Review
Microbiology
Nonna I. Nadolinskaia, Maria S. Kotliarova, Anna V. Goncharenko
Summary: Tuberculosis is a major infectious disease with high mortality rates in certain regions, and the existing BCG vaccine is ineffective for long-term protection. The exact immune factors crucial for preventing Mycobacterium tuberculosis infection and progression of the disease are still unknown after decades of research. Developing a new vaccine to replace BCG and provide better protection is a challenging task due to the intracellular lifestyle of the pathogen and its manipulation of host immunity. This review discusses promising strategies and possibilities for creating a new vaccine, including supplementing mycobacterial strains with immunodominant antigens and genetic engineering to alter the bacterium-host cell interaction.
Article
Immunology
Nicola Campbell, Ayesha J. Verrall, Simon Donkor, Jayne S. Sutherland, Philip C. Hill
Summary: The study found that BCG vaccine protection against Mycobacterium tuberculosis infection decreased with increasing exposure to the pathogen in the Gambia, with the strongest protection observed in the lowest exposure tertile. These findings are consistent with previous results from Indonesia.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Odir Antonio Dellagostin, Sibele Borsuk, Thais Larre Oliveira, Fabiana Kommling Seixas
Summary: This review explores the strategies for developing and using auxotrophic BCG strains, which can serve as a model for studying M. tuberculosis and potentially provide a stable and effective alternative to BCG, as well as a vector for recombinant live vaccines.
Article
Infectious Diseases
Birger Trollfors, Vignir Sigurdsson, Anna Dahlgren-Aronsson
Summary: The study aimed to determine the prevalence of latent tuberculosis infection in immigrant children and adolescents in Sweden, as well as to estimate the effectiveness of Bacillus Calmette-Guerin (BCG) vaccine. Results showed that LTBI was common among immigrant children and BCG vaccine had a significant protective effect against LTBI.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Patricio Retamal, Pedro abalos, Raul Alegria-Moran, Nicolas Valdivieso, Martin Vordermeier, Gareth Jones, Karina Saadi, Carolina Perez Watt, Constanza Salinas, Constanza avila, Valentina Padilla, Belen Benavides, Romina Orellana
Summary: The study evaluated the efficacy of vaccinating dairy cattle with the BCG Russia strain in a high prevalence area of Chile for tuberculosis prevention. Results showed a significant reduction in infection rates and beneficial effects on milk production parameters.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Biotechnology & Applied Microbiology
Mengjin Qu, Xiangmei Zhou, Hao Li
Summary: BCG is the only licensed vaccine against tuberculosis, but its efficacy is variable, calling for the urgent development of a more effective TB vaccine. Strategies like intravenous administration and revaccination have shown promising results, emphasizing the need to revisit BCG vaccination strategies for improving TB prevention.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Pediatrics
Ewa Bernatowska, Malgorzata Pac, Edyta Heropolitanska-Pliszka, Barbara Pietrucha, Nel Dabrowska-Leonik, Malgorzata Skomska-Pawliszak, Katarzyna Bernat-Sitarz, Katarzyna Krzysztopa-Grzybowska, Beata Wolska-Kusnierz, Nadia Bohynikova, Ewa Augustynowicz, Ewa Augustynowicz-Kopec, Maria Korzeniewska-Kosela, Anna Wieteska-Klimczak, Janusz Ksiazyk, Teresa Jackowska, Mirjam Van den Burg, Jean-Laurent Casanova, Capucine Picard, Bozena Mikoluc
