Article
Reproductive Biology
Hieu Nguyen, Jordi Ribas-Maynou, Hongwen Wu, Beverly Quon, Tracy Inouye, Brienne Walker, Caitlin Langaman, Thomas T. F. Huang Jr, W. Steven Ward
Summary: We previously demonstrated that MnCl2 induces double-stranded DNA breaks in sperm, which we term as sperm chromatin fragmentation. Here, we compared the levels of double-stranded DNA breaks induced by MnCl2 to those induced by H2O2, a agent that causes single-stranded DNA breaks. Both methods showed concentration-dependent induction of DNA breaks.
BIOLOGY OF REPRODUCTION
(2023)
Article
Environmental Sciences
Grethel Leon-Mejia, Jose Eduardo Vargas, Milton Quintana-Sosa, Robinson Alvarez Rueda, Jose Perez Perez, Alvaro Miranda-Guevara, Ornella Fiorillo Moreno, Cristiano Trindade, Antonio Acosta-Hoyos, Johnny Dias, Juliana da Silva, Joao Antonio Pegas Henriques
Summary: Coal mining activities release compounds that can cause oxidative damage to DNA. We compared blood samples from 150 individuals exposed to coal mining residues and 120 non-exposed individuals, finding higher concentrations of certain elements and hypokalemia in the exposed group. The enzyme-modified comet assay suggests that coal mining residues cause oxidative DNA damage, especially to purines. Understanding the effects of these inorganic elements on DNA damage and oxidative stress pathways is crucial for understanding the impact of coal mining residues on human health.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Gina Oda, Aditya Sharma, Cynthia Lucero-Obusan, Patricia Schirmer, Mark Holodniy
Summary: This study aims to determine the characteristics and sources of exposure in veterans with elevated blood lead levels. The results showed that firearms were the largest exposure source among veterans with elevated BLL. Potential conditions associated with lead exposure included attention-deficit/hyperactivity disorder and nausea or vomiting.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Andrology
Mojdeh Sabour, Azam Agha-Rahimi, Mahmood Dehghani Ashkezari, Seyed Morteza Seifati, Fatemeh Anbari, Ali Nabi
Summary: Polyvinylpyrrolidone (PVP) is commonly used in intracytoplasmic sperm injection (ICSI) for immobilization and manipulation of spermatozoa. However, this study found that prolonged exposure to PVP significantly affects sperm viability and morphology, leading to increased DNA fragmentation and abnormal chromatin structure.
Article
Environmental Sciences
Jingsi Chen, Yi Chen, Shaojie Liu, Bo Chen, Yingli Lu, Ruihua Dong
Summary: The study revealed significant associations between lead and phthalates with the risk of thyroid nodules, particularly more pronounced in females.
Article
Biochemistry & Molecular Biology
Gennaro Lettieri, Rosaria Notariale, Alessia Ambrosino, Alfredo Di Bonito, Antonella Giarra, Marco Trifuoggi, Caterina Manna, Marina Piscopo
Summary: This study investigates the effects of exposure to different concentrations of mercury ions on sperm and PL proteins of Mytilus galloprovincialis, revealing potential DNA damage and adverse effects on the reproductive system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tiancheng Zhang, Yan Fei Ru, Bin Wu, Haiyan Dong, Liang Chen, Jufen Zheng, Jianhui Li, Xin Wang, Zhikai Wang, Xuemei Wang, Xiaorong Shen, Jun Wu, Jun Qian, Maohua Miao, Yihua Gu, Huijuan Shi
Summary: The study found that low lead exposure may lead to global hypomethylation of sperm DNA, reducing sperm motility and potentially contributing to decreased sperm velocity. Aberrant DNA methylation of the Ca homeostasis pathway induced by low lead exposure may be the underlying cause for reduced sperm velocity.
CELL AND BIOSCIENCE
(2021)
Article
Andrology
Jonatan Axelsson, Christian H. Lindh, Aleksander Giwercman
Summary: This study found no association between nicotine and PAH exposure biomarkers and sperm DNA fragmentation index (DFI) in young men.
