期刊
FERTILITY AND STERILITY
卷 98, 期 2, 页码 284-289出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2012.04.023
关键词
Klinefelter syndrome; fertility preservation; spermatogonial stem cells
Although early development of testis appears normal in boys with Klinefelter syndrome (KS), spermatogonial stem cell (SSC) depletion occurs in midpuberty, leading to infertility. Therefore, freezing of semen samples or testicular tissue sampling could be offered to boys with KS at onset of puberty. However, only in about half of patients with KS, adult or prepubertal, spermatozoa or SSCs can be observed, and to date, no clinical parameters are available to detect patients who might benefit from these techniques. Furthermore, strategies for the further use of the cryopreserved material are still under investigation. Retrieval of spermatogonial cells in prepubertal boys with KS should therefore still be viewed as experimental and patients and their parents must be counseled accordingly. (Fertil Steril (R) 2012;98:284-9. (C) 2012 by American Society for Reproductive Medicine.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据