Review
Biochemistry & Molecular Biology
Evangelos N. Symeonidis, Evangelini Evgeni, Vasileios Palapelas, Dimitra Koumasi, Nikolaos Pyrgidis, Ioannis Sokolakis, Georgios Hatzichristodoulou, Chara Tsiampali, Ioannis Mykoniatis, Athanasios Zachariou, Nikolaos Sofikitis, Ares Kaltsas, Fotios Dimitriadis
Summary: Male infertility is a common medical condition affecting approximately 15% of couples globally, with an estimated 190 million people struggling with it. Urologists face a wide range of male infertility conditions, from typical cases to more complex ones, with oxidative stress being a critical component entailing an imbalance between ROS and antioxidants. The antioxidant paradox poses one of the biggest challenges in andrology, with the emergence of new tools like the MiOXSYS (R) assay offering a quantification of OS and potential solutions for maintaining redox balance.
Review
Biochemistry & Molecular Biology
Cristobal avila, Jose Ignacio Vinay, Marzia Arese, Luciano Saso, Ramon Rodrigo
Summary: Infertility is a common condition that affects a significant percentage of couples worldwide, with male infertility being a prominent cause. Oxidative stress has been increasingly recognized as a key factor in male infertility, but effective antioxidant interventions have not yet been established.
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Fotios Dimitriadis, Evangelos N. Symeonidis, Panagiota Tsounapi, Aris Kaltsas, Georgios Hatzichristodoulou, Ioannis Sokolakis, Athanasios Zachariou, Atsushi Takenaka, Nikolaos Sofikitis
Summary: Although antioxidants have emerged as a promising solution for male infertility induced by oxidative stress, the excessive use of these compounds may be harmful. Further elaborate studies are needed in the future to explore the effects of antioxidants on semen parameters and fertility potential.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Biochemistry & Molecular Biology
Thomas Kalfas, Aris Kaltsas, Evangelos N. Symeonidis, Asterios Symeonidis, Athanasios Zikopoulos, Efthalia Moustakli, Chara Tsiampali, Georgios Tsampoukas, Natalia Palapela, Athanasios Zachariou, Nikolaos Sofikitis, Fotios Dimitriadis
Summary: This study evaluates the effects of COVID-19 on testicular function and the potential role of antioxidants. Although the virus is rarely detectable in sperm and testicular tissue, semen quality and hormonal balance are affected, and testicular pathology in deceased patients shows defects in spermatogenesis, vascular changes, and inflammation. Limited research makes it uncertain whether antioxidants can improve sperm quality after infection.
Article
Biochemistry & Molecular Biology
Emily P. P. Evans, Jorien T. M. Scholten, Aldona Mzyk, Claudia Reyes-San-Martin, Arturo E. Llumbet, Thamir Hamoh, Eus G. J. M. Arts, Romana Schirhagl, Astrid E. P. Cantineau
Summary: Currently, 15% of couples are suffering from infertility, with 45-50% of cases attributed to male factors. Free radicals or reactive oxygen species (ROS) play a key role in the fertility process, while also serving important functions in sperm maturation. These ROS are influenced by lifestyle, age, and disease.
Review
Andrology
Cayde Ritchie, Edmund Y. Ko
Summary: The impact of reactive oxygen species on male fertility is determined by the delicate balance between oxidative stress and antioxidant capacity. Uninhibited reactive oxygen species can lead to damage to sperm, potentially causing male factor infertility. Research has shown that oxidative stress may affect male fertility through various pathological pathways, providing new directions for studying and predicting reproductive success.
