Review
Biology
Rkia Wazzani, Stephane Pallu, Celine Bourzac, Said Ahmaidi, Hugues Portier, Christelle Jaffre
Summary: Physical activity is widely recognized as a biotherapy by WHO for the prevention and treatment of bone diseases such as osteoporosis. It is crucial in reducing the risk of disabling fractures associated with various comorbidities. However, the effects of exercise on bone quality are still unclear and dependent on various factors such as exercise protocols and intensity.
Article
Nanoscience & Nanotechnology
Matthias Schumacher, Pamela Habibovic, Sabine van Rijt
Summary: The slow and disorganized formation of a functional vascular network in large bone defect regeneration can cause delayed healing or implant failure. This study introduces a promising strategy by immobilizing the pro-angiogenic growth factor VEGF on nanosized bioactive glass particles using a binding peptide, which can induce angiogenesis and overcome the problem of insufficient neovascularization.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Peripheral Vascular Disease
Maximilian M. Menger, Matthias W. Laschke, Andreas K. Nussler, Michael D. Menger, Tina Histing
Summary: Despite extensive research on vascularization for bone regeneration, stimulating blood vessel formation alone is not sufficient to address non-union formation. Experimental studies suggest that non-union callus tissue is densely vascularized and expresses pro-angiogenic factors adequately. Further understanding of the molecular and cellular basis of non-union vascularization may lead to improved treatment approaches or prevention strategies.
Article
Agriculture, Dairy & Animal Science
Hisashi Kishi, Wataru Komatsu, Koji Uchiyama, Hidehito Takayama, Tomomi Udagawa, Shuji Ohhira, Gen Kobashi
Summary: VEGF expression in the uterus during the estrous cycle of golden hamsters (Mesocricetus auratus) was investigated. Three different VEGF isoforms (VEGF188, VEGF164, and VEGF120) were identified through reverse transcription polymerase chain reaction. VEGF164 and VEGF120 were predominantly expressed in the uterus during the estrous cycle. In situ hybridization showed that VEGF was expressed in the luminal and glandular epithelium of the endometrium. These findings indicate that VEGF secreted by endometrial epithelial cells plays a role in maintaining blood vessels in the endometrial stroma and preparing for embryo implantation.
ANIMAL SCIENCE JOURNAL
(2023)
Article
Oncology
Susu Wei, Zhichao Li, Qiangqiang Shi, Xiaoyu Luan, Xinying Yuan, Yaxin Li, Chuanlong Guo, Xianggen Wu, Chunying Shi, Guohu Di
Summary: This study investigated the therapeutic effect of CBD-VEGF on liver regeneration using a mouse model of partial hepatectomy. The results demonstrated that CBD-VEGF promoted sinusoidal regeneration and remodeling in the remnant liver tissue, enhanced hepatocyte proliferation, and attenuated liver injury, suggesting its potential as a therapeutic strategy for liver regeneration.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Ezekiel Mecha, Roselydiah Makunja, Jane B. Maoga, Agnes N. Mwaura, Muhammad A. Riaz, Charles O. A. Omwandho, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: Thoracic endometriosis (TE) is a rare form of endometriosis where endometrial tissue is found in or around the lungs, often presenting as catamenial pneumothorax (CP). Immunohistochemical evaluation is considered crucial for diagnosing and classifying the disease effectively.
Article
Obstetrics & Gynecology
Kashmira Bane, Junita Desouza, Diksha Shetty, Prakash Choudhary, Shalaka Kadam, R. R. Katkam, Gwendolyn Fernandes, Raj Sawant, Uddhavraj Dudhedia, Neeta Warty, Anahita Chauhan, Uddhav Chaudhari, Rahul Gajbhiye, Geetanjali Sachdeva
Summary: The study indicates that the DNA damage response is dysregulated in the eutopic endometrium of women with endometriosis, with higher expression of DDR genes compared to those without the disease. Additionally, DNA repair genes are also up-regulated in the eutopic endometrium of women with endometriosis.
