Article
Medicine, General & Internal
Anat Hershko-Klement, Shaul Raviv, Luba Nemerovsky, Tal Rom, Ayelet Itskovich, Danit Bakhshi, Adrian Shulman, Yehudith Ghetler
Summary: This study investigated the predictive value of blastocyst re-expansion as an indicator of treatment success in embryo transfer. The results showed a positive correlation between re-expansion degree and clinical pregnancy rate. This standardized measurement method can be used as a tool for predicting treatment success.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Anette Gabrielsen, Lea Hedegaard Iversen, Jens Fedder, Tilde Veng Eskildsen, Anne Lis Englund, Stine Ravn Hansen, Philippe Pinton
Summary: This study evaluates the characteristics of human IVF embryos before and after vitrification to predict the chance of clinical pregnancy in single vitrified blastocyst transfer cycles. The study found that pre-vitrification parameters such as trophectoderm grading and post-warming blastocyst size were significantly associated with clinical pregnancy, while the numbers and rates of embryo collapse were not.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
Kemal Ozgur, Murat Berkkanoglu, Hasan Bulut, Levent Donmez, Ayhan Isikli, Kevin Coetzee
Summary: By analyzing the age and morphology scores of blastocysts, top-scoring blastocysts with clinical implantation rates greater than 70% can be selected.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Endocrinology & Metabolism
Juwei Hu, Juan Zheng, Jie Li, Haiyue Shi, Hua Wang, Bangxu Zheng, Kun Liang, Chunhao Rong, Liming Zhou
Summary: Based on our research, we suggest prioritizing the selection of high-quality expanded blastocysts, regardless of whether they were vitrified on D5 or D6, as there was no difference in clinical outcomes. For low-quality blastocysts, it is preferable to use D5 expanded blastocysts for transfer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Integrative & Complementary Medicine
Chang Tan, Xiliang Wang, Lishuang Luo, Jinyan Zhang, Pengshu Zou, Wei Wei, Yuexin Yu
Summary: This paper explores the feasibility of D4 frozen-thaw embryo transfer and analyzes the factors affecting the outcome of freeze-thaw embryo transfer. The study found that factors such as woman's age, endometrial thickness on the day of transplantation, BMI, number of embryos transferred, and type of embryos transferred all influence the outcome of FET.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Obstetrics & Gynecology
S. Makieva, M. K. Sachs, M. Xie, A. Velasco, S. El-Hadad, D. R. Kalaitzopoulos, I Dedes, R. Stiller, B. Leeners
Summary: The study found that the live birth rate after double vitrification was comparable to that after single vitrification, indicating that the procedure does not compromise the chance of live birth after a single blastocyst transfer.
HUMAN REPRODUCTION OPEN
(2023)
Article
Biochemistry & Molecular Biology
Cristina Cuello, Cristina A. Martinez, Josep M. Cambra, Inmaculada Parrilla, Heriberto Rodriguez-Martinez, Maria A. Gil, Emilio A. Martinez
Summary: This study investigated the impact of vitrification on the transcriptome profile of porcine blastocysts. The results showed that vitrification altered the gene expression of blastocysts, with minor changes mainly related to cell cycle, cellular senescence, gap junction, and signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Alessandra Alteri, Giovanni Campo, Luca Pagliardini, Laura Privitera, Paolo Ivo Cavoretto, Massimo Candiani, Enrico Papaleo, Paola Vigano
Summary: A retrospective cohort study found that singletons born after vitrified-warmed blastocyst transfer (frozen embryo transfer [FET]) had different postnatal growth compared to children born after fresh blastocyst transfer. Singletons born after FET had higher birth weight and length z-scores, as well as higher height z-scores at 12 months of age. Male infants in the FET group also had higher birth weight z-scores, but showed slower weight growth during the first 12 months.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Endocrinology & Metabolism
Ningling Wang, Xinxi Zhao, Meng Ma, Qianqian Zhu
Summary: The study found that there was a significant increase in live birth rate and birth weight after transfer of single good quality embryo on day 5 and day 6 compared with transfer of single good quality embryo on day 3 in vitrified embryo transfer cycles.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Roni Rahav-Koren, Shmuel Inbar, Netanella Miller, Amir Wiser, Yael Yagur, Chen Berkowitz, Sivan Farladansky-Gershnabel, Adrian Shulman, Arie Berkowitz
Summary: The study suggests that culturing post-thaw cleavage embryos for 2 days and transferring them as blastocysts may increase the chances of ongoing pregnancy and delivery compared to transferring thawed blastocysts directly.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
A. Mengels, A. Van Muylder, K. Peeraer, J. Luyten, A. Laenen, C. Spiessens, S. Debrock
