Article
Multidisciplinary Sciences
Minghua Wang, Yongqi Wu, Yunbiao He, Jing Liu, Yingxing Chen, Jieqiong Huang, Guolong Qi, Ping Li
Summary: This study found that the quantity of endometrial epithelial cells and stromal fibroblasts in endometriosis is correlated with the expression level of SIRT1. Overexpression of SIRT1 in endometrial epithelial cells triggers the EMT process, allowing them to escape senescence induced by damage or oncogenes. This observation supports the hypothesis that genetic and epigenetic factors help endometrial epithelial cells evade senescence and promote the EMT process in endometriosis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Iveta Yotova, Quanah J. Hudson, Florian M. Pauler, Katharina Proestling, Isabella Haslinger, Lorenz Kuessel, Alexandra Perricos, Heinrich Husslein, Rene Wenzl
Summary: LINC01133 is upregulated in endometriosis and may affect pathogenesis through cellular proliferation and migration pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Harriet C. Fitzgerald, Andrew M. Kelleher, Chaman Ranjit, Danny J. Schust, Thomas E. Spencer
Summary: Uterine glands and their secretions play a crucial role in various reproductive processes, such as uterine receptivity, blastocyst implantation, and placental development. Hormones like estrogen and progesterone, as well as external factors, regulate the function of uterine glands. A study using a human endometrial epithelial organoid system found that different proteins secreted by the organoids were modulated by hormone and prostaglandin E2. Additionally, one of the secreted proteins, cystatin C, was shown to attenuate the stromal decidualization response. These findings highlight the impact of uterine gland-derived factors on stromal cell decidualization and its implications for pregnancy establishment and fertility in women.
MOLECULAR HUMAN REPRODUCTION
(2023)
Article
Cell Biology
Hanbi Wang, Simiao Liu, Wanyu Zhang, Meizhi Liu, Chengyan Deng
Summary: In this study, we aimed to investigate the role and molecular mechanisms of human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) in repairing hypoxic injury of endometrial epithelial cells. The results showed that hucMSC-Ex promoted cell proliferation, inhibited cell apoptosis, migration, and epithelial-mesenchymal transition in hypoxia-induced endometrial epithelial cells, possibly through regulating the expression of miR-663a/CDKN2A.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Health Care Sciences & Services
Tetsuo Maruyama
Summary: The stem cell hypothesis has emerged as an important explanation for the pathogenesis of endometriosis, suggesting that stem cells play a role in the formation and cell differentiation of endometriotic lesions. Recent research indicates that the development of endometriosis involves stem/progenitor cells of at least two different origins, but the mechanism behind this dual stem cell theory requires further elucidation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Chemistry, Physical
Masayuki Fujii, Toshiro Sato
Summary: This review highlights the approaches used to generate somatic cell-derived organoids for modeling epithelial tissue and understanding disease progression. It discusses how advancements in understanding the regulation of epithelial tissue stem cells have led to the development of organoids, which retain the characteristics of their tissue of origin. Additionally, it mentions the growing effort in using organoids to model human diseases and their contributions to understanding disease biology.
Article
Multidisciplinary Sciences
Constantine A. Simintiras, Pramod Dhakal, Chaman Ranjit, Harriet C. Fitzgerald, Ahmed Z. Balboula, Thomas E. Spencer
Summary: The study developed a high-throughput method for isolating intraorganoid fluid (IOF) from human endometrial epithelial organoids, revealing distinct biochemical differences between IOF and extraorganoid fluid (EOF). This has the potential to enhance our understanding of uterine fluid composition and regulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biotechnology & Applied Microbiology
Yating Liao, Kailan Peng, Xia Li, Youyuan Ye, Peng Liu, Yanhua Zeng
Summary: This study demonstrated that the adhesion protein in M. genitalium is able to inhibit apoptosis in host cells via the CypA receptor and activate the PI3K/Akt/NF-kappa B signaling pathway through CypA/CD147. Additionally, experiments conducted in mice further supported this conclusion.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Nian-jie Zhang, Yuanwei Zhang, Shuo Yin, Du-ji Ruan, Nian He, Xu Chen, Xue-feng Yang
Summary: In this study, it was found that NP treatment promoted epithelial-mesenchymal transition (EMT) in colorectal cancer (CRC) cells, enhancing their invasive and migratory abilities. The overexpression of regulator of cell cycle (RGCC) was identified as a key factor in this process, as it increased the NP-induced EMT and activated ERK signaling pathways. The findings suggest that NP exposure may contribute to the development of CRC and provide a potential target for further research.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Review
Cell Biology
Ezekiel Mecha, Roselydiah Makunja, Jane B. Maoga, Agnes N. Mwaura, Muhammad A. Riaz, Charles O. A. Omwandho, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: Thoracic endometriosis (TE) is a rare form of endometriosis where endometrial tissue is found in or around the lungs, often presenting as catamenial pneumothorax (CP). Immunohistochemical evaluation is considered crucial for diagnosing and classifying the disease effectively.