HUMAN REPRODUCTION
(2021)
Article
Medicine, General & Internal
Anna C. Loeffelmann, Alena Hoerscher, Muhammad A. Riaz, Felix Zeppernick, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: In endometriosis, the localization of claudin-10 is impaired, but the epithelial phenotype remains preserved. Claudin-10 is highly expressed in endometriosis and adenomyosis, but there are differences in its localization between the two conditions.
Review
Biochemistry & Molecular Biology
Yuri Park, Sang Jun Han
Summary: Endometriosis is an estrogen-dependent inflammatory disease that causes pelvic pain and infertility in women. Immune system defects may contribute to the progression of endometriosis. Elevated levels of interferon, a cytokine, play a crucial role in endometriosis progression, but also have a critical role in normal endometrial function, particularly in pregnancy initiation and maintenance.
Article
Biotechnology & Applied Microbiology
Anika Schumacher, Nadia Roumans, Timo Rademakers, Virginie Joris, Maria Jose Eischen-Loges, Martijn van Griensven, Vanessa L. S. LaPointe
Summary: Studying the modulation of oxygen availability in culture, researchers found that culturing kidney organoids in hypoxia can lead to improved vascularization. The endothelial network in kidney organoids cultured in hypoxia showed enhanced sprouting and interconnectivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Oncology
Nozomi Yachida, Kosuke Yoshihara, Manako Yamaguchi, Kazuaki Suda, Ryo Tamura, Takayuki Enomoto
Summary: Driver gene mutations have been identified in both endometriosis and normal endometrium, potentially leading to endometriosis-associated ovarian cancer. Despite the continuum of genomic alterations, the molecular mechanism of ovarian carcinogenesis from the normal endometrium through endometriosis remains unclear.
Review
Biology
Marjanu Hikmah Elias, Nurunnajah Lazim, Zulazmi Sutaji, Mohammad Azrai Abu, Abdul Kadir Abdul Karim, Azizah Ugusman, Saiful Effendi Syafruddin, Mohd Helmy Mokhtar, Mohd Faizal Ahmad
Summary: Endometriosis is an inflammatory chronic systemic disease causing pelvic pain and infertility. The identification of the disease is insufficient, leading to a high misdiagnosis rate. Our focus is on the abnormal hypermethylation of HOXA10 in endometriosis. A comprehensive literature search was conducted to determine the DNA methylation level of HOXA10 in endometriosis patients across different populations. The gathered evidence demonstrated a higher HOXA10 DNA methylation level in the endometrium tissue of women with endometriosis in all included studies.
Article
Peripheral Vascular Disease
Soheila Salmasi, Mohammadreza Sharifi, Bahman Rashidi
Summary: This research indicates that ovarian stimulation and progesterone administration can enhance endometrial angiogenesis through upregulation of VEGF protein, with the most significant increase seen in the ovarian stimulation + progesterone group. Besides miR-16-5p, other miRNAs and molecules may also be involved in angiogenic pathways, necessitating further studies.
MICROVASCULAR RESEARCH
(2021)
Article
Obstetrics & Gynecology
Paul J. Yong, Mohamed A. Bedaiwy, Fahad Alotaibi, Michael S. Anglesio
Summary: The pathogenesis of bowel endometriosis is multifactorial and involves factors such as reflux of endometrium, uterine attachment rupture and fibrosis, oxidative stress, microbiome, neurogenesis, nerve fiber recruitment, and genetic mutations. Bowel endometriosis may be classified based on molecular features in the future.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ana Paula Ferraz, Fernando A. C. Seara, Emanuelle F. Baptista, Thais S. Barenco, Thais B. B. Sottani, Natalia S. C. Souza, Aina E. Domingos, Raiana A. Q. Barbosa, Christina M. Takiya, Marcos T. Couto, Gabriel O. Resende, Antonio C. Campos de Carvalho, Cristiano G. Ponte, Jose Hamilton M. Nascimento
Summary: The selective BKCa channel opener (compound X) showed significant therapeutic efficacy in rats with MCT-induced PAH, improving hemodynamic parameters and preventing maladaptive RV remodeling.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Nanoscience & Nanotechnology
Dayene de Assis Fernandes Caldeira, Flavia Muniz Mesquita, Felipe Gomes Pinheiro, Dahienne Ferreira Oliveira, Luis Felipe Silva Oliveira, Jose Hamilton Matheus Nascimento, Christina Maeda Takiya, Leonardo Maciel, Walter Araujo Zin
Summary: In a study on male BALB/c mice, exposure to C60 fullerene nanoparticles led to impaired lung mechanics and mitochondrial function, increased reactive oxygen species concentration, and decreased ATP production.
