Article
Obstetrics & Gynecology
Toshihide Sakuragi, Eiji Shibata, Emi Kondo, Shota Higami, Shigeki Fujimoto, Shoko Amimoto, Hiroshi Mori, Satoshi Aramaki, Mayumi Tsuji, Kiyoshi Yoshino
Summary: This study aimed to investigate the correlation between vascularization index (VI), flow index (FI), vascularization flow index (VFI) and the pathological structure of the placenta, as well as the differences in these parameters between the normal and preeclampsia (PE) groups. The results showed no positive correlation between VI, FI, VFI, intervillous blood vessels (IBV), intervillous spaces (IS), and IBV + IS. While there were no differences in VI, FI, and VFI between the normal and PE groups, there were significant differences in IBV, IS, and IBV + IS in the PE group compared to the normal group.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Obstetrics & Gynecology
Ele Hanson, Kristiina Rull, Kaspar Ratnik, Pille Vaas, Pille Teesalu, Maris Laan
Summary: The study aimed to evaluate the value of screening for maternal serum sFlt-1/PlGF ratio in predicting the development of preeclampsia during the third trimester. The results showed that testing sFlt-1/PlGF ratio between 180-259 gestational days could detect approximately half of subsequent preeclampsia cases, with the highest detection rate observed at 225-238 gestational days.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Developmental Biology
Aayushi Hasija, Kirti Balyan, Ekta Debnath, V Ravi, Manisha Kumar
Summary: This study found that in high-risk women for preeclampsia, serum beta hCG levels increased, placental thickness decreased, and uterine artery PI in preeclampsia reached the highest level at 20-24 weeks, making it the best marker.
Article
Physiology
Olivia K. Travis, Geilda A. Tardo, Chelsea Giachelli, Shani Siddiq, Henry T. Nguyen, Madison T. Crosby, Tyler D. Johnson, Andrea K. Brown, George W. Booz, Alex N. Smith, Jan Michael Williams, Denise C. Cornelius
Summary: In this study, neutralization of IFNy was found to reduce MAP, UARI, and placental ROS levels in RUPP recipients. However, fetal and placental weights in RUPP rats were not improved following anti-IFNy treatment. These findings suggest that IFNy may play a role in the pathophysiology of PE and could be a potential therapeutic target for improving maternal outcomes in PE.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Eran Ashwal, Jasmine Ali-Gami, Amir Aviram, Stefania Ronzoni, Elad Mei-Dan, John Kingdom, Nir Melamed
Summary: This study aimed to investigate the association of second-trimester sonographic placental morphology markers with placenta-mediated complications and determine whether these markers are predictive of placental dysfunction independent of uterine artery Doppler. The results showed that placental area is independently associated with the risk of placenta-mediated complications, but when combined with uterine artery Doppler, it did not significantly improve the prediction of such complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Suchada Erjongmanee, Vorapong Phupong
Summary: This study aimed to determine the predictive value of first-trimester serum SHARP1 level and second-trimester uterine artery Doppler in singleton pregnancy for the prediction of preeclampsia. The study demonstrated that combining the first-trimester serum SHARP1 level with the second-trimester uterine artery PI had good sensitivity to predict preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jinsong Gao, Xianghua Huang, Wen Di, Xiaojing Dong, Wenli Gou, Hong Shi, Zilian Wang, Angela Dietl, Sonja Grill, Martin Hund
Summary: This study demonstrates that the sFlt-1/PlGF ratio cutoff of 38 has high predictive performance for short-term prediction of preeclampsia in Chinese women, helping to reduce unnecessary hospitalization for low-risk women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Acoustics
G. Ashoor, A. Syngelaki, I Papastefanou, K. H. Nicolaides, R. Akolekar
Summary: The study demonstrates that a model combining maternal risk factors, UtA-PI, and EFW at 19-24 weeks' gestation can effectively predict antepartum stillbirths due to impaired placentation, especially those occurring preterm.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Adjima Soongsatitanon, Vorapong Phupong
Summary: This study demonstrated that the combination of serum PP13 level and uterine artery Doppler in the first trimester increased the sensitivity for predicting preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Luiza Meelhuysen Sousa Aguiar, Lumena Goncalves Machado Zanotto, Carlos Henrique Mascarenhas Silva, Marianna Amaral Pedroso
