Article
Health Care Sciences & Services
Mardia Lopez-Alarcon, Victor Saul Vital-Reyes, Eduardo Almeida-Gutierrez, Jorge Maldonado-Hernandez, Salvador Flores-Chavez, Juan Manuel Dominguez-Salgado, Jose Vite-Bautista, David Cruz-Martinez, Aly S. Barradas-Vazquez, Ricardo Z'Cruz-Lopez
Summary: Polycystic ovary syndrome (PCOS) is often accompanied by metabolic disturbances related to androgen excess and obesity. This study found that obesity is strongly associated with biomarkers related to glucose and liver metabolism, while free testosterone (FT) is only correlated with glucose and liver-related indicators. Women with obesity are at a higher risk of metabolic disorders compared to lean women, regardless of hyperandrogenemia.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Plant Sciences
Javad Heshmati, Ashraf Moini, Mahdi Sepidarkish, Mojgan Morvaridzadeh, Masoud Salehi, Andriko Palmowski, Maryam Farid Mojtahedi, Farzad Shidfar
Summary: The study found that using curcumin in PCOS patients can effectively improve blood sugar and androgen levels, and is safe and reliable. Longer trials with different dosages are needed to confirm these findings.
Article
Chemistry, Medicinal
Fateme Afandak, Naheed Aryaeian, Maryam Kashanian, Leila Janani, Tandis Namizadeh, Mohammad Yahya Karimi, Mehrnaz Morvaridi
Summary: The purpose of this study was to determine the effect of sumac powder on clinical symptoms and laboratory parameters in women with PCOS. The results showed that sumac powder can reduce inflammation, improve glycemic status and lipid profile in patients, but has no significant effect on anthropometric parameters and sex hormones.
PHYTOTHERAPY RESEARCH
(2023)
Article
Endocrinology & Metabolism
Qing Wen, Song Fang, Yanjing Liang, Yuting Tian, Yiding Chen, Jun Yuan, Qiu Chen
Summary: This study aimed to observe the effect of beinaglutide combined with metformin versus metformin alone on weight loss and metabolic profiles in obese patients with polycystic ovary syndrome. The results showed that the combined treatment was more effective in reducing weight, body mass index, waist circumference, and waist to height ratio compared to metformin monotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Nutrition & Dietetics
Nahla Al-Bayyari, Hayder Al-Domi, Faheem Zayed, Ra'ed Hailat, Arieanna Eaton
Summary: The study demonstrated that weekly treatment with 50,000 IU of vitamin D-3 can improve 25(OH)D levels and decrease hirsutism scores and androgen levels in overweight women with PCOS. These results may lead to increased fertility and better reproductive health for these patients.
CLINICAL NUTRITION
(2021)
Article
Chemistry, Medicinal
Masoome Jabarpour, Ashraf Aleyasin, Maryam Shabani Nashtaei, Fardin Amidi
Summary: This study investigated the effect of astaxanthin on infertile polycystic ovarian syndrome (PCOS) patients. The results showed that astaxanthin improved insulin metabolism, lipid profile parameters, and oxidative stress levels in these patients. The study suggests that astaxanthin may be an effective and safe supplement.
PHYTOTHERAPY RESEARCH
(2023)
Article
Obstetrics & Gynecology
Daniel A. Dumesic, Chloe Winnett, Gwyneth Lu, Tristan R. Grogan, David H. Abbott, Rajanigandha Naik, Gregorio D. Chazenbalk
Summary: This study aimed to examine the effects of low-dose flutamide administration on abdominal fat deposition, lipid accumulation in adipocytes derived from stem cells, and glucose-lipid metabolism in normal-weight women with PCOS. The results showed that flutamide reduced abdominal fat deposition, attenuated lipid accumulation in adipocytes, and altered glucose-lipid homeostasis in PCOS women.
FERTILITY AND STERILITY
(2023)
Article
Chemistry, Medicinal
Fatemeh Pourteymour Fard Tabrizi, Mahdieh Abbasalizad Farhangi, Maryam Vaezi, Salar Hemmati
Summary: The study demonstrates that supplementation of thylakoid-rich spinach extract combined with a hypocaloric diet can improve lipid metabolism in obese women with PCOS, increasing levels of omentin-1 and decreasing fat mass and serum levels of neopterin and chemerin.
PHYTOTHERAPY RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Yunmei Guo, Ying Liu, Xin Yan, Rui Ding, LianHong Wang
Summary: This study confirms that a transtheoretical model based on multidimensional life management has positive effects on healthy behavior, self-efficacy, the number of unplanned outpatient admissions, and anthropometrics in patients with PCOS.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Immunology
Sima Vaez, Kazem Parivr, Fardin Amidi, Nasim Hayati Rudbari, Ashraf Moini, Naser Amini
Summary: Quercetin intake has positive effects on PCOS patients, improving oocyte and embryo grade, increasing pregnancy rate, and reducing inflammation and LH parameters.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Firoozeh Tarkesh, Bahia Namavar Jahromi, Najmeh Hejazi, Golazin Hoseini
Summary: This study aimed to assess the effect of vitamin K2 on depression status in patients with PCOS. The results indicated that the administration of Menaquinone-7 significantly improved depression status.