Article
Surgery
Carlo Amaral, Juliana Rodrigues da Costa, Matheus Oliveira Costa, Joao Paulo Verbicario, Leonardo Dias, Natale F. Gontijo-de-Amorim, Luiz Charles-de-Sa, Christina Maeda Takiya
Summary: The study confirmed that post-bariatric skin retains inflammatory characteristics for two years. Mast cells and M1 macrophages play a role in enhancing dermal extracellular matrix remodeling initiated during obesity, partially due to the presence of MMP-1 in the papillary dermis.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Rodrigo P. Silva-Aguiar, Diogo B. Peruchetti, Lucas S. Florentino, Christina M. Takiya, Maria-Paz Marzolo, Wagner B. Dias, Ana Acacia S. Pinheiro, Celso Caruso-Neves
Summary: Renal proximal tubule cells regulate protein reabsorption through the phosphoinositide-3-kinase/protein kinase B pathway. Physiologic albumin concentration and PI3K/AKT pathway form a positive feedback loop, expanding endocytic capacity and adapting to physiological fluctuations in albumin filtration, preventing urinary excretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Sergio Portovedo, Leonardo Vieira Neto, Paula Soares, Denise Pires de Carvalho, Christina Maeda Takiya, Leandro Miranda-Alves
Summary: This article discusses the aggressive behavior of nonfunctioning pituitary neuroendocrine tumors (NF-PitNETs) and emphasizes the need for a comprehensive definition of aggressive NF-PitNETs based on a multifactorial combination and emerging markers.
BRAIN TUMOR PATHOLOGY
(2022)
Article
Environmental Sciences
Flavia Muniz de Mesquita, Dahienne Ferreira de Oliveira, Dayene de Assis Fernandes Caldeira, Joao Paulo Cavalcante de Albuquerque, Leonardo Matta, Caroline Coelho de Faria, Itanna Isis Araujo de Souza, Christina Maeda Takiya, Rodrigo Soares Fortunato, Jose Hamilton Matheus Nascimento, Sandra Maria Feliciano de Oliveira Azevedo, Walter Araujo Zin, Leonardo Maciela
Summary: This study evaluated the effects of sublethal doses of microcystin-LR (MC-LR) on the lungs. Results showed that MC-LR had a detrimental effect on lung mitochondrial function and histology, and seemed to exert an oligomycin-like effect on lung mitochondria. This study provides new insights into the potential mechanisms of pulmonary damage resulting from oral MC-LR intoxication.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexsandro Tavares Figueiredo-Junior, Samuel Santos Valenca, Priscilla Vanessa Finotelli, Francisca de Fatima dos Anjos, Lycia de Brito-Gitirana, Christina Maeda Takiya, Manuella Lanzetti
Summary: The therapeutic use of annatto pigments has been evaluated in animal models, with beneficial effects attributed to the inhibition of oxidative stress. Bixin nanoparticles were prepared and found to prevent pulmonary inflammation and oxidative stress induced by cigarette smoke.
Article
Polymer Science
Ana Chor, Christina Maeda Takiya, Marcos Lopes Dias, Raquel Pires Goncalves, Tatiana Petithory, Jefferson Cypriano, Leonardo Rodrigues de Andrade, Marcos Farina, Karine Anselme
Summary: The study shows that electrospun PLGA membranes have good biocompatibility and can promote the healing of oral ulcers, mimicking the extracellular matrix and promoting the flow of nutrients for cells.
