Article
Agriculture, Dairy & Animal Science
Adel R. Moawad, Ali Salama, Magdy R. Badr, Mohamed Fathi
Summary: Supplementation of L-Carnitine (LC) during in vitro maturation (IVM) of canine oocytes improves maturation, fertilization, and preimplantation embryo development rates following IVF and in vitro culture (IVC).
Article
Agriculture, Dairy & Animal Science
Avijit Kumar Modak, Md Hasanur Alam, Md Nuronnabi Islam, Nipa Paul, Ireen Akter, Md Abul Hashem, Akm Ahsan Kabir, Mohammad Moniruzzaman
Summary: This study aimed to examine the effect of L-carnitine on the growth and nuclear maturation of buffalo oocytes in vitro. The results showed that L-carnitine enhanced the growth of buffalo oocytes, prevented degeneration, promoted the formation of antrum-like structures, and supported nuclear maturation.
Editorial Material
Biochemistry & Molecular Biology
Joana Soares-de-Oliveira, Helder Maiato
Summary: This study proposes a new perspective that chromosome biorientation is driven by microtubule self-organization at kinetochores, challenging the previous stochastic models.
Article
Agriculture, Dairy & Animal Science
Giovana D. Catandi, Ming-Hao Cheng, Adam J. Chicco, Tom Chen, Elaine M. Carnevale
Summary: Maternal obesity increases NEFA follicular concentrations and affects mitochondrial metabolism and embryo quality. Supplementation with L-carnitine during in vitro maturation of bovine COCs exposed to high NEFA can mitigate the negative effects of excessive lipid exposure on embryonic development and oxidative stress.
ANIMAL REPRODUCTION SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Paolo Giovanni Artini, Giorgia Scarfo, Ilaria Marzi, Jonathan Fusi, Maria Elena Obino, Ferdinando Franzoni, Elisa Zappelli, Elisa Chelucci, Claudia Martini, Vito Cela, Simona Daniele
Summary: The molecular/metabolic composition of follicular fluid (FF) has a significant impact on oocyte development and fertilization. The antioxidant potential of FF is correlated with the number of retrieved/mature oocytes and fertilized ones. FF from normal fertilized oocytes exhibits elevated antioxidant capability, lower levels of pro-inflammatory molecules, and higher IL-10 concentration. Samples giving rise to top-quality embryos display a unique antioxidant capability and further decrease in pro-inflammatory molecules compared to FF from poor-quality embryos. Successful embryo implantation is associated with lower pro-inflammatory molecules and high antioxidant capability. Antioxidant capability and IL-10 show good predictive ability for fertilization and embryo quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Da-Bin Pyeon, Seung-Eun Lee, Jae-Wook Yoon, Hyo-Jin Park, Seung-Hwan Oh, Do-Geon Lee, Eun-Young Kim, Se-Pill Park
Summary: This study investigated the antioxidant activities of Sasa quelpaertensis Nakai extract (SQE), p-coumaric acid (PCA), and myricetin (MY), and their effects on the in vitro maturation and developmental ability of porcine oocytes. The results showed that SQE and MY have antioxidant effects and enhance in vitro maturation and embryonic development.
Article
Food Science & Technology
Cibele F. Teixeira, Ivana B. M. da Cruz, Euler E. Ribeiro, Danieli M. Pillar, Barbara O. Turra, Raquel S. Praia, Fernanda Barbisan, Audrei O. Alves, Douglas K. Sato, Charles E. Assmann, Tais Palma, Romulo P. Barcelos, Igor M. Barbosa, Veronica F. Azzolin
Summary: The study investigated the effects of guarana, selenium, and L-carnitine on human leukocytes, microglia BV-2 cells, and red earthworms. Results showed that GSC has genoprotective potential, reduces oxidative levels, and activates immune response without toxicity, suggesting it may be safe for human consumption.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Nutrition & Dietetics
Matthew Stefan, Matthew Sharp, Raad Gheith, Ryan Lowery, Charlie Ottinger, Jacob Wilson, Shane Durkee, Aouatef Bellamine
Summary: The study indicates that L-carnitine tartrate supplementation can improve short-term recovery among athletes, while longer-term effects in the general population need further research. The experiment found that L-carnitine tartrate supplementation for 5 weeks could enhance perceived recovery and reduce soreness, as well as lower serum creatine kinase levels.
Article
Reproductive Biology
Nasser Ghanem, Md Fakruzzaman, Ashwaq Hassan Batawi, Il-Keun Kong
Summary: This study investigated the effects of supplementing L-carnitine in the in vitro culture medium on preimplantation development, quality, cryotolerance, and gene expression of embryos. The results showed that adding low levels of FCS and LC improved blastocyst formation rate and quality, while regulating genes involved in embryo activities.
Review
Nutrition & Dietetics
Dong-Dong Wang, Tian-Yun Wang, Yang Yang, Su-Mei He, You-Mei Wang
Summary: The study found that l-carnitine can reduce body mass in type 2 diabetes mellitus patients, while no significant effects were observed with acetyl-l-carnitine or propionyl-l-carnitine. To achieve 80% of the maximal effect, a minimum of 2 grams of l-carnitine daily for at least 2 weeks was required.
