Review
Cell Biology
Ezekiel Mecha, Roselydiah Makunja, Jane B. Maoga, Agnes N. Mwaura, Muhammad A. Riaz, Charles O. A. Omwandho, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: Thoracic endometriosis (TE) is a rare form of endometriosis where endometrial tissue is found in or around the lungs, often presenting as catamenial pneumothorax (CP). Immunohistochemical evaluation is considered crucial for diagnosing and classifying the disease effectively.
Article
Obstetrics & Gynecology
Kashmira Bane, Junita Desouza, Diksha Shetty, Prakash Choudhary, Shalaka Kadam, R. R. Katkam, Gwendolyn Fernandes, Raj Sawant, Uddhavraj Dudhedia, Neeta Warty, Anahita Chauhan, Uddhav Chaudhari, Rahul Gajbhiye, Geetanjali Sachdeva
Summary: The study indicates that the DNA damage response is dysregulated in the eutopic endometrium of women with endometriosis, with higher expression of DDR genes compared to those without the disease. Additionally, DNA repair genes are also up-regulated in the eutopic endometrium of women with endometriosis.
HUMAN REPRODUCTION
(2021)
Article
Medicine, General & Internal
Anna C. Loeffelmann, Alena Hoerscher, Muhammad A. Riaz, Felix Zeppernick, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: In endometriosis, the localization of claudin-10 is impaired, but the epithelial phenotype remains preserved. Claudin-10 is highly expressed in endometriosis and adenomyosis, but there are differences in its localization between the two conditions.
Review
Biochemistry & Molecular Biology
Yuri Park, Sang Jun Han
Summary: Endometriosis is an estrogen-dependent inflammatory disease that causes pelvic pain and infertility in women. Immune system defects may contribute to the progression of endometriosis. Elevated levels of interferon, a cytokine, play a crucial role in endometriosis progression, but also have a critical role in normal endometrial function, particularly in pregnancy initiation and maintenance.
Review
Oncology
Nozomi Yachida, Kosuke Yoshihara, Manako Yamaguchi, Kazuaki Suda, Ryo Tamura, Takayuki Enomoto
Summary: Driver gene mutations have been identified in both endometriosis and normal endometrium, potentially leading to endometriosis-associated ovarian cancer. Despite the continuum of genomic alterations, the molecular mechanism of ovarian carcinogenesis from the normal endometrium through endometriosis remains unclear.
Review
Biology
Marjanu Hikmah Elias, Nurunnajah Lazim, Zulazmi Sutaji, Mohammad Azrai Abu, Abdul Kadir Abdul Karim, Azizah Ugusman, Saiful Effendi Syafruddin, Mohd Helmy Mokhtar, Mohd Faizal Ahmad
Summary: Endometriosis is an inflammatory chronic systemic disease causing pelvic pain and infertility. The identification of the disease is insufficient, leading to a high misdiagnosis rate. Our focus is on the abnormal hypermethylation of HOXA10 in endometriosis. A comprehensive literature search was conducted to determine the DNA methylation level of HOXA10 in endometriosis patients across different populations. The gathered evidence demonstrated a higher HOXA10 DNA methylation level in the endometrium tissue of women with endometriosis in all included studies.
Review
Nutrition & Dietetics
Valentina Tassinari, Antonella Smeriglio, Virgilio Stillittano, Domenico Trombetta, Romano Zilli, Roberta Tassinari, Francesca Maranghi, Giulia Frank, Daniele Marcoccia, Laura Di Renzo
Summary: Endometriosis is a chronic inflammatory disease that is estrogen-dependent and characterized by the presence of extrauterine endometrial tissue, causing pelvic pain and fertility impairment. The exact cause of endometriosis is not fully understood, and conventional therapies have shown effectiveness but with considerable side effects. There is a growing interest in the use of herbal medicine for endometriosis treatment, particularly polyphenols that have anti-endometriotic and anti-inflammatory properties. This review aims to provide an overview of the anti-inflammatory activity of polyphenols in the treatment of endometriosis.