Article
Agriculture, Dairy & Animal Science
Jordi Ribas-Maynou, Ariadna Delgado-Bermudez, Yentel Mateo-Otero, Estel Vinolas, Carlos O. Hidalgo, W. Steven Ward, Marc Yeste
Summary: This study analyzed cryopreserved bovine sperm after thawing and found that DNA damage and sperm degradation are influenced by oxidative stress. Evaluating chromatin integrity can help predict bull fertility.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marta Olszewska, Oliwia Kordyl, Marzena Kamieniczna, Monika Fraczek, Piotr Jedrzejczak, Maciej Kurpisz
Summary: Epigenetic modifications, specifically methylation and hydroxymethylation, are associated with sperm chromatin protamination. The levels of these modifications are diversified in different populations of males and may be related to sperm motility and morphology. Measuring the 5mC/5hmC status of sperm DNA may serve as a prognostic marker for reproductive failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Kamal Ibne Amin Chowdhury, Syeda Nurunnahar, Mohammad Lutful Kabir, Mohammad Tauhidul Islam, Musa Baker, M. Saiful Islam, Mahbubur Rahman, M. Aziz Hasan, Arif Sikder, Laura H. Kwong, Gordon K. Binkhorst, Emily Nash, John Keith, Andrew McCartor, Stephen P. Luby, Jenna E. Forsyth
Summary: The study evaluated the intensity and nature of child lead exposure at abandoned used lead acid battery (ULAB) recycling sites in Bangladesh, as well as the feasibility and effectiveness of soil remediation efforts. Results showed a significant decrease in child lead exposure and soil lead concentrations after remediation.
ENVIRONMENTAL RESEARCH
(2021)
Article
Reproductive Biology
Jordi Ribas-Maynou, Estela Garcia-Bonavila, Sergi Bonet, Jaime Catalan, Albert Salas-Huetos, Marc Yeste
Summary: The relationship between sperm DNA fragmentation and reproductive outcomes is inconsistent, and concerns have been raised about its value as a sperm quality parameter. This study found that increasing chromatin decondensation makes the TUNEL assay more sensitive to detect DNA damage in pig sperm.
Article
Multidisciplinary Sciences
Athareh Pabarja, Sepideh Ganjalikhan Hakemi, Elahe Musanejad, Massood Ezzatabadipour, Seyed Noureddin Nematollahi-Mahani, Ali Afgar, Mohammad Reza Afarinesh, Tahereh Haghpanah
Summary: The study showed that maternal co-exposure to alcohol and nicotine during pregnancy and lactation can affect the reproductive system of F1 offspring, leading to changes like sperm DNA fragmentation. Additionally, exposure had significant effects on epigenetic alterations in sperm cells, with combined exposure having less prominent effects compared to exposure to each substance alone.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Christophe Depuydt, Eugene Bosmans, Jef Jonckheere, Francesca Donders, Willem Ombelet, Astrid Coppens, Gilbert Donders
Summary: This longitudinal observational cohort study found that SARS-CoV-2 infection has differential effects on sperm quality and fertility, including parameters such as motility, morphology, DNA damage, and anti-sperm antibodies. These effects may vary among individuals. However, most sperm parameters return to normal after infection.
Article
Engineering, Environmental
Cong Wan, Shangxia Pan, Lifeng Lin, Jun Li, Guanghui Dong, Kevin C. Jones, Fei Liu, Daochuan Li, Jing Liu, Zhiqiang Yu, Gan Zhang, Huimin Ma
Summary: This study identified 43 differentially methylated regions (DMRs) in children aged 9-11 related to the relationship between lead exposure and intelligence decline. Two fragments, FAM50B1 and PTCHD3, significantly mediated this relationship with contribution rates of 30.36% (p = 0.010) and 60.36% (p < 0.001), respectively, suggesting potential biomarkers for neurological diseases.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Ecology
Nicholas T. Minahan, Chi-Hsien Chen, Wei-Chiang Shen, Tzu-Pin Lu, Kraiwuth Kallawicha, Kun-Hsien Tsai, Yue Leon Guo
Summary: The study revealed a correlation between indoor fungal spore richness and surrounding forest cover, with slight variations between different seasons. Specific fungal genera showed changes in richness during hot and cool seasons, reflecting different patterns of fungal spore distribution in the air.