Article
Biochemistry & Molecular Biology
Leonardo Matta, Caroline Coelho de Faria, Dahienne F. De Oliveira, Iris Soares Andrade, Niedson Correia Lima-Junior, Bianca Martins Gregorio, Cristina Maeda Takiya, Andrea Claudia Freitas Ferreira, Jose Hamilton M. Nascimento, Denise Pires de Carvalho, Alexander Bartelt, Leonardo Maciel, Rodrigo Soares Fortunato
Summary: The study reveals that chronic exercise improves redox homeostasis and mitochondrial function in white adipose tissue, leading to enhanced antioxidant capacity. This hormetic remodeling of adipocyte redox balance is directly associated with the beneficial effects of exercise.
Article
Dentistry, Oral Surgery & Medicine
Mariana Alves Soares, Andre Luiz A. Costa, Natalia L. C. Silva, Aline Franca Martins, Daiane Oliveira Matias, Olga M. O. Araujo, RicardoTadeu Lopes, Christina Maeda Takiya, Ana Luisa P. Miranda, Leandro Miranda-Alves, Jorge L. M. Tributino
Summary: This study evaluated the effects of clozapine and olanzapine on periodontitis using an animal model. The results suggest that these drugs may increase the risk of periodontal disease, independent of systemic metabolic alterations.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Biology
Thais S. Rigoni, Natalia S. Vellozo, Kamila Guimaraes-Pinto, Mariela Cabral-Piccin, Laryssa Fabiano-Coelho, Thayane C. Matos-Silva, Alessandra A. Filardy, Christina M. Takiya, Marcela F. Lopes
Summary: Axl receptor participates in the efferocytosis of apoptotic lymphocytes during Trypanosoma cruzi infection, impacting macrophage-mediated immunity. Axl(-/-) macrophages enhance M1 responses induced by immune T cells and improve parasite infection and cardiac inflammation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Physiology
Carla M. Silva, Debora S. Ornellas, Felipe M. Ornellas, Raquel S. Santos, Sabrina V. Martini, Debora Ferreira, Caroline Muiler, Fernanda F. Cruz, Christina M. Takiya, Patricia R. M. Rocco, Marcelo M. Morales, Pedro L. Silva
Summary: This study evaluated the early effects of bone marrow-derived mononuclear cell (BMDMC) therapy on lung and kidney in experimental polymicrobial sepsis. The results showed that BMDMC therapy can reduce lung and kidney damage in a time-dependent manner. Therefore, BMDMCs may represent a potential therapy for sepsis induction.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Davi da Silva Barbirato, Mariana Fampa Fogacci, Taisa Coelho Guimaraes, Denise Pires de Carvalho, Janine Cardoso Rurr, Christina Maeda Takiya, Julio Scharfstein, Alvaro Augusto da Costa Leitao
Summary: This study evaluated the potential protective effect of Chromobacterium violaceum and violacein against periodontitis. The results confirmed that C. violaceum and violacein can reduce bone resorption caused by periodontitis, indicating their potential in preventing and limiting bone loss.
CLINICAL ORAL INVESTIGATIONS
(2023)
Meeting Abstract
Cell & Tissue Engineering
N. G. Blanco, N. M. Machado, L. L. Castro, M. A. Antunes, C. M. Takiya, M. R. O. Trugilho, L. R. Silva, A. F. P. Leme, R. R. Domingues, B. A. Pauletti, B. T. Miranda, J. D. Silva, P. L. Silva, P. R. M. Rocco, F. F. Cruz
Article
Mycology
Glauber R. de S. Araujo, Vinicius Alves, Pedro H. Martins-de-Souza, Allan J. Guimaraes, Leandro Honorato, Leonardo Nimrichter, Christina Maeda Takiya, Bruno Pontes, Susana Frases
Summary: Dexamethasone and methylprednisolone have significant effects on the biology of Cryptococcus neoformans, increasing fungal cell proliferation and surface electronegativity while decreasing capsule and secreted polysaccharide sizes. The use of these glucocorticoids may promote fungal spread to the lungs and alter interleukin secretion patterns.
FRONTIERS IN FUNGAL BIOLOGY
(2021)