Article
Chemistry, Physical
Judyta Dulnik, Pawel Sajkiewicz
Summary: Four chemical crosslinking methods were compared for preventing gelatin leaching in aqueous environment. Among genipin, EDC/NHS, BDDGE, and transglutaminase, EDC/NHS was found to be the most effective with the lowest concentrations and shortest reaction times. This method ensured satisfactory gelatin crosslinking degree and preserved the morphology of the fibers after 24 hours in aqueous medium.
Article
Biotechnology & Applied Microbiology
Xiaoyu Wu, Su Ni, Ting Dai, Jingyan Li, Fang Shao, Chun Liu, Jiafeng Wang, Shijie Fan, Yadong Tan, Linxiang Zhang, Qiting Jiang, Hongbin Zhao
Summary: Researchers developed a PCL/Gelatin composite electrospun membrane with bubble-shaped nanofibrous structures, which improved biomineralization ability by increasing surface roughness and promoting mineralization. The membrane exhibited excellent cell compatibility and adhesion, and it effectively promoted vascularization and bone regeneration. The sustained-release of tetramethylpyrazine showed excellent drug release efficiency.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Bogdanova, Elizaveta Pavlova, Anna Polyanskaya, Marina Volkova, Elena Biryukova, Gleb Filkov, Alexander Trofimenko, Mikhail Durymanov, Dmitry Klinov, Dmitry Bagrov
Summary: Biocompatible polyesters are commonly used in biomedical applications and can be tuned by blending with proteins. This usually improves hydrophilicity and cell adhesion but reduces mechanical properties. In this study, a 9:1 PLA:gelatin blend was found to accelerate the biodegradation of electrospun PLA mats without affecting their strength and extensibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Reem Hasan, Gulum Sumnu, Serpil Sahin, Emel Oz, Fatih Oz
Summary: Nanofibers with gelatin and curcumin were produced using electrospinning, and the effects of gelatin concentration and crosslinking with citric acid on the characteristics of the nanofibers were studied. The obtained nanofibers were characterized and it was found that the films with gelatin and curcumin showed improved antioxidant activity and other properties. These films have potential applications in reducing water loss and oxidation in cut fruits for extended shelf lives.
Article
Biophysics
Kotoko Furuno, Keiichiro Suzuki, Shinji Sakai
Summary: In this study, gelatin nanofiber mats were used as carriers and were able to deliver plasmid DNA (pDNA) through immobilizing Lipofectamine/pDNA complexes. Targeted genome editing and gene therapy were successfully achieved using these mats.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Elisa Roldan, Neil D. Reeves, Glen Cooper, Kirstie Andrews
Summary: This study evaluated the suitability of gelatin as the sole material to manufacture tissue engineering scaffolds. The gelatin-based electrospun scaffolds exhibited comparable mechanical properties to various human tissues, suggesting their potential application in tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Hannah A. Lacy, Vera Jencova, David Lukas, Andrei Stanishevsky
Summary: This study investigates the production of blended nanofibrous biomaterials using high-yield alternating field electrospinning (AFES) of cold-water fish skin gelatin (FGEL) and polycaprolactone (PCL). The resulting FGEL/PCL nanofibers exhibited smooth surface morphology and average diameters ranging from 237-313 nm after thermal crosslinking. In-vitro analysis demonstrated good cellular viability and mesh stability of the FGEL/PCL nanofibrous biomaterials. AFES proves to be an efficient and scalable method for producing FGEL/PCL nanofibrous biomaterials with desired characteristics.
Article
Materials Science, Textiles
Shiqing Li, Wenhui Shi, Xiaoyan Wang, Shujing Li, Xiaojing Pei, Yifan He
Summary: The aim of this study was to analyze the bioactivity of gelatin nanofiber membranes with different concentrations of sesamol nanoparticles. The results showed that sesamol provided the nanofiber membranes with antioxidant and antibacterial activities. In addition, the functional nanofiber membrane exhibited sustained-release capabilities when combined with zein-chitosan and gelatin. Therefore, G-Ses-NPs-NF can be considered as a material with good biologically activity, which has research value in the development of functional food and other fields.
