期刊
FEMS YEAST RESEARCH
卷 15, 期 1, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1111/1567-1364.12187
关键词
high-value metabolites; synthetic biology; Saccharomyces cerevisiae
资金
- Tianjin Key Technology R&D Program of Tianjin Municipal Science and Technology Commission [12ZCZDSY14700]
- National High Technology Research and Development Program [2012AA02A704]
- National Basic Research Program of China [2011CBA00800]
- National Natural Science Foundation of China [81202864]
- Hundred Talent Program of the Chinese Academy of Sciences
Traditionally, high-value metabolites have been produced through direct extraction from natural biological sources which are inefficient, given the low abundance of these compounds. On the other hand, these high-value metabolites are usually difficult to be synthesized chemically, due to their complex structures. In the last few years, the discovery of genes involved in the synthetic pathways of these metabolites, combined with advances in synthetic biology tools, has allowed the construction of increasing numbers of yeast cell factories for production of these metabolites from renewable biomass. This review summarizes recent advances in synthetic biology in terms of the use of yeasts as microbial hosts for the identification of the pathways involved in the synthesis, as well as for the production of high-value metabolites.
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