Article
Obstetrics & Gynecology
Isil Kasapoglu, Adnan Orhan, Kiper Aslan, Esra Sen, Aysenur Kaya, Berrin Avci, Gurkan Uncu
Summary: The study found that a high ratio of small (2-5 mm) basal antral follicles is a predictive factor for higher ovarian response to ovarian hyperstimulation. Small antral follicle count rather than whole antral follicle count may be beneficial for optimizing the ovarian response. Further research may determine the cutoff values of small antral follicle count for high/poor ovarian response.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Carlotta Scarafia, Martina Masciovecchio, Stefano Canosa, Andrea Roberto Carosso, Gianluca Gennarelli, Alberto Revelli, Chiara Benedetto
Summary: The study found that in women with ovarian endometriosis, ICSI can be performed without harming oocytes or affecting the outcome. Additionally, there is no advantage in removing endometrioma before ICSI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alessia Peserico, Chiara Di Berardino, Giulia Capacchietti, ChiaraCamerano Spelta Rapini, Liliana Liverani, Aldo Roberto Boccaccini, Valentina Russo, Annunziata Mauro, Barbara Barboni
Summary: Comparing with the validated cumulus-oocyte complex (COC) protocol, a three-dimensional (3D) scaffold-mediated follicle-enclosed oocytes (FEO) system was found to optimize in vitro maturation (IVM) for ovine early antral (EA)-derived oocytes. By combining hCG stimulation with ovarian surface epithelium (OSE) cells coculture exclusively on the FEO system, the maturation rate and parthenogenetic activation of EA-derived oocytes were significantly improved. The paracrine factors released specifically from OSE enhanced the hCG-triggering of oocyte maturation mechanisms by acting through the mural compartment, stimulating the EGFR signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Diane M. Tober, Kevin Richter, Dougie Zubizarreta, Said Daneshmand
Summary: This study aimed to evaluate self-reported survey data from US oocyte donors on their experiences with ovarian hyperstimulation syndrome (OHSS) and investigate possible correlations between OHSS severity and number of oocytes retrieved, trigger type, and prior OHSS history. An 85-question retrospective survey was conducted online, and the results showed that donors who received GnRH agonist triggers reported milder OHSS compared to those who received hCG or dual triggers. Among donors undergoing multiple retrieval cycles, the severity of OHSS in the second cycle was strongly associated with the severity in the first cycle.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Endocrinology & Metabolism
Bo Sun, Yujia Ma, Lu Li, Linli Hu, Fang Wang, Yile Zhang, Shanjun Dai, Yingpu Sun
Summary: This study identified high antral follicle count (AFC) as a strong predictor of ovarian hyperstimulation syndrome (OHSS) in patients with polycystic ovary syndrome undergoing in vitro fertilization treatment, while basal serum estradiol (E2) was found to be the best predictor of OHSS severity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Elisabeth Reiser, Maria Victoria Bazzano, Maria Emilia Solano, Johannes Haybaeck, Christoph Schatz, Julian Mangesius, Ute Ganswindt, Bettina Toth
Summary: Radiation therapy can lead to reduced ovarian function and depletion of primordial follicles. Studies using mouse models suggest that high doses of radiation cause severe damage to the ovary, while low doses have minimal effect. However, research on the effects of radiation on the ovarian microenvironment is still limited and requires further investigation.
Article
Obstetrics & Gynecology
S. Seshadri, G. Morris, P. Serhal, W. Saab
Summary: Delaying childbearing has led to more AMA women opting for assisted reproduction, but age-related changes in fertility can decrease success rates. AMA women have various fertility options, requiring detailed counseling and screening for underlying medical conditions.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Endocrinology & Metabolism
Laura Melado, Raquel Vitorino, Carol Coughlan, Leyla Depret Bixio, Ana Arnanz, Ibrahim Elkhatib, Neelke De Munck, Human M. Fatemi, Barbara Lawrenz
Summary: This study aimed to describe age-specific serum AMH and AFC values for women native to the Arabian Peninsula. The results showed that AMH and AFC were significantly associated with age, as well as with different styles of head covering among women on the Arabian Peninsula.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Marine Poulain, Rodine Younes, Paul Pirtea, Julie Trichereau, Dominique de Ziegler, Achraf Benammar, Jean Marc Ayoubi
Summary: The study found that the ratios of Oc/AFC and MII/AFC were associated with live birth rate and could be promising indicators for assessing ovarian response. However, the ratios of Oc/AMH and MII/AMH did not affect the live birth rate or implantation rate after the first or cumulative embryo transfer.
