Article
Obstetrics & Gynecology
Jose Vitor C. Zanardi, Rodrigo M. Rocha, Mathew Leonardi, Demi L. Wood, Chuan Lu, Cansu Uzuner, Jason Mak, George Condous
Summary: This study developed a model to predict the need for ureterolysis during laparoscopy based on clinical features and ultrasound findings. The results showed significant correlations between certain clinical features and the need for ureterolysis. Patients with specific lesions had a higher risk of requiring ureterolysis, while those without these features had a lower risk.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Emine Demir, Zeynep Soyman, Sefa Kelekci
Summary: Surgical excision of advanced endometriosis has been shown to improve women's pain symptoms and quality of life, but there is limited evidence on live birth rate. This study found that after conservative surgery for advanced endometriosis, both non-IVF and IVF treatments had similar cumulative pregnancy and live birth rates in patients with good prognosis EFI scores.
Article
Obstetrics & Gynecology
Manuel Maria Ianieri, Alessandra De Cicco Nardone, Matteo Pavone, Greta Benvenga, Maria Pia Pafundi, Federica Campolo, Nazario Foschi, Pierfrancesco Greco, Mariafrancesca Brutto, Giovanni Scambia
Summary: This study classified ureterolysis procedures into three types based on the depth of ureterolysis, and found that conservative treatment of type 3 ureterolysis is associated with a higher risk of ureteral injury and ureteroneocystostomy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Editorial Material
Obstetrics & Gynecology
Jun Li, Jie Duan, Ruonan Mao, Wei Jiang
Summary: The study aims to reduce the occurrence of intraoperative capsule rupture in presumed early-stage ovarian cancer with adhesions to the abdominal wall. The laparoscopic procedure effectively removes the involved adnexa without rupture and the adhered pelvic peritoneum, preventing tumor seeding and improving patient outcomes.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Michelle Soares, Mathieu Luyckx, Charlotte Maillard, Pauline Laurent, Amandine Gerday, Pascale Jadoul, Jean Squifflet
Summary: This retrospective cohort study assessed the efficacy, safety, fertility outcomes, and recurrence after laparoscopic resection of bladder endometriosis (BE) using a CO2 laser. The study demonstrated that laparoscopic BE removal is feasible with low complication rates and is associated with high fertility rates, even in patients with previous infertility. The recurrence rate of BE is lower than that of other endometriosis locations.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Danielle Hardman, Robert Bennett, Emad Mikhail
Summary: The study demonstrates the use of laparoscopic ultrasound guidance for laparoscopic shaving of rectosigmoid endometriosis, which enhances complete excision and decreases recurrence.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Nikolaos Kathopoulis, Dimitrios-Efthimios Vlachos, Konstantinos Kypriotis, Michail Diakosavvas, Ioannis Chatzipapas, Athanasios Protopapas
Summary: This article demonstrates the technique of discoid excision of bowel endometriosis followed by closure of the bowel defect using sutures. It highlights the advantages of using sutures instead of the transanal stapler, specifically in cases where the pathology is located higher than 15 cm from the anal verge or the diameter of the nodule is more than 30 mm.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Article
Health Care Sciences & Services
Alicia Hernandez, Pablo Robles de Zulueta, Emanuela Spagnolo, Cristina Soguero, Ignacio Cristobal, Isabel Pascual, Ana Lopez, David Ramiro-Cortijo
Summary: This study proposes a novel method based on deep learning algorithms for quantifying the level of blood perfusion in anastomosis. The results show that segmentation of the bowel using the U-Net was successful, and textures are appropriate descriptors for characterization of blood perfusion in images where ICG is present. The findings of this study may help predict the occurrence of postoperative complications during surgery and guide clinicians in taking appropriate actions.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Urology & Nephrology
Ali Cansu Bozaci, Mesut Altan, Hakan Bahadir Haberal, Emrullah Sogutdelen, Fazil Tuncay Aki, Ilhan Erkan
Summary: Ureterolysis shows acceptable success rates with low complication rates in patients with retroperitoneal fibrosis. Preoperative high-serum creatinine levels may be considered as a risk factor for long-term renal impairment.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Article
Obstetrics & Gynecology
Alessandro Arena, Simona Del Forno, Benedetta Orsini, Raffaella Iodice, Eugenia Degli Esposti, Anna Chiara Aru, Federica Manzara, Jacopo Lenzi, Diego Raimondo, Renato Seracchioli
Summary: This prospective observational study aimed to predict the risk of ureteral endometriosis based on preoperative findings. The results showed that factors such as adenomyosis, parametrial involvement, and previous endometriosis surgery were associated with a higher probability of ureteral involvement in women with posterior deep infiltrating endometriosis.
