Article
Acoustics
A. Venardos, J. Colquitt, S. A. Morris
Summary: This study compares the rates of left-sided cardiac structure growth and Z-score change in fetuses with severe left-heart hypoplasia (LHH) and severe aortic stenosis (AS). The results show that the left-sided structures grow faster in fetuses with LHH and the Z-scores decrease at a slower rate compared to fetuses with AS. Furthermore, the majority of infants with LHH do not require single-ventricle palliation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
W. J. Hogan, A. J. Moon-Grady, Y. Zhao, N. M. Cresalia, H. Nawaytou, E. Quezada, M. Brook, P. McQuillen, S. Peyvandi
Summary: This study used maternal hyperoxygenation (MH) to evaluate cerebrovascular reactivity in fetuses with specific congenital heart disease (CHD), finding that fetal response to high oxygen varied depending on the underlying CHD diagnosis, suggesting that cardiovascular physiology may influence the autoregulatory capacity of the fetal brain.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Pediatrics
Anita J. J. Moon-Grady, Francesca A. A. Byrne, Leslie A. A. Lusk, Roberta L. L. Keller
Summary: Left heart structures may appear small in fetuses with left-sided congenital diaphragmatic hernia (CDH), but usually normalize after birth in the absence of structural cardiac anomalies. This study establishes normal values for left heart structures in the presence of left CDH and suggests that cardiac evaluation is not predictive in isolation for survival in this population.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cell Biology
Franz Markert, Alexander Storch
Summary: Oxygen tension affects cortical development, and hyperoxygenation during mid-neurogenesis phase accelerates cortical development and increases the number of cortical layer 5 neurons until birth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pediatrics
Sheetal R. Patel, Nitin Madan, Pei-Ni Jone, Mary T. Donofrio
Summary: Fetal echocardiography is a valuable tool for assessing most congenital heart defects, but it has limitations in providing information about the pulmonary vasculature. Acute maternal hyperoxygenation (MH) testing can help determine pulmonary vascular reactivity and predict postnatal compromise in certain complex CHDs. This comprehensive review discusses the findings of studies on acute MH testing and provides practical tips for setting it up in a fetal echocardiography laboratory.
Article
Acoustics
K. Haberer, D. Fruitman, A. Power, L. K. Hornberger, L. Eckersley
Summary: The study found that features such as right-to-left foramen ovale flow and higher mitral valve annulus Z-scores are important predictors of biventricular circulation in fetal HLHC patients. Additionally, certain characteristics such as FO flow direction and specific Z-scores can effectively predict the failure of BV circulation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Physiology
Huseyin Enes Salman, Reema Yousef Kamal, Huseyin Cagatay Yalcin
Summary: This study investigates the hemodynamics of the left heart in human fetuses during gestation, revealing a decrease in wall shear stresses and vorticity levels as the fetus develops. The findings highlight the dynamic nature of left heart hemodynamics and its relevance to the development of congenital heart defects.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew C. Watson, Corin Williams, Raymond M. Wang, Luke R. Perreault, Kelly E. Sullivan, Whitney L. Stoppel, Lauren D. Black III
Summary: This study aimed to determine the proliferation and maturation potential of cardiomyocytes from hypoplastic hearts and investigate whether these behaviors are influenced by biochemical signaling from the extracellular matrix and cyclic mechanical stretch.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Hong Shen Wong, Hadi Wiputra, Andreas Tulzer, Gerald Tulzer, Choon Hwai Yap
Summary: In cases of fetal aortic stenosis and evolving Hypoplastic Left Heart Syndrome (feHLHS), specific abnormalities and altered fluid dynamics are observed in the left ventricles (LV). The feHLHS LV shows narrowed and fast diastole mitral inflow, elevated energy losses, intraventricular pressure gradients, and vortex formation numbers, and poor blood turnover, indicating energy inefficiency of flow and additional burden on the LV.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Meaghan J. Beattie, Lynn A. Sleeper, Minmin Lu, Sarah A. Teele, Roger E. Breitbart, Jesse J. Esch, Joshua W. Salvin, Urvi Kapoor, Olubunmi Oladunjoye, Sitaram M. Emani, Puja Banka
Summary: This study aimed to investigate the long-term morbidity and mortality of patients with borderline hypoplastic left heart undergoing single to biventricular conversion. The results showed that the presence of endocardial fibroelastosis and smaller left ventricular stroke volume/body surface area were independent factors associated with adverse outcomes. Normal preoperative left ventricular end-diastolic pressure was not sufficient to reassure against diastolic dysfunction.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Neurosciences
C. Priyanka, Rajeswaran Rangasami, Indrani Suresh
Summary: This article presents a prenatal case of pontine tegmental cap dysplasia (PTCD) to increase awareness of this rare condition and highlight the importance of early prenatal diagnosis.
