Article
Obstetrics & Gynecology
Joie Z. Guner, Diana Monsivais, Henry Yu, Fabio Stossi, Hannah L. Johnson, William E. Gibbons, Martin M. Matzuk, Stephen Palmer
Summary: TOP5300 appears to stimulate higher E2 production and steroidogenic gene expression in human granulosa cells from patients with polycystic ovary syndrome (PCOS) compared to recombinant human FSH (rh-FSH). FSH receptor (FSHR) membrane localization does not seem to be a limiting step for the stimulation of steroidogenic gene expression and E2 production by TOP5300 or rh-FSH.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Samantha Sperduti, Elia Paradiso, Claudia Anzivino, Clara Lazzaretti, Silvia Limoncella, Sara D'Alessandro, Neena Roy, Francesca Reggianini, Tommaso Ferrari, Beatrice Melli, Giovanni Battista La Sala, Alessia Nicoli, Jessica Daolio, Maria Teresa Villani, Simonetta Tagliavini, Tommaso Trenti, Francesco Poti, Reinhild Sandhowe, Chiara Centonze, Monica Lispi, Manuela Simoni, Livio Casarini
Summary: The addition of LH to FSH can recover the cAMP and progesterone production of sub/poor-responder women's ovarian granulosa cells. This study has important implications for personalized ART stimulation protocols.
HUMAN REPRODUCTION
(2023)
Article
Reproductive Biology
Alireza Khodadadi, Amir Niasari-Naslaji, Darab Nikjou, Behrouz Mohammadi
Summary: This study compared the effects of three gonadotropin products on superovulation in high-producing Holstein lactating dairy cows and investigated the pregnancy outcomes of embryos recovered from donors treated with different gonadotropins. The results showed that Cinnal-f and Menotropins provided similar superovulatory response to Folltropin-V in high-producing Holstein lactating dairy cows. However, the pregnancy rate and the number of healthy calves born from Cinnal-f treated donors were lower.
Article
Obstetrics & Gynecology
Ernesto Bosch, Pilar Alama, Josep Lluis Romero, Marta Mari, Elena Labarta, Antonio Pellicer
Summary: Ovarian stimulation with highly purified (hp)-HMG can prevent elevated progesterone in the follicular phase compared to recombinant FSH (r-FSH) by enhancing the Delta 4 pathway, leading to lower progesterone levels at the end of the cycle.
HUMAN REPRODUCTION
(2023)
Article
Cell Biology
Takeshi Kitano, Tomoaki Takenaka, Hisanori Takagi, Yasutoshi Yoshiura, Yukinori Kazeto, Toshiaki Hirai, Koki Mukai, Ryo Nozu
Summary: In medaka fish, FSH is necessary for follicle development while LH is required for oocyte maturation. However, neither FSH nor LH is essential for spermatogenesis.
Article
Endocrinology & Metabolism
Nidhi Chahal, Anjali Geethadevi, Surleen Kaur, Ruchi Lakra, Anjali Nagendra, T. G. Shrivastav, Francesco De Pascali, Eric Reiter, Pascale Crepieux, M. Gouri Devi, Neena Malhotra, K. Muralidhar, Rita Singh
Summary: The study revealed impaired glucose uptake and glycogen synthesis in granulosa cells of PCOS patients due to selective defect in FSHR activation, with high activation level of LHR inhibiting FSH-mediated metabolic responses through IRS-2 pathway inhibition, leading to depleted glycogen stores and follicular growth arrest.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Obstetrics & Gynecology
E. Bosch, C. Alviggi, M. Lispi, A. Conforti, A. C. Hanyaloglu, D. Chuderland, M. Simoni, N. Raine-Fenning, P. Crepieux, S. Kol, V Rochira, T. D'Hooghe, P. Humaidan
Summary: Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play complementary roles in follicle development and ovulation via a complex interaction. Impairment of gonadotropins can reduce fertility, and recent evidence shows various factors negatively affecting gonadotropin action.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Lizandra Moura Paravidine Sasaki, Bruno Ramalho de Carvalho, Adelino Amaral Silva, Alberto Moreno Zaconeta, Miriam da Silva Wanderley, Luiz Augusto Casulari Roxo da Motta, Adriana Lofrano-Porto
Summary: Selective LH deficiency has been described in both men and women, serving as a valuable model for studying the regulation of late-stage folliculogenesis and ovulation. A woman with LH deficiency due to a genetic mutation was successfully treated with individualized ovarian induction therapy, resulting in a healthy baby being born after an uneventful pregnancy. This case demonstrates that exogenous LH or hCG can effectively induce late-stage follicular development in women with deficient LH production or performance, once early follicular growth is assured by FSH.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Sarah Makolle, Sophie Catteau-Jonard, Geoffroy Robin, Didier Dewailly
Summary: In the general FHA population, serum AMH levels are not decreased, but become significantly lower when patients with PCOM are excluded. Low LH levels in FHA patients may lead to higher AMH levels, indicating a potential issue of epigenetic amplification within granulosa cells in polycystic ovaries.
