Article
Endocrinology & Metabolism
Qiyao Zhang, Jinfeng Su, Wei Kong, Zhou Fang, Yan Li, Ziqiang Huang, Ji Wen, Yue Wang
Summary: This study reveals that miR-103a-3p or miR-10a-5p negatively influence oocyte maturation by regulating BDNF expression in human follicular fluid. The expression levels of miR-103a-3p or miR-10a-5p in follicular fluid may predict the outcomes of IVF, assisting in improving embryo selection and increasing the IVF success rate in clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rimma Sergeevna Kamentseva, Marianna Viktorovna Kharchenko, Gulnara Vladikovna Gabdrahmanova, Michael Alexandrovich Kotov, Vera Vladislavovna Kosheverova, Elena Sergeevna Kornilova
Summary: This study compared the effects of EGF, TGF-α, and AREG on physiological responses in endometrial MSCs and HeLa cells, and investigated the internalization and degradation of EGFR stimulated by these ligands. The study found that while EGF and TGF-α stimulated cell proliferation and prevented differentiation in enMSCs in an EGFR-dependent manner, AREG had no effect. Additionally, differences were observed in the degradation and recovery of EGFR in different cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Caitlin R. Sacha, Irene Souter, Paige L. Williams, Jorge E. Chavarro, Jennifer Ford, Shruthi Mahalingaiah, Patricia K. Donahoe, Russ Hauser, David Pepin, Lidia Minguez-Alarcon
Summary: This study found a negative association between urinary concentrations of certain phthalate metabolites and follicular fluid anti-Mullerian hormone concentrations in women undergoing fertility treatment, which may have implications for antral follicle recruitment and fertility treatment outcomes.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Norio Hanata, Yasuo Nagafuchi, Yusuke Sugimori, Satomi Kobayashi, Yumi Tsuchida, Yukiko Iwasaki, Hirofumi Shoda, Keishi Fujio
Summary: This study found that serum AREG levels were elevated in patients with IIM, especially in those with ILD. Additionally, HB-EGF expression was associated with muscle injury and regeneration in IIM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Hsuan-Ting Chen, Wen-Bin Wu, Jun-Jin Lin, Tsung-Hsuan Lai
Summary: This study identified VEGF-A, eotaxin, and CXCL-6 as key angiogenic factors in follicular fluid (FF) for predicting oocyte maturity during in vitro fertilization (IVF). The combination of VEGF-A and CXCL-6 showed a relatively high prediction accuracy for oocyte maturity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Zohar Barnett-Itzhaki, Sarah Knapp, Chaya Avraham, Catherine Racowsky, Russ Hauser, Valentina Bollati, Andrea A. Baccarelli, Ronit Machtinger
Summary: The study found that phthalate metabolite concentrations are associated with the expression of extracellular vesicle microRNAs (EV-miRNAs) in follicular fluid, potentially impacting pathways related to oocyte development, maturation, and fertilization.
HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Yoshimitsu Kuwabara, Shuichi Ono, Akira Katayama, Sachiko Kurihara, Yumiko Oishi, Toshiyuki Takeshita
Summary: This study evaluated the concentrations of osteopontin (OPN) in blood and follicular fluid (FF) during the ovarian cycle, and found that the plasma OPN concentration may serve as a novel clinical marker for predicting the risk of ovarian hyperstimulation syndrome (OHSS). A positive correlation was observed between OPN concentrations in FF and plasma samples, as well as between plasma OPN and FF VEGF concentrations, irrespective of the blood-sampling period.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ji-Seon Park, Hwon Heo, Min-Seok Kim, Seung-Eun Lee, Sukyoung Park, Ki-Hyun Kim, Young-Ho Kang, Je Seong Kim, Young Hoon Sung, Woo Hyun Shim, Dong-Hou Kim, Youngsup Song, Seung-Yong Yoon
Summary: Social hierarchy has significant effects on social behavior, reward processing, and mental health, and lower social rank can lead to chronic stress and more serious problems. This study reveals that astrocyte-secreted amphiregulin plays a critical role in determining hierarchical ranks, and its regulation is mediated by cAMP response element-binding (CREB)-regulated transcription coactivator 3 (CRTC3) and CREB.