FERTILITY AND STERILITY
(2021)
Editorial Material
Obstetrics & Gynecology
Liron Bar-El, Amanda Chu, Karli Goldstein, Serin Seckin, Tamer Seckin
Summary: This article presents a case of endometriosis within an isthmocele membrane and diffuse peritoneal endometriosis after cesarean sections. A unique surgical repair technique is described, and a possible correlation between isthmocele formation and endometriosis is proposed.
FERTILITY AND STERILITY
(2022)
Editorial Material
Obstetrics & Gynecology
Dong Bach Nguyen, Sebastien Gilbert, Kristina Arendas, Caitlin A. Jago, Sukhbir S. Singh
Summary: The article presents a five-step approach to laparoscopic excision of pericardial and diaphragmatic endometriosis for the treatment of chronic pelvic pain and infertility. The successful completion of the surgical procedure demonstrates that pericardial and diaphragmatic endometriosis can be managed effectively through multidisciplinary and stepwise surgical intervention.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Fabio Barra, Carlotta Zorzi, Mara Albanese, Anna Stepniewska, Xheni Deromemaj, Paola De Mitri, Giovanni Roviglione, Roberto Clarizia, Claudio Gustavino, Simone Ferrero, Marcello Ceccaroni
Summary: The objective of this study was to evaluate ultrasonographic findings as a first-line imaging tool to indirectly predict the presence of par-ametrial endometriosis (PE) in women with suspected deep endometriosis (DE) undergoing surgery. The study found that specific indirect ultrasonographic findings, such as hydronephrosis, absence of posterior sliding sign, multiple endometriomas per ovary, and ovary fixation to the uterine wall, could raise suspicion of PE in women undergoing preoperative assessment for DE. The importance of the study is rated 9 out of 10.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Review
Medicine, General & Internal
Sabrina Rangi, Christine Hur, Elliott Richards, Tommaso Falcone
Summary: Several mechanisms are involved in the infertility caused by endometriosis. For patients considering surgery, the risk of iatrogenic injury is a crucial factor in preserving fertility. Excision of endometriomas significantly reduces ovarian reserve, with a decrease of up to 30% for unilateral and up to 44% for bilateral cases. Surgical interventions should use fertility-conserving methods to minimize postoperative iatrogenic diminished ovarian reserve.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Alicia Hernandez, Elena Munoz, David Ramiro-Cortijo, Emanuela Spagnolo, Ana Lopez, Angela Sanz, Cristina Redondo, Patricia Salas, Ignacio Cristobal
Summary: This study evaluated the quality of life in women who underwent surgical treatment for deep endometriosis and found that their physical and social functions, as well as overall physical health, were lower compared to a healthy reference population. However, body pain, emotional role, vitality, and overall mental health improved in these women.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Maurizio Serati, Alessandro Ferdinando Ruffolo, Chiara Scancarello, Andrea Braga, Stefano Salvatore, Fabio Ghezzi
Summary: This study aimed to investigate the impact of surgeon skills in repairing obstetric anal sphincter injuries (OASIS) on the incidence of pelvic floor dysfunction (PFD). The results showed that skilled surgeons had a protective effect against PFD. Additionally, operative delivery and severe OASIS were associated with PFD.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Obstetrics & Gynecology
Jvan Casarin, Fabio Ghezzi, Ciro Pinelli, Antonio Simone Lagana, Andrea Ambrosoli, Mariangela Longo, Antonella Cromi
Summary: This study investigated surgical outcomes and complications of hysterectomy for benign conditions in elderly patients and found that the abdominal route of hysterectomy was the main factor contributing to prolonged hospitalization. Minimally invasive surgery (MIS) was associated with shorter hospital stays. Additionally, abdominal hysterectomy and longer operative times were independent predictors of prolonged hospitalization.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2023)