Summary: A retrospective study showed that using both transverse and longitudinal Doppler techniques during the first trimester morphological examination can reliably measure the pulsatility index of uterine arteries in pregnant women, without affecting the final outcome of preeclampsia screening.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Review
Medicine, General & Internal
Yifan Wu, Yang Liu, Yiling Ding
Summary: PP13 may be an effective serum biomarker for predicting preeclampsia, but further large prospective cohort studies and randomized controlled trials are needed to determine its clinical application. The heterogeneity of the original trials may limit the use of PP13 in clinical practice.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yixuan Chen, Linlin Wu, Hangkuan Liu, Ziping Li, Linjie Li, Xiaoxia Wu, Qiong Lei, Aiqi Yin, Jianing Tong, Kan Liu, Xiaonian Guan, Cuiping Zeng, Huafan Zhang, Yanmei Wan, Xuna Huang, Pingping Huang, Qing Yang, Xin Zhou, Jianmin Niu
Summary: This study found that maternal chemerin levels in patients with preeclampsia during pregnancy are associated with blood pressure levels after delivery, and chemerin levels can predict the occurrence of postpartum hypertension.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Madalina Nicoleta Nan, Alvaro Garcia-Osuna, Josefina Mora, Cristina Trilla, Assumpta Antonijuan, Vanesa Orantes, Monica Cruz-Lemini, Francisco Blanco-Vaca, Elisa Llurba
Summary: Algorithms for first-trimester prediction of pre-eclampsia lack sensitivity for predicting late-onset pre-eclampsia and other placental complications. This study aimed to assess the screening performance of biomarkers in the prediction of adverse obstetric outcomes related to placental insufficiency. PlGF, sFlt-1, NT-proBNP, and uric acid measurements combined with maternal factors improved the prediction of complications.
Article
Biochemistry & Molecular Biology
Alessandro Rolfo, Stefano Cosma, Anna Maria Nuzzo, Chiara Salio, Laura Moretti, Marco Sassoe-Pognetto, Andrea Roberto Carosso, Fulvio Borella, Juan Carlos Cutrin, Chiara Benedetto
Summary: This study observed oxidative stress and mitochondrial pathological changes in the placenta of pregnant women with SARS-CoV-2 infection during the third trimester, but the pregnant women maintained a good physiological state. This suggests that the placenta has a certain inhibitory effect on oxidative stress during SARS-CoV-2 infection.
Article
Medicine, General & Internal
Urszula Nowacka, Ioannis Papastefanou, Alexandra Bouariu, Argyro Syngelaki, Kypros H. Nicolaides
Summary: A new approach for predicting SGA, considering it a spectrum condition, has better predictive ability than traditional methods. However, the study found that second trimester levels of sFlt-1 and sFlt-1/PlGF are not useful in screening for SGA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Anna Kajdy, Dorota Sys, Artur Pokropek, Steven W. Shaw, Tung-Yao Chang, Pavel Calda, Ganesh Acharya, Maya Ben-Zion, Tal Biron-Shental, Dariusz Borowski, Bartosz Czuba, Adolfo Etchegaray, Stepan Feduniw, Rosario Garcia-Mandujano, Monica Garcia Santacruz, Maria M. Gil, Sonia Hassan, Sebastian Kwiatkowski, Arancha Martin-Arias, Raigam Jafet Martinez-Portilla, Federico Prefumo, Michal Rabijewski, Laurent J. Salomon, Heidi Tiller, Stefan Verlohren, Hian Yan Voon, Omar Fernando Yanque-Robles, Soon Leong Yong, Liona C. Poon
Summary: This study examines risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic. The results indicate that pregnant women in high-income economies experience higher levels of anxiety and depression. Factors such as the need for psychiatric treatment before pregnancy, restrictions in social distancing and access to leisure activities, pregnancy-related complications, fear of adverse outcomes in children related to COVID-19, and financial burden are associated with increased risk of anxiety and depression during pregnancy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Gordon Rukundo, Fouzia Farooq, Kacey Ferguson, Sasha Baumann, Kristina Maria Adams Waldorf, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Elisa Bevilacqua, Nabal Bracero, Justin S. Brandt, Natalie Broutet, Jorge Carrillo, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Maria del Mar Gil, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Irene Fernandez Buhigas, Valerie Flaherman, Christopher Gale, Christine L. Godwin, Sami Gottlieb, Eduard Gratacos, Siran He, Olivia Hernandez, Stephanie Jones, Sheetal Joshi, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen L. Kotloff, Antonio Lanzone, Valentina Laurita Longo, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Torri D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Olof Stephansson, Marleen Temmerman, Anna Thorson, Soe Soe Thwin, Beth A. Tippett Barr, Jorge E. Tolosa, Niyazi Tug, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Clare Whitehead, Mollie Wood, Huixia Yang, Rebecca Zavala, James M. Tielsch
