期刊
FEMS MICROBIOLOGY LETTERS
卷 314, 期 2, 页码 107-111出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2010.02153.x
关键词
iron chelator; 3-hydroxypyridin-4-one; hexadentate; antimicrobial activity
类别
资金
- National Natural Science Foundation of China [20972138]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
- State Education Ministry of China and Qianjiang Scholars Fund, Zhejiang Province [2010R10051]
The antimicrobial activity of the iron(III)-selective 3-hydroxypyridin-4-one chelators, CP251(1) and CP252(2), was evaluated in comparison with that of diethylenetriamine-penta acetic acid (3). CP251 was found to exhibit an inhibitory effect on the growth of both Gram-positive and Gram-negative bacteria. CP251 may find application in the treatment of external infections such as those associated with wounds.
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