Summary: This study compared the cumulative pregnancy rates of supernumerary embryos vitrified on Day 3 and Day 5/6. The results showed no significant difference between the two groups. It is known that extended embryo culture and blastocyst transfer on Day 5/6 yield higher pregnancy and live birth rates in IVF or ICSI treatment. However, this study focused on vitrification for cryopreservation of supernumerary embryos, rather than the traditional slow freezing protocol.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Yulin Du, Yichun Guan, Na Li, Congxing Shi, Yongjie Zhang, Bingnan Ren, Jing Liu, Hua Lou
Summary: A retrospective cohort study found that preimplantation genetic testing for aneuploidy (PGT-A) can improve the pregnancy outcomes of patients aged under 38 years with a history of recurrent implantation failure (RIF). The euploidy rate of good-quality blastocysts was significantly higher than that of poor-quality blastocysts in the PGT-A group. The clinical pregnancy rate was significantly increased after the use of PGT-A compared with the control group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Hui-Ying Jie, Xiu Zhou, Ming-Peng Zhao, Min Hu, Qing-Yun Mai, Can-Quan Zhou
Summary: The study aimed to investigate whether polycystic ovary syndrome (PCOS) is an independent risk factor for pregnancy complications in women undergoing assisted reproductive technology (ART) treatment. Results showed that PCOS may increase the risk of late miscarriage, but other pregnancy outcomes were similar between PCOS patients and the control group.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Danilo Cimadomo, Gemma Fabozzi, Lisa Dovere, Roberta Maggiulli, Laura Albricci, Federica Innocenti, Daria Soscia, Adriano Giancani, Alberto Vaiarelli, Maurizio Guido, Filippo Maria Ubaldi, Laura Rienzi
Summary: The study aimed to evaluate the impact of cryo-storage duration on clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer. It concluded that cryo-storage duration does not affect these outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Laura Melado Vidales, Barbara Lawrenz, Raquel Loja Vitorino, Rachana Patel, Francisco Javier Ruiz, Laura Marqueta Marques, Asina Bayram, Ibrahim Elkhatib, Human Fatemi
Summary: This study aimed to investigate the factors impacting the clinical pregnancy rate (CPR) and live birth rates (LBR) in euploid frozen embryo transfer (eFET) cycles. A retrospective observational study of 1660 eFET cycles with 2439 euploid blastocysts revealed that double embryo transfer (DET) increased CPR and LBR, but also increased the risk of pregnancy loss. Furthermore, body mass index (BMI) and endometrial preparation protocol were associated with LBR in eFET, with higher BMI leading to lower LBR.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Clinical Neurology
Tiantian Wang, Miaofa Ying, Rui Zhao, Danyan Zhu, Lisan Zhang
Summary: In our study, the rate of augmentation in Chinese RLS patients was 15%. Augmentation may be associated with switching from other dopaminergic drugs, longer disease duration before pramipexole use, higher dosage and longer duration of pramipexole, and tolerance to pramipexole.
SLEEP AND BREATHING
(2022)
Article
Physics, Fluids & Plasmas
Liyang Huang, Jin Meng, Danni Zhu, Yuzhang Yuan
Summary: This article discusses the minimum spatial filling rate of ferrite required to excite microwave oscillations in the gyromagnetic NLTL, as well as the influences of the inner radius of the outer conductor and dielectric materials on its performance.
IEEE TRANSACTIONS ON PLASMA SCIENCE
(2022)
Article
Biology
Yalei Zhao, Lingjian Zhang, Qingqing Hu, Danhua Zhu, Zhongyang Xie
Summary: In this study, the role of C17orf53 in hepatocellular carcinoma (HCC) was analyzed using public datasets. The findings suggest that C17orf53 is highly expressed and predicts poor survival in HCC patients. It also correlates positively with the abundance of B cells, macrophages, and dendritic cells. Functional analysis revealed that C17orf53 is involved in cell cycle, DNA replication, and Fanconi anemia pathways. Knockdown of C17orf53 inhibited cell proliferation and decreased the expression of MCM8, cyclin D1, and PCNA. Overall, C17orf53 is a novel prognostic signature for HCC.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Junqing Wu, Wenru Sun, Chao Sun, Chunmiao Xu, Shuang Li, Pengxue Li, Huimin Xu, Danyang Zhu, Meng Li, Liling Yang, Jinbo Wei, Aya Hanzawa, Sumaiya Jannat Tapati, Reiko Uenoyama, Masao Miyazaki, Abidur Rahman, Shuang Wu
Summary: Fruit malformation is a widespread issue in fruit production, causing significant economic losses. Although farmers have long observed the association between chilling temperature before blooming and malformed fruits, the molecular mechanism behind this phenomenon remains unclear. In this study, we investigated how tomato fruit development responded to cold stress and found that short-term cold stress led to increased callose accumulation in both shoot apical and floral meristems. This caused symplastic isolation and altered intercellular movement of WUS, resulting in expanded stem cell population and malformed fruits. Our findings suggest that the callose dynamics during short-term cold stress involve the interplay of abscisic acid and gibberellin, similar to bud dormancy mechanisms. This study provides new insights into the regulation of fruit malformation under cold stress.
