Miscarriage karyotype and its relationship with maternal body mass index, age, and mode of conception

This study investigated the association between miscarriage karyotype and body mass index, maternal age, and mode of conception. Miscarriages after IVF and/or intracytoplasmic sperm injection were less frequently aneuploid; advanced maternal age was associated with an increase in aneuploid products of conception; overweight and obese women aged <35 years were less likely to have aneuploid miscarriages than women in a healthy weight range, suggesting alternate mechanisms for miscarriage in this population. (Fertil Steril (R) 2011;95:1827-9. (C)2011 by American Society for Reproductive Medicine.)