Article
Multidisciplinary Sciences
Yi Tang, Pei Huang, Zhibin Liu, Yijin Tang, Wei Liu, Chang She, Changqing Zhong, Jianqiang Pei, Qinghua Fu, Liang Zhang, Yi Zhang
Summary: The study investigates the prognostic value of LAFI in STEMI patients treated with PCI. A total of 156 patients were studied and the LAFI was found to be a strong and independent predictor of events. Patients with a lower LAFI had more endpoint events. These findings suggest that LAFI can predict prognosis in STEMI patients treated with PCI.
SCIENTIFIC REPORTS
(2023)
Review
Pediatrics
Fu-Tsuen Lee, Davide Marini, Mike Seed, Liqun Sun
Summary: Prenatal diagnosis and fetal intervention have become increasingly important in improving morbidity and mortality rates in congenital heart disease. Recent focus has been on improving outcomes for fetuses diagnosed with left-sided lesions. Maternal hyperoxygenation has been investigated as a diagnostic tool and therapeutic agent for improving heart and brain development in fetuses with CHD.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Anna Claudia Massolo, Anita Romiti, Milena Viggiano, Chiara Vassallo, Marie Anne Ledingham, Antonio Lanzone, Leonardo Caforio, Pietro Bagolan, Neil Patel
Summary: This study found that in CDH cases, mitral valve diameter and left ventricular area were significantly reduced at 24-26 weeks and 35-37 weeks, while tricuspid valve diameter and right ventricular area were also significantly reduced at 24-26 weeks, with the right ventricular area Z-score increasing with advancing gestational age. LV hypoplasia in CDH patients is characterized by a reduction in mitral valve diameter, and the mitral and tricuspid valve diameter ratio may be potential predictors of disease severity.
JOURNAL OF PERINATOLOGY
(2021)
Article
Pediatrics
Jason Gien, Clair Palmer, Kenneth Liechty, John P. Kinsella
Summary: This study aimed to investigate the alteration of blood gas exchange during the first hour of life in infants with congenital diaphragmatic hernia (CDH). The study found that CDH infants exhibited significant acid-base imbalance and mixed respiratory and metabolic acidosis within the first hour of life. Early implementation of adequate cardiopulmonary support may contribute to more timely stabilization of gas exchange.
JOURNAL OF PEDIATRICS
(2022)
Article
Genetics & Heredity
Yuri A. Zarate, Shaine A. Morris, Anna Blackshare, Claudia A. Algaze, Brynn S. Connor, Andrew J. Kim, Katherine E. Yutzey, Erin M. Miller, Kathryn Nicole Weaver, Ronnie Thomas Collins
Summary: This study aimed to develop objective diagnostic criteria for early onset Marfan syndrome (eoMFS) to facilitate early diagnosis and timely interventions. The researchers developed an age-based, diagnostic scoring system based on extensive literature review and expert survey responses. The study found that individuals with eoMFS had significantly higher cardiac, systemic, and FBN1 scores compared to those without eoMFS, and a proposed clinical score cutoff showed excellent sensitivity, specificity, and reliability.