Article
Public, Environmental & Occupational Health
Pierre Masselot, Francesco Sera, Rochelle Schneider, Haidong Kan, Eric Lavigne, Massimo Stafoggia, Aurelio Tobias, Hong Chen, Richard T. Burnett, Joel Schwartz, Antonella Zanobetti, Michelle L. Bell, Bing-Yu Chen, Yue-Liang Leon Guo, Martina S. Ragettli, Ana Maria Vicedo-Cabrera, Christofer Astrom, Bertil Forsberg, Carmen Iniguez, Rebecca M. Garland, Noah Scovronick, Joana Madureira, Baltazar Nunes, Cesar De la Cruz Valencia, Magali Hurtado Diaz, Yasushi Honda, Masahiro Hashizume, Chris Fook Cheng Ng, Evangelia Samoli, Klea Katsouyanni, Alexandra Schneider, Susanne Breitner, Niilo R. Ryti, Jouni J. K. Jaakkola, Marek Maasikmets, Hans Orru, Yuming Guo, Nicolas Valdes Ortega, Patricia Matus Correa, Shilu Tong, Antonio Gasparrini
Summary: This study examined the impact of PM2.5 components on mortality and found associations between several components and relative risk. Increasing the proportion of ammonium increased the risk, while increasing the proportion of nitrate reduced the risk. The findings contribute to the identification of more hazardous emission sources.
Article
Public, Environmental & Occupational Health
Y. S. Ou, H. C. Wu, Y. L. Guo, J. S. C. Shiao
Summary: The study found that countries that adopted the NSPA had lower NSI incidence rates among healthcare workers, with a more significant reduction seen in nurses than physicians. Further research is needed to develop preventive strategies and incorporate them into national regulatory agency standards of care for protecting against NSIs.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ping Shih, Ching-chun Huang, Tung-liang Chiang, Pau-Chung Chen, Yue Leon Guo
Summary: This study investigates the relationship between work-related mental stress during pregnancy and offspring ADHD. Among pregnant female workers, higher levels of job stress were found to be associated with a higher risk of ADHD in their children.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2022)
Article
Audiology & Speech-Language Pathology
I-Fan Lin, Perng-Jy Tsai, Jiunn-Liang Wu, Wei-Shan Chin, Cheng-Yu Lin, Yue Leon Guo
Summary: This study aimed to differentiate noise-induced hearing loss (NIHL) from age-related hearing loss by examining the characteristics of distortion product otoacoustic emissions (DPOAEs). The results showed that DPOAEs and DPOAE signal-to-noise ratios (SNRs) were correlated with age at all frequencies, and were correlated with both age and noise exposure at 2 kHz, 3 kHz, 4 kHz, and 6 kHz. The difference between DPOAE SNRs at 1 kHz and 3 kHz showed significant correlation with noise exposure but not with age.
INTERNATIONAL JOURNAL OF AUDIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Rou-Shiuan Huang, Yi-Chuan Chen, Shang-Yin Tsai, Yan-Siang Eason Huang, Yue-Liang Leon Guo
Summary: This study examined the sleep problems among firefighters in Taiwan and identified the factors associated with poor sleep quality. The results showed that more than three-quarters of firefighters had poor sleep quality and it was influenced by demographic characteristics such as age, working tenure, having children, and chronotype, as well as work-related characteristics including shift schedule and incomplete off-duty hours. The study suggests that firefighters should have complete off-duty days to avoid poor sleep quality and recommends implementing appropriate shift schedules to ensure adequate rest time.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2023)
Article
Clinical Neurology
Ping Shih, Tung-liang Chiang, Chih-Da Wu, Bih-Ching Shu, For-Wey Lung, Yue Leon Guo
Summary: Exposure to ambient PM2.5 during pregnancy is significantly associated with delay in gross motor, fine motor, and personal-social development in infants.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Respiratory System
Yue Leon Guo, Maria R. Ampon, Leanne M. Poulos, Sharon R. Davis, Brett G. Toelle, Guy B. Marks, Helen K. Reddel
Summary: This study estimated the contribution of obesity to breathlessness in Australian adults using the population attributable fraction (PAF). The results showed that obesity accounted for approximately a quarter of breathlessness symptoms and had a higher proportion in women.
