Article
Immunology
N. Sung, S. A. Khan, M. E. Yiu, G. Jubiz, M. D. Salazar, A. Skariah, S. Dambaeva, J. Kwak-Kim
Summary: This study found that immunomodulatory and anticoagulation treatment significantly improved IVF success rates and live birth rates for women with immune etiologies of recurrent pregnancy losses and implantation failures, suggesting the potential benefits of this therapeutic approach for reproductive outcomes in such patients.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Edgardo Somigliana, Andrea Busnelli, Erkan Kalafat, Paola Vigano, Baris Ata
Summary: Most proposed definitions of recurrent implantation failure (RIF) are not statistically based. Recently, statistical approaches have been proposed, but their effectiveness relies on endorsement from the scientific community.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Immunology
Marcelo Borges Cavalcante, Manoel Sarno, Ricardo Barini
Summary: LIT has shown improvement in pregnancy outcomes for couples with RM in most studies. The current evidence mainly consists of quasi-experimental studies, with few randomized, double-blind studies. However, the evidence is not convincing for the use of LIT in RIF patients.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Paul Pirtea, Marcelle I. Cedars, Kate Devine, Baris Ata, Jason Franasiak, Catherine Racowsky, Jim Toner, Richard T. Scott, Dominique de Ziegler, Kurt T. Barnhart
Summary: To date, there is no clear definition and function impairment of recurrent implantation failure (RIF). Therefore, the term RIF is currently used somewhat haphazardly based on clinicians' judgment. International experts in reproductive medicine met in Lugano, Switzerland, in July 2022 to review RIF and determine its diagnosis and management. Rating: 8/10
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Christopher Arkfeld, Eric Han, Reshef Tal, David B. Seifer
Summary: This study investigated the association between AMH levels and miscarriage rates in ART cycles. The results showed that AMH levels were not associated with increased miscarriage rates overall, but there was a significant difference in non-PCOS patients with AMH < 1 ng/ml. The findings suggest that AMH < 1 ng/mL can be an independent predictor of increased miscarriage rate in non-PCOS infertility patients.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Baris Ata, Erkan Kalafat, Edgardo Somigliana
Summary: This study utilized mathematical modeling to explore the impact of female age and anticipated blastocyst euploidy rates on cumulative implantation rates. The results indicate that older patients require more blastocysts to achieve the desired cumulative implantation probability without preimplantation genetic testing. However, assuming an implantation rate of 55% for euploid blastocysts, only 4 blastocysts are needed to reach a cumulative probability rate greater than 95%, regardless of age.
FERTILITY AND STERILITY
(2021)
Review
Immunology
Forough Parhizkar, Roza Motavalli-Khiavi, Leili Aghebati-Maleki, Zahra Parhizkar, Ramin Pourakbari, Hossein Samadi Kafil, Shahla Danaii, Mehdi Yousefi
Summary: Immunomodulatory and immunosuppressive therapies can manage reproductive failures by controlling immune cells, leading to improved pregnancy outcomes and live birth rates.
