Article
Obstetrics & Gynecology
Yanling Zhang, Xuanyu Chen, Sijia Chen, Cheng Wei, Baijia Li, Zilian Wang, Xiaolu Shen, Xiaona Lin
Summary: Intrauterine perfusion of G-CSF can increase endometrial thickness and improve cumulative pregnancy and live birth rates over time in patients with Asherman syndrome, while not preventing the recurrence of intrauterine adhesions.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Yuval Fouks, Adi Kidron, Inbar Lavie, Ziv Shapira, Yoni Cohen, Ishai Levin, Foad Azem, Aviad Cohen
Summary: This study evaluated the impact of Asherman syndrome (AS) on reproductive outcomes and time to achieve pregnancy in infertile women undergoing in vitro fertilization (IVF) treatment. The study found that moderate and severe AS had a detrimental effect on reproductive performance, and endometrial thickness was an important predictor for achieving live births.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Review
Medicine, General & Internal
Liuqing Yang, Ling Wang, Yun Chen, Xiaoshi Guo, Chenyun Miao, Ying Zhao, Lu Li, Qin Zhang
Summary: Comparing the efficacy and safety of hysteroscopic cold scissors and electrosurgery for treating moderate to severe intrauterine adhesion, it was found that hysteroscopic cold scissors were more efficient in preventing adhesion recurrence, reducing intraoperative blood loss, increasing menstrual flow, and shortening operation time.
Article
Obstetrics & Gynecology
Qiaoyun Zhou, Xiaoyu Shi, Sotirios Saravelos, Xiaowu Huang, Yuting Zhao, Rui Huang, Enlan Xia, Tin Chiu Li
Summary: The study investigated the use of auto-cross-linked hyaluronic acid gel for preventing intrauterine adhesion recurrence after hysteroscopic adhesiolysis. However, the application of this gel did not seem to improve the recurrence of intrauterine adhesions based on the study results.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Valentina D'Urso, Ferdinando Antonio Gulino, Giosue Giordano Incognito, Monia Cimino, Valentina Dilisi, Alessandra Di Stefano, Marianna Gulisano, Francesco Cannone, Stella Capriglione, Marco Palumbo
Summary: Hysteroscopy is a valuable tool for both diagnosis and treatment of uterine pathologies. Advancements in technology have made hysteroscopy less invasive and painful, allowing for more procedures to be done in an outpatient setting. This has led to cost savings and reduced need for anesthesia and cervical dilatation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Yuxue Zhang, Xiaohong Zhu, Tengfei Zhang, Yanling Zhang, Mengsi Zhang, Xiaona Lin
Summary: Menstrual pattern and gestational history may be main predictive factors for pregnancy loss in pregnant women who previously underwent hysteroscopic adhesiolysis. The extent of cavity involved and times of adhesive separation surgeries were associated with placenta accreta.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Angelo B. Hooker, Robert A. de Leeuw, Mark Hans Emanuel, Velja Mijatovic, Hans A. M. Brolmann, Judith A. F. Huirne
Summary: Intrauterine adhesions (IUAs) are a common reproductive system disease in women worldwide, leading to impaired reproductive function and outcomes. A precise understanding of the underlying causes, related mechanisms, and processes explaining the association with IUAs and impaired fertility is still lacking.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Pan Gu, Waixing Li, Xingping Zhao, Dabao Xu
Summary: In recent years, there has been an increasing number of studies on intrauterine adhesions, but the quality and progress of these studies lack comprehensive analysis. A bibliometric analysis of research articles published from 1950 to 2020 revealed that the majority of highly cited articles were published in the 2010s, with Chinese authors contributing the most to the top 100 list.
REPRODUCTIVE SCIENCES
(2022)
Review
Obstetrics & Gynecology
Salvatore Giovanni Vitale, Gaetano Riemma, Jose Carugno, Tirso Perez-Medina, Luis Alonso Pacheco, Sergio Haimovich, John Preston Parry, Attilio Di Spiezio Sardo, Pasquale De Franciscis
Summary: This study aims to assess the efficacy of mechanical strategies to avoid the recurrence of intrauterine adhesions, evaluate the impact on subsequent fertility after hysteroscopic adhesiolysis, and rank the available antiadhesive options.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Thuy T. Trinh, Kien D. Nguyen, Huong V. Pham, Thang V. Ho, Huong T. Nguyen, Sean O'Leary, Hien T. T. Le, Hanh M. Pham
Summary: This study compares three secondary prevention therapies in preventing recurrent intrauterine adhesions and increasing pregnancy rates in infertile women after hysteroscopic adhesiolysis. The combination of hyaluronic acid gel and intrauterine devices demonstrates better prevention of recurrent intrauterine adhesions and potential reduction in post-treatment American Fertility Society scores.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Review
Endocrinology & Metabolism
Xu Wenzhi, Xu Xin, Zhou Ping, Wu Hanglin, Lin Xiaona
Summary: This study aims to evaluate the obstetric and neonatal outcomes in women after hysteroscopic adhesiolysis. Through a meta-analysis of placenta-related disorders and other obstetric and neonatal outcomes, it was found that women after hysteroscopic adhesiolysis have a higher probability of placenta previa, while further research is needed for other outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Mary Kathryn Abel, Kaitlyn Wald, Marcelle I. Cedars, Martha Noel
Summary: This case series is the first to suggest a possible effect of endometrial dysfunction on fertility resumption following levonorgestrel IUD removal in nulliparous patients. It is possible that a small subset of patients may be at risk for Asherman syndrome after IUD use. Larger prospective trials are needed to explore this possible association.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Obstetrics & Gynecology
Zaraq Khan
Summary: Asherman syndrome is a condition characterized by pain, menstrual abnormalities, and infertility, resulting from intrauterine scar tissue after surgery. Hysteroscopy is the preferred method for diagnosis and treatment usually involves hysteroscopic-guided lysis of adhesions. Various methods are being explored to reduce the reformation of scar tissue after surgery, including the use of stem cells and platelet-rich plasma for regenerative therapy.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Jiaxin Dan, Yi Cao
Summary: Yangmo decoction can be an effective secondary treatment to prevent intrauterine re-adhesion, reducing the chances of re-adhesion and increasing the chances of successful pregnancies for women.