Review
Biochemistry & Molecular Biology
Ida Osuchowska-Grochowska, Eliza Blicharska, Marek Gogacz, Agata Nogalska, Izabela Winkler, Agnieszka Szopa, Halina Ekiert, Barbara Tymczyna-Borowicz, Mansur Rahnama-Hezavah, Cezary Grochowski
Summary: Endometriosis is a chronic inflammatory condition that depends on estrogen, and its cause is still uncertain, possibly related to oxidative stress. Research mainly focuses on the potential role of trace elements in the disease, but more comprehensive studies are needed to confirm the role of these elements in the pathomechanism of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Ana Kisovar, Christian M. Becker, Ingrid Granne, Jennifer H. Southcombe
Summary: This study systematically evaluated the role of CD8 T cells in endometriosis-associated tissues and found that CD8 T cells are enriched in the lesions. However, their activation potential in other relevant tissues remains unclear. Future research should focus on identifying clinically relevant phenotypes to support the development of non-invasive diagnostic and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Hui-Hui Shen, Tao Zhang, Hui-Li Yang, Zhen-Zhen Lai, Wen-Jie Zhou, Jie Mei, Jia-Wei Shi, Rui Zhu, Feng-Yuan Xu, Jin Li, Jiang-Feng Ye, Ming-Qing Li
Summary: Menstruation is a cyclic physiological phenomenon controlled by ovarian hormones, and a proper understanding of normal endometrial physiology is crucial for regulating menstrual disorders. Autophagy in the endometrium, regulated by ovarian hormones, plays a key role in immune cell infiltration, tissue repair, and infection prevention during menstruation. Abnormal autophagy levels and dysregulated immune system function are associated with the pathogenesis and progression of endometriosis, suggesting the potential value of autophagy as a target for the treatment of menstrual-related and endometrium-related disorders.
Article
Health Care Sciences & Services
Tetsuo Maruyama
Summary: The stem cell hypothesis has emerged as an important explanation for the pathogenesis of endometriosis, suggesting that stem cells play a role in the formation and cell differentiation of endometriotic lesions. Recent research indicates that the development of endometriosis involves stem/progenitor cells of at least two different origins, but the mechanism behind this dual stem cell theory requires further elucidation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Nurunnajah Lazim, Marjanu Hikmah Elias, Zulazmi Sutaji, Abdul Kadir Abdul Karim, Mohammad Azrai Abu, Azizah Ugusman, Saiful Effendi Syafruddin, Mohd Helmy Mokhtar, Mohd Faizal Ahmad
Summary: This review examines the expression differences of the HOXA10 gene in women with endometriosis compared to those without, across different countries, and discusses its impact on women's fertility. The majority of studies found downregulation of the HOXA10 gene expression, although one study showed evidence of both downregulation and upregulation depending on the localization of endometriotic lesions. Clinically, measuring the expression of the HOXA10 gene is crucial in predicting endometriosis, endometrial receptivity, and the development of pinopodes during the luteal phase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell & Tissue Engineering
Yue Kong, Yang Shao, Chunxia Ren, Gong Yang
Summary: Endometrial stem/progenitor cells play crucial roles in cell therapy, immune regulation, and endometriosis, with MenSCs being ideal candidates for their abundant sources and autotransplantation capabilities. Limited BMDSCs in blood circulation can lead to the establishment of deep invasive endometriosis.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Endocrinology & Metabolism
Antonio Mercorio, Pierluigi Giampaolino, Andrea Romano, Patrick Dallenbach, Nicola Pluchino
Summary: This article reviews the endocrine issues and related enzymatic pathways in endometriosis. The clinical role of these enzymes is still controversial and lacks sufficient clinical data. Research on new drug targets is ongoing, but there are challenges, such as evaluating enzyme expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mst Ismat Ara Begum, Lin Chuan, Seong-Tshool Hong, Hee-Suk Chae
Summary: Association studies have shown that miRNA expression is significantly altered in relation to diseases, including endometriosis (EMS), particularly within inflammatory pathways. This article reviews the advancements made in understanding the pathological role of miRNA in EMS and its association with EMS-associated infertility, highlighting the potential for developing miRNA-based therapeutics and diagnostic markers.
