Article
Nutrition & Dietetics
Qianqian Zhang, Chen Zhang, Yi Wang, Jiuru Zhao, Haiyuan Li, Qianwen Shen, Xiaoli Wang, Meng Ni, Fengxiu Ouyang, Angela Vinturache, Hao Chen, Zhiwei Liu
Summary: The study revealed that first trimester insufficient or deficient vitamin D levels and being overweight or obese significantly increased the risk of early fetal growth restriction. Furthermore, a combination of low Vitamin D concentrations and overweight or obesity had a significant effect on early fetal growth.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Lisa Daneels, Dries S. Martens, Soumia Arredouani, Jaak Billen, Gudrun Koppen, Roland Devlieger, Tim S. Nawrot, Manosij Ghosh, Lode Godderis, Sara Pauwels
Summary: The study found a positive association between maternal vitamin D intake (diet + supplements) and newborn TL, particularly during the first trimester. However, there was no significant association between mean maternal serum 25-OHD concentrations during pregnancy and newborn TL.
Article
Nutrition & Dietetics
Barbara Hatzlhoffer C. Lourenco, Marcia C. Castro, Priscila de Morais Sato, Paulo Augusto Ribeiro Neves, Edwin Vivanco, Daniel Leal Lima, Marly Augusto Cardoso
Summary: Maternal consumption of ultra-processed food (UPF) during pregnancy has negative impacts on fetal growth, especially on head circumference, abdominal circumference, and femur length. Daily UPF consumption significantly impairs fetal head circumference, while weekly UPF consumption decreases both head circumference and femur length. Therefore, healthy dietary practices during pregnancy play a crucial role in promoting fetal skeletal growth.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Antonio Gazquez, Maria Sanchez-Campillo, Alejandro Barranco, Ricardo Rueda, Jia P. Chan, Matthew J. Kuchan, Elvira Larque
Summary: Oral 25-OH-D3 provides better vitamin D availability for both mother and fetus during pregnancy compared to vitamin D3. No adverse effects on pregnancy outcomes were observed. The effects of 25-OH-D3 on the expression of VDR and GAD67 in fetal brain require further investigation.
FRONTIERS IN NUTRITION
(2022)
Article
Health Care Sciences & Services
Ki-Wook Kwon, Young-Hyeon Lee, Min-Ho Yeo, Sang-Hyun Park, Hye-Ran Kim, Hye-Sook Kim, Kyung-Soo Chang
Summary: 90% of vitamin D is synthesized in the skin through sunlight, while 10% comes from food. Vitamin D is crucial for skeletal growth, cell proliferation and differentiation, and immune function. This study found that maternal vitamin D concentration had no significant effect on hematological and serological changes, but it was inversely proportional to sexually transmitted infection rates. Additionally, vitamin D concentration influenced fetal bone growth, specifically in humerus and femur lengths. Preventing vitamin D deficiency and promoting outdoor activities or supplementation are recommended.
Article
Genetics & Heredity
Aparna Sampathkumar, Karen M. Tan, Li Chen, Mary F. F. Chong, Fabian Yap, Keith M. Godfrey, Yap Seng Chong, Peter D. Gluckman, Adaikalavan Ramasamy, Neerja Karnani
Summary: Vitamin D deficiency is associated with pregnancy complications and adverse infant outcomes. Early predictive markers of vitamin D inadequacy are important for both mother and offspring health. Genetic risk variants identified in this study allow risk assessment and precision in early intervention of vitamin D deficiency.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Kathy Zhang-Rutledge, Mallory Owen, Nathaly M. Sweeney, David Dimmock, Stephen F. Kingsmore, Louise C. Laurent
Summary: Prenatal genomic sequencing plays an important role in diagnosing critically ill infants, helping to identify potential genetic diseases and abnormalities. If genetic diseases were diagnosed prenatally, clinical management would be altered.
PRENATAL DIAGNOSIS
(2022)
Article
Pediatrics
Karolina Jakubiec-Wisniewska, Hubert Huras, Magdalena Kolak
Summary: This study aimed to examine the effect of vitamin D intake on the rate of fetal growth restriction (FGR). The results showed that vitamin D supplementation at the recommended dose can lead to greater fetal weight gain.
Review
Food Science & Technology
Rizwan Arshad, Aysha Sameen, Mian Anjum Murtaza, Hafiz Rizwan Sharif, Iahtisham-Ul-Haq, Sahifa Dawood, Zahoor Ahmed, Arash Nemat, Muhammad Faisal Manzoor
Summary: The role of vitamin D in improving maternal health and reducing the risk of developmental disorders in fetus has been extensively studied in recent years, with observational studies and clinical trials providing evidence for its impact on various aspects of pregnancy and fetal development.
FOOD SCIENCE & NUTRITION
(2022)
Review
Nutrition & Dietetics
Jose Luis Mansur, Beatriz Oliveri, Evangelina Giacoia, David Fusaro, Pablo Rene Costanzo
Summary: Vitamin D deficiency in pregnancy and infants may lead to health issues such as rickets, preeclampsia, and fetal growth restriction; supplementation with Vitamin D can reduce the risk of complications for pregnant women, fetuses, and newborns.
