: This study assessed the role of preoperative serum CA 19-9 and CEA concentrations in the survival prognosis of patients with periampullary carcinoma and found that CA 19-9 may be a useful marker in predicting prognosis at the time of diagnosis.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Du Fenqi, Liu Yupeng, Zhang Qiuju, Yuan Chao, Song Wenjie, Xia Tianyi, Guo Junnan, Xue Weinan, Jiang Xiufeng, Bai Junge, Jia Chenyang, Xi Hua, Li Yien, Bai Xuefeng, Liu Yanlong
Summary: Early postoperative CEA is an important prognostic marker for stage II CRC patients and has the potential to guide treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jeng-Fu You, Yu-Jen Hsu, Yih-Jong Chern, Ching-Chung Cheng, Bor-Kang Jong, Chun-Kai Liao, Pao-Shiu Hsieh, Hung-Chih Hsu, Wen-Sy Tsai
Summary: The high CIPI index can serve as an independent factor in predicting the prognosis of colorectal cancer, effectively predicting the recurrence rate and survival rate of patients.
Article
Oncology
Hao Cai, Yu Chen, Qiao Zhang, Yang Liu, HouJun Jia
Summary: This study investigated the prognostic significance of preoperative CEA and C-SIRI in patients with resectable colorectal cancer. The results showed that high preoperative C-SIRI was significantly correlated with poorer overall survival and can serve as an important prognostic biomarker.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Thaer S. A. Abdalla, Jan Meiners, Sabine Riethdorf, Alexandra Koenig, Nathaniel Melling, Tobias Gorges, Karl-F. Karstens, Jakob R. Izbicki, Klaus Pantel, Matthias Reeh
Summary: The detection of circulating tumor cells in patients with colorectal cancer before surgery is an independent and strong prognostic factor for overall survival. This study suggests that it could improve the identification of high-risk patients in future clinical trials.
Article
Gastroenterology & Hepatology
Tae-Hoon Lee, Ji-Seon Kim, Se-Jin Baek, Jung-Myun Kwak, Jin Kim
Summary: This study aimed to evaluate the diagnostic accuracy of CEA for detecting colorectal cancer recurrence in patients with normal and elevated initial CEA levels. The results showed that the diagnostic accuracy of CEA depends on the initial CEA level, and an increase in CEA level at recurrence is significantly associated with overall survival in patients with recurrent colorectal cancer.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Medicine, General & Internal
Jing Yu, Lei Nie, Dongde Wu, Jian Chen, Zhifeng Yang, Ling Zhang, Dongqing Li, Xia Zhou
Summary: A clinical biochemistry-based nomogram was developed to predict the progression of COVID-19, with CEA, WBC, CRP, PCT, Fer, D-dimer, Neu%, and L% identified as independent prognostic factors. The nomogram constructed using these biomarkers offers guidance for the diagnosis and treatment of COVID-19.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Yang-Yu Huang, Xuan Liu, Shen-Hua Liang, Yu Hu, Guo-Wei Ma
Summary: This study aimed to investigate whether preoperative tumor biomarkers CEA and NSE could serve as independent predictors for postoperative prognosis in patients with TETs. The results showed that preoperative serum CEA levels and tumor size may be strong predictors of postoperative overall survival in patients with TETs.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Oncology
Jung Kyong Shin, Jung Wook Huh, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Yoon Ah Park
Summary: This study evaluated the prognostic value of serum CEA levels at the time of recurrence in patients with recurrent colorectal cancer. The results showed that patients with high r-CEA levels had a significantly poorer prognosis. This suggests that r-CEA level can be used as a prognostic factor in recurrent colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jianwei Xie, YaJun Zhao, Yanbing Zhou, Qingliang He, Hankun Hao, Xiantu Qiu, Gang Zhao, Yanchang Xu, Fangqin Xue, Jinping Chen, Guoqiang Su, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: The study focused on the long-term outcomes of patients with grade 3 gastric neuroendocrine carcinoma (GNEC) who underwent curative surgery, finding that combining carcinoembryonic antigen (CEA) levels and Ki-67 index can predict patient prognosis. A nomogram was constructed to predict patient survival, showing that the combination of Ki-67 status and AJCC 8th stage performed better in predicting prognosis than the AJCC 8th stage alone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Chih-Yung Yang, Chun-Chi Lin, Sheng-Chieh Huang, Ruey-Hwa Lu, Liang-Chuan Lo, Ju-Yu Tseng, Chien-Yi Tung, Chi-Hung Lin, Jeng-Kai Jiang
Summary: This study found that the number of circulating tumor cells (CTCs) in colorectal cancer (CRC) patients is closely associated with prognosis, and combining CTCs with the tumor marker CEA can provide a more accurate prediction of patient survival.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Letter
Hematology
Richard Dillon, Robert K. Hills, Alan K. Burnett, Nigel H. Russell
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