HUMAN REPRODUCTION
(2021)
Article
Physiology
Yaping Ma, Olubusayo Awe, Sally Radovick, Xiaofeng Yang, Sara Divall, Andrew Wolfe, Sheng Wu
Summary: The kisspeptin receptor plays an important role in the regulation of reproductive function. Deleting the kisspeptin receptor gene in pituitary gonadotropes led to lower follicle-stimulating hormone (FSH) levels in male mice without affecting testis function. Female mice with the deleted gene had normal reproductive function.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Wen-Xiang Liu, Yan-Jie Zhang, Yu-Feng Wang, Francesca Gioia Klinger, Shao-Jing Tan, Donatella Farini, Massimo De Felici, Wei Shen, Shun-Feng Cheng
Summary: The study reveals that LH and FSH can counteract the damage caused by nicotine on germ cell cyst breakdown in mice, improving oocyte quality and follicle number. LH regulates nicotine-induced oocyte autophagy by affecting the phosphorylation level of a specific protein, while FSH acts through a different pathway. Additionally, LH and FSH supplementation enhances maturation rates, fertilization rates, and developmental potential of oocytes exposed to nicotine.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Andrea Sansone, Maria Schubert, Frank Tuettelmann, Claudia Krallmann, Michael Zitzmann, Sabine Kliesch, Joerg Gromoll
Summary: The FSHB-211 G > T polymorphism affects pituitary response to exogenous GnRH stimulation by reducing FSH and increasing LH outputs. TT carriers displayed significantly higher peak levels of LH compared to GT and GG carriers, with no significant difference in stimulated FSH levels.
HUMAN REPRODUCTION
(2021)
Review
Endocrinology & Metabolism
Marie Lindhardt Ljubicic, Trine Holm Johannsen, Margit Bistrup Fischer, Emmie N. Upners, Alexander S. Busch, Katharina M. Main, Anna-Maria Andersson, Casper P. Hagen, Anders Juul
Summary: The ratio between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) has been found to be a reliable marker for sex determination in healthy infants. However, its role in patients with differences of sex development (DSD) remains unclear. This retrospective study aimed to describe LH/FSH in infants with DSD and found that the ratio sometimes corresponds to the assigned sex, but not in all cases.