Article
Endocrinology & Metabolism
Sylvia C. Hewitt, San-pin Wu, Tianyuan Wang, Madhumita Ray, Marja Brolinson, Steven L. Young, Thomas E. Spencer, Alan DeCherney, Francesco J. DeMayo
Summary: This study investigates the molecular processes underlying estrogen responses and their effects on endometrial health. By analyzing the ESR1 cistromes and transcriptomes of endometrial biopsies and organoids, the study identifies candidate ESR1 target genes and reveals differences in the distribution and regulation of ESR1 binding sites between different stages of the menstrual cycle. The findings provide valuable resources for understanding how estrogen affects endometrial function and health.
Article
Obstetrics & Gynecology
Kashmira Bane, Junita Desouza, Diksha Shetty, Prakash Choudhary, Shalaka Kadam, R. R. Katkam, Gwendolyn Fernandes, Raj Sawant, Uddhavraj Dudhedia, Neeta Warty, Anahita Chauhan, Uddhav Chaudhari, Rahul Gajbhiye, Geetanjali Sachdeva
Summary: The study indicates that the DNA damage response is dysregulated in the eutopic endometrium of women with endometriosis, with higher expression of DDR genes compared to those without the disease. Additionally, DNA repair genes are also up-regulated in the eutopic endometrium of women with endometriosis.
HUMAN REPRODUCTION
(2021)
Article
Medicine, General & Internal
Anna C. Loeffelmann, Alena Hoerscher, Muhammad A. Riaz, Felix Zeppernick, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: In endometriosis, the localization of claudin-10 is impaired, but the epithelial phenotype remains preserved. Claudin-10 is highly expressed in endometriosis and adenomyosis, but there are differences in its localization between the two conditions.
Review
Biochemistry & Molecular Biology
Jose Lourenco Reis, Natacha Nurdine Rosa, Miguel Angelo-Dias, Catarina Martins, Luis Miguel Borrego, Jorge Lima
Summary: Endometriosis is a chronic inflammatory disorder characterized by the presence of endometrial cells outside the uterus. Studies indicate a correlation between the immune system, particularly NK receptors (NKR), and endometriosis, suggesting their essential role in the disease's pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yuri Park, Sang Jun Han
Summary: Endometriosis is an estrogen-dependent inflammatory disease that causes pelvic pain and infertility in women. Immune system defects may contribute to the progression of endometriosis. Elevated levels of interferon, a cytokine, play a crucial role in endometriosis progression, but also have a critical role in normal endometrial function, particularly in pregnancy initiation and maintenance.
Review
Toxicology
Huage Liu, Hao Chen
Summary: Tobacco smoke, including thirdhand smoke (THS), contains toxic chemicals that can cause follicle destruction and oocyte dysfunction, posing health risks especially to the reproductive system. Research on THS exposure has shown potential dangers to human health, particularly in terms of reproduction and offspring wellbeing. The findings aim to raise awareness and promote healthier living habits to mitigate the risks associated with THS exposure.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiawei Huang, Kin U. Pong, Fuyuan Yang, Zeyuan Ji, Jiacheng Lin, Zhihui Weng, Lai Ling Tsang, Tobias D. Merson, Ye Chun Ruan, Chao Wan, Gang Li, Xiaohua Jiang
Summary: The use of hPSC-EMSCs shows potential as a treatment avenue for HIE, as they exhibit higher neuroprotective effects compared to hUC-MSCs. These stem cells promote endogenous neurogenesis, alleviate astrogliosis and microgliosis, and enhance brain functional recovery in rats with HIE.