Summary: This sequential, prospective meta-analysis aimed to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to disease severity, maternal morbidities, neonatal mortality and morbidity, and adverse birth outcomes. Data from 21 participating studies were included, and risk factors and outcomes were analyzed. The study found that women with comorbidities, HIV infection, prepregnancy underweight, and anemia were at increased risk for severe COVID-19-related outcomes and adverse birth outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Acoustics
A. Arechvo, D. A. Nikolaidi, M. M. Gil, V. Rolle, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study aimed to examine the relationship between the English index of multiple deprivation (IMD) and the incidence of stillbirth and evaluate whether IMD contributes to the prediction of stillbirth provided by maternal demographic characteristics and elements of medical history. The study found that women living in the most deprived areas in South East England had higher rates of stillbirth, particularly placental dysfunction-related stillbirth. However, including IMD in stillbirth screening did not improve the prediction provided by race, other maternal characteristics, and elements of medical history.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Cynthia Maxwell, Rachelle Shirley, Amy C. O'Higgins, Mary L. Rosser, Patrick O'Brien, Moshe Hod, Sharleen L. O'Reilly, Virna P. Medina, Graeme N. Smith, Mark A. Hanson, Sumaiya Adam, Ronald C. Ma, Anil Kapur, Harold David McIntyre, Bo Jacobsson, Liona C. Poon, Lina Bergman, Lesley Regan, Esraa Algurjia, Fionnuala M. McAuliffe
Summary: Obesity is a chronic, progressive, relapsing, and treatable neurobehavioral disease that affects women's health and requires a focus on optimizing health outcomes rather than weight loss. Appropriate and sensitive language, as well as trauma-informed care, is necessary when discussing obesity.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Liona C. Poon, Long Nguyen-Hoang, Graeme N. Smith, Lina Bergman, Patrick O'Brien, Moshe Hod, Pius Okong, Anil Kapur, Cynthia Maxwell, Harold David McIntyre, Bo Jacobsson, Esraa Algurjia, Mark A. Hanson, Mary L. Rosser, Ronald C. Ma, Sharleen L. O'Reilly, Lesley Regan, Sumaiya Adam, Virna P. Medina, Fionnuala M. McAuliffe
Summary: Hypertensive disorders of pregnancy (HDP) are the leading cause of maternal and perinatal morbidity and mortality, accounting for 16% of maternal deaths in high-income countries and approximately 25% in low- and middle-income countries. HDP increases the risk of future cardiovascular disease. Failure to achieve normal cardiovascular adaptation during pregnancy is associated with the development of HDP. Women with a history of HDP may experience long-term hemodynamic alterations, predisposing them to cardiovascular morbidity and mortality. Therefore, it is crucial to identify underlying cardiovascular risk factors during pregnancy and the postpartum period and develop strategies for lifestyle and therapeutic interventions to reduce the risk of future cardiovascular disease in women with a history of HDP.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Sarah Louise Killeen, Niamh Donnellan, Sharleen L. O'Reilly, Mark A. Hanson, Mary L. Rosser, Virna P. Medina, Chandni Maria Jacob, Hema Divakar, Moshe Hod, Liona C. Poon, Lina Bergman, Patrick O'Brien, Anil Kapur, Bo Jacobsson, Cynthia Maxwell, Harold David McIntyre, Lesley Regan, Esraa Algurjia, Ronald C. Ma, Sumaiya Adam, Fionnuala M. McAuliffe
Summary: The period before and during pregnancy is crucial for addressing malnutrition and reducing noncommunicable disease risks. The FIGO Nutrition Checklist is a tool designed to address these issues by assessing dietary requirements, body mass index, diet quality, and micronutrients. It generates awareness, identifies risks, and collects information for health-promoting conversations between women and healthcare professionals.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Marcos Javier Cuerva, Elena Rodriguez, Marta Perez De Aguado, Maria del Mar Gil, Valeria Rolle, Francisco Lopez, Jose Luis Bartha
