Review
Biochemistry & Molecular Biology
Manizha Shekibi, Sophea Heng, Guiying Nie
Summary: The development of endometrial receptivity is crucial for successful embryo implantation and pregnancy initiation. Recent studies have focused on the role of microRNAs (miRNAs) in the regulation of endometrial receptivity. This review provides an up-to-date knowledge of the miRNAs identified in humans and mice that may play a functional role in the establishment of receptivity. The findings suggest that miRNAs could be potential biomarkers and therapeutic targets for improving endometrial receptivity in human fertility treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Federica Cariati, Consolata Carotenuto, Francesca Bagnulo, Daniela Pacella, Vincenzo Marrone, Rossella Paolillo, Maria Rosaria Catania, Raffaella Di Girolamo, Alessandro Conforti, Ida Strina, Carlo Alviggi
Summary: The study aimed to use a culturomics-based method to analyze the endometrial microbiota and correlate the results with ongoing pregnancy rates. It was found that detection of bacteria by culturomics from catheter tips used for embryo transfer could offer a reliable method to detect pathogen growth. The study highlights the importance of endometrial microbiota testing in improving diagnosis and treatment strategies in IVF patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Jigal Haas, Robert F. Casper
Summary: This brief review examines the investigation of the endometrial cavity before embryo transfer using various techniques, including hysteroscopy, endometrial biopsy, and ultrasound imaging. These investigative tools are currently controversial and require large prospective controlled trials for validation. Retained embryos during embryo transfer do not appear to have a negative impact on pregnancy outcome, and physical activity immediately after embryo transfer has no impact on pregnancy outcome, according to consistent data.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Paul Pirtea, Dominique de Ziegler, Jean Marc Ayoubi
Summary: A review found that assessing endometrial receptivity is difficult in natural conception due to adenomyosis and endometriosis affecting fertility. However, recent data from assisted reproductive technology has allowed the study of endometrial receptivity in affected women, challenging previous beliefs about the disorders' effects on embryo implantation. The existence of altered receptivity in assisted reproductive technology is now being questioned, as frozen euploid blastocyst transfers in estradiol and progesterone cycles have shown unchanged outcomes in both disorders.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
John D. Aplin, Adam Stevens
Summary: The text discusses the importance of precise and personalized timing of the endometrial cycle for optimal embryo replacement, highlighting the challenges and uncertainties in defining the relationship between the endometrial cycle and implantation. Despite advancements in 'omics technologies, there remains a lack of consensus regarding the molecular characterization of the receptive state, suggesting a need for further research and exploration in this area.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Tiffany Stankewicz, Maria Ruiz-Alonso, Marc Soler-Ibanez, Carlos Simon, Diana Valbuena
Summary: The study found that there is no difference in clinical outcomes between day-5 and day-6 blastocysts when transferred during the optimal endometrial receptivity as determined by ERA. This suggests that both day-5 and day-6 blastocysts have similar clinical potential.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Genetics & Heredity
Laura E. Eisman, Margareta D. Pisarska, Sahar Wertheimer, Jessica L. Chan, Alin Lina Akopians, Mark W. Surrey, Hal C. Danzer, Shahin Ghadir, Wendy Y. Chang, Carolyn J. Alexander, Erica T. Wang
Summary: The study evaluated the utility of the endometrial receptivity analysis (ERA) in women with prior failed embryo transfers. The prevalence of non-receptive endometrium was similar among women with >= 1 prior failed ET and controls, but women with >= 3 prior failed ETs had a lower ongoing pregnancy/live birth rate despite personalized FET, indicating additional factors in implantation failure beyond progesterone exposure adjustment.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