JOURNAL OF THE TEXTILE INSTITUTE
(2023)
Article
Biophysics
Yuanyue Shi, Xueke Cao, Zhaozhang Zhu, Jing Ren, Hao Wang, Baohua Kong
Summary: In this study, novel active materials based on cellulose acetate and gelatin were developed for the release of eugenol. The electrospun nanofibers exhibited uniform morphology and efficient encapsulation and release of eugenol. The core-shell structured nanofiber films showed promising antibacterial activity, indicating their potential use in active food packaging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Hannah A. Lacy, Vera Jencova, Sarka Hauzerova, Andrei Stanishevsky
Summary: Nanofibers made from blending natural and synthetic biopolymers have shown potential for better mechanical stability, ECM morphology mimicry, and cellular interaction. This study focuses on AC-electrospinning of poorly miscible blends of gelatin and polycaprolactone, and the results demonstrate the effect of the blend ratio on wettability, crystallinity, and structure. Preliminary in vitro tests confirm favorable cell attachment, proliferation, and spreading on the nanofibrous meshes.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Nazirah Hamdan, Wan Khartini Wan Abdul Khodir, Shafida Abd Hamid, Mohd Hamzah Mohd Nasir, Ahmad Sazali Hamzah, Iriczalli Cruz-Maya, Vincenzo Guarino
Summary: In this study, polycaprolactone (PCL)/gelatin/graphene oxide (PGO) nanofibers were functionalized via plasma treatment with different monomeric groups. The functionalization influenced the morphology, wettability, mechanical properties, and thermal stability of the nanofibers. The results showed that PGO-M1 and PGO-M2 had good antibacterial activity, while PGO-M3 reduced the antibacterial properties compared to PGO nanofibers. The study highlights the importance of surface functionalization in engineering nanofibers with controlled antibacterial properties for various applications.
Article
Polymer Science
Zahra Moazzami Goudarzi, Tayebeh Behzad, Laleh Ghasemi-Mobarakeh, Mahshid Kharaziha
Summary: The study demonstrated that the addition of ACNF significantly improved the tensile strength of PCL/Gel scaffold, while reducing the degradation rate. Incorporation of ACNF showed no cytotoxic effects and promoted cell proliferation.
Article
Polymer Science
Reda Morsy
Summary: The substrate temperature was investigated to broaden the applicability of controlling the morphology of polymeric fibers produced during the electrospinning process. A gelatin polymer was used as an example to obtain beads-free gelatin fibers by fixing the main electrospinning parameters. Heating the substrate at 50 degrees C resulted in a significant decrease in fiber diameter, while increasing substrate temperatures from 75 to 100 degrees C showed stability of the diameter with a significant variation in their diameter distribution.
Article
Engineering, Biomedical
Jiafeng Wang, Longhui Shao, Xiaoyu Wu, Chun Liu, Su Ni, Ting Dai, Hongwei Liu, Hongbin Zhao
Summary: Osteoblasts and osteoclasts play a crucial role in bone regeneration and remodeling. Incorporating naringenin and vitamin K2 stimulates osteogenesis-related genes and proteins while inhibiting the formation and growth of osteoclasts.
MATERIALS TODAY BIO
(2023)
Review
Multidisciplinary Sciences
Hesham R. El-Seedi, Noha S. Said, Nermeen Yosri, Hamada B. Hawash, Dina M. El-Sherif, Mohamed Abouzid, Mohamed M. Abdel-Daim, Mohammed Yaseen, Hany Omar, Qiyang Shou, Nour F. Attia, Xiaobo Zou, Zhiming Guo, Shaden A. M. Khalifa
Summary: The use of gelatin and gelatin-blend polymers for the synthesis of electrospun nanofibers has brought about a revolution in the biomedical field. Gelatin, despite variations in processing technology, is a versatile biopolymer. Electrospinning is an efficient and cost-effective technique for manufacturing gelatin electrospun nanofibers (GNFs), which have high porosity, large surface area, and biocompatibility. However, some limitations, such as rapid degradation and poor mechanical strength, can be overcome through cross-linking, leading to improved biological properties and various biomedical applications of GNFs.