FRONTIERS IN NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Adeleh Sahebnasagh, Razieh Avan, Mahila Monajati, Javad Hashemi, Solomon Habtemariam, Sina Negintaji, Fatemeh Saghafi
Summary: This review discusses the effects of carnitine on immune function and its potential benefits in critically ill patients. Carnitine acts as a potent antioxidant and plays a crucial role in fatty acid metabolism and cardiac tissue regulation. Studies suggest that carnitine supplementation may decrease the need for vasopressors and improve clinical outcomes in septic shock patients.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Psychiatry
Li-Juan Nie, Jun Liang, Feng Shan, Bao-Shi Wang, Yuan-Yuan Mu, Xie-Hai Zhou, Qing-Rong Xia
Summary: The endogenous L-carnitine and its derivative acetyl-L-carnitine play a role in antidepressant effects and may serve as potential biomarkers for diagnosing MDD. The levels of serum LC and ALC are significantly reduced in patients with MDD, with potential diagnostic value. Furthermore, changes in LC and ALC concentrations could differentiate between effective and ineffective treatment of depression, indicating their potential as novel biomarkers.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Mara Simopoulou, Anna Rapani, Sokratis Grigoriadis, Agni Pantou, Petroula Tsioulou, Evangelos Maziotis, Despina Tzanakaki, Olga Triantafyllidou, Theodoros Kalampokas, Charalampos Siristatidis, Panagiotis Bakas, Nikolaos Vlahos
Summary: The article discusses the infertility associated with endometriosis, highlighting the various pathological mechanisms that contribute to impaired reproductive dynamics. Reactive oxygen species, immune system dysregulation, and cellular architectural disruption are key mechanisms affecting oocyte and embryo development potential in endometriosis patients.
Review
Agriculture, Dairy & Animal Science
Diego F. Carrillo-Gonzalez, Darwin Y. Hernandez-Herrera, Juan G. Maldonado-Estrada
Summary: Early embryo development is driven by maternal RNAs and proteins, and ATP synthesis is crucial. Bovine embryos have energy reserves, but glycogen concentration is deficient, while lipids serve as the main energy source. L-carnitine facilitates fatty acid metabolism. However, the effects of adding L-carnitine to culture media on embryo quality are disputed.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Cell Biology
Juan Ge, Congyang Li, Hongzheng Sun, Yongan Xin, Shuai Zhu, Yuan Liu, Shoubin Tang, Longsen Han, Zhenyue Huang, Qiang Wang
Summary: Maternal obesity leads to telomere shortening and defective telomeres in oocytes and early embryos, which in turn affects the development of embryos.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Andrology
A. Agarwal, R. Sharma, A. Singh, S. Gupta, R. Sharma
Article
Genetics & Heredity
Ashok Agarwal, Gulfam Ahmad, Rakesh Sharma
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2015)
Meeting Abstract
Urology & Nephrology
Rakesh Sharma, Ashok Agarwal, Ahmet Ayaz, Edmund Sabanegh
JOURNAL OF UROLOGY
(2015)
Editorial Material
Urology & Nephrology
Ashok Agarwal, Rakesh Sharma
Article
Urology & Nephrology
Ashok Agarwal, Reecha Sharma, Sajal Gupta, Rakesh Sharma
Article
Genetics & Heredity
Rakesh Sharma, Gulfam Ahmad, Sandro C. Esteves, Ashok Agarwal
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2016)
Editorial Material
Urology & Nephrology
Ashok Agarwal, Sandro C. Esteves, Sajal Gupta, Rakesh Sharma, Stefan Du Plessis, Edmund Sabanegh
Article
Obstetrics & Gynecology
Ahmad Majzoub, Nicholas N. Tadros, A. Scott Polackwich, Rakesh Sharma, Ashok Agarwal, Edmund Sabanegh
FERTILITY AND STERILITY
(2017)
Article
Obstetrics & Gynecology
Ashok Agarwal, Shubhadeep Roychoudhury, Rakesh Sharma, Sajal Gupta, Ahmad Majzoub, Edmund Sabanegh
REPRODUCTIVE BIOMEDICINE ONLINE
(2017)
Article
Andrology
S. Ribeiro, R. Sharma, S. Gupta, Z. Cakar, C. De Geyter, A. Agarwal
Article
Andrology
A. Agarwal, R. Henkel, R. Sharma, N. N. Tadros, E. Sabanegh
Article
Andrology
S. Gunes, A. Agarwal, R. Henkel, A. M. Mahmutoglu, R. Sharma, S. C. Esteves, A. Aljowair, D. Emirzeoglu, A. Alkhani, L. Pelegrini, A. Joumah, E. Sabanegh
Article
Andrology
M. Arafa, A. Agarwal, S. Al Said, A. Majzoub, R. Sharma, K. B. Bjugstad, K. AlRumaihi, H. Elbardisi
Article
Andrology
A. Agarwal, R. Sharma, R. Henkel, S. Roychoudhury, S. C. Sikka, S. du Plessis, Y. B. Sarda, C. Speyer, M. Nouh, C. Douglas, Z. Kayali, A. Elshaer, E. Sabanegh
Article
Andrology
G. Ahmad, A. Agarwal, S. C. Esteves, R. Sharma, M. Almasry, A. Al-Gonaim, G. AlHayaza, N. Singh, L. Al Kattan, W. M. Sannaa, E. Sabanegh