Article
Biochemistry & Molecular Biology
Aaron Mendez-Bermudez, Liudmyla Lototska, Melanie Pousse, Florent Tessier, Oliver Croce, Chrysa M. Latrick, Veronica Cherdyntseva, Joe Nassour, Jiang Xiaohua, Yiming Lu, Corinne Abbadie, Sarantis Gagos, Jing Ye, Eric Gilson
Summary: Cellular senescence triggers various types of heterochromatin remodeling, including decondensation, DNA damage, and illegitimate recombination. In this study, it was discovered that at the onset of senescence, pericentromeric heterochromatin is specifically dismantled due to telomere shortening or genotoxic stress. This process is initiated by the TP53-TRF2 axis and involves the downregulation of TRF2, resulting in heterochromatin decondensation and DNA breaks.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Computer Science, Artificial Intelligence
Xi Wang, Fangyao Tang, Hao Chen, Carol Y. Cheung, Pheng-Ann Heng
Summary: Supervised deep learning has achieved success in DME recognition from OCT volumetric images. However, the shortage of labeled data and the expensive annotation make accurate analysis difficult. To tackle this problem, the authors propose a deep semi-supervised multiple instance learning framework that leverages a small amount of labeled data and a large amount of unlabeled data.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Multidisciplinary Sciences
Philip Chiu-Tsun Tang, Jeff Yat-Fai Chung, Jinyue Liao, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Guangyao Cheng, Chunjie Li, Xiao-Ru Huang, Calvin Sze -Hang Ng, Eric W. -F Lam, Dongmei Zhang, Yi-Ping Ho, Ka-Fai To, Kam -Tong Leung, Xiaohua Jiang, Ho Ko, Tin -Lap Lee, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: This study discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de novo neurogenesis, which contributes to a better understanding of tumor innervation. The study also identified a phenomenon of macrophage to neuron-like cell transition (MNT) and identified a crucial regulator for MNT. This finding has potential clinical significance for the treatment of cancer pain.
Article
Andrology
Jian-Wu Shi, Yi-Wen Zhou, Yu-Fei Chen, Mei Ye, Feng Qiao, Jia-Wei Tian, Meng-Ya Zhang, Hao-Cheng Lin, Gang-Cai Xie, Kin Lam Fok, Hui Jiang, Yang Liu, Hao Chen
Summary: This study characterized the cell atlas of the epididymis in a 46,XY disorders of sex development patient with a novel heterozygous mutation in the NR5A1 gene. The patient exhibited feminization of external genitalia and dysplastic testis. Single-cell RNA sequencing analysis revealed an increase in fibroblast cells and a decrease in main epididymal epithelial cells, suggesting an association with the epithelial-to-mesenchymal transition process. This study provides important insights into the pathophysiology of DSD.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Hao Chen, Yanning Zhou, Yi Lin, Ronald C. K. Chan, Jiang Liu, Hao Jiang
Summary: Computational cytology is a critical and rapidly developing topic in medical image computing. Deep learning approaches have achieved significant advancements in cytology image analysis, leading to a substantial increase in publications. This article surveys over 120 publications on deep learning-based cytology image analysis, investigating advanced methods and comprehensive applications. It introduces different deep learning schemes, summarizes public datasets, evaluation metrics, and versatile applications, and discusses current challenges and potential research directions in computational cytology.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Computer Science, Artificial Intelligence
Yu Cai, Hao Chen, Xin Yang, Yu Zhou, Kwang-Ting Cheng
Summary: Medical anomaly detection is essential for recognizing abnormal images in order to assist in diagnosis. Most methods only utilize known normal images during training, ignoring readily available unlabeled images containing anomalies and limiting performance. To address this problem, we propose a one-class semi-supervised learning approach called Dual-distribution Discrepancy for Anomaly Detection (DDAD), which utilizes both known normal and unlabeled images for training. Our method achieves significant gains and outperforms state-of-the-art methods on various medical datasets.