Article
Biotechnology & Applied Microbiology
Simzar Hosseinzadeh, Matin Mahmoudifard, Farzaneh Mohamadyar-Toupkanlou, Masomeh Dodel, Atena Hajarizadeh, Mahdi Adabi, Masoud Soleimani
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2016)
Review
Materials Science, Biomaterials
Basil Mujokoro, Mohsen Adabi, Esmaeil Sadroddiny, Mahdi Adabi, Masood Khosravani
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
Article
Computer Science, Artificial Intelligence
Najmeh Ketabchi, Majid Naghibzadeh, Mahdi Adabi, Seyedeh Sara Esnaashari, Reza Faridi-Majidi
NEURAL COMPUTING & APPLICATIONS
(2017)
Article
Biotechnology & Applied Microbiology
Mahdi Adabi, Majid Naghibzadeh, Mohsen Adabi, Mohammad Ali Zarrinfard, Seyedeh Sara Esnaashari, Alexander M. Seifalian, Reza Faridi-Majidi, Hammed Tanimowo Aiyelabegan, Hossein Ghanbari
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2017)
Review
Chemistry, Multidisciplinary
Farahnaz Behzad, Fateme Najafi Kalyani, Azam Samadi, Mahdi Adabi
Summary: This article reviews the antiviral effects of metal nanoparticles on HIV/AIDS and explores the potential and future challenges of green nanoparticles for treating HIV.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Fatemeh Madani, Seyedeh Sara Esnaashari, Thomas J. Webster, Masood Khosravani, Mahdi Adabi
Summary: This review discusses the challenges of delivering drugs through the blood-brain barrier (BBB) in glioblastoma (GBM) treatment and introduces the latest advances in using nanoparticles for this purpose. It also describes the development of drug delivery and combination modalities using natural and synthetic polymer nanoparticles, as well as adjuvant therapies for GBM treatment. Additionally, it explains the receptor-mediated endocytosis agents that exist in brain endothelial capillary cells and emphasizes future research directions.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biotechnology & Applied Microbiology
Gholamreza Savari Kouzehkonan, Negar Motakef Kazemi, Mahdi Adabi, Seyyedeh Elaheh Mosavi, Seyed Mahdi Rezayat Sorkhabadi
Summary: This study developed a nanofiber nerve guidance channel (NGC) for delivering acetyl L carnitine (ALC) in a rat model of sciatic nerve injury. The results showed that collagen hydrogels containing 5% ALC had a more favorable effect on nerve repair. Therefore, ALC-delivering NGCs have the potential for treating peripheral nerve injury.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2023)
Article
Medicine, Research & Experimental
Morteza Kamali, Thomas J. Webster, Amir Amani, Mahmoud Reza Hadjighassem, Mohammad Reza Malekpour, Fatemeh Tirgar, Masood Khosravani, Mahdi Adabi
Summary: The study aimed to prepare folate-targeted Erlotinib loaded human serum albumin nanoparticles (FA-ERL-HSA NPs) and investigate their cytotoxic and apoptotic effects using cell lines and a rat glioma model. The average size of FA-ERL-HSA NPs prepared using a desolvation method was 135 nm. In vitro experiments showed that FA-ERL-HSA NPs had lower IC50 values and induced higher apoptosis rates compared to free ERL in both cell lines. TUNEL assay indicated that FA-ERL-HSA NPs had a higher apoptosis index and effectively reduced tumor size in the rat model, leading to increased median survival rate.
Article
Materials Science, Multidisciplinary
Somayeh Mohammadi, Kamran Pooshang Bagheri, Rezvan Mousavi Nadushan, Mahdi Adabi
Summary: An electrochemical aptamer-based sensor was developed to detect tetracycline in chicken ham. The sensor utilized electrospun carbon nanofiber (CNF) as the electrode, with the aptamer of tetracycline placed on the surface. The sensor exhibited good repeatability, reproducibility, stability, and specificity for tetracycline detection, with a linear range of 1 x 10(-9) M to 1 x 10(-4) M and a detection limit of 1.2 x 10(-10) M.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Review
Biochemical Research Methods
Farahnaz Behzad, Azam Samadi, Elaheh Rahimpour, Mahdi Adabi, Abolghasem Jouyban
Summary: Aptasensors have gained popularity due to their excellent particularity, selectivity, and responsiveness. When combined with gold nanoparticles (AuNPs), these biosensors can detect various chemical and biological molecules. The changing color of AuNPs provides a simple explanation for the sensor's response. This review summarizes the recent developments in AuNP-based colorimetric aptasensors for sensing different analytes, discusses their uses, challenges, and prospects for forming new aptasensors.
Article
Engineering, Chemical
Majid Naghibzadeh, Mohsen Adabi, Hamid Reza Rahmani, Mohsen Mirali, Mahdi Adabi
ADVANCES IN POLYMER TECHNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Fatemeh Madani, Seyedeh Sara Esnaashari, Basil Mujokoro, Farid Dorkoosh, Masood Khosravani, Mahdi Adabi
ADVANCED PHARMACEUTICAL BULLETIN
(2018)
Article
Chemistry, Applied
Majid Naghibzadeh, Saman Firoozi, Fatemeh Sadeghian Nodoushan, Mohsen Adabi, Arezoo Khoradmehr, Farzaneh Fesahat, Seyedeh Sara Esnaashari, Masood Khosravani, Mandi Adabi, Shima Tavakol, Hamidreza Pazoki-Toroudi, Moein Adel, Masoumeh Zahmatkeshan
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2018)
Review
Chemistry, Applied
Adebileje Tajudeen Ayodele, Alireza Valizadeh, Mohsen Adabi, Seyedeh Sara Esnaashari, Fatemeh Madani, Masood Khosravani, Mahdi Adabi
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2017)
Article
Chemistry, Applied
Mohammad Reza Malekpour, Majid Naghibzadeh, Mohammad Reza H. Najafabadi, Seyedeh Sara Esnaashari, Mohsen Adabi, Basil Mujokoro, Masood Khosravani, Mahdi Adabi
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2018)