Article
Multidisciplinary Sciences
Constantine A. Simintiras, Pramod Dhakal, Chaman Ranjit, Harriet C. Fitzgerald, Ahmed Z. Balboula, Thomas E. Spencer
Summary: The study developed a high-throughput method for isolating intraorganoid fluid (IOF) from human endometrial epithelial organoids, revealing distinct biochemical differences between IOF and extraorganoid fluid (EOF). This has the potential to enhance our understanding of uterine fluid composition and regulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Alisha T. Tolani, Marcelle Cedars, Lydia B. Zablotska, Paolo F. Rinaudo
Summary: This study compared the metabolic differences between children conceived by assisted reproductive technologies (ART) and non-in vitro fertilization fertility treatments (NIFT) and children conceived spontaneously. The results showed that there were no metabolic differences between NIFT-conceived children and spontaneously conceived children, but there were small metabolic differences between ART-conceived children and spontaneously conceived children.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Obstetrics & Gynecology
Summary: There is no significant improvement in live birth rates in fresh assisted reproductive technology cycles with assisted hatching, and the benefits of assisted hatching in patients with poor prognosis or undergoing frozen embryo transfer cycles are inconclusive.
FERTILITY AND STERILITY
(2022)
Review
Biotechnology & Applied Microbiology
Tong Wu, Yangyang Wu, Jinfeng Yan, Jinjin Zhang, Shixuan Wang
Summary: Assisted reproductive technology aims to select high-quality reproductive cells and embryos for successful pregnancy. Microfluidic chips provide a powerful tool for functional evaluation, offering reduced size, precise control, and flexible extension.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Fang Fang, Zili Li, Jiangyu Yu, Yuting Long, Qian Zhao, Xiaofang Ding, Li Wu, Shumin Shao, Ling Zhang, Wenpei Xiang
Summary: The study suggests that miRNAs secreted by human embryos in culture media could serve as potential biomarkers for non-invasive embryo selection in assisted reproductive technology. Embryos with successful pregnancy release different miRNA profiles compared to those with failed pregnancy, indicating their predictive potential in reproductive outcomes. Selected miRNAs like hsa-miR-26b-5p and hsa-miR-21-5p show promising results as potential biomarkers for reproductive outcomes.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Environmental Sciences
Audrey J. Gaskins, Ziyin Tang, Robert B. Hood, Jennifer Ford, Joel D. Schwartz, Dean P. Jones, Francine Laden, Donghai Liang
Summary: Research indicates that periconception air pollution exposure can affect women's metabolic changes, potentially mediating the impact of air pollution on fertility through pathways involving inflammation and oxidative stress.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Obstetrics & Gynecology
Amy Barrie, Garry McDowell, Stephen Troup
Summary: The study revealed that patient and treatment parameters have subtle effects on embryos, with complex relationships between various morphokinetic parameters and specific factors, rather than a systemic effect. These findings emphasize the importance of considering confounding factors when assessing embryo implantation potential.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Baris Ata, Nathalie Vermeulen, Edgar Mocanu, Luca Gianaroli, Kersti Lundin, Satu Rautakallio-Hokkanen, Juha S. Tapanainen, Anna Veiga
Summary: This article summarizes the impact of SARS-CoV-2 and COVID-19 on human fertility and assisted reproduction, as well as the influence of vaccination. It provides answers to relevant questions for individuals considering pregnancy and healthcare professionals. The findings suggest that SARS-CoV-2 can affect spermatogenesis and menstrual patterns, but has minimal impact on ovarian function and embryo development. COVID-19 infection and vaccination do not negatively affect reproductive outcomes.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Chemistry, Multidisciplinary
Doris Spinosa Cheles, Andre Satoshi Ferreira, Isabela Sueitt de Jesus, Eleonora Inacio Fernandez, Gabriel Martins Pinheiro, Eloiza Adriane Dal Molin, Wallace Alves, Rebeca Colauto Milanezi de Souza, Lorena Bori, Marcos Meseguer, Jose Celso Rocha, Marcelo Fabio Gouveia Nogueira
Summary: New techniques and equipment help evaluate embryo quality, but there is still subjectivity in classifications, image processing provides better analysis of embryos and generates variables describing different aspects of embryos.