David C. Linch, Robert K. Hills, Alan K. Burnett, Nigel Russell, Rosemary E. Gale
Summary: The study found an improved outcome for younger adult patients with IDH2(R172)-mutated acute myeloid leukaemia in later trials, attributed to the increased use of allogeneic transplantation for consolidating first remission.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Editorial Material
Hematology
Robert K. Hills
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
Nigel Russell, Robert Hills, Lars Kjeldsen, Mike Dennis, Alan Burnett
Summary: For younger patients with secondary AML, treatment intensification with FLAG-Ida may lead to superior 5-year overall survival and relapse free survival compared to traditional DA/ADE regimens, suggesting that 3 + 7 chemotherapy may not be the optimal comparator for this group of patients in clinical trials.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Letter
Hematology
Robert K. Hills
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Immunology
Ana Pires, Stephanie Burnell, Awen Gallimore
Summary: This review examines the relationship between immune cells and the extracellular matrix in the context of cancer immunotherapy, and discusses how this interaction influences tumor progression.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Article
Immunology
Martin J. Scurr, Wioleta M. Zelek, George Lippiatt, Michelle Somerville, Stephanie E. A. Burnell, Lorenzo Capitani, Kate Davies, Helen Lawton, Thomas Tozer, Tara Rees, Kerry Roberts, Mererid Evans, Amanda Jackson, Charlotte Young, Lucy Fairclough, Paddy Tighe, Mark Wills, Andrew D. Westwell, B. Paul Morgan, Awen Gallimore, Andrew Godkin
Summary: Accurate assessment of SARS-CoV-2 immunity is crucial, with T-cell responses being a key feature for protection. A high-throughput assay was developed to determine T-cell responses, showing significant differences in previously infected individuals and vaccination recipients. IFN-gamma was more effective in identifying asymptomatic donors, but IL-2 had higher specificity in healthy donors.
Letter
Immunology
Rachel E. Bradley, Mark J. Ponsford, Martin J. Scurr, Andrew Godkin, Stephen Jolles
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Hematology
Nigel H. Russell, Robert K. Hills, Lars Kjeldsen, Richard E. Clark, Sahra Ali, Paul Cahalin, Ian F. Thomas, Alan K. Burnett
Summary: The prognosis for young patients with relapsed AML is generally poor. This study compared two treatment regimens for relapsed or refractory AML patients and found no significant difference between the outcomes of the two groups. The results suggest that the prognosis of these patients is not influenced by the treatment regimen.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Editorial Material
Oncology
Awen Gallimore
CANCER IMMUNOLOGY RESEARCH
(2022)
Editorial Material
Hematology
Robert K. Hills
Summary: Prolonged cytopaenia is a recognized issue after CAR-T cell therapy, but the causes and implications are still unknown. Kitamura et al.'s study identified that alterations in the bone marrow niche prior to CAR-T therapy may be a potential predictor for long-term cytopaenia, shedding light on this serious side-effect of treatment.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Editorial Material
Hematology
Robert K. Hills
Summary: The paper by Noor et al. presents significant findings on the incidence and outcomes of patients with acute myeloid leukaemia in Afghanistan. It highlights the lower age of patients compared to the Western standard, reflecting the unique demographics of the country. These findings serve as an important initial step in identifying areas for improvement.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Mhairi Copland, Cono Ariti, Ian F. Thomas, Laura Upton, Mia Sydenham, Priyanka Mehta, Shahid Islam, Lars Kjeldsen, Alan K. Burnett, Robert K. Hills, Nigel Russell, Mike Dennis
Summary: Improving outcomes for older patients with acute myeloid leukaemia is still an unmet need. In this study, we evaluated the effectiveness of lenalidomide in combination with low-dose cytosine arabinoside compared to low-dose cytosine arabinoside alone in unfit patients aged over 60. The combination therapy showed a higher overall response rate, but there was no difference in overall survival between the two arms.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Stefan Milutinovic, Jun Abe, Emma Jones, Inken Kelch, Kathryn Smart, Sarah N. Lauder, Michelle Somerville, Carl Ware, Andrew Godkin, Jens V. Stein, Gib Bogle, Awen Gallimore
Summary: This study examines the remodeling of specialized blood vessels called HEVs in LY LNs and tumors using three-dimensional imaging and computational tools. The analysis reveals significant cancer- and immune-driven alterations to HEV networks, with the presence of these networks within tumors distinguishing responders from nonresponders. Successful treatment response is found to depend on the development of tumor-associated HEVs and T-cell activation.
CANCER RESEARCH COMMUNICATIONS
(2022)