Summary: This study aimed to evaluate the complications of BCG vaccination in patients with Inborn Errors of Immunity (IEI). The results showed that the BCG Moreau vaccine had a superior safety profile compared to other substrains, with significantly fewer cases of disseminated BCG infections (BCGosis) and deaths caused by BCG infection in patients with Severe Combined Immunodeficiency (SCID) and Mendelian susceptibility to mycobacterial diseases (MSMD). The study also confirmed the protecting role of NK cells in preventing BCGosis.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Monalisa Martins Trentini, Alex Issamu Kanno, Dunia Rodriguez, Lazaro Moreira Marques-Neto, Silas Fernandes Eto, Ana Marisa Chudzinki-Tavassi, Luciana Cezar de Cerqueira Leite
Summary: This study evaluated the immunotherapeutic potential of recombinant BCG expressing LTAK63 (rBCG-LTAK63) against tuberculosis (TB). The results showed that mice treated with rBCG-LTAK63 had reduced bacillary load and lung inflammation compared to those treated with BCG, especially when administered intravenously. Furthermore, intravenous administration of rBCG-LTAK63 induced a higher inflammatory response of CD4(+) T cells in the spleen and an increased presence of CD4(+)IL-10(+) and regulatory T cells in the lungs. When combined with short-term chemotherapy, subcutaneous or intravenous administration of rBCG-LTAK63 decreased the bacillary load, increased the anti-inflammatory response, and reduced tissue inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Shivani Singh, Noemi Alejandra Saavedra-Avila, Sangeeta Tiwari, Steven A. Porcelli
Summary: BCG has been used as a tuberculosis vaccine since 1921 and is currently the only approved vaccine for this infection. Recent research has shown that BCG not only protects against disease progression, but also against initial infection, highlighting the importance of understanding the immune mechanisms involved. This review explores the components of immunity enhanced by BCG vaccination, and the efforts to improve its efficacy through recombinant strains and non-traditional routes. The ability of BCG to confer trained immunity in a non-specific manner is also discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
C. Kanipe, P. M. Boggiatto, E. J. Putz, M. V. Palmer
Summary: The study found that BCG vaccination can reduce the number and size of tuberculosis lesions, decrease necrosis, and increase fibrosis in low-grade lesions. Vaccination has minimal impact on mineralization and density of multinucleated giant cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Allergy
Yaqi Wu, Maopeng Tian, Yandi Zhang, Huiming Peng, Qing Lei, Xuefeng Yuan, Shijie Liu, Yulong Xiong, Xiaosong Lin, Banga Ndzouboukou Jo-Lewis, Zongjie Yao, Hui Fu, Xionglin Fan
Summary: The study identified that the insufficient efficacy of the BCG vaccine is due to the important autophagy-inhibition gene BCG_2432c, which blocks the autophagosome-lysosome pathway of antigen presentation. The mutant strain Delta BCG_2432c showed stronger protection against intranasal TB in vaccinated mice, likely attributed to its ability to trigger intracellular ROS-mediated complete autophagic flux in infected cells, resulting in higher antigen presentation.
Article
Immunology
Paulo R. Z. Antas, Andreon S. M. da Silva, Lawrence H. P. Albuquerque, Matheus R. Almeida, Evelyn N. G. S. Pereira, Luiz R. R. Castello-Branco, Carlos G. G. de Ponte
Summary: This study investigates the protective role of BCG in inducing surface biomarkers and analyzes the expression levels of TLR4, B7-1, Dectin-1, EP2, and TIM-3 in monocytes. The results uncover the regulatory effect of BCG on these biomarkers and emphasize the importance of understanding human innate immune responses for vaccine development and infectious disease treatment.