MOLECULAR PSYCHIATRY
(2023)
Article
Dermatology
I Cosgarea, A. T. McConnell, T. Ewen, D. Tang, D. S. Hill, M. Anagnostou, M. Elias, R. A. Ellis, A. Murray, L. C. Spender, P. Giglio, M. Gagliardi, A. Greenwood, M. Piacentini, G. J. Inman, G. M. Fimia, M. Corazzari, J. L. Armstrong, P. E. Lovat
Summary: The loss of AMBRA1 in the peritumoral epidermis is associated with an increased risk of metastasis in early-stage melanoma patients, possibly due to disruption of epidermal integrity. TGF-beta 2 signaling may play a role in this process by downregulating AMBRA1 and other epidermal markers, leading to decreased epidermal integrity and tumor ulceration.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Ophthalmology
Mukharram M. Bikbov, Timur A. Khalimov, Marc Cerrada-Gimenez, Symantas Ragauskas, Giedrius Kalesnykas, Jost B. Jonas
Summary: The study showed that intravitreal injections of EGF in rabbits and amphiregulin in guinea pigs did not cause intraocular specific inflammation or any observed intraocular destructive effects.
INTERNATIONAL OPHTHALMOLOGY
(2021)
Article
Cell Biology
Hong-Mou Shih, Szu-Yu Pan, Chih-Jen Wu, Yu-Hsiang Chou, Chun-Yuan Chen, Fan-Chi Chang, Yi-Ting Chen, Wen-Chih Chiang, Hsing-Chen Tsai, Yung-Ming Chen, Shuei-Liong Lin
Summary: This study found that C3H10T1/2 cells possess the property of HIF2 alpha-dependent Epo expression, and TGF-beta 1 induces both myofibroblast transition and a repressive effect on the Epas1-Epo axis in these cells. The repressive effect of TGF-beta 1 on the Epas1-Epo axis was also confirmed in REP pericytes in vivo, suggesting that inhibition of TGF-beta 1-ALK5 signaling could be a novel treatment approach to rescue EPO expression in REP pericytes of injured kidneys.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Chun Kwon, Seong-Ho Ok, Seung Hyun Ahn, Sung Il Bae, Ji-Yoon Kim, Yeran Hwang, Kyeong-Eon Park, Mingu Kim, Ju-Tae Sohn
Summary: In this study, the researchers investigated the involvement of aortic contraction induced by dexmedetomidine in the transactivation of EGFR in endothelium-denuded rat aortas. They found that the activation of alpha-2 adrenoceptor, Src kinase, and matrix metalloproteinase mediated the contraction and subsequent JNK phosphorylation and increased calcium levels. These findings provide insights into the cellular mechanisms underlying dexmedetomidine-induced effects on aortic contraction and EGFR transactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Wei Zhang, Yiwei Lin, Yang Zong, Xin Ma, Chaolai Jiang, Haojie Shan, Wenyang Xia, Lifu Yin, Nan Wang, Lihui Zhou, Zubin Zhou, Xiaowei Yu
Summary: Hypoxia-induced factor-1 alpha (HIF-1 alpha) and transforming growth factor beta 1 (TGF-beta 1) play important roles in the pathogenesis of osteomyelitis induced by Staphylococcus aureus. This study suggests a novel signaling cascade involving hypoxia/HIF-1 alpha/TGF-beta 1, which could potentially serve as a target for therapeutic measures against osteomyelitis.
Article
Medicine, Research & Experimental
Ricardo Gomez-Oliva, Noelia Geribaldi-Doldan, Samuel Dominguez-Garcia, Ricardo Pardillo-Diaz, Sergio Martinez-Ortega, Jose M. Oliva-Montero, Patricia Perez-Garcia, Francisco J. Garcia-Cozar, Juan P. Munoz-Miranda, Ismael Sanchez-Gomar, Pedro Nunez-Abades, Carmen Castro
Summary: This study found that neurogenesis is increased in cortical brain injuries but neuroblasts cannot reach the injury site. It discovered that microglial cells release TGF-alpha, which activates neuroblast proliferation but delays their maturation and migration. Inhibiting the TGF-alpha signaling pathway promotes neuroblast migration towards the injury site and increases the quantity of neuroblasts in the injured area.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Environmental Sciences
Yi Wang, Yao-Yao Du, Wen Yao, Tao-Ran Deng, Na Guo, Li Yin, Xiao-Qiong Yuan, Qing-Chun Guo, Juan Li, Hong -Mei Liao, Dan-Yu Qin, Yu-Feng Li
Summary: Several studies have shown that phthalates have reproductive and embryonic toxicity, but the underlying mechanisms are largely unknown. This study found associations between phthalate metabolites and inflammatory cytokines in the follicular fluid (FF) of women undergoing in vitro fertilization (IVF), suggesting that inflammation may mediate the effects of phthalate exposure on adverse reproductive outcomes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)