Review
Pharmacology & Pharmacy
Zsolt Kopa, Marton Keszthelyi, Nikolaos Sofikitis
Summary: Antioxidant supplementation may protect sperms against oxidative stress, but excessive exposure can lead to reductive stress, affecting sperm function and embryo development. Studies on antioxidant treatment in male infertility reported improvements in sperm parameters, but also highlighted the uncertainties and biases in the results. There is a need for further research on the balance between oxidant and antioxidant systems to better understand their impact on fertility and potential health risks.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Obstetrics & Gynecology
Teppei Takeshima, Kimitsugu Usui, Kohei Mori, Takuo Asai, Kengo Yasuda, Shinnosuke Kuroda, Yasushi Yumura
Summary: Research has shown that there is a strong connection between oxidative stress and male infertility, leading to the proposal of the term Male Oxidative Stress Infertility (MOSI). Excessive reactive oxygen species (ROS) in ejaculate can lead to oxidative stress, which in turn can lower fertility through various mechanisms. Different assays are available for evaluating oxidative stress, such as the MiOXSYS (R) analyzer, and various measures can be considered for minimizing oxidative stress and improving clinical outcomes.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Petr Slama, Shubhadeep Roychoudhury
Summary: Inflammation and oxidative stress are core causatives of male infertility, with a close connection between the two. Inflammation leads to elevated levels of proinflammatory mediators in the male reproductive tract, while oxidative stress causes oxidative damage to reproductive cells and intracellular components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Filipa G. Mateus, Silvia Moreira, Ana D. Martins, Pedro F. Oliveira, Marco G. Alves, Maria de Lourdes Pereira
Summary: L-Carnitine, a natural antioxidant, supports male reproductive health by improving sperm quality and fertility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lirong Yu, Xuemei Zhang, Feng Zhang, Yingbo Tang, Di Gong, William Oyom, Yongcai Li, Dov Prusky, Gianfranco Romanazzi, Yang Bi
Summary: Both chitosan (CTS) and chitooligosaccharide (COS) can regulate reactive oxygen species (ROS) homeostasis during wound healing of pear fruit by scavenging excessive H2O2 and improving antioxidant capacity. They increase NADPH oxidase and superoxide dismutase activities, promote O2.- and H2O2 production, enhance the activities of several enzymes, and elevate the levels of ascorbic acid and glutathione. In addition, they improve antioxidant capacity in vitro and maintain cell membrane integrity at fruit wounds. COS demonstrates superior performance over CTS.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Medicinal
Jing-Jing Wang, Shu-Xia Wang, Tehmina, Yan Feng, Rui-Fen Zhang, Xin-Yue Li, Qiong Sun, Jian Ding
Summary: Mitochondria play crucial roles in male gametes, producing energy and regulating various cellular processes. Dysfunction and overproduction of ROS in mitochondria may contribute to male infertility. Antioxidant interventions show promising potential in treating male infertility.
Review
Andrology
Saradha Baskaran, Renata Finelli, Ashok Agarwal, Ralf Henkel
Summary: ROS play a crucial role in male fertility by regulating various physiological processes and signaling pathways, but oxidative stress resulting from excessive ROS can damage sperm integrity and function.
Article
Engineering, Biomedical
Chen Shi, Ying Zhang, Guanfu Wu, Zhangyu Zhu, Haiping Zheng, Ximeng Sun, Yongyuan Heng, Shaowei Pan, Haonan Xiu, Jing Zhang, Zhaowei Yin, Ziyi Yu, Bin Liang
Summary: This study developed a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for diabetic wound healing. The hydrogel effectively loaded and released curcumin liposomes and silver nanoparticles (AgNPs), promoting wound healing through ROS scavenging, bactericidal activity, anti-inflammatory effects, and angiogenesis. The hydrogel demonstrated favorable biocompatibility, degradability, and injectivity.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Obstetrics & Gynecology
Mary K. Samplaski, James F. Smith, Kirk C. Lo, James M. Hotaling, Susan Lau, Ethan D. Grober, J. C. Trussell, Thomas J. Walsh, Peter N. Kolettis, Victor D. W. Chow, Armand S. Zini, Aaron Spitz, Marc A. Fischer, Trustin Domes, Scott I. Zeitlin, Eugene F. Fuchs, Jason C. Hedges, Jay I. Sandlow, Robert E. Brannigan, James M. Dupree, Marc Goldstein, Edmund Y. Ko, Tung-Chin M. Hsieh, Jared M. Bieniek, David Shin, Ajay K. Nangia, Keith A. Jarvi
FERTILITY AND STERILITY
(2019)
Article
Urology & Nephrology
Julie W. Cheng, Hillary Wagner, Barbara C. Hernandez, Brian R. Hu, Edmund Y. Ko, Herbert C. Ruckle
Review
Andrology
Cayde Ritchie, Edmund Y. Ko
Summary: The impact of reactive oxygen species on male fertility is determined by the delicate balance between oxidative stress and antioxidant capacity. Uninhibited reactive oxygen species can lead to damage to sperm, potentially causing male factor infertility. Research has shown that oxidative stress may affect male fertility through various pathological pathways, providing new directions for studying and predicting reproductive success.
