Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells

This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase activation. (Fertil Steril (R) 2011;95:1482-6. (C)2011 by American Society for Reproductive Medicine.)