K. M. Wong, M. van Wely, H. R. Verhoeve, E. M. Kaaijk, F. Mol, F. van der Veen, S. Repping, S. Mastenbroek
Summary: A study in the Netherlands compared the freeze-all strategy with the conventional strategy in IVF treatments, and found that the conventional strategy had a higher cumulative ongoing pregnancy rate per woman. However, further research is needed to determine the efficacy of the freeze-all strategy in different patient subgroups and embryonic development stages, and to weigh the potential benefits and risks for mothers and children.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Yifan Chu, Luyao Wang, Jiaxin Xie, Shulin Yang, Si Liu, Dan Hu, Jing Yue
Summary: This study aims to evaluate the impact of growth hormone (GH) on IVF/ICSI outcomes and endometrial receptivity in patients undergoing GnRH-ant protocol with fresh embryo transfer. It will also explore the possible mechanism of GH in improving pregnancy outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Evangelos Maziotis, Theodoros Kalampokas, Polina Giannelou, Sokratis Grigoriadis, Anna Rapani, Marios Anifantakis, Amalia Kotsifaki, Agni Pantou, Olga Triantafyllidou, Despoina Tzanakaki, Spyridoula Neofytou, Paraskevi Vogiatzi, Panagiotis Bakas, Mara Simopoulou, Nikolaos Vlahos
Summary: Despite advances in reproductive medicine, implantation failure remains a challenging condition affecting a significant percentage of IVF patients. Research has focused on identifying molecules and developing predictive tools for efficient detection of the implantation window. However, the clinical value of commercially available novel approaches in evaluating endometrial receptivity remains unclear. This study provides a systematic review and critical analysis of existing evidence, highlighting the heterogeneity of the implantation window and providing insights into technical aspects and potential biomarkers for future research.
Article
Obstetrics & Gynecology
Michael S. Awadalla, Nicole L. Vestal, Lynda K. McGinnis, Ali Ahmady, Richard J. Paulson
Summary: The study found that for women of all ages, the sustained implantation rates for day 5 good quality blastocysts were higher than for day 5 fair, day 5 poor, and day 6 blastocysts. There were also higher sustained implantation rates for younger patients compared to older patients when controlling for morphology and day of biopsy, showing that age plays a significant role in the success of implantation.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Medicine, General & Internal
Yusuf Beebeejaun, Timothy Copeland, Lukasz Polanski, Tarek El Toukhy
Summary: The likelihood of a live birth after single fresh embryo transfer can be predicted based on the number of cryopreserved supernumerary blastocysts, and this relationship is nonlinear and varies based on age group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Zhaojuan Hou, Aihua He, Qiong Zhang, Nenghui Liu, Donge Liu, Yumei Li, Bin Xu, Yonggang Wang, Shuyi Li, Fen Tian, Tingting Liao, Yeqing Zhang, Jianyun Cao, Exiang Cao, Yanping Li
Summary: Endometrial aspiration immediately preceding embryo transfer does not affect IVF/vitrified-warmed embryo transfer outcomes, but it may improve the implantation rate of vitrified-warmed blastocysts.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Maria Ruiz-Alonso, Diana Valbuena, Carlos Gomez, Juliana Cuzzi, Carlos Simon
Summary: This article summarizes the basic and clinical data on the ERA test, showcasing the application of transcriptomics and artificial intelligence in precision medicine. By studying endometrial transcriptomics, the concept of the window of implantation for embryo transfer is defined, enabling personalized embryo transfer to be synchronized with each patient's receptive period.
HUMAN REPRODUCTION OPEN
(2021)
Article
Obstetrics & Gynecology
Aisling Ahlstrom, Kersti Lundin, Anna-Karin Lind, Kristina Gunnarsson, Goran Westlander, Hannah Park, Anna Thurin-Kjellberg, Steinunn A. Thorsteinsdottir, Snorri Einarsson, Mari Astrom, Kristina Lofdahl, Judith Menezes, Susanne Callender, Cina Nyberg, Jens Winerdal, Camilla Stenfelt, Brit-Randi Jonassen, Nan Oldereid, Lisa Nolte, Malin Sundler, Thorir Hardarson
Summary: The use of a commercially available time-lapse algorithm for Day 5 blastocyst selection did not improve ongoing pregnancy rates compared with morphology alone.
HUMAN REPRODUCTION
(2022)