APPLIED SCIENCES-BASEL
(2022)
Article
Materials Science, Multidisciplinary
Farin Yazdan Parast, Moira K. O'Bryan, Reza Nosrati
Summary: Selection of high-quality sperm is crucial for assisted reproduction. This article introduces a scalable technology called 'sperm syringe' that mimics the 3D selection process in vivo to select high-quality sperm. Experimental results show that the sperm syringe significantly improves selected sperm morphology and DNA integrity, making it a promising assisted reproductive technology.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Obstetrics & Gynecology
Kayhan Yakin, Bulent Urman, Basak Balaban
Summary: This study analyzed data on patient demographics and treatment practices in assisted reproductive technology (ART) in Turkey over a 25-year period. The results showed significant changes in patient characteristics, treatment indications, and clinical and laboratory practices. The use of single embryo transfer increased, and improvements in cryopreservation techniques contributed to higher clinical pregnancy rates while reducing multiple births.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Endocrinology & Metabolism
Qiuyuan Li, Ahui Liu, Haofei Shen, Xuehong Zhang
Summary: This study found that in patients with non-thin endometrium, endometrial thickness compaction from the day of HCG to the ET day can significantly reduce the risk of EP.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Siliang Song, Jianzhi Zhang
Summary: Because human same-sex sexual behavior is heritable and leads to fewer offspring, it is puzzling why these alleles have not been purged. The antagonistic pleiotropy hypothesis suggests that these alleles benefit individuals performing opposite-sex sexual behavior. However, our analysis of the UK Biobank data shows that having more sexual partners no longer predicts more offspring, and same-sex behavior is genetically negatively correlated with the number of offspring, indicating a loss of genetic maintenance in modern societies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Endocrinology & Metabolism
Amit D. Joshi, Ali Rahnavard, Priyadarshini Kachroo, Kevin M. Mendez, Wayne Lawrence, Sachelly Julian-Serrano, Xinwei Hua, Harriett Fuller, Nasa Sinnott -Armstrong, Fred K. Tabung, Katherine H. Shutta, Laura M. Raffield, Burcu F. Darst
Summary: Metabolomics holds great promise for uncovering insights around biological processes impacting disease in human epidemiological studies. Metabolomic epidemiology studies face unique challenges in identifying metabolites, defining quality control standards, harmonizing results, and developing statistical methods.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Developmental Biology
Adi Dayan-Schwartz, Nitzan Dana Sela, Raed Salim, Simon Nothman, Gali Garmi, Shira Baram, Noah Zafran, Ronit Beck-Fruchter
Summary: This study aimed to compare the postpartum blood loss among twin pregnancies conceived by different types of medically assisted reproduction (MAR) treatments to spontaneously conceived twins. The results showed a higher incidence of postpartum hemorrhage (PPH) in MAR twin pregnancies, especially in the frozen-thawed ART group. Additionally, a significant difference was observed in the decrease of postpartum hemoglobin levels and the rate of blood transfusion between the frozen-thawed group and the control group.
Article
Obstetrics & Gynecology
Belen Lledo, Ruth Morales, Jose A. Ortiz, Adoracion Rodriguez-Arnedo, Jorge Ten, Juan C. Castilo, Andrea Bernabeu, Joaquin Llacer, Rafael Bernabeu
Summary: This study evaluated the consistency of different chromosomal analysis techniques for niPGT-A, finding that the diagnostic concordance between PGT-A and niPGT-A appears independent of the technique used. Higher mosaicism rates were observed in SCM, and optimizing culture conditions and medium retrieval can potentially improve the reliability of niPGT-A.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Andrology
Alba Cascales, Belen Lledo, Jose A. Ortiz, Ruth Morales, Jorge Ten, Joaquin Llacer, Rafael Bernabeu
Summary: Maternal age plays a critical role in determining chromosome abnormalities in human embryos, while the influence of ovarian stimulation on aneuploidies and mosaicism is controversial. A study found that the duration of ovarian stimulation treatment is correlated with aneuploidy rate, with patients requiring more days of stimulation having a lower rate of aneuploid embryos. Other parameters characterizing controlled ovarian stimulation did not show significant associations with aneuploidy and embryonic mosaicism rates.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2021)
Editorial Material
Obstetrics & Gynecology
Rafael Bernabeu, Jose A. Ortiz, Belen Lledo
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Jorge Ten, Jaime Guerrero, Angel Linares, Adoracion Rodriguez-Arnedo, Ruth Morales, Belen Lledo, Joaquin Llacer, Rafael Bernabeu
Summary: This study found that sperm DNA fragmentation levels do not independently affect assisted reproductive technology outcomes, regardless of gamete quality.
Review
Microbiology
Axel Skafte-Holm, Peter Humaidan, Andrea Bernabeu, Belen Lledo, Jorgen Skov Jensen, Thor Haahr
Summary: The study found that vaginal dysbiosis is a significant risk factor for early pregnancy loss in IVF, leading to a significant reduction in clinical pregnancy rate, but did not significantly affect live birth rate.