Editorial Material
Urology & Nephrology
Julie W. Cheng, Hillary Wagner, Barbara C. Hernandez, Brian R. Hu, Edmund Y. Ko, Herbert C. Ruckle
Review
Andrology
Edmund Ko, Ranjith Ramasamy, Damayanthi Durairajanayagam, Saradha Baskaran, Ashok Agarwal
Editorial Material
Andrology
Damayanthi Durairajanayagam, Ashok Agarwal, Saradha Baskaran, Edmund Ko, Ranjith Ramasamy
Article
Obstetrics & Gynecology
Andrew B. Chen, Keith A. Jarvi, Katherine Lajkosz, James F. Smith, Kirk C. Lo, Ethan D. Grober, Susan Lau, Jared M. Bieniek, Robert E. Brannigan, Victor D. W. Chow, Trustin Domes, James M. Dupree, Marc Goldstein, Jason C. Hedges, James M. Hotaling, Edmund Y. Ko, Peter N. Kolettis, Ajay K. Nangia, Jay Sandlow, David Shin, Aaron Spitz, J. C. Trussell, Scott Zeitlin, Armand S. Zini, Marc A. Fisher, Thomas J. Walsh, Tung-Chin M. Hsieh, Eugene F. Fuchs, Mary K. Samplaski
Summary: Racial differences were found in male fertility evaluation and treatment, with white males seeking evaluation earlier and having a higher rate of vasectomy, while black males sought evaluation later and had a lower rate of vasectomy. Asian/Indo-Canadian/Indo-American patients were younger and had a lower rate of vasectomy.
FERTILITY AND STERILITY
(2021)
Review
Urology & Nephrology
Stephanie Jensen, Edmund Y. Ko
Summary: The review of available literature on varicocele repair (VR) in men with non-obstructive azoospermia (NOA) showed that VR can be beneficial for NOA patients, increasing rates of spontaneous spermatogenesis and sperm retrieval, and improving natural pregnancy rates.
ARAB JOURNAL OF UROLOGY
(2021)
Review
Andrology
Ashok Agarwal, Rakesh Sharma, Sajal Gupta, Renata Finelli, Neel Parekh, Manesh Kumar Panner Selvam, Ralf Henkel, Damayanthi Durairajanayagam, Camila Pompeu, Sarah Madani, Andrea Belo, Neha Singh, Simryn Covarrubias, Sara Darbandi, Raha Sadeghi, Mahsa Darbandi, Paraskevi Vogiatzi, Florence Boitrelle, Mara Simopoulou, Ramadan Saleh, Mohamed Arafa, Ahmad Majzoub, Hussein Kandil, Armand Zini, Edmund Ko, Juan G. Alvarez, Marlon Martinez, Jonathan Ramsay, Sunil Jindal, Gian Maria Busetto, Hassan Sallam, Israel Maldonado, Christina Anagnostopoulou, Marco G. Alves, Pallav Sengupta, Kambiz Gilany, Donald P. Evenson, Sheena E. M. Lewis, Jaime Gosalvez, Rafael F. Ambar, Rupin Shah
Summary: Semen analysis is the first step in evaluating male fertility, but sperm morphology assessment is difficult to standardize and obtain reproducible results. Standardization of laboratory protocols is crucial in ensuring reliable laboratory results.