ENDOCRINE CONNECTIONS
(2023)
Review
Endocrinology & Metabolism
Miklos Koppan, Zsuzsanna Nagy, Inez Bosnyak, Dora Reglodi
Summary: Pituitary adenylate cyclase activating polypeptide (PACAP) plays important roles in female reproduction, including regulating gonadal hormone production, influencing follicular development, participating in fertilization and embryonic/placental development, affecting hormonal changes during and after birth, and influencing maternal behavior. Increasing evidence suggests similar effects of PACAP in humans.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Jing Zhang, Xiaoyu Lu, Yiyong Liu, Xinglong Wu, Yuansong Yu, Xiangyun Li
Summary: The study compared the effects of once daily injection of hMG and twice daily injection of FSH on superovulatory response in Suffolk ewes. The results showed no significant differences between the two groups in terms of superovulatory response and embryo transfer outcomes. Therefore, hMG can be used as a replacement for FSH and reduce the number of injections in ovine superovulatory regimens.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Clinical Neurology
Song Guo, Anne Luise Haulund Vollesen, Young Bae Lee Hansen, Erik Frandsen, Malene Rohr Andersen, Faisal Mohammad Amin, Jan Fahrenkrug, Jes Olesen, Messoud Ashina
Article
Medical Laboratory Technology
Young Bae Hansen, Vibeke Myrhoj, Finn Stener Jorgensen, Claus Oxvig, Steen Sorensen
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2016)
Article
Endocrinology & Metabolism
N. R. Jorgensen, L. T. Mollehave, Y. B. L. Hansen, N. Quardon, L. Lylloff, A. Linneberg
OSTEOPOROSIS INTERNATIONAL
(2017)
Review
Genetics & Heredity
Tanja Schlaikjaer Hartwig, Louise Ambye, Steen Sorensen, Finn Stener Jorgensen
PRENATAL DIAGNOSIS
(2017)
Article
Biochemical Research Methods
Steen Sorensen, Vibeke Myrhoj, Thanh Ha Nguyen, Per Aaslo, Young Bae Hansen
PROTEIN EXPRESSION AND PURIFICATION
(2017)
Article
Obstetrics & Gynecology
Kasper Pihl, Steen Sorensen, Mona Nystad, Ganesh Acharya, Finn S. Jorgensen
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2019)
Article
Infectious Diseases
A. Knudsen, U. S. Kristoffersen, I. Panum, Y. B. Hansen, P. D. Skottrup, P. Hasbak, A. Kjaer, A-M Lebech
Review
Obstetrics & Gynecology
Laura A. Juul, Tanja S. Hartwig, Louise Ambye, Steen Sorensen, Finn S. Jorgensen
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2020)
Article
Immunology
Young Lee Hansen, Vibeke Myrhoj, Steen Sorensen
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2020)
Article
Medical Laboratory Technology
Elias F. Wiwe, Elin R. Carlsson, Christina L. Rasmussen, Pernille Rasmussen, Robert Ougaard, Steen Hansen, Thomas Schioler, Soren Kristiansen, Young B. Hansen, Thore Hillig
Summary: This study evaluated the sensitivity and specificity of various SARS-CoV-2 antibody assays and found that all assays had a sensitivity of over 90% beyond day 18. For detecting previous undocumented Covid-19 cases, total antibody assays are recommended over IgG-specific assays.
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)
Letter
Medical Laboratory Technology
Young Bae Lee Hansen, Koh Furuta, Sridevi Devaraj, Fatma Meric Yilmaz, Gunnar Nordin
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Medical Laboratory Technology
Aneta Radziwon-Balicka, Elias F. Wiwe, Tomas O. Jensen, Signe G. Nielsen, Miljena Copois, Niclas Sunde, Nina C. Peytz, Dhergam A. A. Al-Mousawi, Mie C. Hansen, Jesper F. Petersen, Anne S. Norskov, Maria E. Lendorf, Young B. L. Hansen, Thomas S. Hansen, Melanie A. Burkhardt, Kristian M. Hansen, Claus A. J. Jensen
Summary: This study evaluated a novel antithrombotic formulation blood tube for measuring various blood analytes. The results showed that the novel tube demonstrated comparable results to the gold standard tubes for hematological, biochemical, and D-dimer analyses. This suggests that the novel tube has the potential to be used in clinical laboratories for simultaneous analysis of multiple blood parameters.
CLINICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Young Bae Lee Hansen, Karin Toska, Alice Lund, Robert Flatman, Rebecca Ceder
Summary: The NPU terminology is a constantly evolving international medical laboratory terminology used in healthcare systems, but the literature on the terminology is scattered across at least 16 outdated publications. The objective is to establish an updated online manual for the NPU terminology, which includes its principles and special rules. The manual aims to provide easily searchable and up-to-date information.
PURE AND APPLIED CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Thore Hillig, Josephine R. Kristensen, Claus L. Brasen, Ivan Brandslund, Dorte A. Olsen, Camilla Davidsen, Jonna S. Madsen, Claus A. Jensen, Young B. L. Hansen, Lennart Friis-Hansen
Summary: This study compared the performance of three commercial SARS-CoV-2 nucleoprotein (N) assays in plasma to assess their ability to determine systemic COVID-19 disease. The assays were analyzed on 272 plasma samples obtained in November-December 2021, as well as a dilution series of inactivated virus culture. The assays showed poor agreement on patient samples but excellent performance on virus culture, with differing levels of detection.
SCIENTIFIC REPORTS
(2023)