Article
Oncology
Giorgio Bogani, Isabelle Ray-Coquard, Nicole Concin, Natalie Yan Li Ngoi, Philippe Morice, Giuseppe Caruso, Takayuki Enomoto, Kazuhiro Takehara, Hannelore Denys, Domenica Lorusso, Robert Coleman, Michelle M. Vaughan, Masashi Takano, Diane Michele Provencher, Satoru Sagae, Pauline Wimberger, Robert Poka, Yakir Segev, Se Ik Kim, Jae-Weon Kim, Francisco Jose Candido dos Reis, Pedro T. Ramirez, Andrea Mariani, Mario Leitao, Vicky Makker, Nadeem R. Abu-Rustum, Ignace Vergote, Gianfranco Zannoni, David Tan, Mary McCormack, Biagio Paolini, Marta Bini, Francesco Raspagliesi, Pierluigi Benedetti Panici, Violante Di Donato, Ludovico Muzii, Nicoletta Colombo, Sandro Pignata, Giovanni Scambia, Bradley J. Monk
Summary: Endometrial carcinosarcoma is a rare and aggressive type of cancer, with clinical presentation and diagnostic methods similar to the more common endometrioid carcinoma. It is characterized by the presence of both carcinomatous and sarcomatous elements, and the majority of cases have p53 abnormalities. Treatment involves a multimodal approach for non-metastatic disease and palliative chemotherapy for metastatic or recurrent disease.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Editorial Material
Biochemistry & Molecular Biology
Giuseppe Gullo, Gaspare Cucinella, Vito Chiantera, Miriam Dellino, Eliano Cascardi, Peter Torok, Tunde Herman, Simone Garzon, Stefano Uccella, Antonio Simone Lagana
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Giorgio Bogani, Violante Di Donato, Andrea Papadia, Alessandro Buda, Jvan Casarin, Francesco Multinu, Francesco Plotti, Maria Luisa Gasparri, Ciro Pinelli, Anna Myriam Perrone, Simone Ferrero, Flavia Sorbi, Fabio Landoni, Innocenza Palaia, Giorgia Perniola, Pierandrea De Iaco, Stefano Cianci, Salvatore Gueli Alletti, Marco Petrillo, Giuseppe Vizzielli, Francesco Fanfani, Roberto Angioli, Ludovico Muzii, Fabio Ghezzi, Enrico Vizza, Michael D. Mueller, Giovanni Scambia, Pierluigi Benedetti Panici, Francesco Raspagliesi
Summary: This retrospective study compared outcomes in endometrial cancer patients who underwent hysterectomy with or without sentinel node mapping (SNM). Data from 398 patients who had hysterectomy and 174 patients who had hysterectomy plus SNM were collected. The SNM group had a longer operative time, but length of hospital stay, estimated blood loss, and severe complication rates were similar between groups. Hysterectomy, with or without SNM, was found to be a safe and effective method for managing EC patients.
Review
Oncology
Stefano Restaino, Chiara Paglietti, Martina Arcieri, Anna Biasioli, Monica Della Martina, Laura Mariuzzi, Claudia Andreetta, Francesca Titone, Giorgio Bogani, Diego Raimondo, Federica Perelli, Alessandro Buda, Marco Petrillo, Pantaleo Greco, Alfredo Ercoli, Francesco Fanfani, Giovanni Scambia, Lorenza Driul, Giuseppe Vizzielli
Summary: This article compares the guidelines released by different international gynecological societies and highlights the differences, aiming to provide a useful tool for clinicians. It emphasizes the importance of managing patients diagnosed with endometrial cancer.
Article
Oncology
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Giorgio Bogani, Francesco Sopracordevole, Nicolo Clemente, Giorgio Giorda, Rosa Pasqualina De Vincenzo, Maria Teresa Evangelista, Barbara Gardella, Mattia Dominoni, Ermelinda Monti, Chiara Alessi, Lara Alessandrini, Alessio Pagan, Marta Caretto, Alessandro Ghelardi, Andrea Amadori, Massimo Origoni, Maggiorino Barbero, Francesco Raspagliesi, Tommaso Simoncini, Paolo Vercellini, Giovanni Scambia, Andrea Ciavattini
Summary: This study examined the impact of HPV status on the prognosis of early stage cervical glandular lesions. The results showed that HPV status did not affect the recurrence rate, but most adenocarcinomas were positive for high-risk HPV.
