Review
Biochemistry & Molecular Biology
Sanaz Dastghaib, P. Sravan Kumar, Sajjad Aftabi, Gautam Damera, Azadeh Dalvand, Adel Sepanjnia, Mohammad Kiumarsi, Mohamad-Reza Aghanoori, Sukhwinder Singh Sohal, Sudharsana R. Ande, Javad Alizadeh, Pooneh Mokarram, Saeid Ghavami, Pawan Sharma, Amir A. Zeki
Summary: Lung cells are exposed to internal and external stressors, leading to disruption of protein homeostasis and activation of the UPR. Dysregulation of the UPR is associated with disease development and various human conditions. Compounds targeting the UPR pathway show potential for future therapeutic interventions.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gehan Botrus, Richard M. Miller, Pedro Luiz Serrano Uson Jr, Geoffrey Kannan, Haiyong Han, Daniel D. Von Hoff
Summary: High levels of ER stress and UPR activation are present in pancreatic cancer, leading to adaptive mechanisms and potential apoptosis. This review discusses the mechanisms by which compounds activate the UPR pathways and induce apoptosis, and explores the potential of ER stress inducers for anti-tumor efficacy in pancreatic cancer. A new approach of increasing ER stress and UPR activation to incite apoptotic cell death in pancreatic cancer is hypothesized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Zengyou Ma, Haoyi Zheng, Xiaoping Li, Beibei Yu, Hui Peng
Summary: This study investigates the expression, localization, and function of CSNK1A1 in early embryonic development in mice. CSNK1A1 is expressed in multiple mouse tissues, including the ovary, and its highest expression is observed in two-cell-stage embryos. Inhibition or knockdown of CSNK1A1 leads to a decrease in blastocyst formation and embryonic developmental arrest. These findings provide novel insights into the role of CSNK1A1 in early embryonic development.
Review
Biochemistry & Molecular Biology
Adalberto Merighi, Laura Lossi
Summary: In addition to protein processing, the endoplasmic reticulum (ER) also plays roles in lipid synthesis, molecular transfers, and Ca2+ homeostasis. Proper protein folding and modification in the ER require molecular chaperones and a favorable environment. Disruption in ER conditions or chaperone capacity can lead to the unfolded protein response (UPR), triggering autophagy and potentially causing cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Yang Xu, Jihyun Jang, Myung Chan Gye
Summary: The contamination of phthalate ester plasticizers poses a threat to wildlife and human health. This study evaluated the developmental toxicity and cellular stress-inducing potential of commonly used phthalate esters and emerging alternatives. The results showed that these plasticizers had varying effects on animal development and cellular stress at different concentrations.
ENVIRONMENTAL POLLUTION
(2022)
Review
Immunology
Wolfgang Vivas, Sebastian Weis
Summary: Pathogens and their toxic byproducts can cause tissue damage in infected hosts, triggering stress responses such as the unfolded protein response (UPR) to limit pathogenesis. However, prolonged or excessive activation of UPR may have detrimental effects including cell death.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Yuki Ishiwata-Kimata, Yukio Kimata
Summary: This article reviews the canonical and up-to-date insights regarding yeast UPR, mainly focusing on the functions and regulation of Ire1 and HAC1.
Review
Biochemistry & Molecular Biology
Noel Verjan Garcia, Kyung U. Hong, Nobuyuki Matoba
Summary: The endoplasmic reticulum (ER) plays a vital role in cell homeostasis and disruptions to its functions can lead to diseases. Dysregulated ER stress and UPR are linked to various human diseases, including inflammatory bowel disease (IBD). A recent study has shown that EPICERTIN can induce a protective UPR in colon epithelial cells, promoting mucosal healing in IBD models.
Review
Cell Biology
Xun Gao, Yuanyuan Xu
Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by progressive cognitive impairment and memory loss. Research indicates that endoplasmic reticulum stress and unfolded protein response play a role in the pathogenesis of AD. Targeting ER stress and ER stress-mediated apoptosis may be effective in treating AD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Phuong Thi Mai Nguyen, Yuki Ishiwata-Kimata, Yukio Kimata
Summary: The unfolded protein response (UPR) is a cellular response to deal with the accumulation of unfolded proteins in the endoplasmic reticulum (ER). This study demonstrates that constitutive induction of UPR in nonstress conditions leads to growth retardation, which can be partially rescued by weak ER stress. Additionally, the stable expression of ER-localized GFP in UPR-induced cells enhances UPR activity and promotes the production of triglycerides and heterogenous carotenoids. These findings have implications for metabolic engineering and the production of valuable lipidic molecules.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Di Long, Kai Chen, Yinmo Yang, Xiaodong Tian
Summary: Pancreatic cancer remains a highly dangerous malignant tumor with a poor prognosis, and the efficacy of traditional therapies is limited. Recent studies have highlighted the important roles of autophagy and apoptosis triggered by endoplasmic reticulum stress in the tumorigenesis of pancreatic cancer.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Biology
Mateusz Kowalczyk, Edward Kowalczyk, Pawel Kwiatkowski, Lukasz Lopusiewicz, Monika Talarowska, Monika Sienkiewicz
Summary: Despite numerous scientific studies on depression, there is still no clear understanding of the causes and mechanisms of depression development. Recent research has found a strong relationship between depression and endoplasmic reticulum (ER) stress, with continuous activation of stress response pathways in patients. Therefore, recommended drugs should aim at reducing ER stress while alleviating symptoms of depression.ongoing search for drugs that can effectively reduce ER stress and relieve depression symptoms.