WORLD JOURNAL OF MENS HEALTH
(2022)
Review
Andrology
Sajal Gupta, Rakesh Sharma, Ashok Agarwal, Neel Parekh, Renata Finelli, Rupin Shah, Hussein Kandil, Ramadan Saleh, Mohamed Arafa, Edmund Ko, Mara Simopoulou, Armand Zini, Osvaldo Rajmil, Parviz Kavoussi, Keerti Singh, Rafael F. Ambar, Haitham Elbardisi, Pallav Sengupta, Marlon Martinez, Florence Boitrelle, Marco G. Alves, Kareim Khalafalla, Shubhadeep Roychoudhury, Gian Maria Busetto, Jaime Gosalvez, Nicholas Tadros, Ayad Palani, Marcelo Gabriel Rodriguez, Christina Anagnostopoulou, Sava Micic, Lucia Rocco, Taymour Mostafa, Juan G. Alvarez, Sunil Jindal, Hassan Sallam, Israel Maldonado Rosas, Sheena E. M. Lewis, Sami AlSaid, Mesut Altan, Hyun Jun Park, Jonathan Ramsay, Sijo Parekattil, Marjan Sabbaghian, Kelton Tremellen, Paraskevi Vogiatzi, Mohammad Ali Sadighi Gilani, Donald P. Evenson, Giovanni M. Colpi
Summary: Retrograde ejaculation is a condition where semen flows backward during ejaculation, potentially causing infertility. This may be due to anatomical, neurological, or pharmacological reasons, and treatment approaches depend on the specific cause. Alkalinizing urinary pH or adding sperm wash media before ejaculation may help preserve sperm viability in cases of RE.
WORLD JOURNAL OF MENS HEALTH
(2022)
Review
Andrology
Rakesh Sharma, Sajal Gupta, Ashok Agarwal, Ralf Henkel, Renata Finelli, Neel Parekh, Ramadan Saleh, Mohamed Arafa, Edmund Ko, Armand Zini, Nicholas Tadros, Rupin Shah, Rafael F. Ambar, Haitham Elbardisi, Pallav Sengupta, Marlon Martinez, Florence Boitrelle, Mara Simopoulou, Paraskevi Vogiatzi, Jaime Gosalvez, Parviz Kavoussi, Hussein Kandil, Ayad Palani, Marcelo Rodriguez Pena, Osvaldo Rajmil, Gian Maria Busetto, Christina Anagnostopoulou, Sava Micic, Marco G. Alves, Lucia Rocco, Taymour Mostafa, Juan G. Alvarez, Sunil Jindal, Hassan N. Sallam, Israel Maldonado Rosas, Sheena E. M. Lewis, Sami AlSaid, Mesut Altan, Hyun Jun Park, Jonathan Ramsay, Sijo Parekattil, Marjan Sabbaghian, Kelton Tremellen, Kareim Khalafalla, Damayanthi Durairajanayagam, Giovanni M. Colpi
Summary: Leukocytospermia, defined as the presence of peroxidase-positive leukocytes in semen, may lead to oxidative stress and is associated with issues such as reduced sperm quality and DNA fragmentation. It could be a sign of infection in the male genital tract, caused by common uro-pathogens.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Andrology
Ashok Agarwal, Renata Finelli, Manesh Kumar Panner Selvam, Kristian Leisegang, Ahmad Majzoub, Nicholas Tadros, Edmund Ko, Neel Parekh, Ralf Henkel, Damayanthi Durairajanayagam, Giovanni M. Colpi, Chak Lam Cho, Hassan N. Sallam, Hyun Jun Park, Ramadan Saleh, Sava Micic, Rafael F. Ambar, Armand Zini, Kelton Tremellen, Juan G. Alvarez, Ayad Palani, Mohamed Arafa, Marcello M. Gava, Sunil Jindal, Edouard Amar, Zsolt Kopa, Mohammad Reza Moein, Gian Maria Busetto, Pallav Sengupta, Parviz Kavoussi, Israel Maldonado, Jamal Fikri, Edson Borges, Marlon Martinez, Djordje Bojovic, Osvaldo Rajmil, Kaan Aydos, Sijo Parekattil, Joel L. Marmar, Omar Sefrioui, Andreas Jungwirth, Marcelo Gabriel Rodriguez Pena, Emerson B. Cordts, Haitham Elbardisi, Taymour Mostafa, Marjan Sabbaghian, Mohammad Ali Sadighi Gilani, Yoshiharu Morimoto, Marco G. Alves, Aleksandra Spasic, Uros Kenic, Jonathan Ramsay, Ebenezer Oluwole Akande, Amina Oumeziane, Dmitri Dozortsev, Eric Chung, Ernestine Gwet Bell, Adolfo Allegra, Vasilios Tanos, Moise Fiadjoe, Timur Gurgan, Michel Abou-Abdallah, Hazem Al-Rumaih, Ivana Oborna, Hesham Arab, Sandro Esteves, Medhat Amer, Ates Kadioglu, Oleksandr Yuzko, Vladislav Korsak, Rupin Shah
Summary: This study conducted an online survey to evaluate the practice pattern of reproductive specialists in the use of oxidative stress testing and antioxidant prescriptions for the treatment of male infertility. The results showed a global understanding of the importance of this therapeutic option and a widespread use of antioxidants for male infertility treatment. It emphasizes the necessity of evidence-based clinical practice guidelines from professional societies.
