期刊
FERTILITY AND STERILITY
卷 94, 期 7, 页码 2541-2546出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2010.03.015
关键词
Oxytocin receptor; vasopressin receptor; adenomyosis uteri; smooth muscle metaplasia
Objective: To investigate the expression of oxytocin (OTR) and/or vasopressin (VP1 alpha R) receptor in patients with and without adenomyosis uteri. Design: Retrospective nonrandomized study. Setting: University hospital endometriosis research center. Patient(s): Forty patients with histologically proven adenomyosis and 40 patients without adenomyosis who had undergone hysterectomy for dysmenorrhea, bleeding disorders, and fibroids. Intervention(s): Immunohistochemical examination of both OTR and VP1 alpha R expression in endometrium, myometrium, and adenomyotic lesions, and identification of smooth muscle cells using antibodies against OTR, VP1 alpha R, and smooth muscle actin (sm-actin). Main Outcome Measure(s): The immunoreactive score (IRS) was used for expression of OTR, VP1 alpha R, and sm-actin. Result(s): Expression of OTR in epithelial cells of adenomyotic lesions and surrounding myometrial cells was detectable. VP1 alpha R was expressed only in myometrial cells and blood vessels. Using a specific anti-sm-actin antibody, another spindle cell population was characterized to represent smooth muscle cells which are in direct contact with the adenomyotic stroma. Compared with the unaffected myometrium, the surrounding adenomyosis-associated myometrium overexpressed OTR and showed changes in morphology. In the uteri of patients with adenomyosis, the junctional zone was often seen to be quite fissured. Conclusion(s): In addition to the specific expression of VP1 alpha aR, OTR expression and morphologic changes in the myometrial architecture of uteri having adenomyosis support the hypothesis that dysperistalsis plays an essential role in the development of endometriosis and dysmenorrhea. In the near future, specific inhibition of this receptor might yield a promising treatment for therapy. (Fertil Steril (R) 2010;94:2541-6. (C) 2010 by American Society for Reproductive Medicine.)
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