Editorial Material
Biochemistry & Molecular Biology
Tullio Golia D'Auge, Ilaria Cuccu, Giusi Santangelo, Ludovico Muzii, Andrea Giannini, Giorgio Bogani, Violante Di Donato
Review
Health Care Sciences & Services
Filippo Alberto Ferrari, Francesca Magni, Mariachiara Bosco, Giulia Biancotto, Pier Carlo Zorzato, Antonio Simone Lagana, Vito Chiantera, Ricciarda Raffaelli, Massimo Franchi, Stefano Uccella, Simone Garzon
Summary: There is growing evidence that diet and nutrition play a role in the development of several cancers, including cervical cancer. This review examines the effects of micronutrients, minerals, and vitamins on the history of HPV infection and cervical cancer development. The studies suggest that certain micronutrients may have a protective effect against cervical cancer by interfering in various stages of HPV infection and disease progression. However, more high-quality research is needed to provide clear recommendations for clinical practice.
Review
Health Care Sciences & Services
Ilaria Cuccu, Ottavia D'Oria, Ludovica Sgamba, Emanuele De Angelis, Tullio Golia D'Auge, Camilla Turetta, Camilla Di Dio, Maria Scudo, Giorgio Bogani, Violante Di Donato, Innocenza Palaia, Giorgia Perniola, Federica Tomao, Ludovico Muzii, Andrea Giannini
Summary: Endometrial cancer (EC) is a common gynecological malignancy, and molecular and genomic profiling have shown promise in predicting recurrence risk. However, there is limited data on therapeutic value. Ongoing studies are focused on identifying appropriate adjuvant strategies, especially for patients with positive nodes and low volume disease. Molecular classification has the potential to improve risk stratification and management in EC patients. This review aims to explore the evolution of molecular classification and its impact on research and clinical management.
Article
Urology & Nephrology
Tufan Tarcan, Enrico Finazzi-Agro, Thomas M. Kessler, Maurizio Serati, Eskinder Solomon, Peter F. W. M. Rosier
Summary: This article discusses the design considerations for evaluating the value of urodynamic studies (UDS) in functional urology, suggesting that assessing the value of diagnostic tests based solely on treatment success is conceptually flawed. The article also provides recommendations for the design of a hypothetical randomized controlled trial, including considerations for study population, clinical endpoints, intervention and control group design, among others.
NEUROUROLOGY AND URODYNAMICS
(2023)
Review
Medicine, General & Internal
Andrea Etrusco, Antonio Simone Lagana, Vito Chiantera, Amerigo Vitagliano, Ettore Cicinelli, Mislav Mikus, Marina Sprem Goldstajn, Federico Ferrari, Stefano Uccella, Simone Garzon, Sandro Gerli, Alessandro Favilli
Summary: The latest FIGO classification has reclassified type 3 myomas from intramural to submucosal. Hysteroscopic myomectomy is considered the standard treatment for submucosal myomas, but there are no specific guidelines for managing type 3 myomas, and the optimal surgical approach remains uncertain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Valentina Chiappa, Giorgio Bogani, Matteo Interlenghi, Giulia Vittori Antisari, Christian Salvatore, Lucia Zanchi, Manuela Ludovisi, Umberto Leone Roberti Maggiore, Giuseppina Calareso, Edward Haeusler, Francesco Raspagliesi, Isabella Castiglioni
Summary: Neoadjuvant chemotherapy plus radical surgery may be a safe option for cervical cancer patients who are unwilling to undergo radiotherapy. A machine learning model based on cervix MRI images was developed to stratify the risk of cervical cancer in individual subjects. The response to neoadjuvant chemotherapy was found to be the main factor affecting treatment requirements and survival.
Article
Oncology
Giorgio Bogani, Francesco Sopracordevole, Andrea Ciavattini, Alessandro Ghelardi, Enrico Vizza, Paolo Vercellini, Jvan Casarin, Ciro Pinelli, Fabio Ghezzi, Rosa De Vincenzo, Violante Di Donato, Tullio Golia D'auge, Andrea Giannini, Flavia Sorbi, Marco Petrillo, Giampiero Capobianco, Giuseppe Vizzielli, Stefano Restaino, Stefano Cianci, Giovanni Scambia, Francesco Raspagliesi
Summary: This study aims to evaluate the potential effect of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer. The results showed that the nonavalent HPV vaccination would potentially cover 94.8% of the development of lower genital tract dysplasia, with a beneficial effect of 89% in patients with available HPV data. However, patients with persistent HPV types would not benefit from vaccination, resulting in an estimated potential protective effect of 67%.