FRONTIERS IN MEDICINE
(2021)
Article
Reproductive Biology
Chunxia Yang, Naijun Dong, Feng Li, Yurong Ji, Yu Pan, Hong She
Summary: The study found that rFSH-alfa group had higher number of retrieved oocytes, transferable embryos, fresh embryo transfer rate, and multiple birth rate compared to the uFSH group. However, both groups had similar pregnancy rates and LBR per transfer cycle, with rFSH-alfa group achieving higher CLBR per started cycle. This suggests that rFSH-alfa might produce more transferrable blastocysts and higher overall success rates compared to uFSH.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Reproductive Biology
Marc-Andre Sirard
Summary: This review highlights the key factors influencing the success of in vitro fertilization, including oocyte quality and follicular development. The analogy between apple ripening and folliculogenesis illustrates the complexity and crucial timing of this process.
BIOLOGY OF REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Xingyu Sun, Wang Xiong, Liting Liu, Junjun Xiong, Chenlu Liao, Yunzhu Lan, Feifei Li, Shufei Tao, Muzi Meng, Chenyu Sun, Xiguang Mao
Summary: This study demonstrated that AFC and AMH were positively correlated with the number of retrieved oocytes, while age and BMI were negatively correlated. AFC showed better predictive performance in ovarian response prediction.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Si-Cheng Zhao, Zhi-Ran Xu, Chang-Long Xu, Quan-Kuo He, Guang-Ming Yang, Yan-Ping Li, Yu-Shen Luo, Hai-Long Wang, Zhong-Quan Qi, Yu Liu
Summary: Exposure to nickel sulfate negatively affects ovarian homeostasis and oocyte quality, triggering ovarian fibrosis and inflammation, and causing structural and functional disorders of mitochondria.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Obstetrics & Gynecology
I Yaish, K. Tordjman, H. Amir, G. Malinger, Y. Salemnick, G. Shefer, M. Serebro, F. Azem, N. Golani, Y. Sofer, N. Stern, Y. Greenman
Summary: The study found that testosterone therapy has a slight impact on the ovarian reserve of transgender men, but most participants maintained normal AMH levels. In subjects with PCOS, AMH levels decreased. AFC was not affected over time for the entire cohort.
HUMAN REPRODUCTION
(2021)
Article
Medical Laboratory Technology
J. Bruno-Gaston, J. Jung, T. Kumar, P. Zarutskie, W. Gibbons, S. Devaraj
Summary: This study evaluated the diagnostic performance of high-sensitivity picoAMH ELISA in predicting ovarian response and ovarian hyperstimulation syndrome. The results demonstrated that picoAMH is a valuable tool for predicting ovarian response and outperformed AFC in predicting OHSS.
CLINICAL BIOCHEMISTRY
(2021)
Article
Andrology
Sandro C. Esteves, Francesco Lombardo, Nicolas Garrido, Juan Alvarez, Armand Zini, Giovanni M. Colpi, Jackson Kirkman-Brown, Sheena E. M. Lewis, Lars Bjorndahl, Ahmad Majzoub, Chak-Lam Cho, Pedro Vendeira, Jorge Hallak, Edouard Amar, Marcello Cocuzza, Fabiola C. Bento, Rita C. Figueira, Romualdo Sciorio, Rita J. Laursen, Ahmad M. Metwalley, Sunil K. Jindal, Sijo Parekattil, Ranjith Ramasamy, Carlo Alviggi, Peter Humaidan, John L. Yovich, Ashok Agarwal
Summary: Delaying non-urgent gamete cryopreservation services may be detrimental for subgroups of male infertility patients, and it is suggested to modify the current recommendations and provide a permissive approach similar to that for cancer patients. Postponing diagnostic semen analysis and sperm banking for specific patients may compromise their prospects of biological parenthood.
Article
Obstetrics & Gynecology
Mauro Cozzolino, Irene Hervas, Rocio Rivera-Egea, Antonio Pellicer, Nicolas Garrido
Summary: The study found that using donor spermatozoa after the first failed oocyte donation cycle can improve IVF outcomes. The cumulative live birth rate (CLBR) curves for using autologous or donor spermatozoa can be used to determine the cumulative chances of live birth and provide guidance on when to replace spermatozoa.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Health Care Sciences & Services
Miriam Cervan-Martin, Lara Bossini-Castillo, Rocio Rivera-Egea, Nicolas Garrido, Saturnino Lujan, Gema Romeu, Samuel Santos-Ribeiro, Jose A. Castilla, M. Carmen Gonzalvo, Ana Clavero, F. Javier Vicente, Andrea Guzman-Jimenez, Claudia Costa, Ines Llinares-Burguet, Chiranan Khantham, Miguel Burgos, Francisco J. Barrionuevo, Rafael Jimenez, Josvany Sanchez-Curbelo, Olga Lopez-Rodrigo, M. Fernanda Peraza, Iris Pereira-Caetano, Patricia I. Marques, Filipa Carvalho, Alberto Barros, Lluis Bassas, Susana Seixas, Joao Goncalves, Sara Larriba, Alexandra M. Lopes, Rogelio J. Palomino-Morales, F. David Carmona
Summary: The study identified a significant difference in allele frequencies of USP8-rs7174015 between the NOA group, the control group, and the SO group, suggesting a possible association of this gene with male infertility. Other genetic associations were found for EPSTI1-rs12870438 and PSAT1-rs7867029 with SO, as well as TUSC1-rs10966811 with TESE success in the context of non-obstructive azoospermia.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Editorial Material
Obstetrics & Gynecology
Marcos Meseguer, M. Angeles Valera
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Aila Coello, Mar Nohales, Marcos Meseguer, M. Jose de Los Santos, Jose Remohi, Ana Cobo
Summary: In vitrified-warmed blastocyst transfer cycles, pre-vitrification parameters such as expansion degree and day of vitrification are the most predictive of survival and live birth. Trophoectoderm grade and day of vitrification are the most significant predictors of live birth outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Angel Martin, Lorena Rodrigo, Diana Beltran, Marcos Meseguer, Carmen Rubio, Amparo Mercader, Maria Jose de los Santos
Summary: This study provided a full morphokinetic characterization of embryos with different degrees of chromosomal mosaicism. It was found that the percentage of high-quality blastocysts decreased from euploid to mosaic and aneuploid embryos. Aneuploid blastocysts showed delayed development compared to euploid blastocysts, but embryo morphokinetics were not correlated to the degree of mosaicism or a mosaicism configuration apt for embryo transfer.
