期刊
FERTILITY AND STERILITY
卷 92, 期 2, 页码 648-652出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2008.06.016
关键词
Polycystic ovary syndrome; PCOS; 17 beta-hydroxysteroid dehydrogenase type V gene; HSD17B5 gene polymorphisms
Objective: To evaluate the association of an activating single-nucleotide polymorphism (SNP) at position -71 of the promoter of 17 beta-hydroxysteroid dehydrogenase type 5 gene (-71A/G HSD17B5 SNP) and polycystic ovary syndrome (PCOS) in a well characterized cohort of caucasian PCOS women with biochemical hyperandrogenemia. Design: The PCOS patients and unrelated healthy control subjects were genotyped for the -71A/G HSD17B5 SNP. The acquired genotypic data was tested for association with PCOS and other quantitative phenotypic traits of the syndrome in PCOS patients. Setting: Subjects were recruited from the Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, at the University Hospital of Patras, Greece. Genotyping and biochemical determinations took place at the Laboratory of Molecular Endrocinology, University of Patras Medical School, Rion, Greece. Patient(s): Participants comprised 150 caucasian Greek PCOS women with biochemical hyperandrogenism and chronic anovulation and polycystic ovarian morphology on ultrasound and 51 healthy control subjects. Main Outcome Measure(s): HSD17B5 genotype, serum testosterone, serum androstenedione. Result(s): No association of the -71A/G HSD17B5 SNP with PCOS was detected. However, the -71G HSD17B5 variant was associated with increased serum testosterone levels and decreased androstenedione/testosterone ratio. Conclusion(s): The -71G HSD17B5 variant is not a major component of the molecular pathogenetic mechanisms of PCOS, although it might contribute to the severity of hyperandrogenemia in women with PCOS and biochemical hyperandrogenism. (Fertil Steril (R) 2009;92:648-52. (C)2009 by American Society for Reproductive Medicine.)
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