Article
Biochemistry & Molecular Biology
Shabnam Shahmoradi, Hossein Chiti, Mahdi Tavakolizadeh, Robabeh Hatami, Nima Motamed, Marjan Ghaemi
Summary: This study aimed to evaluate the effects of magnesium supplements on anthropometric, clinical, and metabolic parameters in women with polycystic ovary syndrome (PCOS). The results showed a significant reduction in serum insulin levels and insulin resistance in the group receiving magnesium supplements. Furthermore, magnesium supplements led to a decrease in total cholesterol, low-density lipoprotein, and fasting blood sugar, as well as an increase in high-density lipoprotein levels. However, there were no significant differences in anthropometric parameters or blood pressure between the two groups before and after intervention. Overall, the use of magnesium supplements can improve the metabolic status of PCOS patients by improving insulin resistance and modulating lipid profiles.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jia Zhu, Anders U. Eliasen, Izzuddin M. Aris, Sara E. Stinson, Jens-Christian Holm, Torben Hansen, Marie-France Hivert, Klaus Bonnelykke, Rany M. Salem, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS are associated with alterations in metabolic, growth, and developmental traits in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Public, Environmental & Occupational Health
M. Makenzius, C. Obern, T. Tyden, M. Larsson, K. Gemzell-Danielsson, I Sundstrom-Poromaa, M. Ekstrand Ragnar
Summary: This study investigates women's decision-making on induced abortion in Sweden. The results show that half of the women find the decision relatively easy, while the other half finds it difficult. Reasons for choosing abortion include economic difficulties, early stage in the relationship, desire to work or study first, uncertainty about the relationship, and being too young. Factors predicting difficulty in decision-making include partner's hesitance, being born outside the Nordic countries, discussing the decision with someone, age over 30, the Covid-19 pandemic, and the desire to have children in the future.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2023)
Article
Engineering, Electrical & Electronic
Alexander Grabowski, Johan S. Gustavsson, Anders Larsson
Summary: A model based on two carrier rate equations is used to study the impact of carrier transport and capture on the modulation response of high-speed VCSELs. The effective capture time is found to have a significant effect, with shorter times leading to horizontal eye closure and longer times leading to vertical eye closure. The effective capture time also affects the output power vs current characteristics and various carrier parameters.
IEEE JOURNAL OF QUANTUM ELECTRONICS
(2023)
Review
Medicine, General & Internal
Linnea Malmgren, Carl Oberg, Emil den Bakker, Felicia Leion, Joanna Siodmiak, Anna Akesson, Veronica Lindstrom, Erik Herou, Alain Dardashti, Liana Xhakollari, Gabriel Grubb, Helena Strevens, Magnus Abrahamson, Johanna Helmersson-Karlqvist, Martin Magnusson, Jonas Bjork, Ulf Nyman, Johan Arnlov, Peter Ridefelt, Torbjorn Akerfeldt, Magnus Hansson, Anna Sjostrom, Johan Martensson, Yoshihisa Itoh, David Grubb, Olav Tenstad, Lars-Olov Hansson, Isleifur Olafsson, Araceli Jarquin Campos, Martin Risch, Lorenz Risch, Anders Larsson, Gunnar Nordin, Hans Pottel, Anders Christensson, Henrik Bjursten, Arend Bokenkamp, Anders Grubb
Summary: Estimation of kidney function is commonly done using endogenous GFR-markers creatinine or cystatin C. The recommendation in 2010 to use both markers in parallel led to the identification of selective glomerular hypofiltration syndromes, which are associated with increased mortality and morbidity. These syndromes, characterized by a selective reduction in the glomerular filtration of certain molecules, such as cystatin C, have proteomic changes that promote the development of atherosclerosis and may require new treatment modalities.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sofia Persson, Kumari A. Ubhayasekera, Jonas Bergquist, Sahruh Turkmen, Inger Sundstroem Poromaa, Evangelia Elenis
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and hyperandrogenism can cause psychological morbidity and impaired quality of life. This study aimed to investigate whether hyperandrogenism persists into midlife and its impact on quality of life.
Article
Obstetrics & Gynecology
Anton Sandstrom, Marie Bixo, Torbjoern Backstrom, Anna Moller, Sahruh Turkmen
Summary: A study found that women with painful endometriosis have lower sensitivity to GABA(A) receptor stimulation compared to healthy controls. This indicates altered GABA(A) receptor function in the context of endometriosis-related pain.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Clinical Neurology
Inger Sundstrom-Poromaa, Erika Comasco
Summary: Premenstrual symptoms are common among women of reproductive age, with 5% experiencing premenstrual dysphoric disorder (PMDD) during the luteal phase. Selective serotonin reuptake inhibitors are effective for many patients, but not all. Recent research shows that treatment with a selective progesterone receptor modulator (SPRM) significantly reduces the severity of PMDD symptoms, with minimal side effects.