MEDICAL IMAGE ANALYSIS
(2023)
Review
Endocrinology & Metabolism
P. Dai, F. Qiao, Y. Chen, D. Y. L. Chan, H. C. H. Yim, K. L. Fok, H. Chen
Summary: The COVID-19 pandemic caused significant impacts on global public health, with over 6 million deaths. Male patients had higher complication rates and mortality rates 77% higher than those of female patients. The presence of SARS-CoV-2 in the male reproductive tract and its association with testosterone levels has raised concerns about its effects on male fertility.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Materials Science, Biomaterials
Mengya Zhang, Junyu Nie, Yufei Chen, Xiaofeng Li, Hao Chen
Summary: N6-methyladenosine (m(6)A) is a common RNA modification in eukaryotes, involved in various biological processes. Recent studies suggest its association with spermatogenesis, although the expression patterns and relationships of m(6)A enzymes during different stages of spermatogenesis are still unknown.
Article
Computer Science, Interdisciplinary Applications
Jianwei Lin, Jiatai Lin, Cheng Lu, Hao Chen, Huan Lin, Bingchao Zhao, Zhenwei Shi, Bingjiang Qiu, Xipeng Pan, Zeyan Xu, Biao Huang, Changhong Liang, Guoqiang Han, Zaiyi Liu, Chu Han
Summary: This study proposes a clinical knowledge-driven brain tumor segmentation model that achieves state-of-the-art performance by effectively fusing multi-modality images.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Computer Science, Artificial Intelligence
Yi Lin, Zhiyong Qu, Hao Chen, Zhongke Gao, Yuexiang Li, Lili Xia, Kai Ma, Yefeng Zheng, Kwang-Ting Cheng
Summary: This paper proposes a weakly-supervised learning method for nuclei segmentation using point annotations for training. The method improves the segmentation performance through the derivation of coarse pixel-level labels, co-training strategy, and self supervised visual representation learning. Experimental results demonstrate the superior segmentation performance of the proposed method compared to other methods, and its competitive performance compared to fully-supervised methods.
MEDICAL IMAGE ANALYSIS
(2023)
Review
Cell Biology
Zoey Zeyuan Ji, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Kam-Tong Leung, Xiaohua Jiang, Ka-Fai To, Yi Wu, Patrick Ming-Kuen Tang
Summary: Tumour-Associated Macrophages (TAMs) are a key component of the tumour microenvironment, with complex roles in cancer immunity. TAMs can exhibit both pro-tumour and anti-cancer activities. Advanced single-cell technology has revealed novel dedifferentiation phenomena of TAMs. Additionally, TAMs show potential in cancer immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Lingling Wang, Xinyao Li, Tiao Bu, Xiaolong Wu, Linxi Li, Sheng Gao, Damin Yun, Yan Zhang, Hao Chen, Fei Sun, C. Yan Cheng
Summary: Environmental toxicant cadmium can induce male reproductive dysfunction by disrupting the blood-testis barrier through affecting the cytoskeletons of Sertoli cells. RNA sequencing revealed multiple gene sets related to actin and microtubule cytoskeletons, as well as the mitogen-activated protein kinase (MAPK) signaling pathway, were regulated during cadmium-induced Sertoli cell injury. Inhibition of p38-MAPK activation by a specific inhibitor effectively blocked cadmium-induced Sertoli cell injury.
Article
Computer Science, Artificial Intelligence
Shu Yang, Lu Zhang, Shuai Liu, Huchuan Lu, Hao Chen
Summary: In this article, a densely aggregated bilateral network (DAB-Net) is proposed for real-time semantic segmentation. The network captures local semantic contextual information through a patch wise context enhancement (PCE) module in the context path, and exploits more spatial information through a context-guided spatial path (CGSP). Experimental results demonstrate that the proposed method achieves high accuracy with limited decay in speed.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