Article
Immunology
Rania Bouzeyen, Saurabh Chugh, Tannu Priya Gosain, Mohamed-Ridha Barbouche, Meriam Haoues, Kanury V. S. Rao, Makram Essafi, Ramandeep Singh
Summary: This study demonstrates that enhancing the protective efficacy of M. bovis BCG in mice and guinea pig infection models by inhibiting Akt inhibitor MK-2206 promotes FOXO3 activation and BCG-induced immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Wei Huang, Zhixiong Fang, Si Luo, Sha Lin, Lei Xu, Bo Yan, Yang Yang, Xuhui Liu, Lu Xia, Xiaoyong Fan, Shuihua Lu
Summary: This study aimed to verify the protective effect of BCG vaccination against Mycobacterium tuberculosis (MTB) infection in first-year college students. The results showed a significant association between BCG vaccination and protection against latent tuberculosis infection (LTBI), with better protection observed in rural areas compared to urban areas.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Wei Lv, Pu He, Yanlin Ma, Daquan Tan, Fei Li, Tao Xie, Jiangyuan Han, Juan Wang, Youjun Mi, Hongxia Niu, Bingdong Zhu
Summary: Optimizing the boosting schedule of subunit vaccines can enhance long-term protection against tuberculosis. Boosting with MH twice or immunizing with EC thrice after BCG priming can improve immune memory and increase protection against bacteria.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Hongsheng Wang, Weijing Liu, Yali Jin, Meiwen Yu, Haiqin Jiang, Toshiki Tamura, Yumi Maeda, Masahiko Makino
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2015)
Article
Immunology
Yumiko Tsukamoto, Yumi Maeda, Toshiki Tamura, Tetsu Mukai, Satoshi Mitarai, Saburo Yamamoto, Masahiko Makino
Article
Infectious Diseases
Yuji Miyamoto, Tetsu Mukai, Masanori Matsuoka, Masanori Kai, Yumi Maeda, Masahiko Makino
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Article
Immunology
Malcolm S. Duthie, Maria T. Pena, Gigi J. Ebenezer, Thomas P. Gillis, Rahul Sharma, Kelly Cunningham, Michael Polydefkis, Yumi Maeda, Masahiko Makino, Richard W. Truman, Steven G. Reed
Article
Infectious Diseases
Yumiko Tsukamoto, Yumi Maeda, Toshiki Tamura, Tetsu Mukai, Masahiko Makino
BMC INFECTIOUS DISEASES
(2014)
Article
Immunology
Tetsu Mukai, Yumiko Tsukamoto, Yumi Maeda, Toshiki Tamura, Masahiko Makino
CLINICAL AND VACCINE IMMUNOLOGY
(2014)
Article
Infectious Diseases
Yumiko Tsukamoto, Yumi Maeda, Masahiko Makino
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2014)
Article
Immunology
Malcolm S. Duthie, Rhea N. Coler, John D. Laurance, Lucas H. Sampaio, Regiane M. Oliveira, Ana Lucia M. Sousa, Mariane M. A. Stefani, Yumi Maeda, Masanori Matsuoka, Masahiko Makino, Steven G. Reed
INFECTION AND IMMUNITY
(2014)
Article
Infectious Diseases
M. Kai, N. Nakata, M. Matsuoka, T. Sekizuka, M. Kuroda, M. Makino
INFECTION GENETICS AND EVOLUTION
(2013)
Review
Infectious Diseases
Kazue Nakanaga, Rie Roselyne Yotsu, Yoshihiko Hoshino, Koichi Suzuki, Masahiko Makino, Norihisa Ishii
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2013)
Article
Infectious Diseases
Yoshiro Yamashita, Yoshihiko Hoshino, Mayuko Oka, Sokichi Matsumoto, Haruyuki Ariga, Hideaki Nagai, Masahiko Makino, Koya Ariyoshi, Yasuko Tsunetsugu-Yokota
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2013)
Article
Microbiology
Kazue Nakanaga, Tsuyoshi Sekizuka, Hanako Fukano, Yumi Sakakibara, Fumihiko Takeuchi, Shinpei Wada, Norihisa Ishii, Masahiko Makino, Makoto Kuroda, Yoshihiko Hoshino
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Article
Multidisciplinary Sciences
Tsuyoshi Sekizuka, Masanori Kai, Kazue Nakanaga, Noboru Nakata, Yuko Kazumi, Shinji Maeda, Masahiko Makino, Yoshihiko Hoshino, Makoto Kuroda
Article
Immunology
Yuji Miyamoto, Yumiko Tsukamoto, Yumi Maeda, Toshiki Tamura, Tetsu Mukai, Manabu Ato, Masahiko Makino
Summary: Researchers developed an antibiotic-resistant gene rBCG called BCG-PEST but found it unsuitable for human use, so they created an antibiotic-resistant gene-free rBCG named BCG-LeuPH. BCG-LeuPH successfully activated human naive T cells and inhibited aerosol-challenged MTB in mice, suggesting a potential replacement for antibiotic-resistant gene in selecting vaccine candidates for rBCG.
Correction
Immunology
Malcolm S. Duthie, Maria T. Pena, Gigi J. Ebenezer, Thomas P. Gillis, Rahul Sharma, Kelly Cunningham, Michael Polydefkis, Yumi Maeda, Masahiko Makino, Richard W. Truman, Steven G. Reed