GENETICS IN MEDICINE
(2022)
Meeting Abstract
Genetics & Heredity
Yuri Zarate, Shaine Morris, Anna Blackshare, Claudia Algaze, Brynn Connor, Andrew Kim, Katherine Yutzey, Erin Miller, Kathryn Nicole Weaver, Thomas Collins
GENETICS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kathryn W. Holmes, Sheila Markwardt, Kim A. Eagle, Richard B. Devereux, Jonathan W. Weinsaft, Federico M. Asch, Scott A. LeMaire, Cheryl L. Maslen, Howard K. Song, Dianna M. Milewicz, Siddharth K. Prakash, Dongchuan Guo, Shaine A. Morris, Reed E. Pyeritz, Rita C. Milewski, William J. Ravekes, H. C. Dietz, Ralph Shohet, Michael Silberbach, Mary J. Roman
Summary: The study compared the age distribution and probability of elective surgery and cardiovascular mortality among patients with different etiologies of aortopathy. The results showed differences in age and risk of surgery among patients with different etiologies.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lindsay A. Edwards, Fei Feng, Mehreen Iqbal, Yong Fu, Amy Sanyahumbi, Shiying Hao, Doff B. McElhinney, X. Bruce Ling, Craig Sable, Jiajia Luo
Summary: In this study, a machine learning model was developed to identify mitral regurgitation (MR) on echocardiography. The model achieved high accuracy and F1 score in classifying the view and detecting MR. This is a promising step towards machine learning-based diagnosis of valvular heart disease in pediatric echocardiography.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Genetics & Heredity
Christina Y. Miyake, Erica J. Lay, Claudia Soler-Alfonso, Kevin E. Glinton, Kimberly M. Houck, Mustafa Tosur, Nancy E. Moran, Sara B. Stephens, Fernando Scaglia, Taylor S. Howard, Jeffrey J. Kim, Tam Dam Pham, Santiago O. Valdes, Na Li, Chaya N. Murali, Lilei Zhang, Maina Kava, Deane Yim, Cheyenne Beach, Gregory Webster, Leonardo Liberman, Christopher M. Janson, Prince J. Kannankeril, Samantha Baxter, Moriel Singer-Berk, Jordan Wood, Samuel J. Mackenzie, Michael Sacher, Lina Ghaloul-Gonzalez, Claudia Pedroza, Shaine A. Morris, Saad A. Ehsan, Mahshid S. Azamian, Seema R. Lalani
Summary: This study provides a comprehensive review of the natural history of TANGO2 deficiency disorder and important observational data suggesting that B-complex or multivitamins may prevent metabolic crises.
GENETICS IN MEDICINE
(2023)
Correction
Cardiac & Cardiovascular Systems
Amna Qasim, Tam D. D. Pham, Jeffrey J. J. Kim, Santiago O. O. Valdes, Taylor Howard, Matthew A. A. Diaz, Shaine A. A. Morris, Christina Y. Y. Miyake
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anita J. Moon-Grady, Mary T. Donofrio, Sarah Gelehrter, Lisa Hornberger, Joe Kreeger, Wesley Lee, Erik Michelfelder, Shaine A. Morris, Shabnam Peyvandi, Nelangi M. Pinto, Jay Pruetz, Neeta Sethi, John Simpson, Shubhika Srivastava, Zhiyun Tian
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Anita J. Moon-Grady, Hyejung Lee, Leo Lopez, Oluwatosin Fatusin, Lindsay R. Freud, Whitnee Hogan, Anita Krishnan, Carol Mcfarland, L. LuAnn Minich, Shaine A. Morris, Nelangi Pinto, Angela P. Presson, Theresa A. Tacy, Fetal Heart Society
Summary: This study evaluated the feasibility and variability of measurements in normal fetal echocardiograms, and provided suggestions for further research. The results showed considerable variability in measurements of fetal echocardiography in clinical practice, with good consistency for specific measurements but poor consistency between raters.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Obstetrics & Gynecology
Bettina F. Cuneo, Jill P. Buyon, Lisa Sammaritano, Edgar Jaeggi, Bhawna Arya, Nicholas Behrendt, Julene Carvalho, Jennifer Cohen, Kristopher Cumbermack, Greggory DeVore, Tam Doan, Mary T. Donofrio, Lindsay Freud, Henry L. Galan, Melanie R. F. Gropler, Caitlin Haxel, Lisa K. Hornberger, Lisa W. Howley, Peter Izmirly, Stacy S. Killen, Michelle Kaplinski, Anita Krishnan, Stephanie Lavasseur, Christopher Lindblade, Jyothi Matta, Majd Makhoul, Jena Miller, Shaine Morris, Erin Paul, Erin Perrone, Colin Phoon, Nelangi Pinto, Jack Rychik, Gary Satou, Amit Saxena, Mark Sklansky, James Stranic, Janette F. Strasburger, Shubhika Srivastava, Sharda Srinivasan, Theresa Tacy, Wayne Tworetzky, Orhan Uzun, Simcha Yagel, Michael Zaretsky, Anita J. Moon-Grady
