期刊
FERTILITY AND STERILITY
卷 89, 期 5, 页码 1039-1048出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2008.02.091
关键词
polycystic ovary syndrome; serine phosphorylation; hyperandrogenemia; insulin resistance; steroidogenesis
资金
- NICHD NIH HHS [HD41958] Funding Source: Medline
- NIDDK NIH HHS [T32 DK07161] Funding Source: Medline
Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting 4% - 8% of reproductive-aged women. The syndrome is characterized by hyperandrogenemia and disordered gonadotropin secretion and is often associated with insulin resistance. However, rather than being one disease entity caused by a single molecular defect, PCOS under its current diagnostic criteria most likely includes a number of distinct disease processes with similar clinical phenotypes but different pathophysiologic mechanisms. The serine phosphorylation hypothesis can potentially explain two major features of PCOS - hyperandrogenemia and insulin resistance. Further defining the molecular mechanisms regulating androgen biosynthesis and insulin action in PCOS patients will permit a better understanding of the syndrome and may lead to the generation of novel specific pharmacologic therapies.
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