FERTILITY AND STERILITY
(2021)
Article
Biochemistry & Molecular Biology
Marta Gianzo, Itziar Urizar-Arenaza, Iraia Munoa-Hoyos, Zaloa Larreategui, Nicolas Garrido, Jon Irazusta, Nerea Subiran
Summary: The study confirmed the presence of (pro)renin receptor in human sperm and found that semen samples with higher percentages of PRR-positive spermatozoa are associated with poor sperm motility and embryo development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Andrea Abdala, Ibrahim Elkhatib, Asina Bayram, Ana Arnanz, Ahmed El-Damen, Laura Melado, Barbara Lawrenz, Carol Coughlan, Nicolas Garrido, Human M. Fatemi, Neelke De Munck
Summary: Under controlled in vitro conditions, euploidy rates and embryo development are comparable when embryos are cultured in CCM or SCM.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Genetics & Heredity
Rocio Rivera-Egea, Nerea Sota, Roberto Gonzalez-Martin, Marcos Meseguer, Jose Remohi, Nicolas Garrido, Francisco Dominguez
Summary: This study analyzed proteomic profiles of sperm samples that successfully achieved pregnancy versus those that did not, revealing differences in protein composition related to sperm function and infertility markers. The findings provide insight for the development of male fertility diagnostic tools and therapies in the future.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
Maria Angeles Valera, Carmela Albert, Julian Marcos, Zaloa Larreategui, Lorena Bori, Marcos Meseguer
Summary: Culturing embryos in a high relative humidity atmosphere using a time-lapse integrated incubator and single-step culture medium can improve clinical outcomes, especially for embryos undergoing preimplantation genetic testing.
HUMAN REPRODUCTION
(2022)
Review
Obstetrics & Gynecology
Pedro Brandao, Nicolas Garrido
Summary: Commercial surrogacy is a common practice despite significant ethical and legal dilemmas. Due to the variation in national legislations, patients often turn to international commercial surrogacy programs.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2022)
Editorial Material
Obstetrics & Gynecology
Carla Gimenez-Rodriguez, Marcos Meseguer
FERTILITY AND STERILITY
(2023)
Article
Urology & Nephrology
Sarah Kimmins, Richard A. Anderson, Christopher L. R. Barratt, Hermann M. Behre, Sarah R. Catford, Christopher J. De Jonge, Geraldine Delbes, Michael L. Eisenberg, Nicolas Garrido, Brendan J. Houston, Niels Jorgensen, Csilla Krausz, Ariane Lismer, Robert I. Mclachlan, Suks Minhas, Tim Moss, Allan Pacey, Laerke Priskorn, Stefan Schlatt, Jacquetta Trasler, Leonardo Trasande, Frank Tuettelmann, Monica Hebe Vazquez-Levin, Joris A. Veltman, Feng Zhang, Moira K. O'Bryan
Summary: Currently, there is a lack of understanding and awareness about the causes of male infertility and the importance of male reproductive health. This leads to standardized treatment strategies using medically assisted reproduction techniques, which overlook the potential co-morbidities and shift the burden to women. To improve male reproductive health, it is essential to establish centers for data and sample collection and study the effects of genetics, epigenetics, and environment on fertility and offspring health. Personalized treatment protocols should be developed and education about infertility should be increased.
NATURE REVIEWS UROLOGY
(2023)
Article
Obstetrics & Gynecology
Lorena Bori, Marcos Meseguer
Summary: IVF techniques are increasingly being automated in the laboratory, reducing the manual tasks of embryologists. This shift towards automation will lead to the emergence of new functions related to data capture and communication with other professionals and patients.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)