Article
Endocrinology & Metabolism
Andreanne Michaud, Sofia Laforest, Melissa Pelletier, Melanie Nadeau, Serge Simard, Marleen Daris, Mathieu Leboeuf, Hubert Vidal, Alain Geloen, Andre Tchernof
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Julie Anne Cote, Julie-Anne Nazare, Melanie Nadeau, Mathieu Leboeuf, Line Blackburn, Jean-Pierre Despres, Andre Tchernof
Article
Endocrinology & Metabolism
Halima Rakhila, Mahera Al-Akoum, Charles Doillon, Nicolas Lacroix-Pepin, Mathieu Leboeuf, Madeleine Lemyre, Ali Akoum, Marc Pouliot
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2016)
Article
Immunology
Halima Rakhila, Mahera Al-Akoum, Marie-Eve Bergeron, Mathieu Leboeuf, Madeleine Lemyre, Ali Akoum, Marc Pouliot
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Article
Immunology
Alize Proust, Corinne Barat, Mathieu Leboeuf, Jean Drouin, Michel J. Tremblay
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Neurosciences
Corinne Barat, Alize Proust, Alexandre Deshiere, Mathieu Leboeuf, Jean Drouin, Michel J. Tremblay
Article
Cardiac & Cardiovascular Systems
Julie Anne Cote, Melanie Nadeau, Mathieu Leboeuf, Line Blackburn, Andre Tchernof
Article
Multidisciplinary Sciences
Halima Rakhila, Karine Girard, Mathieu Leboeuf, Madeleine Lemyre, Ali Akoum
Article
Endocrinology & Metabolism
Julie Lessard, Sofia Laforest, Melissa Pelletier, Mathieu Leboeuf, Line Blackburn, Andre Tchernof
Article
Neurosciences
Alize Proust, Corinne Barat, Mathieu Leboeuf, Jean Drouin, Marie-Therese Gagnon, Francois Vanasse, Michel J. Tremblay
Article
Neurosciences
Vincent Senecal, Corinne Barat, Marie-Therese Gagnon, Francois Vanasse, Mathieu Leboeuf, David Gosselin, Michel J. Tremblay
Summary: This study revealed that HIV-1 infection impairs the ability of astrocytes in the central nervous system to produce the neuroprotective factor fractalkine, and specifically blocks the interaction of transcription factor NF-kappa B with its promoter, leading to neuronal damage. Moreover, the study demonstrated the important role of fractalkine in protecting human neurons, suggesting potential new therapeutic strategies for HIV-1-associated neurocognitive disorders.
JOURNAL OF NEUROVIROLOGY
(2021)
Article
Obstetrics & Gynecology
Rabeea F. Omar, Mathieu Leboeuf, Madeleine Lemyre, Isabelle Chabot, Sylvie Trottier, Andre Ulmann, Michel G. Bergeron
Summary: The study evaluated the spermicidal efficacy of non-hormonal vaginal gel in vitro and in a post-coital test, as well as its contraceptive efficacy in Canadian women. The results demonstrated significant spermicidal and contraceptive effects of the vaginal gel.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
(2022)
Article
Obstetrics & Gynecology
Jocelynn Cook, Ashley Waddington, Denise Black, Dustin Costescu, Danica Desjardins, Eve Duchesne, Mathieu LeBoeuf, Unjali Malhotra, William Fisher
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
(2019)
Article
Obstetrics & Gynecology
Joalee Paquette, Mathieu Leboeuf, Emilie Gorak-Savard
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
(2016)