Letter
Respiratory System
Chen He, Renjie Chen, Ho Kim, Masahiro Hashizume, Whanhee Lee, Yasushi Honda, Satbyul Estella Kim, Yue Leon Guo, Alexandra Schneider, Wenzhen Ge, Yixiang Zhu, Lu Zhou, Haidong Kan
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Psychiatry
Ping Shih, Tung-liang Chiang, Ping- Lin, Ming-Yu Lin, Yue Leon Guo
Summary: The study found that higher maternal screen time in early childhood was associated with an increased risk of children developing ADHD, while there was no significant association between children's or fathers' screen time and ADHD. Further research is needed to confirm the specific mechanisms underlying this association.
Article
Environmental Sciences
Mu-Jean Chen, Yue Leon Guo, Pinpin Lin, Hung-Che Chiang, Pau-Chung Chen, Yu-Cheng Chen
Summary: The currently used air quality index (AQI) is criticized for its inability to capture the additive effects of air pollution on health risks and reflect non-threshold concentration-response relationships. In this study, we propose the air quality health index (AQHI) based on daily air pollution-mortality associations and compare its validity in predicting daily mortality and morbidity risks with the existing AQI.
ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Samuel Luthi, Christopher Fairless, Erich M. Fischer, Noah Scovronick, Micheline De Sousa Zanotti Stagliorio Coelho, Yue Leon Guo, Yuming Guo, Yasushi Honda, Veronika Huber, Jan Kysely, Eric Lavigne, Dominic Roye, Niilo Ryti, Susana Silva, Ales Urban, Antonio Gasparrini, David N. Bresch, Ana M. Vicedo-Cabrera
Summary: Current research focuses on the impact of rising temperatures on heat-related mortality, but it is unclear how climate change will exacerbate the effects of extreme summer seasons on human health. This study combines empirical heat-mortality relationships with climate model data to predict future highly impactful summer seasons. The findings emphasize the urgent need for mitigation and adaptation measures to reduce the impact on human lives.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Cong Liu, Renjie Chen, Francesco Sera, Ana Maria Vicedo-Cabrera, Yuming Guo, Shilu Tong, Eric Lavigne, Patricia Matus Correa, Nicolas Valdes Ortega, Souzana Achilleos, Dominic Roye, Jouni J. K. Jaakkola, Niilo Ryti, Mathilde Pascal, Alexandra Schneider, Susanne Breitner, Alireza Entezari, Fatemeh Mayvaneh, Raanan Raz, Yasushi Honda, Masahiro Hashizume, Chris Fook Sheng Ng, Vania Gaio, Joana Madureira, Iulian-Horia Holobaca, Aurelio Tobias, Carmen Iniguez, Yue Leon Guo, Shih-Chun Pan, Pierre Masselot, Michelle L. Bell, Antonella Zanobetti, Joel Schwartz, Antonio Gasparrini, Haidong Kan
Summary: This study investigated the interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at a global level. The results showed a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, particularly in high latitude regions and during cold seasons. This highlights the importance of coordinated control strategies for both pollutants.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Ardha Ardea Prisilla, Yue Leon Guo, Yih-Kuen Jan, Chih-Yang Lin, Fu-Yu Lin, Ben-Yi Liau, Jen-Yung Tsai, Peter Ardhianto, Yori Pusparani, Chi-Wen Lung
Summary: This study aims to detect lumbar disc herniation (LDH) in magnetic resonance imaging (MRI) using deep learning algorithms. The results show that YOLOv5x performs the best in LDH detection, and using a dataset of 550 images with augmentation provides reliable detection in both augmented and non-augmented datasets.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei-Fang Cheng, Yue Leon Guo, Ruoh-Fang Yen, Yen-Wen Wu, Hsiu-Po Wang
Summary: This study aimed to determine whether inflammation levels detected by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) could predict disease relapse in immunoglobulin G4-related disease (IgG4-RD) patients receiving standard induction steroid therapy. The results showed that whole-body total lesion glycolysis (WTLG) > 600 on FDG-PET was an independent risk factor for disease relapse, and could be used for guiding the treatment and management of IgG-RD patients.
KOREAN JOURNAL OF RADIOLOGY
(2023)