Article
Obstetrics & Gynecology
Lingling Yang, Ning Ma, Dongmei Song, Xiaowu Huang, Qiaoyun Zhou, Yan Guo, Enlan Xia, Xiaoyu Shi, Tin Chiu Li
Summary: The study aimed to evaluate whether estrogen therapy can reduce adhesion reformation after hysteroscopic adhesiolysis. The results showed that postoperative estrogen therapy did not reduce the incidence or severity of adhesion reformation, nor did it improve the menstrual pattern, regardless of the severity of the pre-existing intrauterine adhesion.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jennifer Sze Man Mak, Terence T. Lao, Maran Bo Wah Leung, Cathy Hoi Sze Chung, Jacqueline Pui Wah Chung, Lai Ping Cheung, Tin-Chiu Li
JOURNAL OF VIRAL HEPATITIS
(2020)
Article
Surgery
Elisabeth Jacomine Lier, Barend A. W. van den Beukel, Larsa Gawria, Philip J. van der Wees, Leontine van den Hil, Nicole D. Bouvy, Ying Cheong, Rudy-Leon de Wilde, Harry van Goor, Martijn W. J. Stommel, Richard P. G. ten Broek
Summary: The study developed a new clinical adhesion score (CLAS) to measure the overall clinical morbidity of adhesion-related complications in abdominal and pelvic surgery. Through Delphi study and pilot study, the CLAS includes 22 outcomes and 23 weight factors, correcting the likelihood of symptoms being related to adhesions through scoring.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Obstetrics & Gynecology
Linden Jane Stocker, Felino Ramon Cagampang, Shilong Lu, Tom Ladyman, Ying Chin Cheong
Summary: This study aimed to investigate the differences in sleep and activity parameters between women with poor reproductive outcomes and healthy, fertile women using subjective and objective measures. The results showed that women with poor reproductive outcomes had shorter sleep duration, but their sleep quality and quantity were not significantly different. Further research is needed to determine the causality of this association.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Medicine, General & Internal
Justin J. Chu, Adam J. Devall, Leanne E. Beeson, Pollyanna Hardy, Versha Cheed, Yongzhong Sun, Tracy E. Roberts, C. Okeke Ogwulu, Eleanor Williams, Laura L. Jones, Jenny H. La Fontaine Papadopoulos, Ruth Bender-Atik, Jane Brewin, Kim Hinshaw, Meenakshi Choudhary, Amna Ahmed, Joel Naftalin, Natalie Nunes, Abigail Oliver, Feras Izzat, Kalsang Bhatia, Ismail Hassan, Yadava Jeve, Judith Hamilton, Shilpa Deb, Cecilia Bottomley, Jackie Ross, Linda Watkins, Martyn Underwood, Ying Cheong, Chitra S. Kumar, Pratima Gupta, Rachel Small, Stewart Pringle, Frances Hodge, Anupama Shahid, Ioannis D. Gallos, Andrew W. Horne, Siobhan Quenby, Arri Coomarasamy
Article
Biochemistry & Molecular Biology
Alexandra J. Kermack, Susan J. Wellstead, Helena L. Fisk, Ying Cheong, Franchesca D. Houghton, Nicholas S. Macklon, Philip C. Calder
Summary: This study examined the effects of dietary intervention on the fatty acid composition of human follicular fluid, finding that a healthier diet was associated with a lower percentage of arachidonic acid in the follicular fluid. Women in the treatment group had significantly higher levels of EPA and DHA in their follicular fluid compared to the control group. Further research is needed to determine if this intervention can improve oocyte quality.