Article
Nutrition & Dietetics
Jinhua Wu, Bule Shao, Xing Xin, Wenliang Luo, Minjia Mo, Wen Jiang, Shuting Si, Shuojia Wang, Yu Shen, Yunxian Yu
Summary: This study explored the associations of vitamin D metabolic pathway gene polymorphisms with gestational 25(OH)D levels in pregnant women, and found that the associations varied by season and VD supplements. Additionally, the Gc isoform had a significant impact on gestational 25(OH)D levels.
CLINICAL NUTRITION
(2021)
Article
Pharmacology & Pharmacy
N. Gurkan
Summary: The present study revealed that the level of amniotic fluid NF-KB decreased in a dose-dependent manner in pregnant women undergoing VD replacement therapy.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
N. Gurkan
Summary: This study found that the levels of amniotic fluid NF-KB decreased significantly in pregnant women undergoing VD replacement therapy in a dose-dependent manner.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Nutrition & Dietetics
Andreea Bianca Stoica, Claudiu Marginean
Summary: This article reviews the impact of vitamin D deficiency on the health of infants, emphasizing its global significance and the need for further research and strategies. While conflicting results exist regarding the effects of vitamin D, it is clear that deficiency has significant implications, particularly for infants.
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Stefan Pilz, Cedric Annweiler, Fatme Al Anouti
Summary: This study aimed to evaluate the combined effect of maternal and neonatal VDBP polymorphism heterogeneity in conjunction with different maternal and neonatal 25(OH)D cutoffs on neonatal anthropometric profile at birth. The findings suggest a potential role for neonatal VDBP genotypes rs2298850 and rs4588, in conjunction with specific neonatal 25(OH)D cutoffs, in affecting neonatal growth and development. However, no significant effects were observed for maternal VDBP polymorphisms or maternal 25(OH)D concentrations at birth on neonatal anthropometry.
Editorial Material
Obstetrics & Gynecology
Divya Gautam, Gillian A. Ryan, Fionnuala M. McAuliffe, Nikhil Purandare
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Helena C. Bartels, Jennifer M. Walsh, Clare O'Connor, Peter McParland, Stephen Carroll, Shane Higgins, Karen M. Mulligan, Paul Downey, David Brophy, Gabrielle Colleran, Claire Thompson, Tom Walsh, Donal J. O'Brien, Donal J. Brennan, Ruaidhri McVey, Fionnuala M. McAuliffe, Jennifer Donnelly, Siobhan M. Corcoran
Summary: The objective of this study was to evaluate fetal growth in pregnancies complicated by placenta accreta spectrum (PAS) and compare fetal growth between different ultrasound stages of PAS. The results showed that the diagnosis of PAS was not associated with fetal growth restriction.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Nursing
Sharleen L. O'Reilly, Marie C. Conway, Eileen C. O'Brien, Eva Molloy, Hannah Walker, Eimear O'Carroll, Fionnuala M. McAuliffe
Summary: This study aims to explore the barriers and enablers to breastfeeding among women with high body mass indices and identify specific behaviors suitable for intervention. The research found that women with high body mass indices face limitations in terms of knowledge, support, and self-efficacy in breastfeeding. A multifactorial intervention is needed to provide comprehensive support for successful breastfeeding.
JOURNAL OF HUMAN LACTATION
(2023)
Article
Obstetrics & Gynecology
Fiona Cody, Julia Unterscheider, Sean Daly, Michael Geary, Mairead Kennelly, Fionnuala McAuliffe, John Morrison, Keelin O'Donoghue, Alyson Hunter, Patrick Dicker, Elizabeth Tully, Rachel Fhearaigh, Fergal Malone
Summary: A total of 17% of fetuses with initial fetal growth restriction (FGR) outgrew their diagnosis, and this was more common in healthy mothers. Antenatal surveillance could be decreased once the fetus exceeded the 10th centile.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Pediatrics
Helena C. Bartels, Linda M. O'Keeffe, Cara A. Yelverton, Kate N. O'Neill, Aisling A. Geraghty, Eileen C. O'Brien, Sarah Louise Killeen, Ciara McDonnell, Fionnuala M. McAuliffe
Summary: This study aimed to examine the association between maternal metabolic parameters in pregnancy and growth trajectories up to 5 years of age. Data from the ROLO study were analyzed, and no strong evidence of associations between maternal metabolic parameters and fetal to childhood weight and abdominal circumference trajectories was found.
