期刊
FERTILITY AND STERILITY
卷 97, 期 4, 页码 943-947出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2011.12.048
关键词
PGS; array CGH; aneuploidy; mosaicism
Objective: To examine the effect of mosaicism in the array comparative genomic hybridization result during preimplantation genetic screening after blastocyst biopsy. Design: Experimental study. Setting: University laboratory. Material(s): Epithelial cell lines. Intervention(s): Mixing of euploid and aneuploid cells to create mosaic trophectoderm and blastocyst models. Main Outcome Measure(s): The level of aneuploidy in samples with different ratios of aneuploid cells was measured after array comparative genomic hybridization. Result(s): A shift from normality was present when the level of aneuploid cells in the sample was >25%. Aneuploidy could be confidently called when the level of aneuploid cells was >50%. Conclusion(s): This study determined that aneuploidy in mosaic samples can be detected by array comparative genomic hybridization and that the result may also indicate the proportion of the aneuploid cells present in the sample. (Fertil Steril (R) 2012; 97: 943-7. (C) 2012 by American Society for Reproductive Medicine.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据