IMMUNOLOGY LETTERS
(2021)
Article
Endocrinology & Metabolism
Chenyi Zhong, Liusijie Gao, Li Shu, Zhen Hou, Lingbo Cai, Jie Huang, Jiayin Liu, Yundong Mao
Summary: Endometriosis activity has a negative impact on the outcomes of IVF/ICSI cycles in patients with recurrent implantation failure (RIF). Patients with controlled endometriosis activity showed higher cumulative live birth rates, emphasizing the importance of medical treatment for improved prognosis in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Karolina Piekarska, Pawel Radwan, Agnieszka Tarnowska, Andrzej Wisniewski, Michal Radwan, Jacek R. Wilczynski, Andrzej Malinowski, Izabela Nowak
Summary: During early pregnancy, maternal uterine natural killer (NK) cells play a key role in regulating the immune response, with ERAP1 and ERAP2 influencing the HLA class I immunopeptidome formation. This study explores the associations between ERAP1 and ERAP2 polymorphisms, KIR, and HLA-C genes in recurrent implantation failure (RIF), revealing potential impacts of certain ERAP polymorphisms on RIF susceptibility in HLA-C2-positive patients. Moreover, differences in ERAP secretion levels between fertile women and those experiencing IVF procedures suggest potential implications of ERAP1 and ERAP2 in reproductive processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Xin Liu, Ying Han, Xinyan Wang, Yunshan Zhang, Aijun Du, Ruqiang Yao, Jiabei Lv, Haining Luo
Summary: This study aimed to explore the association between serum AMH levels and early miscarriage rates after IVF/ICSI with fresh embryo transfer. The results showed that young women with high AMH levels had a higher risk of early miscarriage in their first IVF/ICSI treatment. Serum AMH levels might be a valuable marker to estimate the risk of early miscarriage.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
D. Cimadomo, M. J. de los Santos, G. Griesinger, G. Lainas, N. Le Clef, D. J. McLernon, D. Montjean, B. Toth, N. Vermeulen, N. Macklon
Summary: This article provides the first ESHRE good practice recommendations for defining and managing recurrent implantation failure (RIF) in patients undergoing ART. RIF is a challenge in the ART clinic, with numerous investigations and interventions offered and applied without clear biological rationale or evidence of benefit. The recommendations include investigating causes and contributing factors of RIF, as well as improving the chances of a successful pregnancy.
HUMAN REPRODUCTION OPEN
(2023)
Review
Biochemistry & Molecular Biology
Konstantinos Pantos, Sokratis Grigoriadis, Evangelos Maziotis, Kalliopi Pistola, Paraskevi Xystra, Agni Pantou, Georgia Kokkali, Athanasios Pappas, Maria Lambropoulou, Konstantinos Sfakianoudis, Mara Simopoulou
Summary: Recurrent implantation failure (RIF) is a complex condition affecting 10-15% of IVF couples. Dysregulation of interleukins (ILs), which are involved in immune responses, plays a crucial role in the pathogenesis of RIF. Further research is needed to understand the molecular mechanisms of ILs in order to provide evidence-based consultancy and decision making for RIF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Marina Jarne-Borras, Francesc Miro-Mur, Ariadna Anunciacion-Llunell, Jaume Alijotas-Reig
Summary: Through a systematic review and meta-analysis, we found that different types of antiphospholipid antibodies are present in women with recurrent implantation failure. Among them, IgG anticardiolipin autoantibodies are associated with recurrent implantation failure. Additionally, anti-beta 2 glycoprotein I-IgA, antiphosphatidylglycerol-IgG, and antiphosphatidylglycerol-IgM are also associated with recurrent implantation failure.
AUTOIMMUNITY REVIEWS
(2022)
Article
Endocrinology & Metabolism
Tianli Yang, Yuanyuan Yang, Qiong Zhang, Donge Liu, Nenghui Liu, Yumei Li, Zhongyuan Yao, Yeqing Zhang, Fen Tian, Jing Zhao, Yanping Li
Summary: This study evaluated the associations between homeostatic model assessment for insulin resistance (HOMA-IR) and pregnancy outcomes in non-dyslipidemic infertile women undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). The results showed that increased HOMA-IR was positively associated with late miscarriage and macrosomia. Controlling insulin resistance might help prevent the occurrence of late miscarriage and macrosomia during assisted reproductive technology.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Fangxiang Mu, Xin Yang, Mei Wang, Lin Liu, Fang Wang
Summary: This meta-analysis aimed to evaluate the effect of G-CSF on the treatment of RM and RIF. The results showed that the use of G-CSF significantly improved the clinical pregnancy rate of RIF patients, but had no significant impact on their abortion rate. For RM patients, the use of G-CSF showed improved clinical pregnancy rates and lower abortion rates than the control group, but the difference was not significant.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)