Article
Environmental Sciences
Doireann Roche, Anthony Rafferty, Sinead Holden, Sarah Louise Killeen, Maria Kennelly, Fionnuala M. McAuliffe
Summary: This study aimed to examine the association between early pregnancy well-being and stage of behavior change during an antenatal lifestyle intervention. The results showed that both maternal well-being and the study group significantly influenced the positive stage of behavior change, highlighting the potential importance of well-being in promoting women's engagement in a healthy lifestyle.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Obstetrics & Gynecology
Catherine McNestry, Sarah L. Killeen, Rachel K. Crowley, Fionnuala M. McAuliffe
Summary: There is an increasing recognition of the association between pregnancy complications and the development of chronic diseases later in life. Pregnancy can be seen as a stress test that reveals underlying predispositions to disease. However, healthcare providers lack awareness of these risks. A narrative literature review shows that various pregnancy complications are associated with increased risk of cardiovascular disease, diabetes, venous thromboembolism, chronic kidney disease, postnatal depression, and mental health disorders. It is important to offer counseling and risk reduction advice for women in the postnatal period following a complicated pregnancy. Further research is needed to determine optimal screening intervals for cardiovascular disease and diabetes after a complicated pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Editorial Material
Medicine, General & Internal
Malachi J. McKenna, Mary A. T. Flynn
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Sarah Louise Killeen, Shauna L. Callaghan, Sharleen L. O'Reilly, Fionnuala M. McAuliffe
Summary: The objective of this study was to develop a core outcome set for pregnancy nutrition. Candidate outcomes were identified from a systematic review and additional data were collected through interviews with women with pregnancy experience. A modified Delphi survey and consensus meeting were conducted to finalize the core outcome set. The set includes critical outcomes for both pregnant women and newborns, providing important guidance for researchers and healthcare professionals.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Multidisciplinary Sciences
Conor Feehily, Ian J. O'Neill, Calum J. Walsh, Rebecca L. Moore, Sarah Louise Killeen, Aisling A. Geraghty, Elaine M. Lawton, David Byrne, Rocio Sanchez-Gallardo, Sai Ravi Chandra Nori, Ida Busch Nielsen, Esther Wortmann, Elizabeth Matthews, Roisin O'Flaherty, Pauline M. Rudd, David Groeger, Fergus Shanahan, Radka Saldova, Fionnuala M. McAuliffe, Douwe Van Sinderen, Paul D. Cotter
Summary: The authors combine isolation and sequencing of bacteria from both mothers and infants to investigate microbial strain transfer, particularly in the genus Bifidobacterium. They reveal that strain transfer occurs in almost 50% of dyads, with factors such as vaginal birth and avoidance of intrapartum antibiotics being important. Dual approaches, combining cultivation and metagenomic sequencing, are necessary for a comprehensive understanding of this transfer process.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Obstetrics & Gynecology
Long Nguyen-Hoang, Graeme N. Smith, Lina Bergman, Fionnuala M. McAuliffe, Liona C. Poon
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Microbiology
Cara A. Yelverton, Sarah Louise Killeen, Conor Feehily, Rebecca L. Moore, Shauna L. Callaghan, Aisling A. Geraghty, David F. Byrne, Calum J. Walsh, Elaine M. Lawton, Eileen F. Murphy, Douwe Van Sinderen, Paul D. Cotter, Fionnuala M. Mcauliffe
Summary: This study explored the relationships among maternal well-being during pregnancy, breastfeeding, and the infant gut microbiome. The results showed that maternal well-being during pregnancy was not associated with infant microbial diversity. However, exclusive breastfeeding at discharge from hospital was associated with infant microbial beta diversity, and any breastfeeding at 1 month postpartum was associated with infant microbial alpha diversity, observed species, and beta diversity. Exclusive breastfeeding at 1 month postpartum was also associated with infant alpha diversity and number of observed microbial species.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Sharleen L. O'Reilly, Rachel Laws, Helle Terkildsen Maindal, Helena Teede, Cheryce Harrison, Fionnuala M. McAuliffe, Aisling Geraghty, Cristina Campoy, Mercedes G. Bermudez, Laura Pirhonen, Christy Burden, Anna Davies, Ditte Hjorth Laursen, Timothy Skinner
Summary: This study aims to explore the feasibility and implementation of the B2B&Me intervention and investigate its effectiveness in women at risk of gestational diabetes.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Obstetrics & Gynecology
Rebecca L. Moore, Conor Feehily, Sarah Louise Killeen, Cara A. Yelverton, Aisling A. Geraghty, Calum J. Walsh, Ian J. O'Neill, Ida Busch Nielsan, Elaine M. Lawton, Rocio Sanchez-Gallardo, Sai Ravi Chandra Nori, Fergus Shanahan, Eileen F. Murphy, Douwe Van Sinderen, Paul D. Cotter, Fionnuala M. McAuliffe
Summary: This study aimed to investigate if maternal probiotic supplementation in pregnancy can affect the infant gut microbiome. The results showed that direct mother-to-infant strain transfer of the supplemented probiotic occurred, albeit infrequently. This study highlights the potential for maternal supplementation to introduce microbial strains into the infant microbiome.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Review
Nutrition & Dietetics
May Loong Tan, Izz Amirah Mohd Shukri, Jacqueline J. Ho, Elizabeth J. O'Sullivan, Amal Omer-Salim, Fionnuala M. McAuliffe
Summary: A breastfeeding-friendly city is a city that provides an enabling environment to support breastfeeding throughout a child's first 2 years or more. However, there are currently no established indicators for defining a breastfeeding-friendly city. This study identified common criteria such as policy, training & education, skilled breastfeeding support, and physical infrastructure, which could be developed into indicators. Further research is needed to determine the importance of these criteria and how they can be measured.
MATERNAL AND CHILD NUTRITION
(2023)