Review
Biochemistry & Molecular Biology
Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi'u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar
Summary: The endoplasmic reticulum (ER) is vital for cellular functions, but disruptions in its homeostasis can lead to ER stress, linked to diseases like cancer, obesity, and diabetes. The mechanisms of ER stress related to chronic hyperglycemia and hyperlipidemia in type II diabetes remain unclear.
Article
Biotechnology & Applied Microbiology
Anja Batel, Mirjana Polovic, Mateo Glumac, Oliver Suman, Stipislav Jadrijevic, Bernarda Lozic, Marija Petrovic, Bobana Samardzija, Nicholas J. Bradshaw, Karlo Skube, Vinko Palada, Mislav Acman, Ivana Marinovic Terzic
Summary: This study reveals the role of the SPRTN gene in hepatocellular carcinoma (HCC) and its association with endoplasmic reticulum (ER) stress, providing new insights into the pathogenesis of HCC.
CANCER GENE THERAPY
(2023)
Review
Plant Sciences
Sofia Reyes-Impellizzeri, Adrian A. Moreno
Summary: This review focuses on the impact of alterations in components of ERQC, ERAD, and UPR on plant responses to abiotic stresses. Evidence shows a clear connection between ERAD and UPR mechanisms, but the connection of ERQC components with these processes or their possible client proteins is lacking. Proteomics approaches are suggested to uncover the identity of these proteins and their connection to ER proteostasis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Developmental Biology
Saffet Ozturk, Aylin Yaba-Ucar, Berna Sozen, Derya Mutlu, Necdet Demir
REPRODUCTION FERTILITY AND DEVELOPMENT
(2016)
Article
Pharmacology & Pharmacy
Evren H. Gokce, Sakine Tuncay Tanriverdi, Ipek Eroglu, Nicolas Tsapis, Goksel Gokce, Isil Tekmen, Elias Fattal, Ozgen Ozer
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2017)
Article
Multidisciplinary Sciences
Sarah Ellys Harrison, Berna Sozen, Neophytos Christodoulou, Christos Kyprianou, Magdalena Zernicka-Goetz
Article
Pharmacology & Pharmacy
Ipek Eroglu, Erkan Azizoglu, Mine Ozyazici, Merve Nenni, Hande Gurer Orhan, Seda Ozbal, Isil Tekmen, Ilgen Ertam, Idil Unal, Ozgen Ozer
Article
Genetics & Heredity
Berna Sozen, Murat Ozekinci, Munire Erman, Tonguc Gunduz, Necdet Demir, Randa Akouri
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2019)
Article
Genetics & Heredity
Nilay Kuscu, Nazli Ece Gungor-Ordueri, Berna Sozen, Dileyra Adiguzel, Ciler Celik-Ozenci
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2019)
Correction
Genetics & Heredity
Nilay Kuscu, Nazli Ece Gungor-Ordueri, Berna Sozen, Dileyra Adiguzel, Ciler Celik-Ozenci
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2019)
Article
Developmental Biology
Berna Sozen, Necdet Demir, Magdalena Zernicka-Goetz
Summary: The study explores the role of BMPs during pre-to post-implantation transition by using a unique protocol and stem cells, showing that canonical BMP activity is crucial for extraembryonic ectoderm development. The findings suggest that BMP signaling maintains stem cell populations within both embryonic and extra-embryonic tissues during pre-to post-implantation development, providing insight into early embryogenesis control.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
I. Orcun Olcay, Berkay Akcay, Mustafa Bahceci, Aydin Arici, Kubra Boynukalin, Cengiz Yakicier, Aysel Ozpinar, Murat Basar
Summary: Assisted reproduction technology faces challenges of low success rates and multiple pregnancies. This study suggests that analyzing the amino acid metabolism profile in the spent culture media may help discriminate between euploid and aneuploid human preimplantation embryos. The findings provide a potential noninvasive method for embryo selection, contributing to the improvement of assisted reproduction techniques.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Raziye Melike Yildirim, Yagmur Ergun, Murat Basar
Summary: This review summarizes the role of mitophagy in preeclampsia and low birth weight, highlighting the association of mitochondrial dysfunction and reactive oxygen species accumulation with these conditions. However, the findings in this field are still controversial.
Meeting Abstract
Obstetrics & Gynecology
Yagmur Ergun, Aysegul Gizem Imamoglu, Mauro Cozzolino, Cem Demirkiran, Murat Basar, Emre Seli
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Yagmur Ergun, Cem Demirkiran, Raziye Melike Yildirim, Murat Basar, Emre Seli
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Gabriela Beroukhim, David B. Seifer, Olga Chaplia, Stephanie M. Nichols-Burns, Murat Basar, Cihan Halicigil
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
M. Gumustekin, A. Arici, S. Cilaker Micili, M. Karaman, M. E. Guneli, I. Tekmen
ACTA ENDOCRINOLOGICA-BUCHAREST
(2017)
Article
Biochemistry & Molecular Biology
Taner Senyigit, Fabio Sonvico, Alessandra Rossi, Isil Tekmen, Patrizia Santi, Paolo Colombo, Sara Nicoli, Ozgen Ozer
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)