Article
Materials Science, Multidisciplinary
Junlin Wu, Jiyang Ding, Xinyou Huang, Zhengfa Dai, Xiaoying Li, Danyang Zhu, Dong Huang, TengFei Xie, Jianrong Zhou, Xingfen Jiang, Zhijia Sun, Dariusz Hreniak, Jiang Li
Summary: Gd2O2S:Tb nanopowders were synthesized by hot water-bath method using Gd2O3 and H2SO4 as raw materials. The properties of precursors and powders were influenced by the initial bathing temperature. The size and thickness of flakes in the precursors and powders increased with the increase of initial temperature. Gd2O2S:Tb scintillation ceramics were fabricated using the obtained powders and showed different properties based on the initial temperature of synthesis.
Article
Physics, Multidisciplinary
Danni Zhu, Yancheng Cui, Jin Meng, Yuzhang Yuan, Haitao Wang, Jiangfeng Han
Summary: Magnetically insulated coaxial diodes are commonly used in high power microwave devices for generating intense annular electron beams. This study conducted electrical and optical measurements on a long-pulse magnetically insulated coaxial diode to observe the emission characteristics and plasma properties. The impact of cathode material, blade angle, diode voltage, and guiding magnetic field on the emission characteristics and plasma properties of six types of annular cathodes was investigated. The metal-dielectric cathode showed excellent emission characteristics and plasma properties, achieving impressive diode performance. Additionally, high voltage and small blade angle were found to enhance the emission capability and uniformity, while a strong magnetic field or large diode voltage reduced the axial and radial expansion velocities.
Article
Engineering, Biomedical
Xiaochan Li, Boon Chin Heng, Yunyang Bai, Qianqian Wang, Min Gao, Ying He, Xinwen Zhang, Xuliang Deng, Xuehui Zhang
Summary: The study confirms the dose-response effect of surface electrical charge on SHED neural differentiation and provides insights into the underlying molecular mechanisms and signaling pathways involved.
BIOACTIVE MATERIALS
(2023)
Article
Toxicology
Zhanxun Wu, Wenping Yan, Ke Wang, Genghua Xu, Danyan Zhu, Xuyun Li, Huafeng Wang, Min Yang, Xiangnan Zhang, Jiaying Wu
Summary: Bortezomib (BTZ) is an effective drug for multiple myeloma treatment, but it often leads to BTZ-induced peripheral neuropathy (BIPN). In this study, it was found that BTZ caused demyelination in sciatic nerves, leading to mechanical hyperalgesia and impaired nerve conduction. The mechanism was identified as the dysfunction of lysosomes and autophagy blockage in Schwann cells. However, the use of the lysosomal activator Torin1 reversed the autophagy blockage and improved the BIPN pathology.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Plant Sciences
Xingnan Ouyang, Danyang Zhu, Yujie Huang, Xuejian Zhao, Rui Xu, Jiaying Wang, Wenjun Li, Xu Shen
Summary: This study found that MAOB was highly overexpressed in the spinal cord and DRG tissues of PIPN mice, rather than MAOA, and Khellin as a selective MAOB inhibitor could improve PIPN-like pathology. Moreover, Khellin promoted neurite outgrowth, alleviated apoptosis, and improved mitochondrial dysfunction of DRG neurons by targeting MAOB, while inhibiting spinal astrocytes activation and suppressing neuroinflammation through the MAOB/NF-kappa B/NLRP3/ASC/Caspase1/IL-1 beta pathway. These findings provide potential therapeutic approaches for treating the side effects of PTX-induced neuropathy using selective MAOB inhibitors.
Article
Engineering, Environmental
Rui Liu, Ying Xu, Liang Song, Shiyu Liu, Zixuan Liang, Danyang Zhu, Xiaohu Dai
Summary: This study investigated the influence of binding strength (BS) of extracellular organic substances (EOS) on organic matter (OM) recovery from sewage sludge. The results revealed the effects of multivalent metals, floc structures, and rheological properties on the release of EOS. The power-law distribution of BS was found to determine the state of organic molecules, stability of floc structures, and rheological properties. Hierarchical cluster analysis identified three levels of BS in EOS, indicating three stages of OM release or recovery from sludge. This study provides a theoretical basis for developing methods for OM release and recovery from sludge.