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Keila N. Lopez, Shaine Morris, Anita B. Krishnan, Marni B. Jacobs, Aarti H. Bhat, Anjali Chelliah, Joanne S. Chiu, Bettina F. Cuneo, Grace Freire, Lisa K. Hornberger, Lisa Howley, Nazia Husain, Catherine Ikemba, Ann Kavanaugh-McHugh, Shelby Kutty, Caroline Lee, Angela McBrien, Erik C. Michelfelder, Nelangi M. Pinto, Rachel Schwartz, Kenan W. D. Stern, Carolyn Taylor, Varsha Thakur, Wayne Tworetzky, Carol Wittlieb-Weber, Kris Woldu, Mary T. Donofrio, Shabnam Peyvandi
Article
Cardiac & Cardiovascular Systems
Kyle D. Hope, Shaine A. Morris, Debra L. Kearney, Kriti Puri, Swati Choudhry, Joseph A. Spinner, Hari P. Tunuguntla, Jack F. Price, William J. Dreyer, Sarah K. Nicholas, Susan W. Denfield
Summary: The presence of atypical infiltrates on endomyocardial biopsy (EMB) after pediatric heart transplant (HTx) is associated with worse post-HTx outcomes. Patients with atypical infiltrates by 1-year post-HTx have a higher risk of reaching the composite outcome.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick S. Connell, Shaine A. Morris, Tam T. Doan, Justin Weigand
Summary: Cardiomyopathy is a common complication in adults with Marfan syndrome (MFS). This study aimed to assess the relationship between ventricular strain, left ventricular ejection fraction (LVEF), aortic root z-score, and vertebral artery tortuosity index corrected for height (VTI-h) in children with MFS. The results showed that abnormal ventricular strain was associated with lower LVEF, but not with aortic dilation or low LVEF within the 5 years post-cardiac magnetic resonance imaging (CMR).
PEDIATRIC CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cassie N. Weyland, Katherine B. Salciccioli, Taylor Beecroft, Emily N. Soludczyk, Shaine A. Morris
Summary: Research indicates significant variation and controversy in the cardiac management of children with hereditary thoracic aortic diseases. While there are areas of general agreement, there are notable differences in genetic evaluation, medication choice, and imaging. This highlights the need for further study to establish consensus guidelines.
PEDIATRIC CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sara B. Stephens, Sherene Shalhub, Nicholas Dodd, Jesse Li, Michael Huang, Seitaro Oda, Kalyan Kancherla, Tam T. Doan, Siddharth K. Prakash, Justin D. Weigand, Federico M. Asch, Taylor Beecroft, Alana Cecchi, Teniola Shittu, Liliana Preiss, Scott A. Lemaire, Richard B. Devereux, Reed E. Pyeritz, Kathryn W. Holmes, Mary J. Roman, Ronald V. Lacro, Ralph V. Shohet, Rajesh Krishnamurthy, Kim Eagle, Peter Byers, Dianna M. Milewicz, Shaine A. Morris
Summary: This study found that arterial tortuosity is associated with a higher incidence rate of cardiovascular events in Vascular Ehlers-Danlos syndrome. The vertebral tortuosity index may be a useful biomarker for prognosis when evaluated in conjunction with genotype and age.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Melissa A. LoPresti, Prazwal Athukuri, A. Basit Khan, Marc Prablek, Rajan Patel, Rory Mayer, David F. Bauer, Frank T. Gerow, Shaine A. Morris, Sandi Lam, Vijay Ravindra
Summary: This retrospective study examined the treatment of pediatric patients with LDS and scoliosis. The results showed that bracing can be used for patients with a Cobb angle (CA) of 20-50°, while surgery can be considered for patients with a CA of >50°. These findings are important for the treatment algorithm of pediatric patients with LDS.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
