期刊
FETAL DIAGNOSIS AND THERAPY
卷 33, 期 2, 页码 122-129出版社
KARGER
DOI: 10.1159/000346566
关键词
Fetal MRI; Intrauterine growth restriction; Small for gestational age; Texture analysis
资金
- Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales/UK)
- Thrasher Research Fund (Salt Lake City, Utah, USA)
- Fundacion Dexeus (Barcelona, Spain)
- Banca Civica de Caja Navarra (Proyecto TETD)
- Instituto de Salud Carlos III Rio Hortega Spain [CM10/00222]
- Instituto de Salud Carlos III Sara Borrell [CD09/00263]
- Comissionat per a Universitat i Recerca del Departament d'Innovacio, Universitats i Empreses de la Generalitat de Catalunya
Objectives: We tested the hypothesis whether a texture analysis (TA) algorithm applied to MRI brain images identified different patterns in small for gestational age (SGA) fetuses as compared with adequate for gestational age (AGA). Study Design: MRI was performed on 83 SGA and 70 AGA at 37 weeks' GA. Texture features were quantified in the frontal lobe, basal ganglia, mesencephalon, cerebellum and cingulum. A classification algorithm based on discriminative models was used to correlate texture features with clinical diagnosis. Results: Region of interest delineation in all areas was achieved in 61 SGA (12 vasodilated) and 52 AGA; this was the sample for TA feature extraction which allowed classifying SGA from AGA with accuracies ranging from 90.9 to 98.9% in SGA versus AGA comparison and from 93.6 to 100% in vasodilated SGA versus AGA comparison. Conclusions: This study demonstrates that TA can detect brain differences in SGA fetuses. This supports the existence of brain microstructural changes in SGA fetuses. Copyright (c) 2013 S. Karger AG, Basel
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