Summary: The aim of this study was to assess whether intrapartum ultrasound (ITU) measurements in maternal lateral posture are comparable to ITU measurements in semi-recumbent position. The results showed that the angle of progression (AOP) and head-perineum distance (HPD) were lower in the lateral posture compared to semi-recumbent position, while they were higher with contractions. Therefore, monitoring the second stage of labor with ITU in lateral maternal posture is feasible.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Oncology
Ignacio Zapardiel, Myriam Gracia Segovia, Ronalds Macuks, Rosanna Mancari, Patriciu Achimas-Cadariu, Giacomo Corrado, Arnoldas Bartusevicius, Vladyslav Sukhin, Juan C. Muruzabal, Pluvio J. Coronado Martin, Barbara Gardella, Jurgen M. Piek, Nicole Concin, Clemente Arab, Dimitrios Papatheodorou, Stephan Polterauer, Sara Iacoponi, Teresa Nieto, Martha C. Lopez-Sanclemente, Hanna Trukhan, Maria M. Gil, Irina Bakinovskaya, Alena Dalamanava, Marc Cucurull, Dzmitry Rovski, Laura Baquedano, Luis Chiva, Marcin Mardas, Siarhei Anatolievich Mavrichev, Jaroslav Klat, Carlos A. Lopez de la Manzanara, Yusuf Yildirim, SARCUT Study Grp
Summary: This retrospective study analyzed 683 patients with uterine sarcoma to identify and evaluate the impact of different prognostic factors on overall survival and disease-free survival. The results showed variations in 5-year overall survival and disease-free survival rates among different subtypes of uterine sarcoma. The presence of residual disease after surgery was identified as the most significant factor affecting overall survival.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Acoustics
D. L. Rolnik, A. Syngelaki, N. O'Gorman, D. Wright, L. C. Poon, K. H. Nicolaides
Summary: This study aimed to investigate the effects of aspirin on mean arterial pressure (MAP) and mean uterine artery pulsatility index (UtA-PI) in women at increased risk of preterm pre-eclampsia. The results showed that aspirin did not significantly affect MAP, but it was associated with a significant decrease in mean UtA-PI, particularly before 20 weeks of gestation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ana M. Fidalgo, Raquel Miguel, Irene Fernandez-Buhigas, Asuncion Aguado, Marcos J. Cuerva, Elisa Corrales, Valeria Rolle, Belen Santacruz, Maria M. Gil, Liona C. Poon
Summary: After appropriate training, attending midwives and obstetricians have a level of agreement in ultrasound measurements to evaluate fetal head position and progress of labor.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Acoustics
S. Moungmaithong, X. Wang, C. S. L. Lau, A. W. T. Tse, N. M. W. Lee, H. H. Y. Leung, L. C. Poon, D. S. Sahota
Summary: Adding GlyFn to the FMF triple test increases the screening sensitivity for both preterm and any-onset pre-eclampsia in an Asian population.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Yan Yu Li, Wing Yi Lok, Liona C. Poon, Choi Wah Kong, William W. K. To
Summary: The objective of this study was to evaluate the acceptance of COVID-19 vaccination among pregnant women and to compare their anxiety and knowledge on COVID-19 with a previous study. A cross-sectional survey was conducted in antenatal clinics in Hong Kong, China. The results showed that pregnant women in the current survey were less worried about COVID-19 compared to the previous survey.
MATERNAL-FETAL MEDICINE
(2023)
Letter
Medicine, General & Internal
Catherine Cluver, Christianne de Groot, Ben W. Mol, Kellie E. Murphy, Jane E. Norman, Rodolfo Pacagnella, Kirsten Palmer, Liona C. Poon, Daniel L. Rolnik, Catherine Y. Spong, Sarah J. Stock, Shakila Thangaratinam, Stephen Tong, Corine Verhoeven, Lan N. Vuong, Sue P. Walker, Liu Xiaohua
Review
Obstetrics & Gynecology
Piya Chaemsaithong, Maria M. Gil, Noppadol Chaiyasit, Diana Cuenca-Gomez, Walter Plasencia, Valeria Rolle, Liona C. Poon
Summary: This study aimed to assess the diagnostic accuracy of placental growth factor and placental growth factor-based models in predicting the development of preeclampsia in asymptomatic women. The findings suggest that placental growth factor combined with maternal factors has the highest predictive performance for early preeclampsia, while placental growth factor-based models perform similarly to soluble fms-like tyrosine kinase-1-placental growth factor ratio for any-onset preeclampsia in the third trimester. Standardized research using consistent models is needed to accurately predict preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)