Article
Engineering, Electrical & Electronic
Muralikrishnan Srinivasan, Jinxiang Song, Alexander Grabowski, Krzysztof Szczerba, Holger K. Iversen, Mikkel N. Schmidt, Darko Zibar, Jochen Schroder, Anders Larsson, Christian Hager, Henk Wymeersch
Summary: Optical interconnects (OIs) based on vertical-cavity surface-emitting lasers (VCSELs) are widely used in data centers, supercomputers, and vehicles for low-cost, high-rate connectivity. Machine learning (ML) techniques, including deep neural networks, have been applied to improve the performance of VCSEL-based OIs. End-to-end (E2E) autoencoder approaches can optimize the entire parameterized transmitters and receivers for ultimate performance. This tutorial paper provides an overview of ML for VCSEL-based OIs, focusing on E2E approaches and addressing the unique challenges of VCSELs.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Medicine, General & Internal
Theodora Kunovac Kallak, Alice Zancanaro, Katja Junus, Anna-Karin Wikstroem, Inger Sundstroem Poromaa, Susanne Lager
Summary: This is a cross-sectional study aiming to investigate the associations between maternal weight, diet, exercise, pregnancy weight gain, and pregnancy outcome. Pregnant women at Uppsala University Hospital, Sweden were included in the study. Questionnaires regarding their dietary and exercise habits were collected, along with samples of maternal adipose tissues and placental tissue for analysis. The results will be published in peer-reviewed, international scientific journals.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Veterinary Sciences
Anna K. Selin, Inger Lilliehook, Johannes Forkman, Anders Larsson, Lena Pelander, Emma M. Strage
Summary: This study investigates the biological variation of specific gravity, osmolality, creatinine, urea, protein, glucose, chloride, sodium, potassium, calcium, and phosphate in urine from healthy pet dogs. For most urine analytes, inter-individual and intra-individual variation were low, indicating that population-based reference intervals are appropriate. However, caution should be exercised when using population-based reference intervals for some analytes.
VETERINARY CLINICAL PATHOLOGY
(2023)
Article
Psychiatry
Louise Stiernman, Manon Dubol, Erika Comasco, Inger Sundstrom-Poromaa, Carl-Johan Boraxbekk, Maja Johansson, Marie Bixo
Summary: Premenstrual dysphoric disorder (PMDD) is associated with altered sensitivity to ALLO and ISO, neurosteroids that affect GABA(A) activity. ISO has been shown to alleviate PMDD symptoms. In this study, PMDD subjects exhibited increased brain activity during emotion processing in the late-luteal phase. The relationship between ISO/ALLO ratio and brain activity differed between PMDD subjects and controls in key emotion processing regions.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Esmeralda Hidalgo-Lopez, Jonas Engman, Inger Sundstrom Poromaa, Malin Gingnell, Belinda Pletzer
Summary: This study investigated the effects of hormonal contraceptives on mood side effects and found that they caused increased connectivity within the default mode network and decreased connectivity within the executive control network. Mood lability was the most consistent and prominent side effect.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Critical Care Medicine
Anna Bandert, Miklos Lipcsey, Robert Frithiof, Anders Larsson, David Smekal
Summary: This study aimed to investigate the impact of different catheter placements on drug clearance during continuous renal replacement therapy (CRRT) using central venous catheter and central venous dialysis catheter. The results showed that drug clearance was higher when both catheter tips were close together in the same external jugular vein, compared to when catheters were placed in different vessels. This suggests that close catheter placement may lead to unreliable drug concentration during CRRT.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Article
Obstetrics & Gynecology
Jenny Niemeyer Hultstrand, Elin Tornroos, Tanja Tyden, Margareta Larsson, Marlene Makenzius, Kristina Gemzell-Danielsson, Inger Sundstrom-Poromaa, Maria Ekstrand Ragnar
Summary: Despite efforts to promote women's sexual and reproductive health in Sweden, many women seeking abortion still have unmet contraceptive needs. This study investigated the contraceptive use among these women, revealing a high rate of non-use and discontinuation of contraception. Limited fertility awareness and negative experiences with contraceptives were identified as factors contributing to the unmet need.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Biochemistry & Molecular Biology
Belinda J. Dunning, Arno R. Bourgonje, Marian L. C. Bulthuis, Jan Alexander, Jan O. Aaseth, Anders Larsson, Harry van Goor, Urban Alehagen
Summary: This study aimed to evaluate the effect of supplementation with selenium and coenzyme Q10 on serum free thiols and to study associations with the risk of cardiovascular mortality in elderly community-dwelling individuals. The results showed that supplementation with selenium and coenzyme Q10 significantly improved serum free thiol levels and reduced the risk of cardiovascular mortality in elderly individuals.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