Article
Obstetrics & Gynecology
F. M. Lozano, A. Bernabeu, B. Lledo, R. Morales, M. Diaz, F. Aranda, J. Llacer, R. Bernabeu
Summary: This study compared the endometrial and vaginal microbiome of women with and without chronic endometritis, demonstrating significant differences in microbial communities between the two groups. The presence of chronic endometritis was associated with distinct microbiome patterns in both the vagina and endometrium, highlighting a potential relationship between changes in the vaginal microbiome and chronic endometritis.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Andrology
Ruth Morales, Belen Lledo, Jose A. Ortiz, Alba Cascales, Helena Codina, Adoracion Rodriguez-Arnedo, Joaquin Llacer, Andrea Bernabeu, Rafael Bernabeu
Summary: The maternal MTHFR genotype was found to have no influence on embryo chromosomal abnormalities, while the embryo MTHFR genotype was not associated with embryo aneuploidy or IVF outcomes when euploid embryos were transferred.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Maria del Carmen Diaz-Martinez, Andrea Bernabeu, Belen Lledo, Concepcion Carratala-Munuera, Jose A. Quesada, Francisca M. Lozano, Vicente Ruiz, Ruth Morales, Joaquin Llacer, Jorge Ten, Juan Carlos Castillo, Adoracion Rodriguez, Rauf Nouni-Garcia, Adriana Lopez-Pineda, Belen Moliner, Rafael Bernabeu
Summary: This study compared the vaginal and endometrial microbiome patterns between women who became pregnant and those who did not after in vitro fertilization. It found that women who achieved clinical pregnancy had a higher relative abundance of Lactobacillus spp. in their vaginal samples.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
M. D. Perez-Murcia, E. Martinez-Sabater, M. A. Domene, A. Gonzalez-Cespedes, M. A. Bustamante, F. C. Marhuenda-Egea, X. Barber, D. B. Lopez-Lluch, R. Moral
Summary: The study found that the degradation of peptides and proteins during composting can affect the biodegradation of remaining organic matter, while thermogravimetric analysis revealed that more recalcitrant compounds become predominant as the composting process progresses.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Genetics & Heredity
R. Morales, B. Lledo, J. A. Ortiz, F. M. Lozano, E. M. Garcia, A. Bernabeu, A. Fuentes, R. Bernabeu
Summary: This study identified new candidate genes and variants associated with premature ovarian insufficiency (POI) through whole-exome sequencing in patients with idiopathic POI, suggesting a polygenic etiology of POI.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Genetics & Heredity
B. Lledo, A. Marco, R. Morales, J. A. Ortiz, E. Garcia-Hernandez, F. M. Lozano, A. Cascales, J. Guerrero, A. Bernabeu, R. Bernabeu
Summary: This study identified novel candidate genes and variants associated with meiotic embryonic aneuploidy through whole-exome sequencing. It provided insights into important biological processes related to cell division and chromosome segregation. Whole-exome sequencing could serve as an efficient tool for identifying high-risk individuals and offering personalized genetic counseling before treatment.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Microbiology
Francisca Maria Lozano, Belen Lledo, Ruth Morales, Alba Cascales, Monica Hortal, Andrea Bernabeu, Rafael Bernabeu
Summary: The study aimed to compare the endometrial microbiome between patients with recurrent implantation failure (RIF) and control patients undergoing assisted reproduction treatment (ART). The results showed differences in bacterial communities between RIF and control patients, suggesting a potential relationship between endometrial microbiota and embryo implantation failure. This finding has implications for improving reproductive outcomes in infertile patients.
Article
Obstetrics & Gynecology
Mina Popovic, Lorena Borot, Aline R. Lorenzon, Ana Luiza Rossi de Castro Lopes, Denny Sakkas, Belen Lledo, Ruth Morales, Jose Antonio Ortiz, Nikolaos P. Polyzos, Monica Parriego, Felicitas Azpiroz, Micaela Galain, Aida Pujol, Bjorn Menten, Lien Dhaenens, Frauke Vanden Meerschaut, Dominic Stoop, Maria Rodriguez, Enrique Perez de la Blanca, Amelia Rodriguez, Rita Vassena
Summary: The diagnosis of mosaicism affects the ploidy rates across different providers offering preimplantation genetic testing for aneuploidies (PGT-A), with providers reporting low rates of mosaicism having significantly higher euploidy rates.
HUMAN REPRODUCTION
(2023)
Article
Plant Sciences
Marta Suarez-Fernandez, Frutos Carlos Marhuenda-Egea, Federico Lopez-Moya, Marino B. Arnao, Francisca Cabrera-Escribano, Maria Jose Nueda, Benet Gunse, Luis Vicente Lopez-Llorca
FRONTIERS IN PLANT SCIENCE
(2020)
Article
Obstetrics & Gynecology
Belen Lledo, Jose Antonio Ortiz, Monica Hortal, Alba Cascales, Ruth Morales, Jaime Guerrero, Andrea Bernabeu, Rafael Bernabeu
Summary: A study of 152 oocyte donors found that the FSH receptor (FSHR) genotype may influence the number and quality of oocytes during ovarian stimulation using corifollitropin alfa.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
