Genotype and haplotype determination of interleukin (IL) 1 beta (g.-511C > T and g.+3954C > T) and IL-1RN in polycystic ovary syndrome

The distribution of genotype frequencies, allele frequencies, and haplotype frequencies of variable number of tandem repeats (VNTR) in interleukin (IL) 1RN and IL-1 beta (-511C>T, exon-5C.>T) polymorphism demonstrated a positive association with the occurrence of polycystic ovary syndrome (PCOS). The carriage of allele V of IL-1RN and allele E1 of exon-5 on the IL-1 beta gene may increase the risk of PCOS. (Fertil Steril(R) 2010; 94: 384-6. (C) 2010 by American Society for Reproductive Medicine.)