Article
Physics, Multidisciplinary
Dan Zhu, Khai-Ming Wong, Guo-Quan Wong
Summary: We further investigate the properties of axially symmetric monopole-antimonopole pair in the standard Weinberg-Salam model. Using a novel data sampling approach, we obtained and analyzed 300 numerical solutions corresponding to specific values of Higgs self-coupling and Weinberg angle. The calculated energy of these solutions falls within the range of 13.1690-21.0221 TeV, and a unique oscillation pattern is observed when the data is arranged based on the system's symmetry.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Microbiology
Zhenghao Zhao, Busen Wang, Shipo Wu, Zhe Zhang, Yi Chen, Jinlong Zhang, Yudong Wang, Danni Zhu, Yao Li, Jinghan Xu, Lihua Hou, Wei Chen
Summary: Designing a modified virus that can be controlled to replicate facilitates the study of viral pathogenic mechanisms and virus-host interactions. A universal switch element has been developed to precisely control virus replication using a small molecule. The insertion of inteins into the vesicular stomatitis virus (VSV) allows for regulated replication of the virus, which can be restored by intein splicing induced by 4-hydroxytamoxifen. This tool provides a simple and highly adaptable method for regulating virus replication.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Oncology
Danhua Zhu, Xiaoxi Ouyang, Yanhong Zhang, Xiaopeng Yu, Kunkai Su, Lanjuan Li
Summary: Long noncoding RNAs (lncRNAs) are noncoding RNAs with a length of more than 200 nucleotides. Dysregulation of lncRNAs is involved in various diseases, and is closely associated with patient clinical features. EGFR-AS1, a lncRNA, is aberrantly expressed in many types of cancers and is associated with multiple clinical characteristics. It regulates various cellular activities, making it a promising marker for cancer management.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biology
Ian Cooney, Deirdre C. Mack, Aaron J. Ferrell, Michael G. Stewart, Shuxin Wang, Helen M. Donelick, Daniela Tamayo-Jaramillo, Dakota L. Greer, Danyang Zhu, Wenyan Li, Peter S. Shen
Summary: Single-particle electron cryo-microscopy (cryo-EM) is an effective method for determining high-resolution structures of macromolecular complexes. This study presents a protocol using budding yeast to isolate tagged proteins and their associated complexes within three hours, prioritizing speed to recover intact, low-abundant complexes for cryo-EM specimen preparation. The protocol is applicable to soluble yeast proteins that tolerate C-terminal epitope tags.
Article
Physics, Nuclear
Zhizhou Ren, Yiwei Yang, Rong Liu, Bangjiao Ye, Zhongwei Wen, Jie Wen, Hairui Guo, Yonghao Chen, Han Yi, Weili Sun, Jie Yan, Zijie Han, Xingyan Liu, Qiping Chen, Tao Ye, Jiangbo Bai, Qi An, Huaiyong Bai, Jie Bao, Ping Cao, Pinjing Cheng, Zengqi Cui, Ruirui Fan, Changqing Feng, Minhao Gu, Fengqin Guo, Changcai Han, Guozhu He, Yongcheng He, Yuefeng He, Hanxiong Huang, Weiling Huang, Xiru Huang, Xiaolu Ji, Xuyang Ji, Haoyu Jiang, Wei Jiang, Hantao Jing, Ling Kang, Mingtao Kang, Bo Li, Lun Li, Qiang Li, Xiao Li, Yang Li, Shubin Liu, Guangyuan Luan, Yinglin Ma, Changjun Ning, Binbin Qi, Jie Ren, Xichao Ruan, Zhaohui Song, Hong Sun, Xiaoyang Sun, Zhijia Sun, Zhixin Tan, Hongqing Tang, Jingyu Tang, Pengcheng Wang, Qi Wang, Taofeng Wang, Yanfeng Wang, Zhaohui Wang, Zheng Wang, Qingbiao Wu, Xiaoguang Wu, Xuan Wu, Likun Xie, Li Yu, Tao Yu, Yongji Yu, Guohui Zhang, Jing Zhang, Linhao Zhang, Liying Zhang, Qingmin Zhang, Qiwei Zhang, Xianpeng Zhang, Yuliang Zhang, Zhiyong Zhang, Yingtan Zhao, Liang Zhou, Zuying Zhou, Danyang Zhu, Kejun Zhu, Peng Zhu
Summary: The neutron-induced uranium fission reactions have significant implications in advanced nuclear energy research and nuclear science. Using the time-of-flight method, the fission cross sections of U-236 and U-238 relative to U-235 were measured, providing valuable experimental data for further research and nuclear data evaluations.
EUROPEAN PHYSICAL JOURNAL A
(2023)