Article
Cell Biology
Mingpeng Zhao, Murong Xu, Hanhui Li, Odai Alqawasmeh, Jacqueline Pui Wah Chung, Tin Chiu Li, Tin-Lap Lee, Patrick Ming-Kuen Tang, David Yiu Leung Chan
Summary: The study utilized convolutional neural network (CNN) for segmenting day-one human embryos in time-lapse imaging, achieving high precision, reproducibility and comparable results with literature-reported values. The CNN system shows potential for practical application in improving efficiency in in vitro fertilization settings.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Obstetrics & Gynecology
Jian Li, Dongmei Song, Xiangdong Feng, Xiaowu Huang, Enlan Xia, Tinchiu Li
Summary: Chronic endometritis is associated with cervical incompetence in Chinese women with mid-trimester loss, but its presence and prior treatment with antibiotics did not significantly influence obstetric outcomes after laparoscopic cervical cerclage.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Review
Food Science & Technology
Xiaoyan Chen, Gene Chi Wai Man, Sze Wan Hung, Tao Zhang, Linda Wen Ying Fung, Chun Wai Cheung, Jacqueline Pui Wah Chung, Tin Chiu Li, Chi Chiu Wang
Summary: Endometriosis, a chronic disorder affecting many women, is currently difficult to treat effectively. However, recent studies have shown that green tea, with its bioactive component EGCG, may have potential therapeutic effects on endometriosis by inhibiting various molecular and cellular mechanisms.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Obstetrics & Gynecology
Xi Guo, Chi Chiu Wang, Jacqueline Pui Wah Chung, Tin Chiu Li, Xiaoyan Chen
Summary: This study investigated the relationship between angiogenic factors (VEGFA, PlGF, and IGF-1) and pregnancy outcomes. The results showed no significant difference in serum levels of these factors between pregnant and non-pregnant women. However, a positive correlation was found between IGF-1 concentration and beta-hCG level in pregnant women.
Review
Obstetrics & Gynecology
Odai Alqawasmeh, Ellis Fok, Howard Yim, Tin Li, Jacqueline Chung, David Chan
Summary: This article discusses the research on the microbiome of the male reproductive system and explores the potential impact of bacteria on male infertility. The potential benefits of probiotics as an alternative treatment for male infertility are highlighted, and the negative impact of certain bacteria on semen parameters as well as the protective effects of Lactobacillus are addressed.
Article
Biochemistry & Molecular Biology
Ziheng Zhou, Cong Tan, Matthew Hoi Kin Chau, Xiaosen Jiang, Ziyuan Ke, Xiaoyan Chen, Ye Cao, Yvonne K. Kwok, Matthew Bellgard, Tak Yeung Leung, Kwong Wai Choy, Zirui Dong
Summary: In this study, we curated and analyzed sequencing data from multiple developmental periods of humans and various model organisms, providing insights into gene expression, chromatin accessibility, and gene-gene regulation interactions. The findings contribute to our understanding of the roles of genes in tissue/organ development and disease mechanisms.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Obstetrics & Gynecology
Ying Li, Matthew Hoi Kin Chau, Ying Xin Zhang, Yilin Zhao, Shuwen Xue, Tin Chiu Li, Ye Cao, Zirui Dong, Kwong Wai Choy, Jacqueline Pui Wah Chung
Summary: This study reveals the significance of multiple-site low-pass genome sequencing (GS) in detecting genetic abnormalities, particularly heterogeneously distributed mosaicisms and homogeneously distributed mosaicisms in products of conception (POCs) of first-trimester miscarriage. The study found that multiple-site sampling combined with low-pass GS significantly increased the genetic diagnostic yield of first-trimester miscarriages and discovered the currently underappreciated heterogeneously distributed mosaicisms. This is important for understanding the implications of mosaic genetic abnormalities in early miscarriages.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Masja Toneman, Tjitske Groenveld, Pepijn Krielen, Angelo Hooker, Rudy de Wilde, Luz Angela Torres-de la Roche, Atillio Di Spiezio Sardo, Philippe Koninckx, Ying Cheong, Annemiek Nap, Harry van Goor, Pille Pargmae, Richard ten Broek
Summary: More than half of women in developed countries undergo surgery, which puts them at risk of adhesion-related complications. This study aimed to predict the risk of readmission and reoperation related to adhesions after gynecological surgery. Risk factors identified included younger age, malignancy as indication, intra-abdominal infection, previous radiotherapy, application of a mesh, and concomitant inflammatory bowel disease. Transvaginal surgery was associated with lower risk of adhesion-related complications compared to laparoscopic or open surgeries.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Jacqueline Pui Wah Chung, Olivia See Yung Chau, Tracy Sze Man Law, Karen Ng, Patricia Nga Ping Ip, Elaine Yee Lee Ng, Tracy Kwan Yi Tso, Daljit Singh Sahota, Tin Chiu Li
Summary: Ultrasound-guided manual vacuum aspiration (USG-MVA) is a feasible and effective outpatient treatment for early pregnancy loss. Compared to electric vacuum aspiration (EVA), USG-MVA can reduce the incidence of intrauterine adhesion.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
I Robertson, F. P. Chmiel, Y. Cheong
Summary: The study suggests that starting follicular tracking on Day 5 of stimulation may reduce the amount of monitoring needed in COS, with previous studies showing minimal monitoring protocols did not adversely impact outcomes.
HUMAN REPRODUCTION
(2021)