WORLD JOURNAL OF MENS HEALTH
(2021)
Review
Andrology
Ashok Agarwal, Kristian Leisegang, Ahmad Majzoub, Ralf Henkel, Renata Finelli, Manesh Kumar Panner Selvam, Nicholas Tadros, Neel Parekh, Edmund Y. Ko, Chak-Lam Cho, Mohamed Arafa, Marco G. Alves, Pedro Fontes Oliveira, Juan G. Alvarez, Rupin Shah
Summary: This study systematically reviewed the role of antioxidants in the treatment of male infertility and proposed evidence-based clinical guidelines. The review showed that antioxidant supplementation improves semen parameters and can be used in specific clinical conditions.
WORLD JOURNAL OF MENS HEALTH
(2021)
Review
Andrology
Ashok Agarwal, Ahmad Majzoub, Saradha Baskaran, Manesh Kumar Panner Selvam, Chak Lam Cho, Ralf Henkel, Renata Finelli, Kristian Leisegang, Pallav Sengupta, Catalina Barbarosie, Neel Parekh, Marco G. Alves, Edmund Ko, Mohamed Arafa, Nicholas Tadros, Ranjith Ramasamy, Parviz Kavoussi, Rafael Ambar, Manish Kuchakulla, Kathy Amy Robert, Concetta Iovine, Damayanthi Durairajanayagam, Sunil Jindal, Rupin Shah
WORLD JOURNAL OF MENS HEALTH
(2020)
Review
Andrology
Ashok Agarwal, Neel Parekh, Manesh Kumar Panner Selvam, Ralf Henkel, Rupin Shah, Sheryl T. Homa, Ranjith Ramasamy, Edmund Ko, Kelton Tremellen, Sandro Esteves, Ahmad Majzoub, Juan G. Alvarez, David K. Gardner, Channa N. Jayasena, Jonathan W. Ramsay, Chak-Lam Cho, Ramadan Saleh, Denny Sakkas, James M. Hotaling, Scott D. Lundy, Sarah Vij, Joel Marmar, Jaime Gosalvez, Edmund Sabanegh, Hyun Jun Park, Armand Zini, Parviz Kavoussi, Sava Micic, Ryan Smith, Gian Maria Busetto, Mustafa Emre Bakircioglu, Gerhard Haidl, Giancarlo Balercia, Nicols Garrido Puchalt, Moncef Ben-Khalifa, Nicholas Tadros, Jackson Kirkman-Browne, Sergey Moskovtsev, Xuefeng Huang, Edson Borges, Daniel Franken, Natan Bar-Chama, Yoshiharu Morimoto, Kazuhisa Tomita, Vasan Satya Srini, Willem Ombelet, Elisabetta Baldi, Monica Muratori, Yasushi Yumura, Sandro La Vignera, Raghavender Kosgi, Marlon P. Martinez, Donald P. Evenson, Daniel Suslik Zylbersztejn, Matheus Roque, Marcello Cocuzza, Marcelo Vieira, Assaf Ben-Meir, Raoul Orvieto, Eliahu Levitas, Amir Wiser, Mohamed Arafa, Vineet Malhotra, Sijo Joseph Parekattil, Haitham Elbardisi, Luiz Carvalho, Rima Dada, Christophe Sifer, Pankaj Talwar, Ahmet Gudeloglu, Ahmed M. A. Mahmoud, Khaled Terras, Chadi Yazbeck, Bojanic Nebojsa, Damayanthi Durairajanayagam, Ajina Mounir, Linda G. Kahn, Saradha Baskaran, Rishma Dhillon Pai, Donatella Paoli, Kristian Leisegang, Mohamed-Reza Moein, Sonia Malik, Onder Yaman, Luna Samanta, Fouad Bayane, Sunil K. Jindal, Muammer Kendirci, Baris Altay, Dragoljub Perovic, Avi Harlev
WORLD JOURNAL OF MENS HEALTH
(2019)