期刊
FEMS YEAST RESEARCH
卷 14, 期 1, 页码 33-39出版社
OXFORD UNIV PRESS
DOI: 10.1111/1567-1364.12070
关键词
hormesis; ROS signalling; oxidative damage; caloric restriction; longevity; ageing
资金
- Fundacao para a Ciencia e Tecnologia (FCT)
- COMPETE/QREN/EU [PTDC/BIA-MIC/114116/2009]
- Roswell Park Alliance Foundation
- National Cancer Institute [P30CA016056]
- Fundação para a Ciência e a Tecnologia [PTDC/BIA-MIC/114116/2009] Funding Source: FCT
For more than 50years, the free radical theory served as the paradigm guiding most investigations of ageing. However, recent studies in a variety of organisms have identified conceptual and practical limitations to this theory. Some of these limitations are related to the recent discovery that caloric restriction and other experimental manipulations promote longevity by inducing hormesis effects in association with increased reactive oxygen species (ROS). The beneficial role of ROS in lifespan extension is consistent with the essential role of these molecules in cell signalling. However, the identity of specific forms of ROS that promote longevity remains unclear. In this article, we argue that in several model systems, hydrogen peroxide plays a crucial role in the induction of hormesis.
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